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| 1 | Impact of postoperative omega-3 fatty acid-supplemented parenteral nutrition on clinical outcomes and immunomodulations in colorectal cancer patients显示文摘AIM: To investigate the effect of omega-3 fatty acid parenteral supplementation postoperatively on clinical outcomes and immunomodulation in colorectal cancer patients. METHODS: Forty-two patients undergoing radical colorectal cancer resection with an indication for total parenteral nutrition postoperatively were enrolled in this prospective, double-blind, randomized, controlled study. Patients received total parenteral nutrition supplemented with either soybean oil (LCT; Intralipid, Fresenius-Kabi, SO group, n = 21) or a combination of omega-3 fish oil and soybean oil (LCT:fish oil = 5:1, fish oil; Omegaven, Fresenius-Kabi, FO group, n = 21), up to a total of 1.2 g lipid/kg per day for 7 d postoperatively. A same volume calorie and nitrogen was administrated. Routine blood test, biochemistry, systemic levels of IL-6 and TNF-α, percentage of CD3+, CD4+, and CD8+ lymphocytes were evaluated preoperatively and on postoperative d 1 and 8. Patient outcome was evaluated considering mortality during the hospital stay, length of postoperative hospital stay, and occurrence of infectious complications. RESULTS: Both lipid regimens were well tolerated. No differences between the two groups were noticed in demographics, baseline blood test, biochemistry, serum levels of IL-6 and TNF-α, percentage of CD4+, CD8+ lymphocytes, and ratios of CD4+/CD8+. Compared with those on postoperative d 1, serum IL-6 levels onpostoperative d 8 were significantly depressed in the FO group than in the reference group (-44.43 ± 30.53 vs -8.39 ± 69.08, P = 0.039). Simultaneously, the ratios of CD4+/CD8+ were significantly increased in the FO group (0.92 ± 0.62 vs 0.25 ± 1.22, P = 0.035). In addition, depression of serum TNF-α levels (-0.82 ± 2.71 vs 0.27 ± 1.67, P = 0.125) and elevation of CD3+ and CD4+ lymphocyte percentage (12.85 ± 11.61 vs 3.84 ± 19.62, P = 0.081, 17.80 ± 10.86 vs 9.66 ± 17.55, P = 0.084, respectively) were higher in the FO group than in the reference group. Patients in the FO group trended to need a shorter postoperative hospital stay (17.45 ± 4.80 d vs 19.62 ± 5.59 d, P = 0.19). No statistically significant difference was found when stratified to mortality and occurrence of infectious complications. CONCLUSION: Postoperative supplementation of omega-3 fatty acids may have a favorable effect on the outcomes in colorectal cancer patients undergoing radical resection by lowering the magnitude of inflammatory responses and modulating the immune response. | Bin Liang, Shan Wang, Ying-Jiang Ye, Xiao-Dong Yang, You-Li Wang, Jun Qu, Qi-Wei Xie, Mu-Jun Yin, Division of Surgical Oncology and Division of Gastroenterological Surgery, Peking University People’s Hospital, Beijing 100044, China Author contributions: Liang B and Wang S contributed equally to this work Liang B and Wang S designed the research Liang B, Ye YJ, Yang XD, Wang YL, Qu J, Xie QW, Yin MJ performed the research and collected the data Wang S and Ye YJ supervised the research Liang B and Ye YJ analyzed the data Liang B wrote the paper and revised the manuscript. | 2008 | World Journal of Gastroenterology2008，14，15： | 31 |
| 2 | Clostridium difficile infections in China显示文摘Clostridium difficile (C. difficile) infection has become one of the major hospital-associated infections in West-ern countries in the last two decades. However, there is limited information on the status of C. difficile infection inChinese healthcare settings. Given the large and increasing elderly population and the well-recognized problem ofover-prescribing of broad spectrum antibiotics in China, it is critical to understand the epidemiology and potentialrisk factors that may contribute to C. difficile infection in China. A literature review of available published studies,including those in Chinese language-based journals, was conducted. A review of the currently available literaturesuggested the presence of C. difficile infections in China, but also suggested that these infections were not particu-larly endemic. This finding should lead to better designed and greatly expanded studies to provide a more reliableepidemiologically-based conclusion on the actual status of C. difficile infection in China, including the identifica-tion of any associated risk factors. Such information is ultimately valuable to develop appropriate strategies to pre-vent C. difficile infection and the vast negative impact of such infections in China and other developing countries. | Ke Jin a,b,c,Shixia Wang c,d,Zuhu Huang a,b,c,Shan Lu b,c,daDepartment of Infectious Diseases,bJiangsu Province Key Laboratory in Infectious Diseases,cChina-US Vaccine ResearchCenter,the First Affiliated Hospital of Nanjing Medical University,Nanjing,Jiangsu 210029,China d Department of Medicine,University of Massachusetts Medical School,Worcester,MA 01655,USA. | 2010 | The Journal of Biomedical Research2010，24，6： | 14 |
| 3 | Strengthening population medicine to promote public health显示文摘As we enter.2022,we are facedwith the fact that coronavirus disease2019(CovID-19)has been devastating the world formore than 2full years.Since the original outbreak of COVID-19in December2019,the disease has proved to be a major threat to global health and,perhaps more importantly,one that is not likely to be resolved soon.Severe_acute respiratory syndrome coronavirus. | Chen Wang Simiao Chen Guangliang Shan Zhiwei Leng Till Bärnighausen Weizhong Yang | 2022 | Chinese Medical Journal2022，，10： | 3 |
| 4 | Basic mechanisms in heart failure: the cytokine hypothesis显示文摘 | Seta Y Shan K Bozkurt B | | 0，，： | 2 |
| 5 | Chemical and pharmacological evaluation of Hypericum perforation extracts显示文摘KEY WORDS Hypericum perforation; High pressure liquid chromatography; serotonin uptake inhibitors; tree radicals; antioxidants; hyperforin; hypericin; quercetin; rutinABSTRACTAIM: To determine the concentrations of chemical characteristic to extracts of leaves and flowers of Hypericum perforatnm (St John’s wort) in a number of selected samples and, following chemical characterization, to investigate the effects of these extracts on several pharmacological properties including effects of the extracts on inhibition of 5-hydroxytryptamine (5-HT) uptake and on an-tioxidant properties. METHODS: The samples were analyzed for the presence of characteristic chemicals by high performance liquid chromatography (HPLC) directly coupled to ultraviolet wavelength absorbance and positive or negative mode electrospray mass spectrometric detection. The effects of extracts on 5-HT uptake were determined by quantifying 3H-5-HT incorporation into rat hip-pocampal prisms. Estimates of effects of extracts on free radical | B Duff SLOLEY Liana J URICHUK LING Lei GU Lie-Dong Ronald T COUTTS Peter K T PANG Jacqueline J SHAN | 2000 | Acta Pharmacologica Sinica2000，21，12： | 2 |
| 6 | Ozone-induced grafting phosphorylcholine polymer onto silicone film grafting 2-methacryloyloxyethyl phosphorylcholine onto silicone film to improve hemocompatibility显示文摘 | Yuan Y L Shan B | 2003 | Colloids and Surfaces B:Biointerfaces2003，30，： | 1 |
| 7 | Preconcentration of trace elements in sea water with poly (acrylaminophosphonic dithiocarbamate)chelating fiber for their determination by inductively coupled plasma mass spectrometry显示文摘 | WEN B SHAN X Q RUI-XIA LIU | 1999 | Journal of Analytical Chemistry1999，363，3： | 1 |
| 8 | Stability of titania nanoparticles in soil suspensions and transport in saturated homogeneous soil columns显示文摘 | Fang J Shan X Q Wen B | 2009 | Environmental Pollution2009，157，： | 1 |
| 9 | Unsaturated fatty acids inhibit transcription of the sterol regulatory element-binding proteinlc (SREBP-lc) gene by antagonizing ligand-dependent activation of the LXR显示文摘 | Ou J Tu H Shan B Luk A DeBose-Boyd RA Bashmakov Y Goldstein JL Brown MS | | 0，，11： | 1 |
| 10 | Highly sensitive acetone sensors based on La-doped et-Fe203 nanotubes显示文摘 | SHAN H LIU C B LIU L | 2013 | Sensors and Actuators B: Chemical2013，184，： | 1 |
| 11 | Study on precision forging technology for a complex-shaped light alloy forging 显示文摘 | SHAN D B XU W C LU Y | 2004 | J of Mat Proc Tech2004，151，13： | 1 |
| 12 | Growth inhibitory effects of extracellular adenosine triphosphate on esophageal carcinoma cells显示文摘 | Wang M X Ren L M Shan B E | 2005 | World J Gastroenterol2005，11，38： | 1 |
| 13 | Determination of forty,two major and trace elements of USGS and NIST SRM glasses by laser ablation-inductively coupled plasma-mass spectrometry 显示文摘 | Gao Shan Liu Xiao-ming Yuan Hong-lin Hattendorf B Gunther D Chen Liang Hu Shen-hong | 2002 | Geostand Newsl2002，26，2： | 1 |
| 14 | Residual Performance of FRP-Retrofitted RC Columns After Being Subjected to Cyclic Loading Damage显示文摘 | Shan B Xiao Y Guo Y R | 2006 | Journal of Composite for Construction ASCE2006，，10： | 1 |
| 15 | RSUME is implicated in HIF-1-induced VEGF-A production in pituitary tumour cells 显示文摘 | Shan B Gerez J Haedo M et ol | 2012 | Endocr Relat Cancer2012，19，1： | 1 |
| 16 | Blueshift of near band emission inMg-doped ZnO thin films and aging显示文摘 | SHAN F K KIN B I LIU G X | 2004 | JAppl Phys2004，95，： | 1 |
| 17 | High voltage fast ramp pulse generation using avalanche transistor显示文摘 | Liu J Shan B Chang Z H | 1998 | Review of Scientific Instruments1998，69，8： | 1 |
| 18 | Bequirement of HDAC6 for transforming growth factor-bctal-induced epithelial mesenchymal transition显示文摘 | Shan B Yao TP Nguyen HT | | 0，，30： | 1 |
| 19 | Production environmental impact and mechanical properties of glubam 显示文摘 | Xiao Y Yang R Z Shan B | 2013 | Journal of Construction and Building Materials2013，44，11： | 1 |
| 20 | Social capital, structural holes and the formation of an industry network显示文摘 | Walker G Kogut B Shan W J | 1997 | Organization Science1997，8，2： | 1 |
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