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| 1 | MicroRNAs, development of Barrett’s esophagus, and progression to esophageal adenocarcinoma显示文摘Barrett's esophagus is a premalignant condition caused by gastroesophageal reflux. Once developed, it can progress through varying grades of dysplasia to esoph-ageal adenocarcinoma. Whilst it is well accepted that Barrett's esophagus is caused by gastroesophageal reflux, the molecular mechanisms of its pathogenesis and progression to cancer remain unclear. MicroRNAs (miRNAs) are short segments of RNA that have been shown to control the expression of many human genes. They have been implicated in most cellular processes, and the role of miRNAs in disease development is be-coming increasingly evident. Understanding altered miRNA expression is likely to help unravel the molecular mechanisms that underpin the development of Barrett's esophagus and its progression to cancer. | Cameron M Smith David I Watson Michael Z Michael Damian J Hussey | 2010 | World Journal of Gastroenterology2010，16，5： | 23 |
| 2 | miR-200 family expression is downregulated upon neoplastic progression of Barrett's esophagus显示文摘AIM: To investigate miR-200 family expression in Barrett's epithelium, gastric and duodenal epithelia, and esophageal adenocarcinoma. METHODS: Real-time reverse transcriptase-polymerase chain reaction was used to measure miR-200, ZEB1 and ZEB2 expression. Ingenuity Pathway Analysis of miR-200 targets was used to predict biological outcomes. RESULTS: Barrett's epithelium expressed lower levels of miR-141 and miR-200c than did gastric and duodenal epithelia (P < 0.001). In silico analysis indicated roles for the miR-200 family in molecular pathways that distinguish Barrett's epithelium from gastric and duodenalepithelia, and which control apoptosis and proliferation. All miR-200 members were downregulated in adenocarcinoma (P < 0.02), and miR-200c expression was also downregulated in non-invasive epithelium adjacent to adenocarcinoma (P < 0.02). The expression of all miR-200 members was lower in Barrett's epithelium derived high-grade dysplastic cell lines than in a cell line derived from benign Barrett's epithelium. We observed signif icant inverse correlations between miR-200 family expression and ZEB1 and ZEB2 expression in Barrett's epithelium and esophageal adenocarcinoma (P < 0.05). CONCLUSION: miR-200 expression might contribute to the anti-apoptotic and proliferative phenotype of Barrett's epithelium and regulate key neoplastic processes in this epithelium. | Cameron M Smith David I Watson Mary P Leong George C Mayne Michael Z Michael Bas PL Wijnhoven Damian J Hussey | 2011 | World Journal of Gastroenterology2011，17，8： | 13 |
| 3 | 高龄对男性生育力的影响显示文摘在过去的几十年里,现代社会的压力和期望使得育龄夫妇生育年龄总体推迟。已知女性在临近40岁时卵母细胞的产生将会明显减少,而高龄对男性精子生成能力的影响还知之甚少。男性生育年龄无明确限制,因而高龄对男性生育能力的影响还不完全清楚。本文将就目前已知的高龄对男性精子质量、生育能力和子代健康的影响进行综述,希望能在医生就男性推迟生育及高龄相关的风险咨询时起到一定的指导作用。 | Jason R Kovac Josephine Addai Ryan P Smith Robert M Coward Dolores J Lamb Larry I Lipshultz | 2013 | Asian Journal of Andrology2013，15，6： | 12 |
| 4 | 热带大气10~20天振荡的大气环流模式数值模拟显示文摘利用大气环流模式对热带大气10~20天振荡进行了数值模拟研究,其结果同观测资料分析基本一致。模式资料的功率谱及动能的分析表明,10~20天振荡确实比30~60天振荡更突出地存在于热带大气中。同热带大气30~60天振荡的结构有些不同,对于在热带10~20天振荡,除纬向1波外,纬向2波也很明显;流动的斜压结构特征欠佳;系统以较快速度沿赤道西移。暖SST事件对热带大气10~20天振荡的影响也进行了模拟,对结果的比较分析表明,暖STT将使10~20天大气振荡减弱,使其结构更趋正压性。 | 李崇银 Smith,I | 1996 | 大气科学1996，20，1： | 7 |
| 5 | Men with a complete absence of normal sperm morphology exhibit high rates of success without assisted reproduction显示文摘在里面结合不孕, 0% 正常形式(NF ) 的反常严格的形态学是一个标准很快继续到在 vitro 授精(IVF ) 。自从没有数据,当前存在,我们与 0% NF 为人调查了结果没有帮助繁殖技术(艺术) 的使用,决定繁殖成功。有 0% NF 的 24 个人的一个队被识别(2010-2013 ) 随机与 ≥ 与 27 选择了人;是的 4% NF 控制。耐心的图表与联系并且管理同意的一块机构的评论板(IRB ) 的人一起被考察查明结果的电话问询表。在 2.5 年的一中部的后续时间以后,有 0% NF 的 29.2% 人没为他们的第一怀孕要求艺术(控制 =55.6% , P ≤0.05 ) 。当所有怀孕一起被分析时,有 0% NF 的人完成了 75% 没要求 IVF 的二十怀孕(控制 = 三十怀孕;76.7% 没要求 IVF ) 。人和女搭挡的平均年龄在有 0% NF 和 ≥ 的人之间是类似的; 4% NF。所有人有正常刺激滤泡的荷尔蒙(FSH ) ,睾丸激素,催乳激素,性别荷尔蒙绑定血球素(SHBG ) ,和 estradiol。尽管,当第一怀孕是一个自然概念(NC ) 时,全球精液参数在有 0% NF 的人是更坏的,有 0% NF (n = 7/7 ) 的人的 100% 并且 37.5% 控制(n = 3/8 ) 继续了经由 NC 有随后的怀孕。没有 IVF,有 0% NF 的人与 55.6% 控制相比在 29.2% 盒子中怀孕了。严格的形态学不应该被用来预言授精,怀孕,或实时出生潜力。在有 0% NF 的人,其他的形式应该被认为 IVF 以前立即。 | Jason R Kovac Ryan P Smith Miguel Cajipe Dolores J Lamb Larry I Lipshultz | 2017 | Asian Journal of Andrology2017，19，1： | 7 |
| 6 | 肠道SOCS3蛋白调控炎症性肠病发展显示文摘根据Lancaster大学科学家开展的一项研究发现:炎性肠病(IBD)的发展会受到肠道中一种能导致炎症的蛋白质的影响。在英国,每百人中有一人在其一生中将罹患IBD,包括克罗恩病和溃疡性结肠炎。肠衬里被修复的速度取决于其与肠道中细菌的相互作用。肠道微生物的改变影响肠衬里被修复的速度,肠衬里提供了抵御肠道内传染性病原体的第一道防线。整个肠道衬有单层上皮细胞,在IBD情况下,单层上皮细胞UI发炎和被毁坏。研究人员发现,其在IBD情况下。 | Thagia I Shaw EJ Smith E | 2015 | 中华结直肠疾病电子杂志2015，4，2： | 6 |
| 7 | Measurement of protein using bicinchoninic acid 显示文摘 | Smith P K Krohn R I Hermanson G T | 1985 | Anal Biochem1985，150，： | 2 |
| 8 | Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration显示文摘 | Joanna M Wardlaw Eric E Smith Geert J Biessels Charlotte Cordonnier Franz Fazekas Richard Frayne Richard I Lindley John T O’Brien Frederik Barkhof Oscar R Benavente Sandra E Black Carol Brayne Monique Breteler Hugues Chabriat Charles DeCarli Frank-Erik de | 2013 | Lancet Neurology2013，，8： | 2 |
| 9 | Phytoremediation 显示文摘 | Salted Smith R D Raskin I | 1998 | Annual Rev Plant Phys Plant Mol Bio1998，49，： | 2 |
| 10 | Pentoxifylline treatment and penile calcifications in men Nith Peyronie's disease显示文摘 | James F Smith Alan W Shindel Yun-Ching Huang Raul I Clavijo Lawrence Flechner Benjamin N Breyer Michael L Eisenberg Tom F Lue | 2011 | Asian Journal of Andrology2011，13，2： | 2 |
| 11 | Adjuvant endocrine therapy for early breast cancer显示文摘 | Andreetta C Smith I | 2007 | Cancer Letters2007，251，1： | 1 |
| 12 | Mycorrhizal fungi can dominate phosphate supply to plants irrespecrive of growth responses 显示文摘 | Smith SE Smith FA Jakobsen I | 2003 | Plant Physiology2003，133，： | 1 |
| 13 | Preoperative chemotherapy in patients with resectable non -small cell lung cancer: results of the MRC LU22/NVALT 2/EORTC 08012 multieentre randomised trial and update of systematic review 显示文摘 | Gilligan D Nieolson M Smith I | 2007 | Lancet2007，369，9577： | 1 |
| 14 | Premenopausal bone loss in the lumbar spine and neck of femur: A study of 225 Caucasian women 显示文摘 | Rodin A Murby B Smith MA Caleffi M Fentiman I Chapman MG Fogelman I | 1990 | Bone1990，，11： | 1 |
| 15 | Bax and Bak coalesce into novel mitochondria-associated clusters during apoptosis显示文摘 | Smith CL Lamensdorf I | 2001 | J Cell Biol2001，153，： | 1 |
| 16 | MMP-2 and MMP-9 type Ⅳ collagenases in colorectal cancer显示文摘 | Talbot I Smith RA | 1996 | Cancer Res1996，56，1： | 1 |
| 17 | Seizure prediction using scalp Electroencephalogram 显示文摘 | Drury I Smith B Li Dingzhou | 2003 | Experimental Neurology2003，184，1： | 1 |
| 18 | Carbon emission offsets for avia tion--generated emissions due to international travel to and from New Zealand显示文摘 | Smith I Rodger C | 2009 | Energy Policy2009，37，9： | 1 |
| 19 | Magnetic Nitrides显示文摘 | Coey J M D Smith P A I | 1999 | J Magn Magn Mater1999，200，123： | 1 |
| 20 | Culture industries, culture clusters and the city: the example of natural history film - making in Bristol显示文摘 | Bassett K Griffiths R Smith I | 2002 | Geoforum2002，33，2： | 1 |
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