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| 1 | Gene expression signatures for phlegm-dampness constitution of Chinese Medicine显示文摘Dear Editor,The term'individualized medicine'was first used in Biochemistry Individuality in 1956 by Williams(Williams et al.,1956).With the emergence of the post-genome era in the21st century,individualized precision medicine has attracted increasing attention.In traditional Chinese medicine(TCM),there is also concept of individualized medicine,which is known as the Chinese constitutional theory,proposed in the1970s(Wang,2012).According to this theory,the | Lingru Li Juan Feng Haiqiang Yao Lan Xie Yu Chen Lingling Yang Shujuan Hou Shipeng Zhao Ranran Sun Yanling Wu Tongtong Bai Yingshuai Li Ruoxi Yu Ji Wang Qi Wang | 2017 | Science China(Life Sciences)2017，60，1： | 13 |
| 2 | Cancer metabolism and tumor microenvironment:fostering each other?显示文摘The changes associated with malignancy are not only in cancer cells but also in environment in which cancer cells live.Metabolic reprogramming supports tumor cells’high demand of biogenesis for their rapid proliferation,and helps tumor cells to survive under certain genetic or environmental stresses.Emerging evidence suggests that metabolic alteration is ultimately and tightly associated with genetic changes,in particular the dysregulation of key oncogenic and tumor suppressive signaling pathways.Cancer cells activate HIF signaling even in the presence of oxygen and in the absence of growth factor stimulation.This cancer metabolic phenotype,described firstly by German physiologist Otto Warburg,ensures enhanced glycolytic metabolism for the biosynthesis of macromolecules.The conception of metabolite signaling,i.e.,metabolites are regulators of cell signaling,provides novel insights into how reactive oxygen species(ROS)and other metabolites deregulation may regulate redox homeostasis,epigenetics,and proliferation of cancer cells.Moreover,the unveiling of noncanonical functions of metabolic enzymes,such as the moonlighting functions of phosphoglycerate kinase 1(PGK1),reassures the importance of metabolism in cancer development.The metabolic,microRNAs,and ncRNAs alterations in cancer cells can be sorted and delivered either to intercellular matrix or to cancer adjacent cells to shape cancer microenvironment via media such as exosome.Among them,cancer microenvironmental cells are immune cells which exert profound effects on cancer cells.Understanding of all these processes is a prerequisite for the development of a more effective strategy to contain cancers. | Yiyuan Yuan Huimin Li Wang Pu Leilei Chen Dong Guo Hongfei Jiang Bo He Siyuan Qin Kui Wang Na Li Jingwei Feng Jing Wen Shipeng Cheng Yaguang Zhang Weiwei Yang Dan Ye Zhimin Lu Canhua Huang Jun Mei Hua-Feng Zhang Ping Gao Peng Jiang Shicheng Su Bing Sun Shi-Min Zhao | 2022 | Science China(Life Sciences)2022，65，2： | 5 |
| 3 | Effect of concentration of cadmium sulfate solution on structural,optical and electric properties of Cd_(1-x)Zn_(x)S thin films显示文摘Cd_(1-x)Zn_(x)S thin films were deposited by chemical bath deposition(CBD)on the glass substrate to study the influence of cadmium sulfate concentration on the structural characteristics of the thin film.The SEM results show that the thin film surfaces under the cadmium sulfate concentration of 0.005 M exhibit better compactness and uniformity.The distribution diagrams of thin film elements illustrate the film growth rate changes on the trend of the increase,decrease,and increase with the increase of cadmium sulfate concentration.XRD studies exhibit the crystal structure of the film is the hexagonal phase,and there are obvious diffraction peaks and better crystallinity when the concentration is 0.005 M.Spectrophotometer test results demonstrate that the relationship between zinc content x and optical band gap value E_(g) can be expressed by the equation E_(g)(x)=0.59x^(2)+0.69x+2.43.Increasing the zinc content can increase the optical band gap,and the absorbance of the thin film can be improved by decreasing the cadmium sulfate concentration,however,all of them have good transmittance.At a concentration of 0.005 M,the thin film has good absorbance in the 300-800 nm range,80%transmittance,and band gap value of 3.24 eV,which is suitable for use as a buffer layer for solar cells. | Yuming Xue Shipeng Zhang Dianyou Song Liming Zhang Xinyu Wang Lang Wang Hang Sun | 2021 | Journal of Semiconductors2021，42，11： | 3 |
| 4 | Protective humoral immunity in SARS-CoV-2 infected pediatric patients显示文摘After the rapid spread of SARS-CoV-2 in Wuhan,China,at the beginning of 2020,about 1.5 million confirmed cases and over 80,000 deaths have been reported around 200 countries and territories all over the world and the number continues to increase.However,we still have limited knowledge of this new coronavirus,especially the interaction between SARS-CoV-2 and our immune system. | Yaguang Zhang Jin Xu Ran Jia Chunyan Yi Wangpeng Gu Pengcheng Liu Xinran Dong Hao Zhou Bo Shang Shipeng Cheng Xiaoyu Sun Jing Ye Xuezhen Li Jia Zhang Zhiyang Ling Liyan Ma Bingbing Wu Mei Zeng Wenhao Zhou Bing Sun | 2020 | Cellular & Molecular Immunology2020，17，7： | 2 |
| 5 | Lactate anions participate in T cell cytokine production and function显示文摘After antigen stimulation, T cells preferentially increase aerobic glycolysis to meet the bioenergetic and biosynthetic demands of T cell activation, proliferation, and effector functions. Lactate, a by-product of glycolysis, has been reported to function as an important energy source and signaling molecule. Here, we found that lactate anions are involved in cytokine production in Tcells after TCR activation. During ex vivo T cell activation, the addition of excess sodium lactate(Na L) increased the production of cytokines(such as IFNγ/IL-2/TNFα) more than the addition of sodium chloride(NaCl). This enhanced cytokine production was dependent on TCR/CD3 activation but not CD28 activation. In vivo, Na L treatment inhibited tumour growth in subcutaneously transplanted tumour models in a T cell-dependent manner, which was consistent with increased T cell cytokine production in the Na L treatment group compared to the Na Cl treatment group. Furthermore, a mechanistic experiment showed that this enhanced cytokine production was regulated by GAPDH-mediated post-transcriptional regulation. Taken together, our findings indicate a new regulatory mechanism involved in glycolysis that promotes T cell function. | Jing Wen Shipeng Cheng Yaguang Zhang Ran Wang Jiefang Xu Zhiyang Ling Liyan Ma Xinghao Ai Bing Sun | 2021 | Science China(Life Sciences)2021，64，11： | 2 |
| 6 | Chelating polymer modified P84 nanofiltration(NF)hollow fiber membranes for high efficient heavy metal removal显示文摘 | Gao Jie Sun Shipeng Zhu Wenping | 2014 | Water Research2014，63，15： | 1 |
| 7 | HTR2A agonists play a therapeutic role by restricting ILC2 activation in papain-induced lung inflammation显示文摘Group 2 innate lymphoid cells(ILC2s)are a category of heterogeneous cells that produce the cytokines IL-5 and IL-13,which mediate the type 2 immune response.However,specific drug targets on lung ILC2s have rarely been reported.Previous studies have shown that type 2 cytokines,such as IL-5 and IL-13,are related to depression.Here,we demonstrated the negative correlation between the depression-associated monoamine neurotransmitter serotonin and secretion of the cytokines IL-5 and IL-13 by ILC2s in individuals with depression.Interestingly,serotonin ameliorates papain-induced lung inflammation by suppressing ILC2 activation.Our data showed that the serotonin receptor HTR2A was highly expressed on ILC2s from mouse lungs and human PBMCs.Furthermore,an HTR2A selective agonist(DOI)impaired ILC2 activation and alleviated the type 2 immune response in vivo and in vitro.Mice with ILC2-specific depletion of HTR2A(Il5^(cre/+)·Htr2a^(flox/flox)mice)abolished the DOI-mediated inhibition of ILC2s in a papain-induced mouse model of inflammation.In conclusion,serotonin and DOI could restrict the type 2 lung immune response,indicating a potential treatment strategy for type 2 lung inflammation by targeting HTR2A on ST2+ILC2s. | Zhishuo Wang Chenghua Yan Qizhen Du Yuying Huang Xuezhen Li Dan Zeng Ruizhi Mao Rama Krishna Gurram Shipeng Cheng Wangpeng Gu Lin Zhu Weiguo Fan Liyan Ma Zhiyang Ling Ju Qiu Dangsheng Li Enmei Liu Yaguang Zhang Yiru Fang Jinfang Zhu Bing Sun | 2023 | Cellular & Molecular Immunology2023，20，4： | 1 |
| 8 | Syntheses, structures, and properties of Ni(II) complexes with 5,5′-bis(4-halogenphenyl)diazo-dipyrromethane显示文摘 | Zhenming Yin Ying Yan Shipeng Sun Wuyan Wang | 2012 | Journal of Coordination Chemistry2012，，5： | 1 |
| 9 | Vitamin B6 regulates IL-33 homeostasis to alleviate type 2 inflammation显示文摘Interleukin-33(IL-33)is a crucial nuclear cytokine that induces the type 2 immune response and maintains immune homeostasis.The fine-tuned regulation of IL-33 in tissue cells is critical to control of the type 2 immune response in airway inflammation,but the mechanism is still unclear.Here,we found that healthy individuals had higher phosphate-pyridoxal(PLP,an active form of vitamin B6)concentrations in the serum than asthma patients.Lower serum PLP concentrations in asthma patients were strongly associated with worse lung function and inflammation.In a mouse model of lung inflammation,we revealed that PLP alleviated the type 2 immune response and that this inhibitory effect relied on the activity of IL-33.A mechanistic study showed that in vivo,pyridoxal(PL)needed to be converted into PLP,which inhibited the type 2 response by regulating IL-33 stability.In mice heterozygous for pyridoxal kinase(PDXK),the conversion of PL to PLP was limited,and IL-33 levels were increased in the lungs,aggravating type 2 inflammation.Furthermore,we found that the mouse double minute 2 homolog(MDM2)protein,an E3 ubiquitin-protein ligase,could ubiquitinate the N-terminus of IL-33 and sustain IL-33 stability in epithelial cells.PLP reduced MDM2-mediated IL-33 polyubiquitination and decreased the level of IL-33 through the proteasome pathway.In addition,inhalation of PLP alleviated asthma-related effects in mouse models.In summary,our data indicate that vitamin B6 regulates MDM2-mediated IL-33 stability to constrain the type 2 response,which might help develop a potential preventive and therapeutic agent for allergy-related diseases. | Songling Zhu Shufen Zhong Kebin Cheng Li-Sha Zhang Jiu-wu Bai Zu Cao Su Wang Wen Chen Shipeng Cheng Liyan Ma Zhiyang Ling Yuying Huang Wangpeng Gu Xiaoyu Sun Chunyan Yi Meng Zhao Shuo Liang Jin-Fu Xu Bing Sun Yaguang Zhang | 2023 | Cellular & Molecular Immunology2023，20，7： | 1 |
| 10 | Seamless Switching of Seal- able Video Bit Streams for Efficient Streaming 显示文摘 | Sun X Wu F Li Shipeng | 2004 | IEEE Transactions on Multimedia2004，6，2： | 1 |
| 11 | Seamless switching of scalable video bitstreams for efficient streaming显示文摘 | Sun Xiaoyan Wu Feng Li Shipeng | 2004 | IEEE Trans on Multimedia2004，6，2： | 1 |
| 12 | Mechanical design and analysis of a novel variable stiffness actuator with symmetrical pivot adjustment显示文摘The safety of human-robot interaction is an essential requirement for designing collaborative robotics.Thus,this paper aims to design a novel variable stiffiiess actuator(VSA)that can provide safer physical human-robot interaction for collaborative robotics.VS A follows the idea of modular design,mainly including a variable stiffiiess module and a drive module.The variable stiffiiess module transmits the motion from the drive module in a roundabout maimer,making the modularization of VS A possible.As the key component of the variable stiffiiess module,a stiffness adjustment mechanism with a symmetrical structure is applied to change the positions of a pair of pivots in two levers linearly and simultaneously,which can eliminate the additional bending moment caused by the asymmetric structure.The design of the doubledeck grooves in the lever allows the pivot to move freely in the groove,avoiding the geometric constraint between the parts.Consequently,the VSA stiffiiess can change from zero to infinity as the pivot moves from one end of the groove to the other.To facilitate building a manipulator in the future,an expandable electrical system with a distributed structure is also proposed.Stiffiiess calibration and control experiments are performed to evaluate the physical performance of the designed VSA.Experiment results show that the VSA stiffiiess is close to the theoretical design stiffness.Furthermore,the VSA with a proportional-derivative feedback plus feedforward controller exhibits a fast response for stiffiiess regulation and a good performance for position tracking. | Yiwei LIU Shipeng CUI Yongjun SUN | 2021 | Frontiers of Mechanical Engineering2021，16，4： | 1 |
| 13 | An analytical solution of wave exciting loads on CALM buoy with skirt显示文摘 | WANG Dong~iao SUN Shipeng | 2014 | Applied Mechanics and Materials2014，，： | 1 |
| 14 | Hyperbranched polyethyleneimine induced cross-linking of polyamide-imide nanofiltration hollow fiber membranes for removal of ciprofloxacin显示文摘 | Sun Shipeng Alan Hatton T Chung Tai-Shung | 2011 | Environmental Science&Technology2011，45，9： | 1 |
| 15 | External quality assessment for enterovirus 71 and coxsackievirus A16 de- tection by reverse transcription-PCR using armored RNA as a virus surrogate显示文摘 | Song Liqiong Sun Shipeng Li Bo | 2011 | Journal of Clinical Microbiology2011，49，10： | 1 |
| 16 | External quality assessment for enterovirus 71and coxsackievirus A16detection by reverse transcription-PCR using armored RNA as a virus surrogate显示文摘 | Liqiong Song Shipeng Sun Bo Li Yang Pan Wenli Li Kuo Zhang Jinming Li | 2011 | J Clin Microbiol2011，49，10： | 1 |
| 17 | Resource types, formation, distribution and prospects of coal-measure gas显示文摘Coal-measure gas is the natural gas generated by coal, carbonaceous shale, and dark shale in coal-measure strata. It includes resources of continuous-type coalbed methane (CBM), shale gas and tight gas reservoirs, and trap-type coal-bearing gas reservoirs. Huge in resources, it is an important gas source in the natural gas industry. The formation and distribution characteristics of coal-measure gas in San Juan, Surat, West Siberia and Ordos basins are introduced in this paper. By reviewing the progress of exploration and development of coal-measure gas around the world, the coal-measure gas is confirmed as an important strategic option for gas supply. This understanding is mainly manifested in three aspects. First, globally, the Eurasian east-west coal-accumulation belt and North American north-south coal-accumulation belt are two major coal-accumulation areas in the world, and the Late Carboniferous–Permian, Jurassic and end of Late Cretaceous–Neogene are 3 main coal-accumulation periods. Second, continuous-type and trap-type are two main accumulation modes of coal-measure gas;it is proposed that the area with gas generation intensity of greater than 10×10^8 m^3/km^2 is essential for the formation of large coal-measure gas field, and the CBM generated by medium- to high-rank coal is usually enriched in syncline, while CBM generated by low-rank coal is likely to accumulate when the source rock and caprock are in good configuration. Third, it is predicted that coal-measure gas around the world has huge remaining resources, coal-measure gas outside source is concentrated in Central Asia-Russia, the United States, Canada and other countries/regions, while CBM inside source is largely concentrated in 12 countries. The production of coal-measure gas in China is expected to exceed 1000×10^8 m^3 by 2030, including (500–550)×10^8 m^3 conventional coal-measure gas,(400–450)×10^8 m^3 coal-measure tight gas, and (150–200)×10^8 m^3 CBM. | ZOU Caineng YANG Zhi HUANG Shipeng MA Feng SUN Qinping LI Fuheng PAN Songqi TIAN Wenguang | 2019 | Petroleum Exploration and Development2019，46，3： | 1 |
| 18 | Image Compression With Edge-Based Inpainting显示文摘 | Dong Liu Xiaoyan Sun Feng Wu Shipeng Li Ya-Qin Zhang | 2007 | IEEE Transaction on Circuits and Systems for Video Technology2007，17，10： | 1 |
| 19 | Dual-layer polybenzimidazole/polyethersulfone(PBI/PES)nanofiltration(NF)hollow fiber membranes for heavy metals removal from wastewater显示文摘 | Zhu Wenping Sun Shipeng Gao Jie | 2014 | J Membr Sci2014，456，： | 1 |
| 20 | Effects of agent heterogeneity in the presence of a land-market: A systematic test in an agent-based laboratory显示文摘 | Huang Qingxu Parker D C Sun Shipeng | 2013 | Computers Environment & Urban Systems2013，，41： | 1 |
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