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| 1 | Testicular defense systems: immune privilege and innate immunity显示文摘因为它显著有免疫力的特权和有效本地天生的免疫的性质,哺乳动物的睾丸拥有特殊免疫学的环境。阴囊的有免疫力的特权保护产生免疫性的细菌房间免受全身的有免疫力的攻击的伤害,并且本地天生的免疫在阻止阴囊的微生物引起的感染是重要的。本地阴囊的有免疫力的动态平衡的故障可以导致睾丸炎,男不孕的一个 etiological 因素。位于阴囊的有免疫力的特权下面的机制很长时间被调查了。增加的证据两个都显示出那本地抑制免疫力的周围和全身的有免疫力的忍耐涉及维持阴囊的有免疫力的特权地位。位于阴囊的天生的免疫下面的机制基于模式识别的调查正在出现在阴囊的房间的调停受体的天生的有免疫力的反应。这评论总结我们阴囊的防卫机制的当前的理解并且鉴别应得的话题推进调查。 | Shutao Zhao Weiwei Zhu Shepu Xue Daishu Han | 2014 | Cellular & Molecular Immunology2014，11，5： | 10 |
| 2 | Analysis of gene expression patterns with cDNA microarray during late stage of spermatogenesis in mice显示文摘The differentiation process of round spermat-ids to spermatozoa during the late stage of spermatogenesis is called spermiogenesis. To explore spermiogenesis-related genes, cDNA microarray was used to study expression patterns of 1176 genes in pachytene spermatocytes, round spermatids and elongating spermatids of Balb/c mice. The results showed that 208 genes were detected in all the three cell types. Most of them were down-regulated from pachytene spermatocytes to round spermatids and elongating spermatids. However, up-regulation of 7 genes expression in round spermatids and 3 genes in elongating spermatids were found. Expression of 7 differentially expressed genes in cDNA arrays was further confirmed by semi-quantitative RT-PCR study. The RT-PCR results indicated that the expression of 6 genes was consistent with that in cDNA arrays, only one gene did not show differential expression by RT-PCR. These results may provide important clues for studying of expression, regulation, and function of | YU Zuoren GUAN Jikui GE Yehua MA Jing GUO Rui LI Sai XUE Shepu HAN Daishu | 2002 | Chinese Science Bulletin2002，47，24： | 3 |
| 3 | Abnormal expression of cen-trosome protein (centrin) in spermatozoa of male human infertility显示文摘To study the relations between male infertility and centrosome protein (centrin) and the functions of centrin in spermatogenesis, the matured spermatozoa of 10 normal male people and 18 male infertility patients were stained by immunofluorescence labeling antibody against centrin. The results showed that two fluorescence signal dots appeared in the normal male spermatozoa and were located at the base of flagellum. They are proximal centriole and distal centriole. However, in some spermatozoa of the male infertility, centrin protein was located abnormally at the base of flagellum and its staining signals were spread, the normal proximal and distal centrioles were confused and could not be recognized separately. These results suggest that abnormality of centrosome protein may be related to male infertility. This discovery may be used as a marker of abnormal sperm and male infertility. | SUN Xiaodong MA Jing GE Yehua LI Sai YU Zuoren XUE Shepu HAN Daishu | 2002 | Chinese Science Bulletin2002，47，10： | 1 |
| 4 | Isolation and characterization of a novel mouse erythroid differentiation-denucleation related gene(MEDDF)显示文摘Using subtractive cDNA cloning method, a series of cDNA fragments have been isolated. One of them has been selected, that expressed differentially in the mouse intermediatelate erythroblasts, as a probe for the screening of mouse erythroid differentiation related gene from a cDNA library constructed from mouse mid-late erythroids. A positive cDNA clone has been obtained using phage in situ hybridization coupled with PCR technique. Sequencing of this cDNA by utilizing the Bluescript-SK( + ) phage vector system demonstrates that it has a full length of 505 bp with an open reading frame of 309 bp (from 53 to 359 bp) encoded a protein of 102 amino acids. There is a tailing signal AATAA at 462 bp and a 26-bp long poly A tail terminal at the 3′UTR. Searches of GenBank databases failed to find any homologous sequences (GenBank Accession Number: Banklt 180846 AF 060220) and it was proved to be a novel gene designated mouse erythroid differentiation-denucleation related gene (MEDDF). Northern blot analysis | Zhengyan Zhang Shiguang Liu Jingbo Zhang Shepu Xue | 1999 | Chinese Science Bulletin1999，44，15： | 0 |
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