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| 1 | Connexin 43 hemichannels protect bone loss during estrogen deficiency显示文摘Estrogen deficiency in postmenopausal women is a major cause of bone loss,resulting in osteopenia,osteoporosis,and a high risk for bone fracture.Connexin 43 (Cx43) hemichannels (HCs) in osteocytes play an important role in osteocyte viability,bone formation,and remodeling.We showed here that estrogen deficiency reduced Cx43 expression and HC function.To determine if functional HCs protect osteocytes and bone loss during estrogen deficiency,we adopted an ovariectomy model in wild-type (WT) and two transgenic Cx43 mice:R76W (dominant-negative mutant inhibiting only gap junction channels) and Cx43 Δ130–136 (dominant-negative mutant compromising both gap junction channels and HCs).The bone mineral density (BMD),bone structure,and histomorphometric changes of cortical and trabecular bones after ovariectomy were investigated.Our results showed that the Δ130–136 transgenic cohort had greatly decreased vertebral trabecular bone mass compared to WT and R76W mice,associated with a significant increase in the number of apoptotic osteocyte and empty lacunae.Moreover,osteoclast surfaces in trabecular and cortical bones were increased after ovariectomy in the R76W and WT mice,respectively,but not in Δ130–136 mice.These data demonstrate that impairment of Cx43 HCs in osteocytes accelerates vertebral trabecular bone loss and increase in osteocyte apoptosis,and further suggest that Cx43 HCs in osteocytes protect trabecular bone against catabolic effects due to estrogen deficiency. | Liang Ma Rui Hua Yi Tian Hongyun Cheng Roberto Jose Fajardo Joseph J. Pearson Teja Guda Daniel Brian Shropshire Sumin Gu Jean X. Jiang | 2019 | Bone Research2019，7，2： | 11 |
| 2 | Benefits and cost implications from integrating small flexible nuclear reactors with off-shore wind farms in a virtual power plant显示文摘 | Shropshire D Purvins A Papaioannou I | 2012 | Energy Policy2012，46，： | 1 |
| 3 | Directors' muhiple identities, identification, and board monito- ring and resource provision 显示文摘 | Hillman A J Nicholson G Shropshire C | 2008 | Organization Sci- ence2008，19，3： | 1 |
| 4 | The catalyst of the electrochemical oxidation of formaldehyde and methanol by molybdates 显示文摘 | SHROPSHIRE J A | 1965 | J Electrochem Soc1965，112，： | 1 |
| 5 | Sensitivity of Leguminous Crops to Saflufenacil显示文摘 | SOLTANI N SHROPSHIRE C SIKUEMA P H | 2010 | Weed Technol2010，24，： | 1 |
| 6 | The influence of the infor- mal social learning environment on information privacy policy com- pliance efficacy and intention 显示文摘 | Warkentin M Johnston A Shropshire J | 2011 | European Journal of Information Systems2011，20，3： | 1 |
| 7 | Tolerance of black beans (Phaseolus vulgaris) to soil applications of S-metolachlor and imazethapyr显示文摘 | Soltani N Shropshire C Cowan T | 2004 | Weed Technol2004，18，： | 1 |
| 8 | The Role of the Interlocking Director and Board Receptivity in the Diffusion of Practices 显示文摘 | SHROPSHIRE C | 2010 | Academy of Management Review2010，35，2： | 1 |
| 9 | Benefits and cost implications from integrating small flexible nuclear reactors with off-shore wind farms in a virtual power plant显示文摘 | David Shropshire Arturs Purvins Ioulia Papaioannou Isabella Maschio | 2012 | Energy Policy2012，，： | 1 |
| 10 | Directors' Multiple Identities, Identification, and Board Monitoring and Resource Provision 显示文摘 | Hillman A J Nicholson G Shropshire C | 2008 | Organization Science2008，19，3： | 1 |
| 11 | What I Like About You:A Multilevel Study of Shareholder Discontent with Di- rector Monitoring 显示文摘 | Hillman A J Shropshire C Certo S T | 2011 | Organization Science2011，22，3： | 1 |
| 12 | Sensitivity of Leguminous Crops to Saflufenacil 显示文摘 | Soltani N Shropshire C Sikkcma P H | 2010 | Weed Technol2010，24，： | 1 |
| 13 | Beyond the Design and Evaluation of Library Web Sites:An Analysis and Four Case Studies显示文摘 | Sandra Shropshire | 2003 | The Journal of Academic Librarianship2003，，2： | 1 |
| 14 | Direc- tars'multiple identities, identification, and board monito- ring and resource provision 显示文摘 | Hillman A J Nicholson G Shropshire C | 2008 | Organization Science2008，19，3： | 1 |
| 15 | The role of the interlocking di- rector and board recepti,vity in the diffusion of practices 显示文摘 | Shropshire C | 2010 | Acad~emy of Management Review2010，35，2： | 1 |
| 16 | Benefits and cost implications from integrating small flexible nuclear reactors with of shore wind farms in a virtual power plant显示文摘 | SHROPSHIRE D PURVINS A PAPAIOANNOU I | 2012 | Energy Policy2012，46，： | 1 |
| 17 | Directors' multiple identities,identification,and boardmonitoring and resource provision显示文摘 | Hillman A J Nicholson G and Shropshire C | 2008 | Organization Science2008，19，3： | 1 |
| 18 | A unifying scheme for the electrochemical oxidation of carbonaceous fuels on platinum in sulphuric acid显示文摘 | Shropshire J A | 1967 | Electrochim Acta1967，12，： | 1 |
| 19 | Tolerance of black beans (Phaseolus vulgaris) to soil applications of S-metolachlor and imazethapyr显示文摘 | Soltani N Shropshire C Cowan T | 2004 | Weed Technol2004，18，： | 1 |
| 20 | Organizational predictors of women on corporate boards显示文摘 | Hillman A J Shropshire C Cannella A | 2007 | Academy of Management Journal2007，50，4： | 1 |
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