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| 1 | Towards a standard diet-induced and biopsy-confirmed mouse model of non-alcoholic steatohepatitis: Impact of dietary fat source显示文摘BACKGROUND The trans-fat containing AMLN(amylin liver non-alcoholic steatohepatitis,NASH)diet has been extensively validated in C57BL/6J mice with or without the Lep^ob/Lep^ob(ob/ob)mutation in the leptin gene for reliably inducing metabolic and liver histopathological changes recapitulating hallmarks of NASH.Due to a recent ban on trans-fats as food additive,there is a marked need for developing a new diet capable of promoting a compatible level of disease in ob/ob and C57BL/6J mice.AIM To develop a biopsy-confirmed mouse model of NASH based on an obesogenic diet with trans-fat substituted by saturated fat.METHODS Male ob/ob mice were fed AMLN diet or a modified AMLN diet with trans-fat(Primex shortening)substituted by equivalent amounts of palm oil[Gubra amylin NASH,(GAN)diet]for 8,12 and 16 wk.C57BL/6J mice were fed the same diets for 28 wk.AMLN and GAN diets had similar caloric content(40%fat kcal),fructose(22%)and cholesterol(2%)level.RESULTS The GAN diet was more obesogenic compared to the AMLN diet and impaired glucose tolerance.Biopsy-confirmed steatosis,lobular inflammation,hepatocyte ballooning,fibrotic liver lesions and hepatic transcriptome changes were similar in ob/ob mice fed the GAN or AMLN diet.C57BL/6J mice developed a mild to moderate fibrotic NASH phenotype when fed the same diets.CONCLUSION Substitution of Primex with palm oil promotes a similar phenotype of biopsyconfirmed NASH in ob/ob and C57BL/6J mice,making GAN diet-induced obese mouse models suitable for characterizing novel NASH treatments. | Michelle L Boland Denise Oro Kirstine S T■lb■l Sebastian T Thrane Jens Christian Nielsen Taylor S Cohen David E Tabor Fiona Fernandes Andrey Tovchigrechko Sanne S Veidal Paul Warrener Bret R Sellman Jacob Jelsing Michael Feigh Niels Vrang James L Trevaskis Henrik H Hansen | 2019 | World Journal of Gastroenterology2019，25，33： | 3 |
| 2 | Algorithms for Non-negative Matrix Factorization显示文摘 | Lee D D Sebastian S H | 2001 | Advances in Neural Information Processing Systems2001，2001，13： | 1 |
| 3 | Effect of operating condition and input variation on the partition of metals in a municipal solid waste incinerator显示文摘 | Leo S Morf Paul H Brunner Sebastian Spaun | 2000 | Waste Manage Res2000，18，1： | 1 |
| 4 | Effect of operating conditions and input variations on the partitioning of metals in a municipal solid waste incinerator 显示文摘 | Morf Leo S Brunner Paul H Spaun Sebastian | 2000 | Waste Management and Research2000，18，1： | 1 |
| 5 | The Manifold Ways of Perception显示文摘 | Sebastian H S Lee D D | 2000 | Science2000，290，12： | 1 |
| 6 | The manifold ways of perception显示文摘 | SEBASTIAN H S LEE D D | 2000 | Science2000，290，12： | 1 |
| 7 | Learning the Parts of Objects by Non-negative Matrix Factorization显示文摘 | Daniel D L Sebastian H S | 1999 | Nature1999，401，6755： | 1 |
| 8 | Microbial degradation of the benzonitrile herbicides dichlobenil, bromoxynil and ioxynil in soil and subsurface environments-Insights into degradation pathways, persistent metabolites and involved degrader organisms显示文摘 | Maria S H Sebastian R S Jan S | 2008 | Environmental Pollution2008，154，： | 1 |
| 9 | The English strain of rat cytomegalovirus (CMV) contains a novel captured CD200 (vOX2) gene and a spliced CC chemokine upstream from the major immediate-early region:further evidence for a separate evolutionary lineage from that of rat CMV Maastricht显示文摘 | Sebastian V Gordon R S Gary S H | 2005 | J Gen Virol2005，86，： | 1 |
| 10 | 查看详情显示文摘 | Huang Q. H Wang X. Y Li J Dai C.L Gamboa S Sebastian P J | | 0，，： | 1 |
| 11 | The manifold ways of perception显示文摘 | SEBASTIAN H S LEE D D | 2000 | Science2000，290，12： | 1 |
| 12 | Automated determination of ziprasidone by HPLC with column switching and spectrophotometric detection 显示文摘 | JULIA S SEBASTIAN H CHRISTOPH H | 2005 | Therapeutic Drug Monitoring2005，27，2： | 1 |
| 13 | International validation of novel pyrogen tests based on human monocytoid cells 显示文摘 | Sebastian H Anja P Stefanie S | 2005 | Journal of Immunological Methods2005，298，12： | 1 |
| 14 | Comparative analysis of occluded branch characteristics for Fraxinus excelsior and Acer pseudoplatanus with natural and artificial pruning显示文摘 | Sebastian H Heinrich S | 2007 | Canadian Journal of Forest Research2007，37，： | 1 |
| 15 | Comparison of three different technologies for pupil diameter measurement 显示文摘 | Sabline S Frank K Sebastian H | 2003 | Graefes Arch Clin Exp Ophthalmol2003，241，6： | 1 |
| 16 | Effect of operating condition and input variation on the partition of metals in a municipal solid waste incinerator显示文摘 | Leo S M Paul H B Sebastian S | 2000 | Waste Management and Research2000，18，1： | 1 |
| 17 | Failure of poly(ether-ether-ketone) in high speed contacts显示文摘 | Briscoe B J Stuart B H Sebastian S | 1993 | Wear1993，，： | 1 |
| 18 | Measurement of movement patterns of Caenorhabditis elegans (Nematode)with the multispecies freshwater biomonitor1 (MFB):A potential new method to study a behavioral toxicity parameter of nematodes in sediments显示文摘 | ALMUT G STEFANlE S SEBASTIAN H | 2002 | Environmental Pollution2002，120，： | 1 |
| 19 | Algorithms for Non-negative Matrix Factorization显示文摘 | Daniel D L Sebastian S H | 2001 | Advances in Neural Infor-mation Processing Systems2001，19，13： | 1 |
| 20 | Evaluation of hydrogen peroxide vapor for the inactivation of nosocomial pathogens on porous and nonporous surfaces显示文摘 | Sebastian L Simone S Helga H | 2015 | Am J Infect Control2015，43，1： | 1 |
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