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| 1 | Scaffolds based therapy for osteochondral lesions of the talus:A systematic review显示文摘AIM To clarify the effectiveness of scaffold-based therapy for osteochondral lesions of the talus(OLT). METHODS A systematic search of MEDLINE and EMBASE databases was performed during August 2016 and updated in January 2017. Included studies were evaluated with regard to the level of evidence(LOE) and quality of evidence(QOE) using the Modified Coleman Methodology Score. Variable reporting outcome data, clinical outcomes, and the percentage of patients who returned to sport at previous level were also evaluated. RESULTS Twenty-eight studies for a total of 897 ankles were included; 96% were either LOE Ⅲ or Ⅳ. Studies were designated as either of poor or fair quality. There were 30 treatment groups reporting six different scaffold repair techniques: 13 matrix-induced autologous chondrocyte transplantation(MACT), nine bone marrow derived cell transplantation(BMDCT), four autologous matrixinduced chondrogeneis(AMIC), and four studies of other techniques. The categories of general demographics(93%) and patient-reported outcome data(85%) were well reported. Study design(73%), imaging data(73%), clinical variables(49%), and patient history(30%) were also included. The weighted mean American Orthopaedic Foot and Ankle Society(AOFAS) score at final follow-up was: 86.7 in MACT, 88.2 in BMDCT, and 82.3 in AMIC. Eight studies reported that a weighted mean of 68.3% ofpatients returned to a previous level of sport activity. CONCLUSION Scaffold-based therapy for OLT may produce favorable clinical outcomes, but low LOE, poor QOE, and variability of the data have confounded the effectiveness of this treatment. | Yoshiharu Shimozono Youichi Yasui Andrew W Ross Wataru Miyamoto John G Kennedy | 2017 | World Journal of Orthopedics2017，8，10： | 4 |
| 2 | A robotic driver on roller dynamometer with vehicle performance self learning algorithm显示文摘 | MORIYAMA Akinobu MURASE Isao SHIMOZONO Akira TAKEUCHI Tohru | | SAE Paper0，91，： | 1 |
| 3 | Visualization of an endogenous retinoie acid gradient across embryonic development 显示文摘 | Shimozono S Iimura T Kitaguchi T | 2013 | Nature2013，496，7445： | 1 |
| 4 | Suppression of the melanogenesis of mouse melanoma B 16 cells by sweet potato extract显示文摘 | SHIMOZONO H KOBORI M SHINMOTO H | 1996 | Nippon Shokuhin Kagaku Kogaku Kaishi1996，43，3： | 1 |
| 5 | How should nurses overcome patients' unexpected suicide? 显示文摘 | Shimozono S | 2003 | Expert Nurse2003，19，10： | 1 |
| 6 | The Significance of Cone Outer Segment Tips as a Prognostic Factor in Epiretinal Membrane Surgery显示文摘 | Masataka Shimozono Akio Oishi Masayuki Hata Takaaki Matsuki Shinichiro Ito Kazuhiro Ishida Yasuo Kurimoto | 2012 | American Journal of Ophthalmology2012，，4： | 1 |
| 7 | Preparation and characterization of hetero-biftmctional cross-linking reagents for protein modifications 显示文摘 | Kitagawa T Shimozono T Aikawa T | 1981 | Chem Pharm Bull1981，29，4： | 1 |
| 8 | K^+ secretion in strial marginal cells is stimulated via beta 1-adrenergic receptors but not via beta 2-adrenergic or vasopressin receptors显示文摘 | Wangemann P Liu J Shimozono M | 2000 | J Membr Biol2000，175，3： | 1 |
| 9 | Caffeoylquinic Acid-Rich Purple Sweet Potato Extract, with or without Anthocyanin, Imparts Neuroprotection and Contributes to the Improvement of Spatial Learning and Memory of SAMP8 Mouse 显示文摘 | KAZUNORI Sasaki JUNKYU Han HIDETOSHI Shimozono | 2013 | Journal of Agricuhural and Food Chemistry2013，，61： | 1 |
| 10 | The significance of cone outer segment tips as a progrostic factor in epiretinal membrane surgery 显示文摘 | Shimozono M Oishi A Hata M | 2012 | Am J Ophthalmol2012，153，4： | 1 |
| 11 | Suppression of the melanogenesis of mouse melanoma B16 cells by sweet potato extract显示文摘 | SHIMOZONO H KOBORI M SHINMOTO H | 1996 | Nippon Shokuhin Kagaku Kogaku Kaishi1996，，43： | 1 |
| 12 | The significance of cone outer segment tips as a prognostic factor in epiretinal membrane surgery 显示文摘 | Shimozono M Oishi A Hata M | 2012 | Am J Ophthalmol2012，153，： | 1 |
| 13 | Caffeoylquinic AcidRich Purple Sweet Potato Extract, with or without Anthocyanin, Imparts Neuroprotection and Contributes to the Improvement of Spatial Learning and Memory of SAMP8显示文摘 | Sasaki K Han J Shimozono H | 2013 | J Agric Food Chem2013，61，21： | 1 |
| 14 | Measurement of intracellular free Ca2+ concentration in guinea pig spiral ganglion cells显示文摘 | Shimozono M Tono T Morimitsu T | 1995 | Neuroreport1995，6，： | 1 |
| 15 | The significance of external limiting membrane status for visual acuity in age-related macular degeneration 显示文摘 | Oishi A Hata M Shimozono M | 2010 | Am J Ophthalmol2010，150，： | 1 |
| 16 | Polyclonal proliferation of lymphocytes containing the Epsteiu-Barr virus genome in a patient dying of myocarditis in chronic active Epstein-Ban' virus infection 显示文摘 | Fujiwara M Shimozono H Ono H | 2003 | J Pediatr Hematol Oncol2003，25，1： | 1 |
| 17 | α1A-Adrenergic teceptors mediate vasoconatriction of the isolated spiral modiolar artery in vitro显示文摘 | Dang H Shimozono M | 1998 | Hear Res1998，119，： | 1 |
| 18 | A design method for cable network structures considering the flexibility of supporting structures显示文摘 | TANAKA H SHIMOZONO N NATORI M C | 2008 | Transactions of the Japan Society for Aeronautical and Space Sciences2008，50，170： | 1 |
| 19 | The significance of externallimiting membrane status for visual acuity in age-related macu-lar degeneration显示文摘 | Oishi A HataM Shimozono M | 2010 | Am J Ophthalmol2010，150，1： | 1 |
| 20 | Acute vision loss resulting from complications of ethanol abuse 显示文摘 | Shimozono M Townsend JC llsen PF | 1998 | J Am Optom Assoc1998，69，5： | 1 |
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