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您的检索式：作者名="Sebastiano Miscia"
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| 1 | Neurodegenerative diseases as proteinopathies-driven immune disorders显示文摘In the pathophysiology of neurodegenerative disorders,the role of misfolded protein deposition leading to neurodegeneration has been primarily discussed.In the last decade,however,it has been proposed a parallel involvement of innate immune activation,chronic inflammation and adaptive immunity in the neurodegeneration mechanisms triggered by proteinopathies.New insights in the neurodegenerative field strongly suggest a role for the immune system in the pathophysiology of neurodegenerative disorders.Therefore,the hypothesis underlining the modulation of the innate and the adaptive immune system in the events linked to brain deposition of misfolded proteins could open new perspectives in the setting of specific immunotherapeutic strategies for the treatment of neurodegenerative diseases.Therefore,we have reviewed the pathogenic hypothesis in neurodegenerative pathologies,underling the links between the deposition of misfolded protein mechanisms and the immune activation. | Fausta Ciccocioppo Giuseppina Bologna Eva Ercolino Laura Pierdomenico Pasquale Simeone Paola Lanuti Damiana Pieragostino Piero Del Boccio Marco Marchisio Sebastiano Miscia | 2020 | Neural Regeneration Research2020，15，5： | 2 |
| 2 | Enhancement of TRAIL cytotoxicity by AG-490 in human ALL cells is characterized by downregulation of cIAP-1 and cIAP-2 through inhibition of Jak2/Stat3显示文摘导致死亡的肿瘤坏死的能力因素相关的导致 apoptosis ligand (小道) 大部分被描述了有选择地杀死许多癌症房间,但是有治疗的主要担心之一是药抵抗和可能的有毒的副作用的出现。这里,我们报导那条小道在 Jurkat 和 SUPT1 T 房间线并且在人的高强风然而并非在健康的导出题目的外部血 mononuclear 房间导致 apoptosis。在平行,有小道和 Tyrphostin ( AG-490 )的治疗,选择 Janus kinase 2 禁止者,生产 cytotoxicity 的明显的改进,与控制相比或到由 Stat3 phosphorylation 的重要抑制描绘了落后于独自一个对待的样品,并且与 cIAP-1 和 cIAP-2 mRNA 层次的戏剧的减少联系了。由特定的小干扰 RNA 的 cIAP-1 和 cIAP-2 的 Downregulation 显著地放大减少小道的 cytotoxicity。所有一起,这些调查结果强烈显示 cIAP-1 和 cIAP-2 downregulation 是在调停的发信号的小径的基本的步 T 上的小道和 AG-490 的组合效果房间白血病。这些调查结果可以帮助在小道敏感的白血病影响的病人的治疗为不太有毒的药理学策略的发展打开新线路。 | Paola Lanuti Valeria Bertagnolo Laura Pierdomenico Adriana Bascelli Eugenio Santavenere Lapo Alinari Silvano Capitani Sebastiano Miscia Marco Marchisio | 2009 | Cell Research2009，19，9： | 0 |
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