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| 1 | Histotype-based prognostic classification of gastric cancer显示文摘AIM:To test the efficiency of a recently proposed histotype-based grading system in a consecutive series of gastric cancers.METHODS:Two hundred advanced gastric cancers operated upon in 1980-1987 and followed for a median 159 mo were investigated on hematoxylin-eosinstained sections to identify low-grade [muconodular,well differentiated tubular,diffuse desmoplastic and high lymphoid response (HLR)],high-grade (anaplastic and mucinous invasive) and intermediate-grade (ordinary cohesive,diffuse and mucinous) cancers,in parallel with a previously investigated series of 292 cases.In addition,immunohistochemical analyses for CD8,CD11 and HLA-DR antigens,pancytokeratin and podoplanin,as well as immunohistochemical and molecular tests for microsatellite DNA instability and in situ hybridization for the Epstein-Barr virus (EBV) EBER1 gene were performed.Patient survival was assessed with death rates per 100 person-years and with Kaplan-Meier or Cox model estimates.RESULTS:Collectively,the four low-grade histotypes accounted for 22% and the two high-grade histotypes for 7% of the consecutive cancers investigated,while the remaining 71% of cases were intermediate-grade cancers,with highly significant,stage-independent,survival differences among the three tumor grades (P=0.004 for grade 1 vs 2 and P=0.0019 for grade 2 vs grade 3),thus confirming the results in the original series.A combined analysis of 492 cases showed an improved prognostic value of histotype-based grading compared with the Lauren classification.In addition,it allowed better characterization of rare histotypes,particularly the three subsets of prognostically different mucinous neoplasms,of which 10 ordinary mucinous cancers showed stage-inclusive survival worse than that of 20 muconodular (P=0.037) and better than that of 21 high-grade (P<0.001) cases.Tumors with high-level microsatellite DNA instability (MSI-H) or EBV infection,together with a third subset negative for both conditions,formed the T8 cell-rich HLR group,the largest group among low-grade histotypes.Coexisting HLR proved to be a factor in improved prognosis in tumors with microsatellite instability (P=0.0015 vs HLR-/MSI-H tumors) or DR type human leukocyte antigen expression (P=0.033 vs HLR/HLA-DR+ tumors).CONCLUSION:Identification of lowand high-grade histotypes can improve the prognostic assessment of a substantial proportion of gastric cancers in routine diagnostic practice. | Anna Maria Chiaravalli Catherine Klersy Alessandro Vanoli Andrea Ferretti Carlo Capella Enrico Solcia | 2012 | World Journal of Gastroenterology2012，18，9： | 3 |
| 2 | Intraductal papillary-mucinous tumours represent a distinct group of pancreatic neoplasms: an investigation of tumour cell differentiation and K-ras, p53 and c-erbB-2 abnormalities in 26 patients显示文摘 | F. Sessa E. Solcia C. Capella M. Bonato A. Scarpa G. Zamboni N. S. Pellegata G. N. Ranzani F. Rickaert G. Kl?ppel | 1994 | Virchows Archiv1994，，4： | 3 |
| 3 | Intracellular, Intercellular, and Stromal Invasion of Gastric Mucosa, Preneoplastic Lesions, and Cancer by Helicobacter pylori显示文摘 | Vittorio Necchi Maria Elena Candusso Francesca Tava Ombretta Luinetti Ulderico Ventura Roberto Fiocca Vittorio Ricci Enrico Solcia | 2007 | Gastroenterology2007，，3： | 2 |
| 4 | Endocrine tumors of the colon and rectum显示文摘 | Solcia E Arnold R | 2000 | 137-1392000，，： | 1 |
| 5 | Spiral CT angiography and surgical correlations in the evaluation of intracranial aneurysms显示文摘 | L. Preda P. Gaetani R. Rodriguez y Baena E. M. Di Maggio A. La Fianza R. Dore I. Fulle M. Solcia A. Cecchini L. Infuso R. Campani | 1998 | European Radiology1998，，5： | 1 |
| 6 | Endocrine cells of the gastric mucosa显示文摘 | SOLCIA E CAPELLA C VASSALLO G | 1975 | Int Rev Cytol1975，42，： | 1 |
| 7 | Intestinal and diffuse gastric cancers arise in a different gene involvement显示文摘 | Solcia E Fiocca R Luinetti O | 1996 | Am J Surg Pathol1996，20，1： | 1 |
| 8 | Endocrinee cells of the gastric mucosa显示文摘 | Solcia E Capella C Vassallo G | 1975 | Int Rev Cytol1975，42，： | 1 |
| 9 | Endocrine cells of the gastric mucosa显示文摘 | Solcia E Capella C Vassallo G | 1975 | Int Rev Cytol1975，42，： | 1 |
| 10 | The contribution of cell phenotype to the behavior of gastric cancer显示文摘 | Enrico Solcia Catherine Klersy Alessandro Vanoli Federica Grillo Rachele Manca Francesca Tava Ombretta Luinetti Roberto Fiocca | 2013 | Gastric Cancer2013，，4： | 1 |
| 11 | Endocrine cells of the gastric mucosa显示文摘 | Solcia E Capella C VassalloG | | Int RevCytol0，42，： | 1 |
| 12 | The contribution of immunohistochemistry to the diagnosis of neuroendocrine tumors 显示文摘 | SOLCIA E CAPELLA C BUFFA R | 1984 | Seminars in Diagnostic Pathology1984，1，4： | 1 |
| 13 | Gastric endocrine cells:types,function and growth显示文摘 | SOLCIA E RINDI G BUFFA R | 2000 | Regul Pept2000，93，123： | 1 |
| 14 | Histologic changes in type A chronic atrophic gastritis indicating increased risk of neuroendocrine tumor development: the predictive role of dysplastic and severely hyperplastic enterochromaffin-like cell lesions显示文摘 | Alessandro Vanoli Stefano La Rosa Ombretta Luinetti Catherine Klersy Rachele Manca Costanza Alvisi Sandro Rossi Erminio Trespi Adriano Zangrandi Fausto Sessa Carlo Capella Enrico Solcia | 2013 | Human Pathology2013，，9： | 1 |
| 15 | Effects of very long (up to10 years) proton pump blockade on human gastric mucosa显示文摘 | Lamberts R Brunner G Solcia E | 2001 | Digestion2001，64，： | 1 |
| 16 | Endocrine cells of the gastric mucosa 显示文摘 | Solcia E Capella C VassaUo G | 1975 | Int Rev Cytol1975，42，： | 1 |
| 17 | Morphological,molecular,and arognostfc aspeca of gastric endocrine tumors显示文摘 | Solcia E Rindi G Larosa S et ai | 2000 | Microsc ges fech2000，48，： | 1 |
| 18 | Cell biology, clinicopathological profile, and classification of gastro-enteropancreatic endocrine tumors显示文摘 | Guido Rindi Carlo Capella E. Solcia | 1998 | Journal of Molecular Medicine1998，，6： | 1 |
| 19 | Endocrine cells of the gastric mucosa 显示文摘 | SOLCIA E CAPELLA C | 1975 | International Review of Cytology1975，，42： | 1 |
| 20 | ECL cell tumor and poorly differentiated endocrine carcinoma of the stomach: Prognostic evaluation by pathological analysis显示文摘 | Guido Rindi Cinzia Azzoni Stefano La Rosa Catherine Klersy Donatella Paolotti Sigrid Rappel Manfred Stolte Carlo Capella Cesare Bordi Enrico Solcia | 1999 | Gastroenterology1999，，3： | 1 |
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