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| 1 | Sclerostin activity plays a key role in the negative effect of glucocorticoid signaling on osteoblast function in mice显示文摘Stress during prenatal development is correlated with detrimental cognitive and behavioral outcomes in offspring. However, the long-term impact of prenatal stress(PS) and disrupted glucocorticoid signaling on bone mass and strength is not understood. In contrast, the detrimental effect of lead(Pb) on skeletal health is well documented. As stress and Pb act on common biological targets via glucocorticoid signaling pathways and co-occur in the environment, this study first sought to assess the combined effect of stress and Pb on bone quality in association with alterations in glucocorticoid signaling. Bone parameters were evaluated using microCT, histomorphometry, and strength determination in 8-month-old male mouse offspring subjected to PS on gestational days 16 and 17, lifetime Pb exposure(100 p.p.m. Pb in drinking water), or to both. Pb reduced trabecular bone mass and, when combined with PS, Pb unmasked an exaggerated decrement in bone mass and tensile strength. Next, to characterize a mechanism of glucocorticoid effect on bone, prednisolone was implanted subcutaneously(controlled-release pellet, 5 mg·kg^(-1) per day) in 5-month-old mice that decreased osteoblastic activity and increased sclerostin and leptin levels. Furthermore, the synthetic glucocorticoid dexamethasone alters the anabolic Wnt signaling pathway. The Wnt pathway inhibitor sclerostin has several glucocorticoid response elements, and dexamethasone administration to osteoblastic cells induces sclerostin expression. Dexamethasone treatment of isolated bone marrow cells decreased bone nodule formation, whereas removal of sclerostin protected against this decrement in mineralization.Collectively, these findings suggest that bone loss associated with steroid-induced osteoporosis is a consequence of sclerostin-mediated restriction of Wnt signaling, which may mechanistically facilitate glucocorticoid toxicity in bone. | Eric E Beier Tzong-Jen Sheu Emily A Resseguie Masahiko Takahata Hani A Awad Deborah A Cory-Slechta J Edward Puzas | 2017 | Bone Research2017，5，2： | 3 |
| 2 | Flocculation of asphaltenes in heavy oil at elevated temperatures显示文摘 | Storm D Barresi R J Sheu E | 1996 | Fuel Science & Tech- nology International1996，14，12： | 1 |
| 3 | Heavy Metal Lead Exposure, Osteoporotie-like Phenotype in an Animal Model, and Depression of Wnt Signaling显示文摘 | Beier E E Maher J Sheu T J | 2013 | Environ Health Perspeet2013，121，1： | 1 |
| 4 | A polymorphism in the beta1 adrenergic receptor is associated with resting heart rate显示文摘 | Ranade K Jorgenson E Sheu WH | 2002 | Am J Hum Genet2002，70，4： | 1 |
| 5 | Molecular weightmeasurement of UG8 asphaltene using APCI mass spec-troscopy显示文摘 | Cunico R L Sheu E Y Mullins O C | 2004 | Petroleum Science and Technology2004，2278，： | 1 |
| 6 | Hyalinizing trabecular tumour of the thyroid - differential expression of distinct miRNAs compared with papillary thyroid carcinoma 显示文摘 | Sheu SY Vogel E Worm K | 2010 | Histopathology2010，56，5： | 1 |
| 7 | Characterization of colloidal asphaltenic particles in heavy oil显示文摘 | STORM D A SHEU E Y | 1995 | Fuel1995，74，8： | 1 |
| 8 | A polymor- phism in the betal adrenergic receptor is associated with rest- ing heart rate 显示文摘 | RANADE K JORGENSON E SHEU WH | 2002 | Am J Hum Genet2002，70，4： | 1 |
| 9 | Asphaltene structure using Raman spectrometry and X-ray diffraction显示文摘 | Bouhadda Y Bormann E Sheu C D | 2007 | Fuel2007，86，： | 1 |
| 10 | 显示文摘 | Bouhadda Y Bormann D Sheu E | 2007 | Fuel2007，86，1213： | 1 |
| 11 | Separation of functionalities in pyrolytic tar by gel permeation chromatography-gas chromatography显示文摘 | SHEU Y-H E PHILIP C V ANTHONY R G | 1984 | J Chromatogr Sci1984，22，1： | 1 |
| 12 | The blank design and spring back control of a stamping die by using the hi-are sur- face model 显示文摘 | SHEU J J JIANG M E | 2007 | Journal of Materials Processing Tech- nology2007，，： | 1 |
| 13 | Reduced activities of thiamine-dependent enzymes in brains and peripheral tissues of pa- tients with Mzheimer' s patients 显示文摘 | Gibson G E Sheu K F R Baker A C | 1988 | Arch Neurol1988，45，8： | 1 |
| 14 | A polymorphism in the beta 1 adrenergic receptor is associated with resting heart rate显示文摘 | Ranade K Jorgenson E Sheu WH | 2002 | Am J Hum Genet2002，70，4： | 1 |
| 15 | Mold filling behavior in vertical gating lost foam aluminum alloy显示文摘 | Pan E N Sheu G L | 2001 | AFS Transaction2001，79，： | 1 |
| 16 | Kinetic studies of upgrading pine pyrolytic oil by hydrotreatment显示文摘 | Sheu Y H E Anthony R G Sohes E J | 1988 | Fuel Processing Technology1988，，19： | 1 |
| 17 | Some observations of the frost formation in free convection: with and without the presence of electric field 显示文摘 | Wang C C Huang R Sheu E J | 2004 | International Journal of Heat and Mass Transfer2004，47，： | 1 |
| 18 | Surveillance for neuraminidase inhibitor resistance among human influenza A and B viruses circulating worldwide from 2004to 2008显示文摘 | Sheu T G Deyde V M Okomo-adhiambo M Garten R J Xu X Bright R A Butler E N Wallis T R Klimov A I Gubareva L V | 2008 | Antimicrob Agents Chemother2008，52，9： | 1 |
| 19 | Aggregation and kinetics of asphaltenes in organic solvents显示文摘 | SHEU E Y de TAR M M STORM D A DeCANIO S J | 1992 | Fuel1992，71，3： | 1 |
| 20 | Hybrid solar- geothermal power generation: Optimal retrofitting显示文摘 | Ghasemi H Sheu E Tizzanini A | 2014 | Applied Energy2014，131，： | 1 |
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