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| 1 | Activation of plasma membrane H ( + )-ATPase and expression of PMA1 and PMA2 genes in Saccharomyces cerevisiae cells grown at supraoptimal temperatures显示文摘 | Viegas C A Sebastiao P B Nunes A G | 1995 | Applied and Environmental Microbiology1995，61，5： | 1 |
| 2 | Effect of the Annealing Temperature on the Structure and Magnetic Properties of 3% Si Non- Oriented Steel 显示文摘 | Marco A C Sebastiao C P | 2003 | Journal of Magnetism and Magnetic Materials2003，254，： | 1 |
| 3 | Modeling the Fate of Oil Spills at Sea显示文摘 | Sebastiao P Guedes S C | 1995 | Spill Science & TechnoIogr Bdelin1995，2，213： | 1 |
| 4 | Modeling the fate of oil spill at sea显示文摘 | Sebastiao P Guedes-Soares C | 1995 | Spill Science & Technology Bulletin1995，2，2： | 1 |
| 5 | Modeling the fate of oil spill at sea显示文摘 | SEBASTIAO P GUEDES-SOARES C | 1995 | Spill Science and Technology Bulletin1995，2，2： | 1 |
| 6 | Effect of the annealing temperature on the structure and magnetic properties of 3% Si non-oriented steel显示文摘 | Marco A C Sebastiao C P | 2003 | Journal of Magnetism and Magnetic Materials2003，，： | 1 |
| 7 | Uncertainty in predictions of oil spill trajectories in open sea 显示文摘 | SEBASTIAO P GUEDES S C | 2007 | Ocean Engineering2007，34，： | 1 |
| 8 | Uncertainty in predictions of oil spill trajectories in a coastal zone显示文摘 | SEBASTIAO P GUEDES S C | 2006 | Journal of Marine Systems2006，63，25： | 1 |
| 9 | Inhibitory and excitatory effects of adenosine receptor agonists On evoked transmitter release from phrenic nerve ending of the rat 显示文摘 | CORREIA-DE-SA P SEBASTIAO A M RIBEIRO J A | 1991 | Br J Pharmacol1991，103，2： | 1 |
| 10 | Modeling the fate ofoil spills at sea显示文摘 | Sebastiao P Soares G C 1995 | 1995 | Spill Science & Technology Bulletin1995，2，23： | 1 |
| 11 | On Evalua- ting Stream Learning Algorithms 显示文摘 | Gama J Sebastiao R Rodrigues P P | 2013 | Machine Learning2013，90，3： | 1 |
| 12 | Feasibility of focaltranscranial DC polarization with simultaneous EEG recording :preliminary assessment in healthy subjects and human epilepsy显示文摘 | Faria P Fregni F Sebastiao F | 2012 | Epilepsy Behav2012，25，3： | 1 |
| 13 | Hypolactasia is associated with insulin resistance in nonalcoholic steatohepatitis显示文摘AIM To assess lactase gene(LCT)-13910C>T polymorphisms in Brazilian non-alcoholic fatty liver disease(NAFLD) and nonalcoholic steatohepatitis(NASH) patients in comparison with healthy controls.METHODS This was a transverse observational clinical study with NAFLD patients who were followed at the Hepatology Outpatient Unit of the Hospital das Clínicas, S?o Paulo, Brazil. The polymorphism of lactase non-persistence/lactase persistence(LCT-13910C>T) was examined by PCR-restriction fragment length polymorphism technique in 102 liver biopsy-proven NAFLD patients(steatosis in 9 and NASH in 93) and compared to those of 501 unrelated healthy volunteers. Anthropometric, clinical, biochemical and liver histology data were analyzed. Continuous variables were compared using the t or Mann-Whitney tests, and categorical data were compared with the Fisher's exact test. Univariate logistic regression and multivariate logistic regression adjusted for gender and age were performed.RESULTS No differences in the LCT-13910 genotype frequencies were noted between the NAFLD patients(66.67% of the patients with steatosis were CC, 33.33% were CT, and none were TT; 55.91% of the patients with NASH were CC, 39.78% were CT, and 4.3% were TT; P = 0.941) and the healthy controls(59.12% were CC, 35.67% were CT, and 5.21% were TT) or between the steatosis and NASH patients. That is, the distribution of the lactase non-persistence/lactase persistence polymorphism(LCT-13910C>T) in the patients with NAFLD was equal to that in the general population. In the NASH patients, the univariate analysis revealed that the lactase nonpersistence(low lactase activity or hypolactasia) phenotype was associated with higher insulin levels(23.47 ± 15.94 μU/m L vs 15.8 ± 8.33 μU/m L, P = 0.027) and a higher frequency of insulin resistance(91.84% vs 72.22%, P = 0.02) compared with the lactase persistence phenotype. There were no associations between the LCT genotypes and diabetes(P = 0.651), dyslipidaemia(P = 0.328), hypertension(P = 0.507) or liver histology in these patients. Moreover, in the NASH patients, hypolactasia was an independent risk factor for insulin resistance even after adjusting for gender and age [OR = 5.0(95%CI: 1.35-20; P = 0.017)].CONCLUSION The LCT-13910 genotype distribution in Brazilian NAFLD patients was the same as that of the general population, but hypolactasia increased the risk of insulin resistance in the NASH patients. | Daniel Ferraz de Campos Mazo Rejane Mattar Jose Tadeu Stefano Joyce Matie Kinoshita da Silva-Etto Marcio Augusto Diniz Sebastiao Mauro Bezerra Duarte Fabíola Rabelo Rodrigo Vieira Costa Lima Priscila Brizolla de Campos Flair Jose Carrilho Claudia P Oliveira | 2016 | World Journal of Hepatology2016，8，24： | 0 |
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