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| 1 | Subcurative radiation significantly increases cell proliferation, invasion, and migration of primary glioblastoma multiforme in vivo显示文摘Tumor cell proliferation, infiltration, migration, and neovascularization are known causes of treatment resistance in glioblastoma multiforme(GBM). The purpose of this study was to determine the effect of radiation on the growth characteristics of primary human GBM developed in a nude rat. Primary GBM cells grown from explanted GBM tissues were implanted orthotopically in nude rats. Tumor growth was confirmed by magnetic resonance imaging on day 77(baseline) after implantation. The rats underwent irradiation to a dose of 50 Gy delivered subcuratively on day 84 postimplantation(n = 8), or underwent no radiation(n = 8). Brain tissues were obtained on day 112(nonirradiated) or day 133(irradiated). Immunohistochemistry was performed to determine tumor cell proliferation(Ki-67) and to assess the expression of infiltration marker(matrix metalloproteinase-2, MMP-2) and cell migration marker(CD44). Tumor neovascularization was assessed by microvessel density using von-Willebrand factor(vWF) staining. Magnetic resonance imaging showed well-developed, infiltrative tumors in 11 weeks postimplantation. The proportion of Ki-67-positive cells in tumors undergoing radiation was(71 ± 15)% compared with(25 ± 12)% in the nonirradiated group(P = 0.02). The number of MMP-2-positive areas and proportion of CD44-positive cells were also high in tumors receiving radiation, indicating great invasion and infiltration. Microvessel density analysis did not show a significant difference between nonirradiated and irradiated tumors. Taken together, we found that subcurative radiation significantly increased proliferation, invasion, and migration of primary GBM. Our study provides insights into possible mechanisms of treatment resistance following radiation therapy for GBM. | Adarsh Shankar Sanath Kumar Asm Iskander Nadimpalli RS Varma Branislava Janic Ana deCarvalho Tom Mikkelsen Joseph A Frank Meser M Ali Robert A Knight Stephen Brown Ali S Arbab | 2014 | Chinese Journal of Cancer2014，33，3： | 5 |
| 2 | Effects of sequential treatments with chemotherapeutic drugs followed by TRAIL on prostate cancer in vitro and in vivo显示文摘 | Shankar S Chen X Srivastava RK | 2005 | Prostate2005，62，2： | 1 |
| 3 | initial clinical experience with RF ablation of lung tumors 显示文摘 | Van Sonnenberg E Shankar S Tuncali KT | 2002 | Radiology2002，，： | 1 |
| 4 | Solar photocatalyticdegradation of azo dye: Comparison of photocatalytic efficiency of ZnO and TiO2 显示文摘 | SAKTHIVEL S NEPPOLIAN B SHANKAR M V ARABINDOO B PALANICHAMY M MOORAGESAN V | 2003 | Solar Energy Materials & Solar Cells2003，77，： | 1 |
| 5 | Chemoprevention by resveratrol: molecular mechanisms and therapeutic potential 显示文摘 | Shankar S Singh G Srivastava RK | 2007 | Front Biosci2007，12，： | 1 |
| 6 | Characterization of microstructures in Inconel 625 using X-ray diffraction peak broad- ening and lattice parameter measurements显示文摘 | RAI S K KUMAR A SHANKAR V | 2004 | Scripta Materialia2004，51，1： | 1 |
| 7 | Purification and characterization of thermostable a-galactosidase from Aspergillus terreus GR显示文摘 | SHANKAR S K DHANANJAY S K MUL1MANI V H | 2009 | Applied Biochemistry and Biotechnology2009，152，2： | 1 |
| 8 | FOXO transcrip- tion factors and VEGF neutralizing antibody enhance antian- giogenic effects of resveratrol 显示文摘 | Srivastava RK Untemlan TG Shankar S | 2010 | Mol Cell Bioehem2010，337，12： | 1 |
| 9 | Infection- derived Enterocoecusfaecalis strain mrfare enriched in esp, a gene encoding a novel surface protein显示文摘 | Shankar V Baghdayan A S Huyeke M M | 1999 | Infect Immun1999，67，： | 1 |
| 10 | Three dimensional simulation for an open channel flow with a constriction 显示文摘 | SHANKAR N J CHAN E S ZHANG Q Y | 2001 | Journal of Hydraulic Reserach2001，39，2： | 1 |
| 11 | Transaction processing in replicated data in the DDBMS显示文摘 | Srivastava A Shankar U Tiwari S K | 2012 | International Journal of Modern Engineering Research2012，2，4： | 1 |
| 12 | Distributed recognition of human actions using wearable motion sensor networks显示文摘 | Yang Y Jafari R Shankar S | | 0，，02： | 1 |
| 13 | Application of indigenous microbial consortia in bioremediation of oil-contaminated soils显示文摘 | Shankar S Kansrajh C Dinesh M G | 2014 | Int J Environ Sci Technol2014，11，36： | 1 |
| 14 | Anodic Growth of Highly Ordered TiO2 Nanotube Arrays to 134 fxm in Length显示文摘 | PAULOSE M SHANKAR K YORIYA S | 2006 | The Journal of Physical Chemistry B2006，111，16： | 1 |
| 15 | Transforming growth factor-beta negatively modulates T-cell responses in sepsis 显示文摘 | Ahmad S Choudhry MA Shankar R | 1997 | FEBS Lett1997，402，23： | 1 |
| 16 | Pathogenic enterocoeci: new developments in the 21st century显示文摘 | Tendolkar P M Baghdayan A S Shankar N | 2003 | Cell Mol Life Sci2003，60，12： | 1 |
| 17 | Transform domain LMS algorithm显示文摘 | S Shankar Narayan Allen M P M J Narsimaha | 1983 | IEEE Trans ASSP1983，31，3： | 1 |
| 18 | Synergistic interactions of chemotherapeutic drugs and tumor necrosis factor-related apoptosis-inducing ligand/Apo-2 ligand on apoptosis and on regression of breast carcinoma in vivo显示文摘 | Singh TR Shankar S Chen X | 2003 | Cancer Res2003，63，17： | 1 |
| 19 | Diagnosis and treatment of intrahepatic biloma complicating radiofrequency ablation of hepatic metastases显示文摘 | Shankar S van Sonnenberg E Silverman SG | 2003 | American Journal of Roentgenology2003，181，2： | 1 |
| 20 | Role of Enterococcus faecalis surface protein Esp in the pathogenesis of ascending urinary tract infection显示文摘 | Shankar N Lockatell C V Baghdayan A S | 2001 | Infect Immun2001，69，： | 1 |
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