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| 1 | Molecular Cloning and Functional Characterization of Porcine MyD88 Essential for TLR Signaling显示文摘We isolated cDNA encoding porcine MyD88 (poMyD88) from Peyer's patches (Pps) of GALT. The complete open reading frame (ORF) of poMyD88 contains 879 bp encoding a deduced 293 aa residues. The amino acid sequence of poMyD88 was characterized by N-terminal death,intermediate and C-terminal Toll/IL-1 receptor (TIR) domains. The putative poMyD88 protein shares a higher level of homology with its human (87.2% amino acid identity) than with its mouse (77.4% amino acid identity) counterpart. Overexpression of poMyD88 participated in the further enhanced activation of NF-κB in human embryonic kidney (HEK) 293 cells expressing porcine TLR2 and porcine TLR4/MD-2,but not porcine RP105/MD-1 after stimulation with the corresponding ligands. The expression levels of MyD88 were highest in the spleen and mesenteric lymph nodes (MLNs),and lower in digestive tissues of newborn swine. In adult swine,the expression levels in the digestive tissues were lower than those in MLNs and the spleen. These results suggest that an MyD88-dependent signaling pathway is present in newborn as well as in adult swine and that it is involved in the innate immune system of these animals. | Masanori Tohno Tomoyuki Shimazu Hisashi Aso Yasushi Kawai Tadao Saito Haruki Kitazawa | 2007 | Cellular & Molecular Immunology2007，4，5： | 20 |
| 2 | High circulating tumor cell concentrations in a specific subtype of gastric cancer with diffuse bone metastasis at diagnosis显示文摘AIM: To clarify the biological feature contributing to gastric cancer with diffuse bone metastases at diagnosis.METHODS: The participants visited the Department of Clinical Oncology, Akita University Hospital, from January 2014 to August 2015. The selection criterion for gastric cancer with diffuse bone metastases at diagnosis includes over 29 hot spots of bone scintigraphy. Circulating tumor cell were collected from 20 m L of peripheral venous blood drawn using a Cell Search kit and a Cell Tracks Auto Prep system by SRL, a clinical laboratory. The endpoints of this study were correlations between circulating tumor cells(CTC) count and therapeutic outcomes. RESULTS: Among 39 patients with gastric cancer, 5 patients met the criterion. The incidence of this subtype was 12.8%. CTC counts ranged from 235 to 6440 cells/7.5 m L of peripheral blood(median of 1724). These values were much higher than common gastric cancers(2 cells). In chemo-sensitive cases, CTC counts decreased within 14 d(median) from 275, 235 and 1724 to 2, 7 and 66, respectively. On the other hand, CTC counts increased after treatment failure or insensitive case from 2, 7 and 6440 to 787, 513 and 7885, respectively. The correlation between CTC count and survival time showed a trend, but did not reach significance(Y = 234.6- 0.03 X, P = 0.085).CONCLUSION: High CTC count is a biological hallmark of this subtype, and can be used as a direct and definitive indicator of therapeutic outcome. | Kazuhiro Shimazu Koji Fukuda Taichi Yoshida Masahiro Inoue Hiroyuki Shibata | 2016 | World Journal of Gastroenterology2016，22，26： | 9 |
| 3 | The inverse association between tuberculin responses and atopic disorder显示文摘 | Shirakawa T Enomoto T Shimazu S | | 0，，： | 6 |
| 4 | Fulminant phlegmonitis of the esophagus, stomach,and duodenum due to Bacillus thuringiensis显示文摘We report a case of phlegmonitis of the esophagus, stomach, and duodenum in patient in an immunocompromised state. Culture of gastric juice and blood yielded Bacillus thuringiensis. This case showed that even low-virulence bacilli can cause lethal gastrointestinalphlegmonous gastritis in conditions of immunodeficiency. | Hisatake Matsumoto Hiroshi Ogura Masafumi Seki Mitsuo Ohnishi Takeshi Shimazu | 2015 | World Journal of Gastroenterology2015，21，12： | 3 |
| 5 | MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4显示文摘 | Shimazu R Akashi S Ogata H | 1999 | J Exp Med1999，189，11： | 2 |
| 6 | Consumption of n-3 Fatty Acids and Fish Reduces Risk of Hepatocellular Carcinoma显示文摘 | Norie Sawada Manami Inoue Motoki Iwasaki Shizuka Sasazuki Taichi Shimazu Taiki Yamaji Ribeka Takachi Yasuhito Tanaka Masashi Mizokami Shoichiro Tsugane | 2012 | Gastroenterology2012，，7： | 2 |
| 7 | Association of gastric cancer risk factors with DNA methylation levels in gastric mucosa of healthy Japanese: a cross-sectional study显示文摘 | Shimazu Taichi Asada Kiyoshi Charvat Hadrien Kusano Chika Otake Yosuke Kakugawa Yasuo Watanabe Hidenobu Gotoda Takuji Ushijima Toshikazu Tsugane Shoichiro | 2015 | Carcinogenesis2015，，： | 2 |
| 8 | Miniaturization of Bubbles by Shock Waves in Gas-Liquid Two-phase Flow in the Venturi Tube显示文摘Fine bubbles have been widely applied in many fields such as industry,medical engineering and agricultures.Therefore,many attentions have been paid to the study of fine bubble generations in order to increase the yield while decrease the cost.However,the generation process of fine bubbles is a quite complicated process in which multiple hydrodynamic forces are interacted in the gas-liquid two-phase flow.Many studies focus on the techniques of the converging-diverging nozzle(venturi tube)generator,which is famous for its simple and cheap features,and generates fine bubbles by using the miniaturization phenomenon of bubbles occurring in the venturi tube.However,the impact conditions on the amount and size of bubbles such as nozzle geometry and bleed air haven’t been investigated clearly.In this work,we implement many experiments on the venturi tube fine bubble generators with different geometries and generating conditions,and evaluate different factors impacting the production components such as the volume and the bubble size.The experimental results show that the supersonic flow filed in the venturi tube promotes the miniaturization of the bubbles,and the convergent angle of the nozzle and air bleed have a great impact on the size and volume of bubbles. | JIANG Xin YASUNOBU Tsuyoshi NAKAMURA Arisa SHIMAZU Masaki | 2021 | Journal of Thermal Science2021，30，3： | 2 |
| 9 | Transfer of the von Hippel-Lindau gene to neuronal progenitor cells in treatment for Parkinson's disease显示文摘 | Yamada H Dezawa M Shimazu S | 2003 | Ann Neurol2003，54，3： | 1 |
| 10 | Influence of Ar Gas Flow Rate in Organosilicon Plasma for the Fabrication of SiO:CH Thin Films by PECVD Method显示文摘 | Yongsup Yun Takanori Yoshida Norifumi Shimazu | 2008 | Surface and Coatings Technology2008，202，： | 1 |
| 11 | Wire Rod for Higher Breaking Strength Steel Cord显示文摘 | Yamada Y Shimazu S | 1986 | Wire Journal International1986，，4： | 1 |
| 12 | Vascular endothelial growth factor activating matrix metalloproteinases in ascitic fluid during peritoneal dissemination of ovarian cancer显示文摘 | Yabushita H Shimazu M Noguchi M | 2003 | Oncol Rep2003，10，： | 1 |
| 13 | Paecilomyces cateniannulatus Liang,a commonly found, but an unrecorded entomogenous fungus in Japan 显示文摘 | Shimazu M | 2001 | Appl Entomol Zool2001，36，3： | 1 |
| 14 | Prognostic significance of Ki -67 index after neoadjuvant chemotherapy in breast cancer显示文摘 | Tanei T Shimomura A Shimazu K | 2011 | Eur J Surg Oncol2011，37，2： | 1 |
| 15 | Modified pancreati-cogastrostomy following pancreaticoduodenectomy 显示文摘 | Takao S Shimazu H Maenohara S | 1993 | Am JSurg1993，165，3： | 1 |
| 16 | Effects of genome ar-chitecture and epigenetic factors on susceptibility of promoter CpGislands to aberrant DNA methylation induction 显示文摘 | Takeshima H Yamashita S Shimazu T | 2011 | Genomics2011，98，3： | 1 |
| 17 | Soluble TRAIL prevents RANTES-de- pendent restenosis after percutaneous coronary intervention in patients with coronm'y artery disease 显示文摘 | Satoh D Inami N Shimazu T | 2010 | J Thromb Thrombolysis2010，29，： | 1 |
| 18 | Novel photodynamic therapy against biliary tract carcinoma using mono-L:-aspartyl chlorine e6:basic evaluation for its feasibility and efficacy显示文摘 | Kasuya K Shimazu M Suzuki M | | 0，，03： | 1 |
| 19 | NT-3 facilitates hippocampal plasticity and learning and memory by regulating neurogenesis 显示文摘 | Shimazu K Zhao M Sakata K | 2006 | Learn Mem2006，13，： | 1 |
| 20 | Persistence of host-specific Bacteroides-Prevotel- la 16S rRNA genetic markers in environmental waters:Effects of tem- perature and salinity显示文摘 | Okabe SI Shimazu Y | 2007 | Applied Microbiology and Biotechnology2007，76，4： | 1 |
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