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| 1 | Efficacy of capecitabine-based combination therapy and singleagent capecitabine maintenance therapy in patients with metastatic breast cancer显示文摘Objective: The purpose of this study was to observe the efficacy and toxicities of capecitabine-based chemotherapy and capecitabine monotherapy as maintenance therapy in the treatment of metastatic breast cancer(MBC).Patients and methods: A total of 98 MBC patients were treated with capecitabine combined with vinorelbine(NX). Results: The median number of treatment was 6 cycles(1-7 cycles). There were two cases of complete remission(CR), 58 partial remission, 27 stable disease(SD), 11 progression disease. The overall response rate(ORR)(CR + PR) was 61.2%. The clinical benefit rate(CBR) was 75.5%. Fifty of effective patients received with capecitabine monotherapy as maintenance therapy. The ORR(CR + PR) was 4%. The CBR was 48%. The median progression-free survival(PFS) was 12 months. In maintenance therapy or not, the median post metastasis survival rate(MSR) was 63 and 28 months, respectively. In the combination therapy group, the major grade 3/4 toxicities included hand-foot syndrome(3.1%), skin pigmentation(2.0%), diarrhoea and abdominal distension(5.1%), stomatitis(1.0%), and leukopenia(20.4%).Conclusions: Capecitabine-based combination therapy and single-agent capecitabine maintenance therapy were well tolerated and effective to MBC. | Huimin Lv Min Yan Mengwei Zhang Limin Niu Huiai Zeng Shude Cui | 2014 | Chinese Journal of Cancer Research2014，26，6： | 8 |
| 2 | Improving Joint Features and Mechanical Properties of Pinless Fiction Stir Welding of Alcald 2A12-T4 Aluminum Alloy显示文摘As a new solid state welding,pinless friction stir welding(PFSW) can be used to join thin-wall structures.In this study,four new pinless tools with different groove distributions were designed and manufactured in order to enrich technological storage of PFSW and obtain sound joint with high quality of alclad 2A12-T4 alloy.The results show that the small-obliquity tool is detrimental to the transfer of plasticized materials,resulting in the formation of kissing bond defect.For the through-groove tool or the large-curvature tool,bigger flashes form on the joint surface and alclad layer is observed in the nugget zone(NZ),deteriorating mechanical properties.Compared with the above-mentioned three tools,using the six-groove tool with rational curvature and obliquity can not only yield sound joint with small flashes and thickness reduction,but also prevent alclad from flowing into NZ,which has potential to weld thin alclad aluminum alloys.Meanwhile,the tensile strength and elongation of joint using the six-groove tool reach the maximum values of 362 MPa and 8.3%,up to 85.1% and 64% of BM. | Zhenlei Liu Hutao Cui Shude Ji Minqiang Xu Xiangchen Meng | 2016 | Journal of Materials Science & Technology2016，32，12： | 7 |
| 3 | Achieving High‑Quality Aluminum to Copper Dissimilar Metals Joint via Friction Stir Double‑Riveting Welding显示文摘In order to achieve a high-quality joining of aluminum(Al)and copper(Cu)dissimilar metals,a new friction stir doubleriveting welding(FSDRW)with a Cu rod as the rivet was proposed,and the rotating tool with a large concave angle shoulder was specially designed.The results showed that under the thermal–mechanical effect of rotating tool,the Cu rod was deformed to be a double riveting heads structure with a Cu anchor at the upper surface of Al plate and an Al anchor above the lap interface of joint,and these two anchors greatly enhanced the mechanical interlocking of Al/Cu joint.The effective bonding interfaces were formed among the double riveting heads structure,the upper Al plate and the lower Cu plate,which contained the Cu/Cu interface and the Al/Cu interface.The Cu/Cu interface without the kissing bond and the Al/Cu interface with the rationally thin AlCu and Al_(2)Cu intermetallic compounds(IMCs)layers were beneficial to heightening the joint tensile shear strength.The maximum tensile shear load of the FSDRW joint achieved 5.52 kN,and the joint under different plunging depths of rotating tool presented a mixed mode of ductile fracture and brittle fracture.This novel FSDRW technique owns the advantages of strong mechanical interlocking and superb metallurgical bonding,and provides a new approach to acquiring a high-quality Al/Cu dissimilar metals joint. | Shude Ji Xiao Cui Lin Ma Hua Liu Yingying Zuo Zhiqing Zhang | 2023 | Acta Metallurgica Sinica(English Letters)2023，36，4： | 1 |
| 4 | Microstructural formation and mechanical performance of friction stir double-riveting welded Al-Cu joints显示文摘A novel friction stir double-riveting welding(FSDRW) technology was proposed in order to realize the high-quality joining of upper aluminum(Al) and lower copper(Cu) plates,and this technology employed a Cu column as a rivet and a specially designed welding tool with a large concave-angle shoulder. The formations, interfacial characteristics, mechanical properties and fracture features of Al/Cu FSDRW joints under different rotational velocities and dwell times were investigated. The results showed that the well-formed FSDRW joint was successfully obtained.The cylindrical Cu column was transformed into a double riveting heads structure with a Cu anchor at the top and an Al anchor at the bottom, thereby providing an excellent mechanical interlocking.The defect-free Cu/Cu interface was formed at the lap interface due to the sufficient metallurgical bonding between the Cu column and the Cu plate, thereby effectively inhibiting the propagation of crack from the intermetallic compound layer at the lap interface between the Al and Cu plates. The tensile shear load of joint was increased first and then decreased when the rotational velocity and dwell time of welding tool increased, and the maximum value was 5.52 k N. The FSDRW joint presented a mixed mode of ductile and brittle fractures. | Shude JI Zhiqing ZHANG Peng GONG Hua LIU Xiao CUI Yewei ZHANG | 2023 | Chinese Journal of Aeronautics2023，36，8： | 0 |
| 5 | Adjuvant tamoxifen switched to exemestane treatment in postmenopausal women with estrogen receptor-positive early breast cancer:A pragmatic,multicenter,and prospective clinical trial in China显示文摘Objective:This post-approval safety study assessed the efficacy and safety of exemestane after 2-3 years of tamoxifen treatment among postmenopausal women with estrogen receptor-positive(ER+)early breast cancer in China.Methods:Enrolled patients had received 2-3 years of tamoxifen and were then switched to exemestane for completion of 5 consecutive years of adjuvant endocrine therapy.The primary endpoint was the time from enrollment to the first occurrence of locoregional/distant recurrence of the primary breast cancer,appearance of a second primary or contralateral breast cancer,or death due to any cause.Other endpoints included the proportion of patients experiencing each event,incidence rate per annum,relationships between human epidermal growth factor receptor 2 status and time to event,and relationship between disease history variables and time to event.Results:Overall,558 patients were included in the full analysis set:397(71.1%)completed the study,20experienced an event,and 141 discontinued[47 owing to an adverse event(AE);37 no longer willing to participate].Median duration of treatment was 29.5(range,0.1-57.7)months.Median time to event was not reached.Eventfree survival probability at 36 months was 91.4%(95%CI,87.7%-95.1%).The event incidence over the total exposure time of exemestane therapy was 3.5 events/100 person-years(20/565).Multivariate analysis showed an association between tumor,lymph node,and metastasis stage at initial diagnosis and time to event[hazard ratio:1.532(95%CI,1.129-2.080);P=0.006].Most AEs were grade 1 or 2 in severity,with arthralgia(7.7%)being the most common treatment-related AE.Conclusions:This study supports the efficacy and safety of exemestane in postmenopausal Chinese women with ER+breast cancer previously treated with adjuvant tamoxifen for 2-3 years.No new safety signals were identified in the Chinese population. | Binghe Xu Huiping Li Zefei Jiang Lin Gu Jinhai Tang Hui Xie Yueyin Pan Yunjiang Liu Shude Cui Xiaojia Wang Li Cai Yiqiong Zhang Huadong Zhao Zhimin Shao | 2022 | Chinese Journal of Cancer Research2022，34，6： | 0 |
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