3篇
您的检索式：作者名="Sharon Manley"
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| 1 | Role of farnesoid X receptor and bile acids in alcoholic liver disease显示文摘Alcoholic liver disease(ALD) is one of the major causes of liver morbidity and mortality worldwide. Chronic alcohol consumption leads to development of liver pathogenesis encompassing steatosis, inflammation, fibrosis, cirrhosis, and in extreme cases, hepatocellular carcinoma. Moreover,ALD may also associate with cholestasis. Emerging evidence now suggests that farnesoid X receptor(FXR) and bile acids also play important roles in ALD. In this review, we discuss the effects of alcohol consumption on FXR, bile acids and gut microbiome as well as their impacts on ALD. Moreover, we summarize the findings on FXR, Fox O3a(forkhead box-containing protein class O3a) and PPARα(peroxisome proliferator-activated receptor alpha) in regulation of autophagy-related gene transcription program and liver injury in response to alcohol exposure. | Sharon Manley Wenxing Ding | 2015 | Acta Pharmaceutica Sinica B2015，5，2： | 12 |
| 2 | New advances in molecular mechanisms and emerging therapeutic targets in alcoholic liver diseases显示文摘Alcoholic liver disease is a major health problem in the United States and worldwide. Chronic alcohol consumption can cause steatosis, inflammation, fibrosis, cirrhosis and even liver cancer. Significant progress has been made to understand key events and molecular players for the onset and progression of alcoholic liver disease from both experimental and clinical alcohol studies. No successful treatments are currently available for treating alcoholic liver disease; therefore, development of novel pathophysiological-targeted therapies is urgently needed. This review summarizes the recent progress on animal models used to study alcoholic liver disease and the detrimental factors that contribute to alcoholic liver disease pathogenesis including miRNAs, S-adenosylmethionine, Zinc deficiency, cytosolic lipin-1β, IRF3-mediated apoptosis, RIP3-mediated necrosis and hepcidin. In addition, we summarize emerging adaptive protective effects induced by alcohol to attenuate alcohol-induced liver pathogenesis including FoxO3, IL-22, autophagy and nuclear lipin-1α. | Jessica A Williams Sharon Manley Wen-Xing Ding | 2014 | World Journal of Gastroenterology2014，20，36： | 10 |
| 3 | Fatty acid synthase effects on bovine adipose fat and milk fat显示文摘 | Chris A. Morris Neil G. Cullen Belinda C. Glass Dianne L. Hyndman Tim R. Manley Sharon M. Hickey John C. McEwan Wayne S. Pitchford Cynthia D.K. Bottema Michael A.H. Lee | 2007 | Mammalian Genome2007，，1： | 1 |
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