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| 1 | Long-term survival following radiofrequency ablation of colorectal liver metastases: A retrospective study显示文摘AIM: To retrospectively evaluate the long-term survivalof patients that received radiofrequency ablation(RFA) therapies of colorectal liver metastases. METHODS: In 2005 to 2008, RFA of 105 colorectal liver metastases(CRLM) were performed on 49 patients in our institution. The liver metastases were evaluated, both before and after ablation therapies, with contrast enhanced computerised tomography and contrast enhanced ultrasonography. Histological evidence of malignant liver metastases was obtained in the few instances where contrast enhanced ultrasonography gave equivocal results. Accesses to the CRLM were guided ultrasonically in all patients. The data obtained from records of these ablations were retrospectively analysed and survival data were compared with existing studies in the literature.RESULTS: 1-, 2-, 3-, 4- and 5-year survival rates, when no stringent selection criteria were applied, were 92%, 65%, 51%, 41% and 29% respectively. To explore the impact of the number and size of CRLM on patients' survival, an exclusion of 13 patients(26.5%) with number of CRLM ≥ 5 and tumour size ≥ 40 mm resulted in 1-, 2-, 3-, 4- and 5-year survival rates improving to 94%, 69%, 53%, 42% and 31% respectively. It is of note that 9 of 49 patients developed extra-hepatic metastases, not visible or seen on pretreatment scans, just after RFA treatment. These patients had poorer survival. The development of extra-hepatic metastases in nearly 20% of the patients included in our study can partly account for modestly lower survival rates as compared with earlier studies in the literature.CONCLUSION: Our study underscores the fact that optimum patients' selection before embarking on RFA treatment is vitally important to achieving a superior outcome. | Simeon Niyi Babawale Thomas MandФe Jensen Jens BrФndum FrФkjr | 2015 | World Journal of Gastrointestinal Surgery2015，7，3： | 11 |
| 2 | The maize ALDH protein superfamily:linking structural features to functional specificities显示文摘 | Jimenez-Lopez J C Gachomo E W Seufferheld M J Simeon O Kotchoni S O | | 0，，： | 1 |
| 3 | Phenothiazines inhibit hepatitis C virus entry, likely by in- creasing the fluidity of cholesterol-rich membranes显示文摘 | Chamouu-Emanuelli A M Pecheur E I Simeon R L | 2013 | Antimi- crob Agents Chemother2013，57，6： | 1 |
| 4 | Immunomodulating antibodies in the treatment of metastatic melanoma:the experience with anti-CTLA-4,anti-CD137,and anti-PD1显示文摘 | Simeone E Ascierto PA | | 0，，3： | 1 |
| 5 | Surgical treatment of ureteral obstruction from edometriosis:our experience with thirteen cases显示文摘 | Antonelli A Simeone C Frego E | 2004 | Int Urogynecol Jpelvic Floor Dysfunct2004，15，： | 1 |
| 6 | Biology and clinical applications of pancreatic cancer stem cells 显示文摘 | Abel E V Simeone D M | 2013 | Gastroenterology2013，114，6： | 1 |
| 7 | Soluble interleukin-2 receptor in stage Ⅰ-Ⅲ melanoma显示文摘 | Ottaiano A Leonardi E Simeone E | 2006 | Cytokine2006，33，3： | 1 |
| 8 | Efficacy of liposomal daunorubicin and cytarabine as reinduction chemotherapy in relapsed acute lymphoblastic leukaemia despite expression of multidrug resistance-related proteins显示文摘 | Candoni A Michelutti A Simeone E | 2006 | Eur J Haematol2006，77，4： | 1 |
| 9 | Clinical experiences with anti-CD137 and anti-PD1 therapeutic antibodies显示文摘 | Ascierto PA Simeone E Sznol M | | 0，，： | 1 |
| 10 | Body dysmorphic disorder in the DSM-Ⅳ field trial for obsessive-compulsive disorder显示文摘 | Simeon D Hollander E Stein DJ | 1995 | AmJ Psychiatry1995，152，8： | 1 |
| 11 | Functional gastrointesti-nal disorders in children: An Italian prospective survey显示文摘 | MIELE E SIMEONE D MARINO A | 2004 | Pediat-rics2004，114，1： | 1 |
| 12 | Molecular characterization of a LMW-GS gene located on chromosome 1B and the development of primers specific for the Glu-B3 complex locus in durum wheat显示文摘 | D'ovidio R Simeone M Masci S Porceddu E | 1997 | Theoretical and Applied Genetics1997，95，： | 1 |
| 13 | Functional gastrointestinal disorders in children:an Italian prospective survey显示文摘 | MIELE E SIMEONE D MARINO A | 2004 | Pediatrics2004，114，1： | 1 |
| 14 | Surgical treatment of ureteral obstruction from endometriosis:our experience with thirteen case显示文摘 | Antonelli A Simeone C Frego E | 2004 | Int Urolgynecol J Pelvic Floor Dysfunct2004，15，6： | 1 |
| 15 | Functional gastrointestinal disorders in children:an Italian prospective survey显示文摘 | Miele E Simeone D Marino A | 2004 | Pediatrics2004，114，1： | 1 |
| 16 | Public health science agenda for congenital heart defects report from a Centers for Disease Control and Prevention experts meeting 显示文摘 | Oster M E Riehie-Colarusso T Simeone R M | 2013 | J Am Heart Assoc2013，2，00： | 1 |
| 17 | Public health science agenda for congenital heart defects:report from a centers for disease control and prevention experts meeting显示文摘 | Oster M E Riehle C T Simeone R M | 2013 | J Am Heart Assoc2013，2，00： | 1 |
| 18 | Functional gastrointestinal disorders in children : An Italian prospective survey 显示文摘 | Miele E Simeone D Marino A | 2004 | Pediatrics2004，114，1： | 1 |
| 19 | Isoprenoid pathway optimization for Taxol precursor overproduction in Escherichia coli显示文摘 | Ajikumar P K Xiao W H Tyo K E Wang Y Simeon F Leonard E Mucha O Phon T H Pfeifer B Stephanopoulos G | | 0，，： | 1 |
| 20 | Soluble interleukin-2 receptor in stage Ⅰ- Ⅲ melanoma显示文摘 | Ottaiano A Ottaiano A Simeone E | 2006 | Cytokine2006，33，3： | 1 |
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