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75篇 您的检索式:作者名="Shona"
    题名 作者 年代 出处 被引量
1高效液相色谱与电感耦合等离子体质谱联用测定矿泉水中的三价铬与六价铬显示文摘Shona McSheehy Matin Nash 2009环境化学2009,28,4:16
2iCAP TQ ICP-MS准确测定环境样品中的砷和硒显示文摘本文介绍了Thermo Scientific TM iCAPTM TQ ICP-MS定量检测含稀土元素样品中砷和硒的方法,评估三重四极杆(TQ)-ICP-MS测量模式的性能,并与单四极杆(SQ)ICP-MS测量模式进行比较.为了验证方法的稳定性和准确性,在最佳参数条件下分析了深海沉积物和地球化学参考标准这两个样品.Marcus Manecki Simon Lofthouse Philipp Boening Shona McSheehy Ducos 2017环境化学2017,36,12:11
3Cell signalling pathways underlying induced pluripotent stem cell reprogramming显示文摘Induced pluripotent stem(i PS) cells, somatic cells reprogrammed to the pluripotent state by forced expression of defined factors, represent a uniquely valuable resource for research and regenerative medicine. However, this methodology remains inefficient due to incomplete mechanistic understanding of the reprogramming process. In recent years, various groups have endeavoured to interrogate the cell signalling that governs the reprogramming process, including LIF/STAT3, BMP, PI3 K, FGF2, Wnt, TGFβ and MAPK pathways, with the aim of increasing our understanding and identifying new mechanisms of improving safety, reproducibility and efficiency. This has led to a unified model of reprogramming that consists of 3 stages: initiation, maturation and stabilisation. Initiation of reprogramming occurs in almost all cells that receive the reprogramming transgenes; most commonly Oct4, Sox2, Klf4 and c Myc, and involves a phenotypic mesenchymal-to-epithelial transition. The initiation stage is also characterised by increased proliferation and a metabolic switch from oxidative phosphorylation to glycolysis. The maturation stage is considered the major bottleneck within the process, resulting in very few 'stabilisation competent' cells progressing to the final stabilisation phase. To reach this stage in both mouse and human cells, pre-i PS cells must activate endogenous expression of the core circuitry of pluripotency, comprising Oct4, Sox2, and Nanog, and thus reach a state of transgene independence. By the stabilisation stage, i PS cells generally use the same signalling networks that govern pluripotency in embryonic stem cells. These pathways differ between mouse and human cells although recent work has demonstrated that this is context dependent. As i PS cell generation technologies move forward, tools are being developed to interrogate the process in more detail, thus allowing a greater understanding of this intriguing biological phenomenon.Kate Hawkins Shona Joy Tristan Mc Kay 2014World Journal of Stem Cells2014,6,5:5
4Short-Term Outcomes of the Australasian Randomized Clinical Study Comparing Laparoscopic and Conventional Open Surgical Treatments for Colon Cancer: The ALCCaS Trial显示文摘Peter J. Hewett Randall A. Allardyce Philip F. Bagshaw Christopher M. Frampton Francis A. Frizelle Nicholas A. Rieger J Shona Smith Michael J. Solomon Jacqueline H. Stephens Andrew R. L. Stevenson 2008Annals of Surgery2008,,5:3
5Causal Effects of Aroma Compounds on Royal Gala Apple Flavours显示文摘HarryYoung Janine MGilbert Shona HMurray Roderick DBall 1999J Sci Food Agric1999,,3:2
6Assessing patient outcomes in hypertension: the predictive ability of proteinuria and estimated glomerular filtration rate 显示文摘] Shona M Bruce M 2011Scottish Medical Journal2011,56,:1
7Primary prevention of cardiovascular disease with atorvastatin in type 2 diabetes in the Collaborative Atorvastatin Diabetes Study (CARDS): multicentre randomised placebo-controlled trial显示文摘Helen M Colhoun D John Betteridge Paul N Durrington Graham A Hitman H Andrew W Neil Shona J Livingstone Margaret J Thomason Michael I Mackness Valentine Charlton-Menys John H Fuller 2004The Lancet . 2004 (9435)2004,,9435:1
8Effects of Atorvastatin on Kidney Outcomes and Cardiovascular Disease in Patients With Diabetes: An Analysis From the Collaborative Atorvastatin Diabetes Study (CARDS)显示文摘Helen M. Colhoun D. John Betteridge Paul N. Durrington Graham A. Hitman H. Andrew W. Neil Shona J. Livingstone Valentine Charlton-Menys David A. DeMicco John H. Fuller 2009American Journal of Kidney Diseases2009,,5:1
9Levels of Neonatal Thyroid Hormone in Preterm Infants and Neurodevelopmental Outcome at 5? Years: Millennium Cohort Study显示文摘Caroline Delahunty Shona Falconer Robert Hume Lesley Jackson Paula Midgley Marie Mirfield Simon Ogston Oliver Perra Judith Simpson Jennifer Watson Peter Willatts Fiona Williams 2010The Journal of Clinical Endocrinology & Metabolism2010,,11:1
10Increase in primary liver cancer in the UK, 1979–94显示文摘Simon D Taylor-Robinson Graham R Foster Shona Arora Sally Hargreaves Howard C Thomas 1997The Lancet . 1997 (9085)1997,,9085:1
11Long-term prospective study ofHelicobacter pylori in nonulcer dyspepsia显示文摘Conor McCarthy MRCPI Stephen Patchett MRCPI Rose Mary Collins MB Shona Beattie SRN Conor Keane MD Professor Colm O’Morain MD 1995Digestive Diseases and Sciences1995,,1:1
12Standardization of disk diffusion test and its clinical significance for susceptibility testing of metronidazole against Helicobacter pyloni, antimierobial agents and chemotherapy显示文摘Huaxiang X Conor TK Shona B 199438 (10) :2357 - 23611994,38,10:1
13Atmospheric CO2 enrichment and nutrient additions to planted soil increase mineralization of soil organic matters, but do not alter microbial utilization of plant- and soilC-sources显示文摘Eric P Barry T Andrew JM Shona MO Allan S Pete M 2008Soil Biology Biochemistry2008,40,9:1
14Competing on the Edge: Strategy as Structured Chaos显示文摘Kathleen M Eisenhardt Shona L Brown 1998Long Range Planning1998,,5:1
15CD133,a novel marker for human prostatic epithelial stem cells显示文摘Gavin D Craig N Shona H 2004J Cell Science2004,117,16:1
16Effect of high-dose simvastatin on brain atrophy and disability in secondary progressive multiple sclerosis (MS-STAT): a randomised, placebo-controlled, phase 2 trial显示文摘Jeremy Chataway Nadine Schuerer Ali Alsanousi Dennis Chan David MacManus Kelvin Hunter Val Anderson Charles R M Bangham Shona Clegg Casper Nielsen Nick C Fox David Wilkie Jennifer M Nicholas Virginia L Calder John Greenwood Chris Frost Richard Nicholas 2014The Lancet2014,,:1
17Product Development : Past Research, Present Findings, and Future Directions 显示文摘Shona L Brown Kathleen M Eisenhardt 1995The Academy ofManagement Review1995,,2:1
18Effect of socioeconomic status on mortality among people with type 2 diabetes显示文摘Jeremy JW Shona JL Helen MC 2011Diabetes Care2011,34,5:1
19Dimensions of adolescent subjective social status within the school community: Description and correlates显示文摘Helen Sweeting Patrick West Robert Young Shona Kelly 2010Journal of Adolescence2010,,3:1
20Residential Black Carbon Exposure and Circulating Markers of Systemic Inflammation in Elderly Males: The Normative Aging Study显示文摘Fang Shona C Mehta Amar J Alexeeff Stacey E Gryparis Alexandros Coull Brent Vokonas Pantel Christiani David C Schwartz Joel 2012EN2012,,5:1
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