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| 1 | The role of gut microbiota(commensal bacteria)and the mucosal barrier in the pathogenesis of inflammatory and autoimmune diseases and cancer:contribution of germ-free and gnotobiotic animal models of human diseases显示文摘Metagenomic approaches are currently being used to decipher the genome of the microbiota(microbiome),and,in parallel,functional studies are being performed to analyze the effects of the microbiota on the host.Gnotobiological methods are an indispensable tool for studying the consequences of bacterial colonization.Animals used as models of human diseases can be maintained in sterile conditions(isolators used for germ-free rearing)and specifically colonized with defined microbes(including non-cultivable commensal bacteria).The effects of the germ-free state or the effects of colonization on disease initiation and maintenance can be observed in these models.Using this approach we demonstrated direct involvement of components of the microbiota in chronic intestinal inflammation and development of colonic neoplasia(i.e.,using models of human inflammatory bowel disease and colorectal carcinoma).In contrast,a protective effect of microbiota colonization was demonstrated for the development of autoimmune diabetes in non-obese diabetic(NOD)mice.Interestingly,the development of atherosclerosis in germ-free apolipoprotein E(ApoE)-deficient mice fed by a standard low-cholesterol diet is accelerated compared with conventionally reared animals.Mucosal induction of tolerance to allergen Bet v1 was not influenced by the presence or absence of microbiota.Identification of components of the microbiota and elucidation of the molecular mechanisms of their action in inducing pathological changes or exerting beneficial,disease-protective activities could aid in our ability to influence the composition of the microbiota and to find bacterial strains and components(e.g.,probiotics and prebiotics)whose administration may aid in disease prevention and treatment. | Helena Tlaskalova-Hogenova Renata Stepankova Hana Kozakova Tomas Hudcovic Luca Vannucci Ludmila Tuckova Pavel Rossmann TomasHrncır Miloslav Kverka Zuzana Zakostelska Klara Klimesova Jaroslava Pribylova Jirina Bartova Daniel Sanchez Petra Fundova Dana Borovska Dagmar Sru˚tkova Zdenek Zıdek Martin Schwarzer Pavel Drastich David P Funda | 2011 | Cellular & Molecular Immunology2011，8，2： | 47 |
| 2 | Optimistic self-beliefs:Assessment of general perceived self-efficacy in thirteen euhures显示文摘 | Schwarzer R Aristi B | 1997 | World Psychology1997，3，12： | 1 |
| 3 | Measuring optimistic self-beliefs:A Chinese adaptation of the general self-efficacy scale显示文摘 | ZHANG J X SCHWARZER R | 1995 | Psychologia1995，38，3： | 1 |
| 4 | Measuring optimistic self-beliefs:a Chinese adaptation of the general self-efficacy scale显示文摘 | Zhang JX Schwarzer R | 1995 | Psychologia1995，38，3： | 1 |
| 5 | Optimistic self-beliefs assessment of gen- eral perceived self-efficacy in thirteen cultures显示文摘 | Schwarzer R Aristi B | 1997 | Word Psychology1997，3，12： | 1 |
| 6 | Optimistic self-beliefs: assessment of general perceived self-efficacy in thirteen cultures显示文摘 | Schwarzer R Aristi B | 1997 | World Psy- chol1997，3，12： | 1 |
| 7 | Measuring optimistic self - beliefs: A Chinese adaptation of the General Self - efficacy Scale 显示文摘 | ZHANG J X SCHWARZER R | 1995 | Psychologia1995，38，3： | 1 |
| 8 | The re1 ative con- tributions of the disc and zygapophyseal joint in chronic low back pain 显示文摘 | Schwarzer AC Aprill CN Derby R | 1994 | Spine1994，19，7： | 1 |
| 9 | Measuring Optimistic Self-Beliefs: A Chinese Adaptation of the General Self-Efficacy Scale显示文摘 | Zhang J X Schwarzer R | 1995 | Psychologia1995，38，3： | 1 |
| 10 | Notch is an essential up- stream regulator of NF-κB and is relevant for survival of Hodgkin and Reed-Sternberg cells 显示文摘 | Schwarzer R Dorken B Jundt F | 2012 | Leukemia2012，26，4： | 1 |
| 11 | Changes in finding benefit after cancer surgery and the prediction of well - being one year later显示文摘 | Schwarzer R Luszczynska A Boehmer S | 2006 | Soc Sei Med2006，63，6： | 1 |
| 12 | Measuring optimistic self-beliefs: A Chinese adaptation of the general sell'efficacy scale 显示文摘 | ZHANG JX SCHWARZER R | 1995 | Psychologia1995，38，3： | 1 |
| 13 | Optimistic Self-beliefs:Assessment of General Perceived Self-efficacy in Thirteen Cultures显示文摘 | Schwarzer R Aristi B | 1997 | World Psychology1997，3，12： | 1 |
| 14 | Quantitative Analyses of SMN1 and SMN2 Based on Real-Time Light Cycler PCR: Fast and Highly Reliable Carrier Testing and Prediction of Severity of Spinal Muscular Atrophy显示文摘 | Feldkotter M Schwarzer V Wirth R | 2002 | Am J Hum Genet2002，70，2： | 1 |
| 15 | Measuring Optimistic Self-beliefs: A Chinese Adaptation of the General Self-efficacy Scale 显示文摘 | Zhang J X Schwarzer R | 1995 | Psycho Logia1995，38，3： | 1 |
| 16 | Optimistic self-beliefs: assess- ment of general perceived self-efficacy in thirteen cul- tures显示文摘 | Schwarzer R Aristi B | 1997 | Word Psychology1997，3，12： | 1 |
| 17 | Theassessment of :Comparison of Chinese, Indonesian, Japanese, and Korean version of the Genera self--EffieaeySeale 显示文摘 | Schwarzer R | | Psyehologia0，40，： | 1 |
| 18 | Aestivation in Pieris brassicae (Lepidoptera:Pieridae):Implications for parasitism显示文摘 | SPIETH H R SCHWARZER E | 2001 | Eur J Entomol2001，98，2： | 1 |
| 19 | Measuring optimistic self-be- liefs: a Chinese adaptation of the General Self-efficacy Scale显示文摘 | Zhang J X Schwarzer R | 1995 | Phycologia1995，38，3： | 1 |
| 20 | Measuring optimistic self-beliefs - a Chinese adaptation of the General Self-efflcacy Scale 显示文摘 | ZHANG JX Schwarzer R | 1995 | Psychologia1995，38，3： | 1 |
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