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| 1 | Neoadjuvant radiotherapy for rectal cancer management显示文摘Thirty per cent of all colorectal tumours develop in the rectum.The location of the rectum within the bony pelvis and its proximity to vital structures presents significant therapeutic challenges when considering neoadjuvant options and surgical interventions.Most patients with early rectal cancer can be adequately managed by surgery alone.However,a significant proportion of patients with rectal cancer present with locally advanced disease and will potentially benefit from down staging prior to surgery.Neoadjuvant therapy involves a variety of options including radiotherapy,chemotherapy used alone or in combination.Neoadjuvant radiotherapy in rectal cancer has been shown to be effective in reducing tumour burden in advance of curative surgery.The gold standard surgical rectal cancer management aims to achieve surgical removal of the tumour and all draining lymph nodes,within an intact mesorectal package,in order to minimise local recurrence.It is critically important that all rectal cancer cases are discussed at a multidisciplinary meeting represented by all relevant specialties.Pre-operative staging including CT thorax,abdomen,pelvis to assess for distal disease and magnetic resonance imaging to assess local involvement is essential.Staging radiology and MDT discussion are integral in identifying patients who require neoadjuvant radiotherapy.While Neoadjuvant radiotherapy is potentially beneficial it may also result in morbidity and thus should be reserved for those patients who are at a high risk of local failure,which includes patients with nodal involvement,extramural venous invasion and threatened circumferential margin.The aim of this review is to discuss the role of neoadjuvant radiotherapy in the management of rectal cancer. | Gerard Feeney Rishabh Sehgal Margaret Sheehan Aisling Hogan Mark Regan Myles Joyce Michael Kerin | 2019 | World Journal of Gastroenterology2019，25，33： | 28 |
| 2 | 压水堆熔融物堆内滞留策略:历史回顾与研究展望显示文摘本文对广泛应用于第三代压水堆的严重事故缓解措施——熔融物堆内滞留(IVR)进行了历史回顾。IVR策略最早源自于第二代反应堆Lovissa VVER-440的改进设计,以应对堆芯熔化事故。随后,IVR策略被应用于许多新设计的反应堆,如西屋的AP1000、韩国的APR1400以及中国的先进压水堆CAP1400和华龙一号。对IVR策略有效性影响最大的因素分别为堆内堆芯熔化进程、熔融物加载于压力容器壁面的热流密度和压力容器外部冷却。对于堆芯熔化进程,过去人们一直仅关注压力容器下腔室内熔池的换热行为。但通过回顾与分析,本文认为堆内的其他现象,如堆芯的降级和迁移、碎片床的形成及其可冷却性以及熔池的动态形成过程等,可能也会对熔池的最终状态及其作用于下封头的热负荷产生影响。通过对相关研究的回顾,本文希望找出IVR策略的研究中有待完善的部分,并据目前发展水平提出未来IVR研究的需求。 | 马卫民 元一单 Bal Raj Sehgal | 2016 | Engineering2016，2，1： | 14 |
| 3 | Inhibition of hepatitis B virus DNA replicative intermediate forms by recombinant interferon-γ显示文摘AIM: To evaluate the in vitro anti-HBV activity of recombinant human IFN-γ, alone and in combination with lamivudine. METHODS: A recombinant baculovirus-HBV/HepG2 culture system was developed which could support productive HBV infection in vitro. Expression of HBsAg and HBeAg in infected HepG2 culture medium was detected by commercial enzyme immunoassays. HBV DNA replication intermediates were detected in infected cells by Southern hybridization and viral DNA load was determined by dot hybridization. RESULTS: IFN-γat 0.1 to 5μg/L efficiently down regulated HBsAg expression in transduced HepG2 cells. At 5μg/L, IFN-γalso suppressed HBV DNA replication in these cells. While treatment with a combination of lamivudine and IFN-γshowed no additive effect, sequential treatment first with lamivudine and then IFN-γwas found to be promising. In this culture system the best HBV suppression was observed with a pulse of 2μmol/L lamivudine for two days, followed by 1μg/L IFN-γfor another four days. Compared to treatment with lamivudine alone, the sequential use of 0.2μmol/L lamivudine for two days, followed by 5μg/L IFN-γfor six days showed a 72% reduction in HBV cccDNA pool. CONCLUSION: This in vitro study warrants further evaluation of a combination of IFN-γand lamivudine, especially in IFN-αnon-responder chronic hepatitis B patients. A reduced duration of lamivudine treatment would also restrict the emergence of drug-resistant HBV mutants. | Mohammad Khalid Parvez Deepak Sehgal Shiv Kumar Sarin Seemi Farhat Basir Shahid Jameel | 2006 | World Journal of Gastroenterology2006，12，19： | 10 |
| 4 | To evaluate the role of platelet-rich plasma in healing of acute diaphyseal fractures of the femur显示文摘 | Roop Singh Rajesh Rohilla Jeetesh Gawande Paramjit Kumar Sehgal | 2017 | Chinese Journal of Traumatology2017，20，1： | 8 |
| 5 | Historical development of mesenteric anatomy provides a universally applicable anatomic paradigm for complete/total mesocolic excision显示文摘Although total mesorectal excision has now become the‘gold standard’for the surgical management of rectal cancer,this is not so for colon cancer.Recent data,provided by Hohenberger and West et al.and others,have demonstrated excellent oncological outcomes when mesenterectomy is extensive(as is implicit in the concept of a‘high tie’)and the mesenteric package not violated.Such studies highlight the importance of understanding the basics of the mesenteric organ(including the small intestinal mesentery,mesocolon,mesosigmoid and mesorectum)and of abiding to principles of planar surgery.In this review,we first offer classic descriptions of the mesocolon and then detail contemporary thinking.In so doing,we provide an anatomical basis for safe and effective complete mesocolic excision(CME)in the management of colon cancer.Finally we list opportunities associated with the new anatomical paradigm,demonstrating benefits across multiple disciplines.Perhaps most importantly,we feel that a crystallized view of mesenteric anatomy will overcome factors that have hindered the general uptake of CME. | Rishabh Sehgal J.Calvin Coffey | 2014 | Gastroenterology Report2014，2，4： | 5 |
| 6 | Inversion of radiative transfer model for retrieval of wheat biophysical parameters from broadband reflectance measurements显示文摘This study describes the retrieval of wheat biophysical variables of leaf chlorophyll(Cab),leaf area index(LAI),canopy chlorophyll(CCC),and leaf wetness(Cw)from broadband reflectance data corresponding to IRS LISS-3(Linear Imaging Self Scanner)sensor by inversion of PROSAIL5B canopy radiative transfer model.Reflectance data of wheat crop,grown under different treatments,were measured by hand-held spectroradiometer and later integrated to LISS-3 reflectance using its band-wise relative spectral response function.Three inversion techniques were used and their performance was compared using different statistical parameters and target diagram.The inversion techniques tried were:a look up table with best solution(LUT-I),a look up table with mean of best 10%solutions(LUT-II)and an artificial neural network(ANN).All the techniques could estimate the biophysical variables by capturing variability in their observed values,though accuracy of estimation varied among the three techniques.Target diagram clearly depicted the superiority of LUT-II over the other two approaches indicating that a mean of best 10%solutions is a better strategy while ANN was worst performer showing highest bias for all the parameters.In all the three inversion techniques,the general order of retrieval accuracy was LAI>Cab>CCC>Cw.The range of Cw was very narrow and none of the techniques could estimate variations in it.In most of the cases,the parameters were underestimated by model inversion.The best identified LUT-II technique was then applied to retrieve wheat LAI from IRS LISS-3 satellite image of 5-Feb-2012 in Sheopur district.The comparison with ground observations showed that the RMSE of LAI retrieval was about 0.56,similar to that observed in ground experimentation.The findings of this study may help in refining the protocol for generating operational crop biophysical products from IRS LISS-3 or similar sensors. | Vinay Kumar Sehgal Debasish Chakraborty Rabi Narayan Sahoo | 2016 | Information Processing in Agriculture2016，3，2： | 5 |
| 7 | Improving sessile serrated adenoma detection rates with high definition colonoscopy:A retrospective study显示文摘BACKGROUND Sessile serrated adenomas(SSAs)are important premalignant lesions that are difficult to detect during colonoscopy due to poor definition,concealment by mucous caps,and flat appearance.High definition(HD)colonoscopy may uniquely aid in the detection of these inconspicuous lesions compared to standard definition(SD)colonoscopes.In the absence of existing clinical guidelines to obligate the use of HD colonoscopy for colorectal cancer screening in average-risk patients,demonstrating the benefit of HD colonoscopy on SSA detection rate(SSADR)may help strengthen the evidence to recommend its use in all settings.AIM To evaluate the benefit of HD colonoscopy compared to SD colonoscopy on SSADR in average-risk patients undergoing screening colonoscopy.METHODS Data from screening colonoscopies for patients aged 50-76 years two years before and two years after the transition from SD colonoscopy to HD colonoscopy at our large,academic teaching center were collected.Patients with symptoms of colorectal disease,positive occult blood test,history of colon polyps,cancer,polyposis syndrome,inflammatory bowel disease or family history of colon cancer or polyps were excluded.Patients whose endoscopists did not perform colonoscopies both before and after scope definition change were also excluded.Differences in individual endoscopist SSADR,average SSADR,and overall SSADR with SD colonoscopy vs HD colonoscopy were also evaluated for significance.RESULTS A total of 3657 colonoscopies met eligibility criteria with 2012 colonoscopies from the SD colonoscopy period and 1645 colonoscopies from the HD colonoscopy period from a pool of 11 endoscopists.Statistically significant improvements of 2.30%in mean SSADR and 2.53%in overall SSADR were noted with HD colonoscopy(P=0.00028 and P=0.00849,respectively).On the individual level,three endoscopists experienced statistically significant benefit with HD colonoscopy(+5.74%,P=0.0056;+4.50%,P=0.0278;+4.84%,P=0.03486).CONCLUSION Our study suggests that HD colonoscopy statistically significantly improves sessile serrated adenoma detection rate in the screening of average risk patients during screening colonoscopy.By improving the detection and removal of these lesions,adoption of HD colonoscopy may reduce the significant premalignant burden of sessile serrated adenomas. | Abhinav Sehgal Soorya Aggarwal Rohan Mandaliya Thomas Loughney Mark C Mattar | 2022 | World Journal of Gastrointestinal Endoscopy2022，14，4： | 2 |
| 8 | Development of a polymerase chain reaction dot-blotting system for detecting cutaneous tuberculosis显示文摘 | Arora SK Kumar B Sehgal S | 2000 | Br J Dermatol2000，142，： | 2 |
| 9 | 坏死性筋膜炎1例显示文摘报告1例具有典型症状的坏死性筋膜炎。患者女,70岁。皮损位于左臀部和左大腿,为显著性红斑、硬结、片状坏死,皮损有恶臭,组织中有产气现象,自觉疼痛剧烈。经组织病理检查确诊为坏死性筋膜炎。对患者施行清创术和对症支持治疗,包括消炎、镇痛和补液,获得令人满意的疗效。 | Virendra N Sehgal Naresh Sehgal Ruchi Sehgal Sujay Khandpur Sonal Sharma | 2005 | 临床皮肤科杂志2005，34，2： | 2 |
| 10 | Molecu|ar characterization of CXCR-d:a potential brain tumor-associated gene 显示文摘 | Sehgal A Ricks S Boynton AL | 1995 | J Surg Oncol1995，69，4： | 1 |
| 11 | The prevahnoe of uveitis in juvenile rheumatoid arthritis显示文摘 | Oren B Sehgal A Simon JW | | 0，，01： | 1 |
| 12 | Interdialytic weight gain,compliance with dialysis regimen,and age are inde- pendent predictors of blood pressure in hemodialysis pa- tients显示文摘 | Rahman M Fu P Sehgal AR | 2000 | Am J Kidney Dis2000，3，2： | 1 |
| 13 | Utility of IgE (total and Aspergillus fumigatus specific) in monitoring for response and exacerbations in allergic bronchopulmonary aspergillosis显示文摘 | Agarwal R Aggarwal AN Sehgal IS | 2016 | Mycoses2016，59，1： | 1 |
| 14 | Diagnostic utility of fac et joint in jections in chronic spinal pain: a systematic review of evidence 显示文摘 | Sehgal N Shah R V Brown A M | 2005 | Pain Physician2005，8，2： | 1 |
| 15 | Lucio's phenomenon/erythema necroticans显示文摘 | Sehgal VN | 2005 | Int J Dermatol2005，44，7： | 1 |
| 16 | Cyclotomic units and the unit group of an elementary abelian group ring显示文摘 | Hoechsmann K Sehgal S K Weiss A | 1985 | Archiv der Mathematik1985，45，1： | 1 |
| 17 | Factors associated with prolonged wound drainage after primary total hip and knee arthroplasty显示文摘 | PATEL VP WALSH M SEHGAL B | 2007 | J Bone Joint Surg(Am)2007，89，1： | 1 |
| 18 | Susceptibility-weighted imaging to visualize blood products and improve tumorcontrast in the study of brain masses显示文摘 | Sehgal V Delproposto Z Haddar D | 2006 | J Magn Reson Imaging2006，24，1： | 1 |
| 19 | Treatment of chronic symptomatic vertebral compression fractures with percutaneous vertebroplasty显示文摘 | Brown DB Gilula LA Sehgal M | | 0，，： | 1 |
| 20 | Prevalenee, recog-nition and modialysis Tyrrell J, undergoing depressive Aging Ment implications of mental impairment among he- patients显示文摘 | Sehgal AR Grey SF DeOreo PB | 1997 | Am J Kidney Dis1997，30，： | 1 |
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