|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Clinically detected gastroenteropancreatic neuroendocrine tumors are on the rise: Epidemiological changes in Germany显示文摘AIM:To study the epidemiologic changes of gastroenteropancreatic neuroendocrine tumors(GEP-NET)in Germany,we analyzed two time periods 1976-1988 and1998-2006.METHODS:We evaluated epidemiological data of GEP-NET from the former East German National Cancer Registry(DDR Krebsregister,1976-1988)and its successor,the Joint Cancer Registry(GKR,1998-2006),which was founded after German reunification.Due to a particularly substantial database the epidemiological data from the federal states of Mecklenburg-Western Pomerania,Saxony,Brandenburg and Thuringia,covering a population of more than 10.8 million people,were analyzed.Survival probabilities were calculated using life table analysis.In addition,GEP-NET patients were evaluated for one or more second(non-GEP-NET)primary malignancies.RESULTS:A total of 2821 GEP neuroendocrine neoplasms were identified in the two registries.The overall incidence increased significantly between 1976 and2006 from 0.31(per 100.000 inhabitants per year)to2.27 for men and from 0.57 to 2.38 for women.In the later period studied(2004-2006),the small intestine was the most common site.Neuroendocrine(NE)neoplasms of the small intestine showed the largest absolute increase in incidence,while rectal NE neoplasms exhibited the greatest relative increase.Only the incidence of appendiceal NET in women showed little change between 1976 and 2006.Overall survival of patients varied for sex,tumor site and the two periods studied but improved significantly over time.Interestingly,about 20%of the GEP-NET patients developed one or more second malignancies.Their most common location was the gastrointestinal tract.GEP-NET patients without second malignancies fared better than those with one or more of them.CONCLUSION:The number of detected GEP-NET increased about 5-fold in Germany between 1976 and2006.At the same time,their anatomic distribution changed,and the survival of GEP-NET patients improved significantly.Second malignancies are common and influence the overall survival of GEP-NET patients.Thus,GEP-NET warrant our attention as well as intensive research on their tumorigenesis. | Hans Scherübl Brigitte Streller Roland Stabenow Hermann Herbst Michael Hopfner Christoph Schwertner Joachim Steinberg Jan Eick Wanda Ring Krishna Tiwari Soren M Zappe | 2013 | World Journal of Gastroenterology2013，19，47： | 16 |
| 2 | Association of low serum concentration of bilirubin with increased risk of coronary artery disease 显示文摘 | Schwertner H A Jackson W G Tolan G | 1994 | Clin Chem1994，40，1： | 1 |
| 3 | Association of cow serumconcertration of bilirubin with increased risk of coronary artery disease显示文摘 | Schwertner HA Jackson WG Tolan G | 1994 | Clin Chem1994，40，： | 1 |
| 4 | Intra‐ and interobserver reliability of levator ani muscle biometry and avulsion using three‐dimensional endovaginal ultrasonography显示文摘 | K. van Delft S. A. Shobeiri R. Thakar N. Schwertner‐Tiepelmann A. H. Sultan | 2014 | Ultrasound Obstet Gynecol2014，，2： | 1 |
| 5 | Association of low serum concentration of bilirubin with increased risk of coronary artery disease 显示文摘 | Schwertner HA Jackson WG Tolan G | 1994 | Clin Chem1994，40，1： | 1 |
| 6 | Association of low serum concentration of bilirubin with increased risk of coronary artery disease显示文摘 | Jackson WG Tolan G | 1994 | Clin Chem1994，40，： | 1 |
| 7 | Association of low serum concentration of bilirubin with increased risk of coronary artery disease显示文摘 | Schwertner HA Jackson WG Tolan G | 1994 | Clin Chem1994，40，1： | 1 |
| 8 | Association of low serumconcentration of bilirubin with increased risk of coronary arterydisease显示文摘 | Schwertner HA Jackson WG Tolan G | 1994 | Clin Chem1994，40，1： | 1 |
| 9 | Gilbert syndrome, UGT1A1 * 28 allele, and cardiovascular disease risk: possible protective effects and therapeutic applications of bilirubin 显示文摘 | Schwertner H A Vitek L | 2008 | Atherosclerosis2008，198，1： | 1 |
| 10 | Determination of modafinil in plasma and urine by reversed phase high- performance liquid- chromatography 显示文摘 | Schwertner HA Kong SB | 2005 | J Pharm Biomed Anal2005，37，3： | 1 |
| 11 | Association of low serum concertatino of bilirubin with increased risk of coronary artery disease显示文摘 | Schwertner HA Jackon WG Tolam G | 1994 | Clin chem1994，40，： | 1 |
| 12 | Association of low serum concentration of bilirubin with increased risk of coronary artery disease显示文摘 | Schwertner HA Jackson WG Tolan G | 1994 | Clin Chem1994，40，1： | 1 |
| 13 | Association of Low Serum Concentration of Bilirubin with Increase Risk of Coronary Artery Disease 显示文摘 | Schwertner H A Jackson W G Tolan G | 1994 | Clin Chem1994，40，1： | 1 |
| 14 | Association of low serum concentration of bilirubin with increased risk of coronary artery disease显示文摘 | SCHWERTNER H A JACKSON W G TOLAN G | 1994 | Clin Chem1994，40，1： | 1 |
| 15 | Association of smoking and low serum bilirubin antioxidant concentrations 1 The views expressed in this article are those of the author and do not reflect the official policy of the Department of Defense or other Departments of the US Government. 1显示文摘 | Harvey A Schwertner | 1998 | Atherosclerosis1998，，2： | 1 |
| 16 | Association of low serum concentration of bilirubin with increased risk of coronary artery disease显示文摘 | Schwertner H A Jackson W G Tolan G | 2000 | Clin Chem2000，40，1： | 1 |
| 17 | Association of low serum concentration of bilirubin with increased risk of coronary artery disease显示文摘 | Jackson WG Tolan G | 1994 | Clin Chem1994，40，： | 1 |
| 18 | Association of low serum concentration of bilirubin with increased risk of coronary artery disease显示文摘 | Schwertner HA Jackson WG Tolan G | 1994 | Clin Chem1994，40，1： | 1 |
| 19 | Association of low serum concentration of bilirubin with increased risk of coronary artery disease显示文摘 | Schwertner HA Jackson WG Tolan G | 1994 | Clin Chem1994，40，1： | 1 |
| 20 | Association of smoking and low serum bilirubin antioxidant-concentrations显示文摘 | SCHWERTNER H A | 1998 | Atherosclerosis1998，136，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员