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| 1 | Systematic cloning of Treponema pollidum open reading frames for protein expression and antigen discovery 显示文摘 | McKevitt M Patel K Smajs D | 2003 | Genome Res2003，13，7： | 1 |
| 2 | Characterization of coliein S4 and its receptor, OmpW, a minor protein of the Escherichia coli outer membrane显示文摘 | PILSL H SMAJS D BRAUN V | 1999 | Journal of Bacteriology1999，181，11： | 1 |
| 3 | Systematic cloning of Treponema pallidum open reading frames for protein expression and antigen discovery显示文摘 | McKevitt M Patel K Smajs D | | 0，，07： | 1 |
| 4 | Transcriptome of Treponema pallidum: gene expression profile during experimental rabbit infection显示文摘 | Smajs D McKevitt M Howell JK | 2005 | J Bacteriol2005，187，5： | 1 |
| 5 | Transcriptome of Trepo- nema pallidum: gene expression profile during experimental rab- bit infection显示文摘 | Smajs D McKevitt M Howell JK | 2005 | J Bacteriol2005，187，5： | 1 |
| 6 | Systematic cloning of Treponema pallidum open reading frames for protein expression and antigen discov- ery 显示文摘 | McKevitt M Patel K Smajs D | 2003 | Genome Res2003，13，7： | 1 |
| 7 | Detection of rrrepo- nema pallidum subsp, pallidum from skin lesions, serum, and cerebrospinal fluid in an infant with congenital syphilis after clin- damycin treatment of the mother during pregnancy显示文摘 | Woznicova V Smajs D Wechsler D | 2007 | J Clin Mi- crobio12007，45，2： | 1 |
| 8 | Detection of Treponema pallidum subsp, pallidum from skin lesions, serum, and eerebrospinal fluid in an infant with congenital syphilis after clindamycin treatment of the mother during pregnancy 显示文摘 | Woznicovd V Smajs D Wechsler D | 2007 | J Clin Microbiol2007，45，2： | 1 |
| 9 | S-layers on cell walls of cyanobacteria显示文摘 | Smarda J Smajs D Komrska J | 2002 | Micron2002，33，3： | 1 |
| 10 | Exoproducts of the Escherichia coli strain H22 inhibiting some enteric pathogens both in vitro and in vivo显示文摘 | Cursino L Smajs D Smarda J | 2006 | Appl Microbiol2006，100，： | 1 |
| 11 | S-layers on cell walls of cya- nobacteria 显示文摘 | Smarda J Smajs D Komrska J | 2002 | Micron2002，33，3： | 1 |
| 12 | Transcriptome of Treponema pallidum: gene expression profile during experimental rabbit infection显示文摘 | Smajs D McKevitt M Howell JK | 2005 | J Bacteriol2005，187，5： | 1 |
| 13 | Systematic cloning of Treponema pallidum open reading frames for protein expression and antigen discovery显示文摘 | McKevitt M Patel K Smajs D | 2003 | Genome Res2003，13，7： | 1 |
| 14 | Bacteriocinogeny in experimental pigs treated with indomethacin and Escherichia coli Nissle显示文摘AIM:To evaluate bacteriocinogeny in short-term highdose indomethacin administration with or without probiotic Escherichia coli Nissle 1917(EcN) in experimental pigs.METHODS:Twenty-four pigs entered the study:Group A(controls),Group B(probiotics alone),Group C(indomethacin alone) and Group D(probiotics and indomethacin).EcN(3.5 × 1010 bacteria/d for 14 d) and/or indomethacin(15 mg/kg per day for 10 d) were administrated orally.Anal smears before and smears from the small and large intestine were taken from all animals.Bacteriocin production was determined with 6 different indicator strains;all strains were polymerase chain reaction tested for the presence of 29 individual bacteriocinencoding determinants.RESULTS:The general microbiota profile was rather uniform in all animals but there was a broad diversity in coliform bacteria(parallel genotypes A,B1,B2 and D found).In total,637 bacterial strains were tested,mostly Escherichia coli(E.coli).There was a higher incidence of non-E.coli strains among samples taken from the jejunum and ileum compared to that of the colon and rectum indicating predominance of E.coli strains in the large intestine.Bacteriocinogeny was found in 24/77(31%) before and in 155/560(28%) isolated bacteria at the end of the study.Altogether,13 individual bacteriocin types(out of 29 tested) were identified among investigated strains.Incidence of four E.coli genotypes was equally distributed in all groups of E.coli strains,with majority of genotype A(ranging from 81% to 88%).The following types of bacteriocins were most commonly revealed:colicins Ia/Ib(44%),microcin V(18%),colicin E1(16%) and microcin H47(6%).There was a difference in bacteriocinogeny between control group A(52/149,35%) and groups with treatment at the end of the study:B:31/122(25%,P = 0.120);C:43/155(28%,P = 0.222);D:29/134(22%,P = 0.020).There was a significantly lower prevalence of colicin Ib,microcins H47 and V(probiotics group,P < 0.001),colicin E1 and microcin H47(indomethacin group,P < 0.001) and microcins H47 and V(probiotics and indomethacin group,P = 0.025) compared to controls.Escherichia fergusonii(E.fergusonii) was identified in 6 animals(6/11 isolates from the rectum).One strain was non-colicinogenic,while all other strains of E.fergusonii solely produced colicin E1.All animals started and remained methanogenic despite the fact that EcN is a substantial hydrogen producer.There was an increase in breath methane(after the treatment) in 5/6 pigs from the indomethacin group(C).CONCLUSION:EcN did not exert long-term liveability in the porcine intestine.All experimental pigs remained methanogenic.Indomethacin and EcN administered together might produce the worst impact on bacteriocinogeny. | Jan Bures David Smajs Jaroslav Kvetina Miroslav Frstl Jan Smarda Darina Kohoutova Martin Kunes Jiri Cyrany Ilja Tacheci Stanislav Rejchrt Jirina Lesna Viktor Vorisek Marcela Kopacova | 2011 | World Journal of Gastroenterology2011，17，5： | 0 |
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