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| 1 | Blood glucose control in patients with severe sepsis and septic shock显示文摘The main pathophysiological feature of sepsis is the uncontrollable activation of both pro-and anti-inflammatory responses arising from the overwhelming pro-duction of mediators such as pro-and anti-inflammatory cytokines. Such an uncontrollable inflammatory response would cause many kinds of metabolic derangements. One such metabolic derangement is hyperglycemia. Accordingly, control of hyperglycemia in sepsis is considered to be a very effective therapeutic approach. However, despite the initial enthusiasm, recent studies reported that tight glycemic control with intensive insulin therapy failed to show a beneficial effect on mortality of patients with severe sepsis and septic shock. One of the main reasons for this disappointing result is the incidence of harmful hypoglycemia during intensive insulin therapy. Therefore, avoidance of hypoglycemia during intensive insulin therapy may be a key issue in effective tight glycemic control. It is generally accepted that glycemic control aimed at a blood glucose level of 80-100 mg/dL, as initially proposed by van den Berghe, seems to be too tight and that such a level of tight glycemic control puts septic patients at increased risk of hypoglycemia. Therefore, now many researchers suggest less strict glycemic control with a target blood glucose level of 140-180 mg/dL. Also specific targeting of glycemic control in diabetic patients should be considered. Since there is a significantcorrelation between success rate of glycemic control and the degree of hypercytokinemia in septic patients, some countermeasures to hypercytokinemia may be an important aspect of successful glycemic control. Thus, in future, use of an artificial pancreas to avoid hypoglycemia during insulin therapy, special consideration of septic diabetic patients, and control of hypercytokinemia should be considered for more effective glycemic control in patients with severe sepsis and septic shock. | Hiroyuki Hirasawa Shigeto Oda Masataka Nakamura | 2009 | World Journal of Gastroenterology2009，15，33： | 13 |
| 2 | Tumor necrosis factor ?308 polymorphism (rs1800629) is associated with mortality and ventilator duration in 1057 Caucasian patients显示文摘 | Eizo Watanabe Barbara A. Zehnbauer Shigeto Oda Yasunori Sato Hiroyuki Hirasawa Timothy G. Buchman | 2012 | Cytokine2012，，1： | 1 |
| 3 | Effects of a peripheral cholinesterase inhibitor on cytokine production and autonomic nervous activity in a rat model of sepsis显示文摘 | Daisuke Setoguchi Henry Yatsuki Tomohito Sadahiro Masataka Nakamura Yo Hirayama Eizo Watanabe Yoshihisa Tateishi Shigeto Oda | 2011 | Cytokine2011，，2： | 1 |
| 4 | Continuous Hemodiafiltration with PMMA Hemofilter in the Treatment of Patients with Septic Shock显示文摘 | Taka-aki Nakada Shigeto Oda Ken-ichi Matsuda etal | 2008 | MOL MED2008，14，56： | 1 |
| 5 | Oral Care Reduces Incidence of Ventilator-Associated Pneumonia in ICU Populations显示文摘 | Hideo Mori Hiroyuki Hirasawa Shigeto Oda Hidetoshi Shiga Kenichi Matsuda Masataka Nakamura | 2006 | Intensive Care Medicine2006，，2： | 1 |
| 6 | Modulation of polymorphonuclear leukocyte apoptosis in the critically ill by removal of cytokines with continuous hemodiafiltration显示文摘 | Takeshi Hirano Hiroyuki Hirasawa Shigeto Oda | 2004 | Blood Pu-rif2004，，22： | 1 |
| 7 | Modulation of polymorphonuclear leukocyte apoptosis in the critically ill by removal of eytokines with continuous hemodiafiltration显示文摘 | Takeshi Hirano Hiroyuki Hirasawa Shigeto Oda | 2004 | Blood Purif2004，22，： | 1 |
| 8 | Oral care reduces incidence of ventilator-associated pneumonia in ICU populations显示文摘 | Hideo Mori Hiroyuki Hirasawa Shigeto Oda | 2006 | Intensive Care Medicine2006，9，11： | 1 |
| 9 | Efficacy of combination therapy of antiviral and immunosuppressive drugs for the treatment of severe acute exacerbation of chronic hepatitis B显示文摘 | Keiichi Fujiwara Shin Yasui Yutaka Yonemitsu Kenichi Fukai Makoto Arai Fumio Imazeki Akihiro Suzuki Hiroshi Suzuki Tomohito Sadahiro Shigeto Oda Osamu Yokosuka | 2008 | Journal of Gastroenterology2008，，9： | 1 |
| 10 | Blood ammonia and lactate levels on hospital arrival as a predictive biomarker in patients with out-of-hospital cardiac arrest显示文摘 | Koichiro Shinozaki Shigeto Oda Tomohito Sadahiro Masataka Nakamura Yo Hirayama Eizo Watanabe Yoshihisa Tateishi Kazuya Nakanishi Nobuya Kitamura Yasunori Sato Hiroyuki Hirasawa | 2010 | Resuscitation2010，，4： | 1 |
| 11 | Opportunistic infection in patients with acute liver failure显示文摘 | Makoto Arai Tatsuo Kanda Shin Yasui Keiichi Fujiwara Fumio Imazeki Akira Watanabe Takeyuki Sato Shigeto Oda Osamu Yokosuka | 2014 | Hepatology International2014，，2： | 1 |
| 12 | Usefulness of plasma exchange plus continuous hemofiltration to reduce adverse effects assotiated with plasma exchange in patients with acute liver 显示文摘 | Tomohito Sadahiro MD Hiroyuki Hirasawa MD Shigeto Oda | 2001 | Crit Care Med2001，7，： | 1 |
| 13 | Opportunistic infection in the patients with acute liver failure: a report of three cases with one fatality显示文摘 | Makoto Arai Fumio Imazeki Yutaka Yonemitsu Tatsuo Kanda Keiichi Fujiwara Kenichi Fukai Akira Watanabe Takeyuki Sato Shigeto Oda Osamu Yokosuka | 2009 | Clinical Journal of Gastroenterology2009，，6： | 1 |
| 14 | Oral Care Reduces Incidence of Ventilator-Associated Pneumonia in ICU Populations显示文摘 | Hideo Mori Hiroyuki Hirasawa Shigeto Oda Hidetoshi Shiga Kenichi Matsuda Masataka Nakamura | 2006 | Intensive Care Medicine2006，，： | 1 |
| 15 | Sequential measurement of IL-6 blood levels in patients with systemic inflammatory response syndrome (SIRS)/sepsis显示文摘 | Shigeto Oda Hiroyuki Hirasawa Hidetoshi Shiga Kazuya Nakanishi Ken-ichi Matsuda Masataka Nakamua | 2004 | Cytokine2004，，4： | 1 |
| 16 | Effects of therapeutic plasma exchange on survival in patients with postoperative liver failure:a retrospective single-center study显示文摘Background:Recent decreases in the incidence of postoperative liver failure(POLF)have been attributed to advances in surgical techniques,critical care,and postoperative management.However,POLF management remains a challenge,and worsening POLF is a significant cause of morbidity and mortality.Therapeutic plasma exchange(TPE)is used as a salvage strategy for POLF in some countries,and several studies conducted between 1980 and 1990 have reported the use of TPE for POLF.We conducted this retrospective single-center study to investigate the outcomes of patients with POLF treated with TPE.Methods:We retrospectively reviewed the charts of patients with POLF admitted to the intensive care unit who underwent TPE between November 2010 and March 2017.POLF was defined as the presence of persistent hyperbilirubinemia.Data on patient demographics,Glasgow Coma Scale score,platelet count,prothrombin time,and serum total bilirubin level were collected,and their Sequential Organ Failure Assessment scores were calculated.The lengths of postoperative hospital stays,lengths of post-TPE hospital stays,and patient outcomes were also analyzed.Results:TPE was performed in 20 patients with POLF during the study period.TPE was initiated on the 49th postoperative day and was performed for a median of five sessions.TPE improved hyperbilirubinemia and coagulopathy but had no effect on neurological and clinical symptoms.All 20 patients treated with TPE died after the 36th day(median)from the initial TPE.Conclusions:Although TPE may improve laboratory values in patients with POLF,the current study suggests that it has no survival benefit. | Yoshiro Kobe Yoshihisa Tateishi Shigeto Oda | 2021 | Emergency and Critical Care Medicine2021，1，2： | 0 |
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