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| 1 | 术中应用荧光素钠有利于胶质母细胞瘤浸润边缘的手术切除(英文)显示文摘Objective Extent of resection is an important prognostic factor in patients undergoing surgery for glioblastoma( GBM).Recent evidence suggests that intravenously administered fluorescein sodium associates with tumor tissue,facilitating safe maximal resection of GBM. In this study,the authors evaluate the safety and utility of intraoperative fluorescein guidance for the prediction of histopathological alteration both in the contrast-enhancing( CE) regions,where this relationship has been established,and into the nonCE( NCE),diffusely infiltrated margins. Methods Thirty-two patients received fluorescein sodium( 3 mg/kg) intravenously prior to resection. Fluorescence was intraoperatively visualized using a Zeiss Pentero surgical microscope equipped with a YELLOW 560 filter.Stereotactically localized biopsy specimens were acquired from CE and NCE regions based on preoperative MRI in conjunction with neuronavigation. The fluorescence intensity of these specimens was subjectively classified in real time with subsequent quantitative image analysis,histopathological evaluation of localized biopsy specimens,and radiological volumetric assessment of the extent of resection.Results Bright fluorescence was observed in all GBMs and localized to the CE regions and portions of the NCE margins of the tumors,thus serving as a visual guide during resection. Gross-total resection( GTR) was achieved in 84% of the patients with an average resected volume of 95%,and this rate was higher among patients for whom GTR was the surgical goal( GTR achieved in 93. 1% of patients,average resected volume of 99. 7%). Intraoperative fluorescein staining correlated with histopathological alteration in both CE and NCE regions,with positive predictive values by subjective fluorescence evaluation greater than 96% in NCE regions. Conclusions Intraoperative administration of fluorescein provides an easily visualized marker for glioma pathology in both CE and NCE regions of GBM. These findingssupport the use of fluorescein as a microsurgical adjunct for guiding GBM resection to facilitate safe maximal removal. | Neira JA Ung TH Sims J Malone HR Chow DS Samanamud JL Zanazzi GJ Guo X Bowden SG Zhao B Sheth SA McKhann GM 2nd Sisti MB Canoll P D'Amico RS Bruce JN | 2016 | 中华神经外科疾病研究杂志2016，15，5： | 2 |
| 2 | Federated database system for managing distributed, heterogeneous, and autonomous database 显示文摘 | SHETH A P LARSON J A | 1990 | AGM Computing Suweys1990，22，3： | 1 |
| 3 | Quality of service for workflows and Web service processes显示文摘 | CARDOSO J SHETH A P MILLER J A | 2004 | Web Semantics2004，1，3： | 1 |
| 4 | Federated database systems for managing distributed, heterogeneous, and autonomous databases显示文摘 | Sheth A P Larson J A | 1990 | ACM Computing Surveys1990，22，3： | 1 |
| 5 | Federated database systems for managing distributed, heterogeneous, and autonomous database 显示文摘 | Sheth A P Larson J A | 1990 | ACM Computing Surveys1990，922，3： | 1 |
| 6 | Role of Chain Symmetry and Hydrogen Bonding in Segmen- ted Copolymers with Monodisperse Hard Segments 显示文摘 | SHETH J P KLINEDINST D B WILKES G L | 2005 | Polymer2005，46，18： | 1 |
| 7 | Federated Database Systems for Managing Distributed, Heterogeneous and Autonomous Database 显示文摘 | A P Sheth J a Larson | 1990 | ACM Computing Surveys1990，22，3： | 1 |
| 8 | Role of chain symmetry and hydrogen bonding in aegmnented copolymers with monodisperse hard segments显示文摘 | Sheth J P Klinedinst D B Wilkes G L | 2005 | Polymer2005，46，： | 1 |
| 9 | WebWork: METEOR2's Web- Based Workflow Management System显示文摘 | Miller J A Palaniswami D Sheth A P | 1998 | Journal of Intelligent Information Systems1998，，10： | 1 |
| 10 | Influence of system variables on the morphological and dynamic mechanical behavior of polydimethylsiloxane based segmented polyurethane and polyurea copolymers:a comparative perspective显示文摘 | SHETH J P ANEJA A WILKES G L | 2004 | Polymer2004，45，： | 1 |
| 11 | Mapping of acute ( type I ) spi- nal muscular atrophy to chromosome 5q12 -q14 显示文摘 | Meki J Sheth P Abdelhak S | 1990 | The Lancet1990，336，： | 1 |
| 12 | Federated database systems for managing distributed, heterogeneous, and autonomous database显示文摘 | SHETH A P LARSON J A | 1990 | ACM Computing Surveys1990，22，3： | 1 |
| 13 | The hydrodynamically balanced system(HBS(tm)):a novel drug delivery system for oral use显示文摘 | SHETH P TOSSOUNIAN J | 1984 | Drug Dev Ind Pharm1984，10，2： | 1 |
| 14 | Modeling quality of service for workflows and Web service processes显示文摘 | Cardoso J Sheth A P Miller J A | 2004 | Journal of Web Semantics2004，1，3： | 1 |
| 15 | Gene for chronic proximal spinal muscular atrophies maps to chromosome 5q显示文摘 | Melki J A bdelhak P Sheth MF | 1990 | Nature1990，344，6268： | 1 |
| 16 | Solid state structure-property behavior of semicrystallinepoly ( ether-block-amide) PEBAX thermoplastic elastomers 显示文摘 | SHETH J P XU J WIKES G | 2003 | Polymer2003，44，3： | 1 |
| 17 | Semantic e-workflow composition显示文摘 | CARDOSO J SHETH P | 2003 | Journal of Intelligent Information Systems2003，21，3： | 1 |
| 18 | Gene for chronic proximal spinal muscular atrophies maps to chromosome 5q显示文摘 | MEIKI J ABDELHAK P SHETH M F | 1990 | Nature1990，344，6268： | 1 |
| 19 | Federated database system for managing distributed,heterogeneous and autonomous databases显示文摘 | Sheth A P Larson J A | 1990 | ACM Computing Surveys1990，22，3： | 1 |
| 20 | Nanofiltration - based diafiltration process for solvent exchange in pharmaceutical manufacturing显示文摘 | Sheth J P Qin Y J Sirkar K K | 2003 | J Membr Sci2003，211，： | 1 |
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