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| 1 | Ythdc2 is an N^6-methyladenosine binding protein that regulates mammalian spermatogenesis显示文摘N 6-methyladenosine (m 6 一) 是在真核细胞的 mRNA 的最普通的内部修正。它动态地被安装并且搬迁,并且充当 mRNA 新陈代谢,包括干细胞 pluripotency 的调整生物过程,房间区别,和精力动态平衡的新层。m 6 A 被选择有约束力的蛋白质认出;YTHDF1 和 YTHDF3 在音乐会工作影响 m 6包含 A 的 mRNAs, YTHDF2 帮助 mRNA 腐烂,和 YTHDC1 影响它的目标的原子处理。YTHDC2 的生物功能, YTH 蛋白质家庭,的最后的成员仍然保持未知。我们报导 YTHDC2 有选择地绑 m 6 在它的一致主题的 A。YTHDC2 提高它的目标的翻译效率并且也减少他们的 mRNA 丰富。Ythdc2 猛烈老鼠是不肥沃的;男性们让显著地更小的睾丸和女性同窝出生的人与那些相比有显著地更小的卵巢。Ythdc2 猛烈老鼠的细菌房间不经过 zygotene 阶段发展,因此,当成熟分裂开始, Ythdc2 是在睾丸的 upregulated。因此, YTHDC2 是 m 6 在精子发生期间起关键作用的 A 绑定蛋白质。 | Phillip J Hsu Yunfei Zhu Honghui Ma Yueshuai Guo Xiaodan Shi Yuanyuan Liu Meijie Qi Zhike Lu Hailing Shi Jianying Wang Yiwei Cheng Guanzheng Luo Qing Dai Mingxi Liu Xuejiang Guo Jiahao Sha Bin Shen Chuan He | 2017 | Cell Research2017，27，9： | 96 |
| 2 | Roux-en-Y gastric bypass promotes expression of PDX-1 and regeneration of β-cells in Goto-Kakizaki rats显示文摘AIM:To study the effects of Roux-en-Y gastric bypass(RYGB) on the expression of pancreatic duodenal homeobox-1(PDX-1) and pancreatic β-cell regeneration/neogenesis,and their possible mechanisms in diabetics.METHODS:Three groups of randomly selected nonobese diabetic Goto-Kakizaki(GK) rats were subjected to RYGB,sham-RYGB and sham-operation(sham-op) surgery,respectively.The rats were euthanized at postoperative 1,2,4 and 12 wk.Their pancreases were resected and analyzed using reverse transcription polymerase chain reaction to detect the mRNA of PDX-1.Anti-PDX-1 immunohistochemical(IHC) staining and Western blotting were used to detect the protein of PDX-1.Double IHC staining of anti-Brdu and-insulin was performed to detect regenerated β-cells.The index of double Brdu and insulin positive cells was calculated.RESULTS:In comparison with sham-RYGB and sham-op groups,a significant increase in the expressions of PDX-1 mRNA in RYGB group was observed at all experimental time points(1 wk:0.378 ± 0.013 vs 0.120 ± 0.010,0.100 ± 0.010,F = 727.717,P < 0.001;2 wk:0.318 ± 0.013 vs 0.110 ± 0.010,0.143 ± 0.015,F = 301.509,P < 0.001;4 wk:0.172 ± 0.011 vs 0.107 ± 0.012,0.090 ± 0.010,F = 64.297,P < 0.001;12 wk:0.140 ± 0.007 vs 0.120 ± 0.010,0.097 ± 0.015,F = 16.392,P < 0.001);PDX-1 protein in RYGB group was also increased significantly(1 wk:0.61 ± 0.01 vs 0.21 ± 0.01,0.15 ± 0.01,F = 3031.127,P < 0.001;2 wk:0.55 ± 0.00 vs 0.15 ± 0.01,0.17 ± 0.01,F = 3426.455,P < 0.001;4 wk:0.39 ± 0.01 vs 0.18 ± 0.01,0.22 ± 0.01,F = 882.909,P < 0.001;12 wk:0.41 ± 0.01 vs 0.20 ± 0.01,0.18 ± 0.01,F = 515.833,P < 0.001).PDX-1 mRNA and PDX-1 protein production showed no statistical significance between the two sham groups.Many PDX-1 positive cells could be found in the pancreatic islets of the rats in RYGB group at all time points.In addition,the percentage of Brdu-insulin double staining positive cells was higher in RYGB group than in the other two groups(1 wk:0.22 ± 0.13 vs 0.03 ± 0.06,0.03 ± 0.06,P < 0.05;2 wk:0.28 ± 0.08 vs 0.00 ± 0.00,0.03 ± 0.06,P < 0.05;4 wk:0.24 ± 0.11 vs 0.07 ± 0.06,0.00 ± 0.00,P < 0.001;12 wk:0.20 ± 0.07 vs 0.03 ± 0.06,0.00 ± 0.00,P < 0.05).CONCLUSION:RYGB can increase the expression of pancreatic PDX-1 and induce the regeneration of β-cells in GK rats.The associated regeneration of islet cells may be a possible mechanism that how RYGB could improve type 2 diabetes mellitus. | Zhen Li,Dong-Fei Li,Jing-Xing Dai,Yu Bai,Lin Yuan,Southern Medical University,Institute of Basic Medical Anatomy National Key Disciplines,Guangzhou 510515,Guangdong Province,China Hong-Ya Zhang,Lu-Xian Lv,Wen-Qiang Li,Second Affiliated Hospital,Xinxiang Medical College,Henan Province Key Laboratory of Biological Psychiatry,Xinxiang 453002,Henan Province,China Ou Sha,Department of Anatomy,Faculty of Medicine,Shenzhen University,Shenzhen 518060,Guangdong Province,China | 2010 | World Journal of Gastroenterology2010，16，18： | 14 |
| 3 | Effects of Salvia miltiorrhiza on intestinal microflora in rats with ischemia/reperfusion liver injury显示文摘BACKGROUND: Hepatic ischemia/reperfusion injury may induce intestinal microflora imbalance. Salvia miltiorrhiza is effective in promoting blood circulation and counteracting peroxidation in tissues. The aim of the present study was to determine the effects of Salvia miltiorrhiza on intestinal mi- croflora, endotoxemia, and bacterial translocation in rats with hepatic I/R injury. METHODS: Sprague-Dawley rats in specific pathogen free grade were divided into 3 groups: group I(n =6) for sham operation: groups ( n = 7) for liver ische- mia for 20 minutes and reperfusion for 22 hours. Group was also pretreated with 4 ml/day of Salvia miltiorrhiza solu- tion (250 mg/kg) by daily gavage for 7 days. The levels of serum alanine aminotransferase (ALT), aspartate amino- transferase (AST), malondialdehyde ( MDA) and supero- xide dismutase ( SOD ) in liver tissues, serum endotoxin, intestinal bacterial counts, intestinal mucosal histology and bacterial translocation were studied. RESULTS: The levels of ALT, AST, plasma endotoxin and MDA in liver tissues were decreased more markedly in group (57.57 ± 18.08 U/L, 147.57 ±40.84 U/L, 0.42 ± 0.144 EU/ml and 0. 52 ±0.19 nmol/mg-prot respectively) in group 295.9±216.92 U/L, 0.80± 0.262 EU/ml and 0.72±0.12 nmol/mg-prot; P <0.05-0.01 respectively). Liver SOD activity was increased more sig- nificantly in group (318.47±64.62 U/mg-prot) than in group U/mg-prot, P<0.05). The counts of Bifidobacteria and Bacteroides increased more significantly in group than in group but were similar to those in group I. Bacterial translocation to the kidney in group was 50% (5/10), whereas no bacterial translocation to the kidney occurred in the other two groups (P <0. 01). Ileal mucosal structure was markedly ameliorated in group as compared with group CONCLUSIONS: Salviae miltiorrhiza could partially restore intestinal microflora balance, improve intestinal mucosal integrity, and reduce bacterial translocation and plasma en- dotoxin in rats with hepatic ischemia/reperfusion injury. | Hui-Chun Xing, Lan-Juan Li, Kai-Jin Xu, Tian Shen, Yun-Bo Chen, Yu Chen, Su-Zhen Fu, Ji-Fang Sheng, Chun-Lei Chen, Jian-Guo Wang, Dong Yan, Fang-Wei Dai and Xiao-Ying Sha Hangzhou, China Key Laboratory of Infectious Diseases, Ministry of Public Health of China, and Institute of Infectious Diseases, Department of Infectious Diseases, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China Zhejiang Academy of Medical Sciences, Hangzhou 310012, China | 2005 | Hepatobiliary & Pancreatic Diseases International2005，4，2： | 14 |
| 4 | PepperHub, an Informatics Hub for the Chili Pepper Research Community显示文摘 | Feng Liu Huiyang Vu Yingtian Deng Jingyuan Zheng Minglei Liu Lijun Ou Bozhi Yang Xiongze Dai Yanqing Ma Shengyu Feng Shuang He Xuefeng Li Zhuqing Zhang Wenchao Chen Shudong Zhou Rong Chen Minmin Liu Sha Yang Ruimin Wei Huadong Li Feng Li Bo Ouyang Xuexiao Zou | 2017 | Molecular Plant2017，10，8： | 13 |
| 5 | Conversion therapy and suitable timing for subsequent salvage surgery for initially unresectable hepatocellular carcinoma: What is new?显示文摘AIM To review the conversion therapy for initially unre-sectable hepatocellular carcinoma(HCC) patients and the suitable timing for subsequent salvage surgery. METHODS A Pub Med search was undertaken from 1987 to 2017 to identify articles using the keywords including 'unresectable' 'hepatocellular carcinoma', 'hepate-ctomy', 'conversion therapy', 'resection', 'salvage surgery' and 'downstaging'. Additional studies were investigated through a manual search of the references from the articles. The exclusion criteria were duplicates, case reports, case series, videos, contents unrelated to the topic, comments, and editorial essays. The main and widely used conversion therapies and the suitable timing for subsequent salvage surgery were discussed in detail. Two members of our group independently performed the literature search and data extraction. RESULTS Liver volume measurements [future liver remnant(FLR)/total liver volume or residual liver volume/bodyweight ratio] and function tests(scoring systems and liver stiffness) were often performed in order to justify whether patients were suitable candidates for surgery. Successful conversion therapy was usually defined as downstaging the tumor, increasing FLR and providing subsequent salvage surgery, without increasing com-plications, morbidity or mortality. The requirementsfor performing salvage surgery after transcatheter arterial chemoembolization were the achievement of a partial remission in radiology, the disappearance of the portal vein thrombosis, and the lack of extrahepatic metastasis. Patients with a standardized FLR(sF LR) > 20% were good candidates for surgery after portal vein embolization, while other predictive parameters like growth rate, kinetic growth rate were treated as an effective supplementary. There was probably not enough evidence to provide a standard operation time after associating liver partition and portal vein ligation for staged hepatectomy or yttrium-90 microsphere radioembolization. The indications of any combinations of conversion therapies and the subsequent salvage surgery time still need to be carefully and comprehen-sively evaluated. CONCLUSION Conversion therapy is recommended for the treatment of initially unresectable HCC, and the suitable subse-quent salvage surgery time should be reappraised and is closely related to its previous therapeutic effect. | Ze-Feng Zhang Yu-Jun Luo Quan Lu Shi-Xue Dai Wei-Hong Sha | 2018 | World Journal of Clinical Cases2018，6，9： | 11 |
| 6 | Cholesterol-tuned liposomal membrane rigidity directs tumor penetration and anti-tumor effect显示文摘Recently, liposomes have been widely used in cancer therapeutics, but their anti-tumor effects are suboptimal due to limited tumor penetration. To solve this problem, researchers have made significant efforts to optimize liposomal diameters and potentials, but little attention has been paid to liposomal membrane rigidity. Herein, we sought to demonstrate the effects of cholesterol-tuned liposomal membrane rigidity on tumor penetration and anti-tumor effects. In this study, liposomes composed of hydrogenated soybean phospholipids(HSPC), 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000](DSPE-PEG2000) and different concentrations of cholesterol were prepared. It was revealed that liposomal membrane rigidity decreased with the addition of cholesterol. Moderate cholesterol content conferred excellent diffusivity to liposomes in simulated diffusion medium, while excessive cholesterol limited the diffusion process. We concluded that the differences of the diffusion rates likely stemmed from the alterations in liposomal membrane rigidity, with moderate rigidity leading to improved diffusion. Next, the in vitro tumor penetration and the in vivo anti-tumor effects were analyzed. The results showed that liposomes with moderate rigidity gained excellent tumor penetration and enhanced anti-tumor effects. These findings illustrate a feasible and effective way to improve tumor penetration and therapeutic efficacy of liposomes by changing the cholesterol content, and highlight the importance of liposomal membrane rigidity. | Hangyi Wu Miaorong Yu Yunqiu Miao Shufang He Zhuo Dai Wenyi Song Yuan Liu Sha Song Ejaj Ahmad Dongkai Wang Yong Gan | 2019 | Acta Pharmaceutica Sinica B2019，9，4： | 5 |
| 7 | Carcinogenesis of asbestos switched on by inducing cross-linkage between DNA complementary pair bases显示文摘Since the beginning of the 1980s, Dai Qianhuan predicted based upon his di-region theory that the carcino-genesis switched on by the so-called physical carcinogenic factors including radiation, asbestos and foreign matter implantation, is just initiated through the cross-linking between DNA complementary pair bases induced by them. In this note, it was evidenced with the DNA filter elution method that the oxygenase activated by asbestos induces the cross-linking between DNA inter-strands and DNA-protein with dosage correlation, in which over 80% of DNA inter-strand cross-link ratio account for the total cross-link ratio. Obviously, both of the cross-linkages are just induced by hydroxyl free radical, HO·, because the ferrous ion increased the cross-link ratios up to several times through Fenton reaction and vitamin C inhibited the cross-link ratios with factors of 8-9 by destroying the hydroxyl radical. Non-carcinogen but with lower free radical formation energy, pyrene, by culturing with asbestos | DAI Qianhuan CHEN Sha LI Yingxia | 2002 | Chinese Science Bulletin2002，47，13： | 5 |
| 8 | A Teosinte-derived Allele of a MYB Transcription Repressor Confers Multiple Disease Resistance in Maize.显示文摘Natural alleles controlling multiple disease resistances (MDR) are valuable for crop breeding. However, only one MDR gene have been cloned in maize, and molecular mechanisms of MDR are not clear. By map-based cloning, we have cloned a teosinte-derived allele of a resistance gene, Mexicana lesion mimic 1 (ZmMM1), which has a lesion mimic phenotype and confers resistance to northern leaf blight (NLB), gray leaf spot (GLS) and southern corn rust (SCR). Strong MDR conferred by the teosinte allele is linked with the polymorphisms in the 3' untranslated region of the ZmMM1 gene that cause increased accumulation of ZmMM1 protein. ZmMM1 acts as a transcription repressor and negatively regulates transcription of specific target genes including ZmMM1-target gene 3 (ZmMT3), which functions as a negative regulator of plant immunity and associated cell death. The successful isolation of the ZmMM1 resistance gene will help not only in developing broad-spectrum and durable disease resistance but also in understanding the molecular mechanisms underlying MDR. | Hongze Wang Jiabao Hou Pei Ye Long Hu Junshi Huang Zhikang Dai Bao Zhang Sha Dai Jiamin Que Haoxuan Min Gengshen Chen Yanbo Wang Min Jiang Yan Liang Lin Li Xuecai Zhang Zhibing Lai | 2021 | Molecular Plant2021，14，11： | 4 |
| 9 | Rapid intelligent evaluation method and technology for determining engineering rock mass quality显示文摘The evaluation of engineering rock mass quality is fundamental work for the engineering activities of rock mass.The increasing scale of rock mass engineering necessitates higher intelligence,timeliness,and accuracy in engineering rock mass quality evaluation.As the core aspects of engineering rock mass quality evaluation,the structural characteristics,mechanical characteristics,and quality classification of rock mass have been innovated in recent years.The non-contact measurement technology for rock mass structure and rapid interpretation of rock mass structure information enables the intelligent extraction and analysis of rock mass structure parameters.The modular backpack laboratory system of rock mechanics provides an effective means to acquire rock mechanical parameters on-site conveniently.The theory of statistical mechanics of rock mass(SMRM)integrates various factors such as the rock mass properties,geological environment,and engineering disturbance,providing a theoretical basis for accurately evaluating the weakening and anisotropy of rock mass.The cloud computing platform established based on SMRM can provide technical support for the rapid calculation of rock mass parameters and instant evaluation of the rock mass quality.The development of intelligent evaluation method and technology is altering the conventional technical state of qualitative and semi-quantitative evaluation of engineering rock mass quality,supporting the realization of rock mass engineering construction with intellectualization and informatization. | Faquan Wu Jie Wu Han Bao Zhongxi Bai Lei Qiao Fang Zhang Bo Li Fuan Si Lei Yu Shenggong Guan Peng Sha Deheng Kong Zhenzhong Dai Kun Chen Yun Tian Changqing Liu | 2023 | Rock Mechanics Bulletin2023，2，2： | 3 |
| 10 | Results of Clinical Trial of Superficially-placed Tumor Therapy with Carbon Ions at Heavy Ion Research Facility in Lanzhou(HIRFL显示文摘 | Zhang Hong Li Sha Wang Xiaohu Li Qiang Zhao Weiping Dai Zhongying Wei Shihua Gao Liying Xiao Guoqing Xu Hushan Hu Zhengguo Mao Ruishi Yue Yangjun Ran Juntao Tian Zhongze Song Mingtao Zhao Hongwei Zhan Wenlong | 2007 | 近代物理研究所和兰州重离子加速器实验室年报:英文版2007，，1： | 2 |
| 11 | 中性植酸酶对鲫鱼生长及磷利用的影响(英文)显示文摘目的:比较研究在无机磷(磷酸二氢钙)添加不足时,添加不同剂量中性植酸酶对鲫鱼生长和磷利用的影响,为水产养殖更好地应用植酸酶提供依据并减少磷的排放,保护环境。创新点:试验采用的中性植酸酶能够耐受饲料加工温度,并从营养物质消化及磷利用等方面研究中性植酸酶对鲫鱼的影响,探究低磷日粮在水产养殖的应用。方法:384条鲫鱼((1.50±0.01)g)随机分为6组,分别饲喂对照组(未添加中性植酸酶)跟试验组(添加不同剂量中性植酸酶)日粮63天,比较3组间各项指标差异。结论:在以植物蛋白为主的日粮中,添加中性植酸酶能够促进植酸磷水解,提高鲫鱼对饲粮中磷、粗蛋白等营养物质的利用,促进钙、磷等矿物质在鲫鱼体中的沉积,降低粪磷排出量,促进鲫鱼生长。说明可以在鲫鱼日粮中添加中性植酸酶,减少无机磷的添加,降低粪磷排放,从而减轻环境污染。 | Xin-zheng NIE Sha CHEN Xiao-xu ZHANG Bin-yang DAI Li-chun QIAN | 2017 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2017，18，10： | 2 |
| 12 | First Clinical Trial of Cancer Therapy with Heavy Ions at IMP显示文摘 | Zhang Hong Li Sha Li Qiang Wei Shihua Hu Zhengguo Mao Ruishi Dai Zhongying Xu Hushan Tian Zhongze Yue Yangjun ZhaoWeiping Xiao Guoqing | 2006 | 近代物理研究所和兰州重离子加速器实验室年报:英文版2006，，1： | 2 |
| 13 | Association of assisted reproductive technology, germline de novo mutations and congenital heart defects in a prospective birth cohort study显示文摘Emerging evidence suggests that children conceived through assisted reproductive technology(ART)have a higher risk of congenital heart defects(CHDs)even when there is no family history.De novo mutation(DNM)is a well-known cause of sporadic congenital diseases;however,whether ART procedures increase the number of germline DNM(gDNM)has not yet been well studied.Here,we performed whole-genome sequencing of 1137 individuals from 160 families conceived through ART and 205 families conceived spontaneously.Children conceived via ART carried 4.59 more gDNMs than children conceived spontaneously,including 332 paternal and 1.26 maternal DNMs,after correcting for parental age at conception,cigarette smoking,alcohol drinking,and exercise behaviors.Paternal DNMs in offspring conceived via ART are characterized by C>T substitutions at CpG sites,which potentially affect protein-coding genes and are significantly associated with the increased risk of CHD.In addition,the accumulation of non-coding functional mutations was independently associated with CHD and 87.9% of the mutations were originated from the father.Among ART offspring,infertility of the father was associated with elevated paternal DNMs;usage of both recombinant and urinary follicle-stimulating hormone and high-dosage human chorionic gonadotropin trigger was associated with an increase of maternal DNMs.In sum,the increased gDNMs in offspring conceived by ART were primarily originated from fathers,indicating that ART itself may not be a major reason for the accumulation of gDNMs.Our findings emphasize the importance of evaluating the germline status of the fathers in families with the use of ART. | Cheng Wang Hong Lv Xiufeng Ling Hong Li Feiyang Diao Juncheng Dai Jiangbo Du Ting Chen Qi Xi Yang Zhao Kun Zhou Bo Xu Xiumei Han Xiaoyu Liu Meijuan Peng Congcong Chen Shiyao Tao Lei Huang Cong Liu Mingyang Wen Yangqian Jiang Tao Jiang Chuncheng Lu Wei Wu Di Wu Minjian Chen Yuan Lin Xuejiang Guo Ran Huo Jiayin Liu Hongxia Ma Guangfu Jin Yankai Xia Jiahao Sha Hongbing Shen Zhibin Hu | 2021 | Cell Research2021，31，8： | 2 |
| 14 | Antigen-binding characteristics of AbCD71 and its inhibitory effect on PHA-induced lymphoproliferation显示文摘瞄准:调查准备 recombinant 的 anti-lymphoproliferative 效果 71 单音的同种细胞的抗体(AbCD71 ) 它是创作了的区别(CD ) 的妄想的人 / 鼠科的反簇导出老鼠,抗原绑定变量区域和导出人的经常的区域。方法:在原生质标志建设和 transfection 以后,在 transfectoma 上层清液的 AbCD71 的表示被三明治 ELISA 决定。间接免疫荧光试金被用来测量抗原绑定特征和百分比表示 CD71 的外部血单音的原子房间(PBMC ) 。抗体经由 diethylaminoethyl (DEAE ) 从腹水被净化 -Sephadex A-50 层析然后由 SDS 页识别了。最后,导致公众房产管理局的 PBMC 增长上的 AbCD71 的禁止的效果被甲基 thiazolyl tetrazolium (MTT ) 计算试金。结果:重链(C (H)) 和 AbCD71 的轻链(C (L)) 的经常的领域分别地在人的 Cgamma 家庭和人的 Ckappa 家庭。AbCD71 能与它的原来的鼠科的 mAb 竞争与 CD71 积极的人的白血病房间线 CEM 房间绑。AbCD71 能禁止单音的原子房间增长由 phytohemagglutinin (公众房产管理局) 导致了的外部血以一种剂量依赖者方式的在试管内,特别在时间点 0 和 12 h 在以后感应。没有统计差别什么时候与原来的鼠科的 mAb 相比。结论:AbCD71 是有希望的抑制免疫力的药。我们与妄想的人 / 鼠科的 mAb 堵住 CD71 的途径为延长紧密相联的接枝幸存提供新奇策略。 | Ping LEI Yong HE Qing YE Hui-fen ZHU Xiao-mei YUAN Jing LIE Wei XING Sha WO Wei DAI Xin SHEN Guo-bin WANG Guan-xin SHEN | 2007 | Acta Pharmacologica Sinica2007，28，10： | 2 |
| 15 | The ChinaMAP reference panel for the accurate genotypeimputation in Chinese populations显示文摘Dear Editor,The genotype imputation is an efficient and pivotal approach to estimate the unobserved genotypes in the genomic data from the single nucleotide polymorphism(SNP)genotyping arrays or whole-genome sequencing(WGS).The fine mapping of variants in the genome-wide association study(GWAS)could be critically improved by the imputation with an optimal reference panel based on the population-specific haplotypes. | Lin Li Peide Huang Xiaohui Sun Siyu Wang Min Xu Sha Liu Zhimin Feng Qing Zhang Xiaoji Wang Xiaole Zheng Mengyao Dai Yufang Bi Guang Ning Yanan Cao Weiqing Wang | 2021 | Cell Research2021，31，12： | 2 |
| 16 | Application of Probiotics in Pig Industry as a Substitute of Antibiotics显示文摘Antibiotics plays a positive role in the development of livestock breeding and feed industry,but has also disadvantages impossible to overcome,so it is an inevitable trend of prohibiting application of antibiotics in feed.This paper reviewed concept and action mechanism of the antibiotics substitute—probiotics,and its application in piglets,growing and fattening pigs and sows. | Sha Wenfeng Zhu Juan Gu Yongjian Dai Hui Qiu Liangwei | 2015 | Animal Husbandry and Feed Science2015，7，1： | 2 |
| 17 | Positioning taxonomic research for the future显示文摘Why do taxonomists matter? The work of taxonomists is often understated if not completely misunderstood. Without taxonomists, organisms cannot be accurately identified, neither can these organisms be given universally accepted names, and reliably positioned in the phylogenetic tree of life. Thanks to the work of taxonomists over the last 269 years since Carl Linnaeus established the binomial system, we can now measure the health and wealth of our biodiversity in a refined, science-based inventory prescribed by stringent nomenclatural rules. | Deyuan Hong Wenying Zhuang Min Zhu Keping Ma Xiaoquan Wang Dawei Huang Yalin Zhang Guodong Ren Wenjun Bu Wanzhi Cai Dong Ren Ding Yang Aiping Liang Fengyan Bai Runzhi Zhang Fumin Lei Shuqiang Li Hongzhi Kong Lei Cai Yucheng Dai Chaodong Zhu Qisen Yang Jun Chen Zhongli Sha Jianping Jiang Jing Che Donghui Wu Jiatang Li Qiang Wang Xinli Wei Ming Bai Xingyue Liu Xuexin Chen Gexia Qiao | 2022 | Zoological Systematics2022，47，3： | 2 |
| 18 | Mechanical properties and fracture characteristics of CNTs-doped W-Nb alloys显示文摘 | SHA J J HAO X N LI J DAI J X YANG X L YOON H K | 2014 | Journal of Nuclear Materials2014，445，： | 1 |
| 19 | Quantitative morphology of facial nerve based on three-dimensional reconstruction of temporal bone 显示文摘 | NI Y SHA Y DAI P | 2008 | Otolaryngol Head Neck Surg2008，138，1： | 1 |
| 20 | A joint call for actions to advance taxonomy in China显示文摘Taxonomy plays an important role in understanding the origin, evolution, and ecological functionality of biodiversity. There are large number of unknown species yet to be described by taxonomists, which together with their ecosystem services cannot be effectively protected prior to description. Despite this, taxonomy has been increasingly underrated insufficient funds and permanent positions to retain young talents. Further, the impact factordriven evaluation systems in China exacerbate this downward trend, so alternative evaluation metrics are urgently necessary. When the current generation of outstanding taxonomists retires,there will be too few remaining taxonomists left to train the next generation. In light of these challenges, all co-authors worked together on this paper to analyze the current situation of taxonomy and put out a joint call for immediate actions to advance taxonomy in China. | Chaodong Zhu Arong Luo Ming Bai Michael COrr Zhonge Hou Siqin Ge Jun Chen Yibo Hu Xuming Zhou Gexia Qiao Hongzhi Kong Limin Lu Xiaohua Jin Lei Cai Xinli Wei Ruilin Zhao Wei Miao Qingfeng Wang Zhongli Sha Qiang Lin Meng Qu Jianping Jiang Jiatang Li Jing Che Xuelong Jiang Xiaoyong Chen Lianming Gao Zongxin Ren Chunlei Xiang Shixiao Luo Donghui Wu Dong Liu Yanqiong Peng Tao Su Chenyang Cai Tianqi Zhu Wanzhi Cai Xingyue Liu Hu Li Huaijun Xue Zhen Ye Xuexin Chen Pu Tang Shujun Wei Hong Pang Qiang Xie Feng Zhang Feng Zhang Xianjin Peng Aibing Zhang Taiping Gao Changfa Zhou Chen Shao Libin Ma Zhaoming Wei Yunxia Luan Ziwei Yin Wu Dai Cong Wei Xiaolei Huang Jingxian Liu Xiangsheng Chen Tianci Yi Zhisheng Zhang Zhulidezi Aishan Qin Li Hongying Hu | 2022 | Zoological Systematics2022，47，3： | 1 |
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