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| 1 | Surfactant enhanced alkaline flooding for Western Canadian heavy oil recovery显示文摘 | Qiang Liu Mingzhe Dong Shanzhou Ma Yun Tu | 2006 | Colloids and Surfaces A: Physicochemical and Engineering Aspects2006，，1： | 2 |
| 2 | Enhanced heavy oil recovery through interracial instability:A study of chemi- cal flooding for Brintnell heavy oil显示文摘 | Mingzhe Dong Shanzhou Ma Qiang Liu | 2009 | Fuel2009，88，6： | 1 |
| 3 | Enhanced heavy oil recovery through interracial instability: A study of chemical flooding for Brintnell heavy oil显示文摘 | Mingzhe Dong Shanzhou Ma Qiang Liu | 2009 | Fuel2009，88，： | 1 |
| 4 | Sur-factant enhanced alkaline flooding for western Canadianheavy oil recovery 显示文摘 | LIU Qiang DONG Mingzhe MA Shanzhou | 2007 | Colloids and Surfaces A : Physi-cochemical and Engineering Aspects2007，293，13： | 1 |
| 5 | Surfactant enhanced alkaline flooding for Western Canadian heavy oil recovery显示文摘 | Liu Qiang Dong Mingzhe Ma Shanzhou | 2007 | Colloids and Surface A:Physicochem Eng Aspects2007，293，： | 1 |
| 6 | Enhanced heavy oil re- covery through interfacial instability: a study of chemical flooding for brintnell heavy oil 显示文摘 | Dong Mingzhe Ma Shanzhou Liu Qiang | 2009 | Fuel2009，88，6： | 1 |
| 7 | Enhanced heavy oil recovery through interfacial instability: A study of chemical flooding for Brintnell heavy oil显示文摘 | Mingzhe Dong Shanzhou Ma Qiang Liu | 2008 | Fuel2008，，6： | 1 |
| 8 | Surfactant enhanced alkaline flooding for westen Canadian heavy oil recovery显示文摘 | Dong Mingzhe Ma Shanzhou | 2006 | Colloids and Surface A:physicochem Eng A spects2006，273，： | 1 |
| 9 | Surfactant enhanced alkaline flooding for westen canadian heavy oil recovery 显示文摘 | Liu Qiang Dong Mingzhe Ma Shanzhou | 2007 | Colloids and Surface A : Physico - chemical and Engineering Aspect2007，293，1： | 1 |
| 10 | Enhanced heavy oil recovery through inteffaeial instability A study of chemical flooding for Brintnell heavy oil显示文摘 | Dong Mingzhe Ma Shanzhou Liu Qiang | 2008 | Fuel2008，8，： | 1 |
| 11 | Enhanced heavy oil recovery through interfacial instability: a study of chemical flooding for Brintnell heavy oil 显示文摘 | DONG Mingzhe MA Shanzhou LIU Qiang | 2009 | Fuel2009，88，6： | 1 |
| 12 | Surfactant enhanced alkaline flooding for western Canadian heavy oil recovery 显示文摘 | LIU Qiang DONG Mingzhe MA Shanzhou | 2007 | Colloids Surf A: Physicochem Eng Aspects2007，293，1： | 1 |
| 13 | Macrophage-targeting gene silencing orchestrates myocardial microenvironment remodeling toward the anti-inflammatory treatment of ischemia-reperfusion (IR) injury显示文摘Ischemia-reperfusion (IR) injury represents a major cause of myocardial dysfunction after infarction and thrombolytic therapy, and it is closely related to the free radical explosion and overwhelming inflammatory responses. Herein, macrophage-targeting nanocomplexes (NCs) are developed to mediate efficient co-delivery of siRNA against MOF (siMOF) and microRNA-21 (miR21) into myocardial macrophages, cooperatively orches-trating the myocardial microenvironment against IR injury. Bioreducible, branched poly(β-amino ester) (BPAE-SS) is designed to co-condense siMOF and miR21 into NCs in a multivalency-reinforced approach, and they are surface-decorated with carboxylated mannan (Man-COOH) to shield the positive surface charges and enhance the serum stability. The final MBSsm NCs are efficiently internalized by myocardial macrophages after systemic administration, wherein BPAE-SS is degraded into small segments by intracellular glutathione to promote the siMOF/miR21 release, finally provoking efficient gene silencing. Thus, cardiomyocyte protection and macro-phage modulation are realized via the combined effects of ROS scavenging, inflammation inhibition, and autophagy attenuation, which ameliorates the myocardial microenvironment and restores the cardiac function via positive cellular crosstalk. This study renders promising solutions to address the multiple systemic barriers against in vivo nucleic acid delivery, and it also offers new options for IR injury by manipulating multiple reciprocal bio-reactions. | Yao Wang Mengying Hou Shanzhou Duan Ziyin Zhao Xuejie Wu Yongbing Chen Lichen Yin | 2022 | Bioactive Materials2022，7，11： | 1 |
| 14 | Engineering blood-brain barrier-permeable and tumor cell-ingestible pro-proteins for glioblastoma treatment显示文摘Intracellular protein therapeutics holds great potentials for the treatment of glioblastoma, which however, is greatly challenged by the unmet demands to concomitantly penetrate the blood-brain barrier(BBB) and glioblastoma cell membrane barrier with high efficiency and selectivity. Herein, a unique pro-protein platform was developed via facile green synthesis, which allowed efficient and selective delivery into glioblastoma cells in a carrier-free manner. Pro-proteins were engineered via reversible modification of native proteins in the aqueous buffer with 3,4-dihydroxy-phenylalanine, the substrate of L-type amino acid transporter(LAT1), bridged with a phenylboronic acid-containing linker. By harnessing the LAT1-mediated direct transport mechanism, the optimized pro-protein, named protein-M2-D, can efficiently penetrate BBB after i.v. injection, and subsequently enable selective and endocytosis-free delivery of various proteins including enzymes, toxins, and antibodies into glioblastoma cells, wherein intracellular H_(2)O_(2) triggered traceless restoration of the native protein structure. Systemic administration of saporin-M2-D provoked potent anti-tumor efficacy against orthotopic U87 glioblastoma in mice, without inducing systemic toxicity. Such a facile, versatile, and robust platform renders a promising paradigm for cytosolic protein delivery and glioblastoma treatment. | Xun Liu Wenting Si Ziyin Zhao Ningyu Liu Qiang Yang Renxiang Zhou Rongying Zhu Shanzhou Duan Yongbing Chen Lichen Yin | 2023 | Science China Chemistry2023，66，9： | 0 |
| 15 | MicroRNA-208a silencing against myocardial ischemia/reperfusion injury mediated by reversibly camouflaged biomimetic nanocomplexes显示文摘MicroRNA-208a(miR-208a)plays critical roles in the severe fibrosis and heart failure post myocardial ischemia/reperfusion(IR)injury.MiR-208a inhibitor(mI)with complementary RNA sequence can silence the expression of miR-208a,while it is challenging to achieve efficient and myocardium-targeted delivery.Herein,biomimetic nanocomplexes(NCs)reversibly coated with red blood cell membrane(RM)were developed for the myocardial delivery of mI.To construct the NCs,membrane-penetrating helical polypeptide(PG)was first adopted to condense mI and form the cationic inner core,which subsequently adsorbed catalase(CAT)via electrostatic interaction followed by surface coating with RM.The membrane-coated NCs enabled prolonged blood circulation after systemic administration,and could accumulate in the injured myocardium via passive targeting.In the oxidative microenvironment of injured myocardium,CAT decomposed H_(2)O_(2)to produce O_(2)bubbles,which drove the shedding of the outer RM to expose the positively charged inner core,thus facilitated effective internalization by cardiac cells.Based on the combined contribution of mI-mediated miR-208a silencing and CAT-mediated alleviation of oxidative stress,NCs effectively ameliorated the myocardial microenvironment,hence reducing the infarct size as well as fibrosis and promoting recovery of cardiac functions.This study provides an effective strategy for the cytosolic delivery of nucleic acid cargoes in the myocardium,and it renders an enlightened approach to resolve the blood circulation/cell internalization dilemma of cell membrane-coated delivery systems. | Jianhui Lu Jiaheng Zhang Wen Yan Chenglong Ge Yang Zhou Rongying Zhu Shanzhou Duan Lichen Yin Yongbing Chen | 2023 | Nano Research2023，16，8： | 0 |
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