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您的检索式：作者名="Sefa Tuzun"
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| 1 | Levels of matrix metalloproteinase-1 and tissue inhibitors of metalloproteinase-1 in gastric cancer显示文摘AIM:To evaluate the levels of preoperative serum matrix metalloproteinase-1 (MMP-1) and tissue inhibitor of metalloproteinase-1 (TIMP-1) in gastric cancer.METHODS:One hundred gastric cancer patients who underwent gastrectomy were enrolled in this study.The serum concentrations of MMP-1 and TIMP-1 in these patients and in fifty healthy controls were determined using an enzyme-linked immunosorbent assay.RESULTS:Higher serum MMP-1 and TIMP-1 levels were observed in patients than in controls (P < 0.001).Serum MMP-1 and TIMP-1 levels were positively associated with morphological appearance,tumor size,depth of wall invasion,lymph node metastasis,liver metastasis,perineural invasion,and pathological stage.They were not significantly associated with age,gender,tumor location,or histological type.CONCLUSION:Increased MMP-1 and TIMP-1 were associated with gastric cancer.Although these markers are not good markers for diagnosis,these markers show in advanced gastric cancer. | Ozgur Kemik Ahu Sarbay Kemik Aziz Sümer Ahmet Cumhur Dulger Mine Adas Huseyin Begenik Ismail Hasirci Ozkan Yilmaz Sevim Purisa Erol Kisli Sefa Tuzun Cetin Kotan | 2011 | World Journal of Gastroenterology2011，17，16： | 10 |
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