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| 1 | Formation mechanism of volatile and non-volatile compounds in peptide–xylose Maillard reaction显示文摘 | Qianqian Xu Jianbin Liu Huanlu Song Tingting Zou Ye Liu Songpei Zhang | 2013 | Food Research International2013，，1： | 2 |
| 2 | Sketch Guided Solid Texturing 显示文摘 | Zhang Guoxin Du Songpei Lai Yukun | 2011 | Graphical Models2011，73，4： | 1 |
| 3 | Changing Perspective in Stereoscopic Images 显示文摘 | Du Songpei Hu Shimin Ralph Martin | 2013 | Visualization and Computer Graphics2013，19，8： | 1 |
| 4 | Preparation and preliminary biological evaluation of ^(99m)Tc-ANMdU显示文摘Technetium-99m-labeled-5-{2-sulfanylethyl-[2-(2-sulfanylethylamino)acetyl]amino}-methyl-2′-deoxy- uridine (99mTc-ANMdU) was reported. The precursor ANMdU was synthesized by six-step reactions and all intermediates were verified with MS and 1HNMR. Using SnCl2 as reducing agent, a labeling reaction was carried out at 100°C for 30 min. The radiochemical purity of the 99mTc-ANMdU was 96.68%. Partition coefficients were 0.92 and 0.70 at pH 7.0 and 7.4 of the phosphate buffer saline, respectively. Biodistribution of 99mTc-ANMdU in normal mice showed that the initial uptake of 99mTc-ANMdU in vivo and the clearance was rapid. | LU Chunxiong JIANG Quanfu YU Huixin WANG Songpei Li Xiaomin WANG Zhengwu | 2010 | Nuclear Science and Techniques2010，21，2： | 1 |
| 5 | Repurposing matrine for the treatment of hepatosteatosis and associated disorders in glucose homeostasis in mice显示文摘现在的学习为 hepatosteatosis 为它的新申请调查了 hepatoprotective 药 matrine (Mtr ) 的功效并且在葡萄糖动态平衡联系了混乱。学习与各种各样的反常葡萄糖动态平衡在老鼠在 hepatosteatosis 的二个营养的模型被执行:(1 ) 高度果糖的饮食(HFru ) 导致了 hepatosteatosis 和葡萄糖不耐从肝,并且(2 ) hepatosteatosis 和多糖症导致了由高脂肪(HF ) 与 streptozotocin (STZ ) 的低剂量在联合节食。Mtr 的管理(100mg/kg 每天在为 4 个星期的饮食) 废除导致 HFru 的 hepatosteatosis 和葡萄糖不耐。没有改变肝的丰满的酸氧化,这些效果与刺激 HFru 的 de novo lipogenesis (DNL ) 的抑制被联系。进一步的调查揭示了那个导致 HFru 的 endoplasmic 蜂窝胃(嗯) 应力被禁止,而(可诱导的陪伴蛋白质) 热吃惊蛋白质 72 被 Mtr 增加。在 2 糖尿病的模型由 HF-STZ 导致了的一种类型, Mtr 减少了 hepatosteatosis 并且改进了稀释多糖症。hepatoprotective 药 Mtr 可以是为 hepatosteatosis 的处理的 repurposed 并且在葡萄糖动态平衡联系混乱。抑制嗯强调联系 DNL 和丰满的酸流入看起来在这些新陈代谢的效果起一个重要作用。 | Ali Mahzari Xiao-Yi Zeng Xiu Zhou Songpei Li Jun Xu Wen Tan Ross Vlahos Stephen Robinson Ji-Ming YE | 2018 | Acta Pharmacologica Sinica2018，39，11： | 1 |
| 6 | Carbon Monoxide Signal Breaks Primary Seed Dormancy by Transcriptional Silence of DOG1 in Arabidopsis thaliana显示文摘Primary seed dormancy is an adaptive strategy that prevents germination for viable seeds in harsh environment,ensuring seeds germination under favorable condition.Accurately inducing seeds germination in a controllable manner is important for crop production.Thus searching the chemicals that efficiently breaks seed dormancy is valuable.DOG1 protein abundance in the freshly harvested seed is high,and its level is correlated to seed dormancy intensity,thus DOG1 is regarded as the timer to evaluate the seed dormancy degree.In this study,we found the carbon monoxide(CO)donor treatment,the transgenic line with high CO content,showed lower seed dormancy,while scavenging CO,or the mutant with lower CO level,presented strong primary seed dormancy,genetic analysis showed that DOG1 was targeted by CO signal and was prerequisite for CO-dependent seed dormancy release.Furthermore,we found CO signal activated the expression of ERF/AP2 transcriptional factor ERF12,as well as enhanced the binding of ERF12 to the promoter of DOG1,ultimately transcriptional silence of DOG1 expression to break primary seed dormancy.Meanwhile CO signal reduced the histone acetylation level at the chromatin of DOG1 locus to suppress its expression.Together,our results revealed that CO acts as the novel regulator to suppress DOG1 expression and efficiently break primary seed dormancy through activating the negative factor ERF12. | Danni He Guoli Deng Songpei Ying Wenjuan Yang Jiali Wei Ping Li | 2020 | Phyton-International Journal of Experimental Botany2020，89，3： | 1 |
| 7 | Prenylf avonoids from Glycyrrhiza uralensis and their protein tyrosine phosphatase-1B inhibitory activities显示文摘 | Songpei Li Wei Li Yinghua Wang | 2010 | Bioorganic & Medicinal Chemistry Letters2010，，20： | 1 |
| 8 | Bioassay-guided isolation and quantification of the alpha-glucosidase inhibitory compound,glycyrrhisoflavone,from Glycyrrhiza uralensis显示文摘 | Wei Li Songpei Li Lin Lin | 2010 | Nat Prod Commun2010，5，7： | 1 |
| 9 | Prenylflavonoids from Glyeyrrhi- za uralensis and their protein tyrosine phosphatase - 1B inhibitory activ- ities显示文摘 | Li Songpei Li Wei Yinghua W | 2010 | Bioorganic & Medicinal Chemistry Letters2010，20，18： | 1 |
| 10 | Prenylflavonoids from Glycyrrhiza uralensis and their protein tyrosine phosphatase-1B inhibitory activities显示文摘 | Songpei Li Wei Li Yinghua Wang | 2010 | Bioorganic & Medicinal Chemistry Letters2010，，20： | 1 |
| 11 | Biological evaluation on ^(125)I-ADAM as serotonin transporter ligand显示文摘ADAM (2-((2-((dimethylamino)methyl)phenyl)thio)-5-iodophenylamine) is suggested as a promising serotonin transporter (SERT) imaging agent for central nervous system. In this paper, biodistribution studies in rats showed that the initial uptake of 131I-ADAM in the brain was high (1.087%ID at 2 min post-injection), and consistently displayed the highest binding (between 60~240 min post-injection) in hypothalamus, a region known with the highest density of SERT. The specific binding((T/CB)-1) of 131I-ADAM in hypothalamus were 2.94, 3.03 and 3.09 at 60, 120 and 240 min post-injection, respectively. The (T/CB)-1 was significantly blocked by pretreatment with paroxetine, which is known as a serotonin site reuptake inhibitor, while another nonselective competing drug (5HT2A antagonist) Ketanserin, showed no block effect. The rat brain autoradiography and analysis showed that there was a high 131I-ADAM uptake in hypothalamus, the ratio of hypothalamus/cerebellum was significantly reduced from 7.94±0.39 to 1.30±0.56 by pretreatment with paroxetine at 60 min post-injection. Blood clearance kinetics was performed in rats, and the initial half-life of 13.79 min and late half-life of 357.14 min were obtained. The kinetic equation is: C=3.6147e-0.0725t + 1.0413e-0.0028t. The thyroid uptake was 0.009% ID and 1.421% ID at 2 min and 120 min post-injection, respectively, suggesting that in vivo deiodination may be the major route of metabolism. Toxicity trial showed that the dose per kilogram administered to mice was 1000 times greater than that to humans, assuming a weight of 50kg. These data suggest that 131I-ADAM may be useful for SPECT imaging of SERT binding sites in the brain. | LEI Bei ZHU Junqing LU Chunxiong JIANG Quanfu ZOU Meifeng WANG Songpei LI Xiaomin WU Chunying | 2007 | Nuclear Science and Techniques2007，18，4： | 0 |
| 12 | The preclinical pharmacological study of dopamine transporter imaging agent ^(18)F-FP-β-CIT显示文摘The paper is to study pharmacologic characteristics of 18F-FP-β-CIT (18F-N-(3-fluoropropyl)-2β-carbomethoxy-3β- (4-iodophenyl)nortropane) as an imaging agent for dopamine transporter. The radiochemical purity of 18F-FP-β-CIT in aqueous solution was over 95% after standing at room temperature for 4h. Biodistribution displayed rapid uptake in rat brain (1.375 %ID/organ at 5min and 0.100 %ID/organ at 180 min) and the striatal uptake was 1.444, 0.731, 0.397, 0.230 and 0.146 %ID/g at 5, 30, 60, 120 and 180 min, respectively. The values of striatum/cerebellum, striatum /frontal cortex and striatum / hippocampus in rat's brain at 30 min were 3.38, 2.17 and 2.40 respectively. The uptake in striatum can be blocked by β-CFT, suggesting that 18F-FP-β-CIT binds to DAT peculiarly. The compound was rapidly cleared from monkey's blood. The striatal uptake was bilaterally decreased in the left-sided lesioned PD rats, compared with normal control. Brain PET imaging studies in normal monkey showed that 18F-FP-β-CIT was concentrated in striatum. The test of undue toxicity showed that the dose received by mice was 1250 times as by human, which indicates that 18F-FP-β-CIT is very safe. So 18F-FP-β-CIT is a promising PET imaging agent for DAT with safety and validity. | LI Xiaominx CHEN Zhengping WANG Songpei TANG Jie LIN Yansong ZHU Zhaohui2 FANG Ping | 2007 | Nuclear Science and Techniques2007，18，4： | 0 |
| 13 | Deepening the economic reform from the relationship be-tween man and nature显示文摘 | Wang Songpei | 2006 | Ecological Economy2006，2，3： | 0 |
| 14 | Gli1 promotes epithelial-mesenchymal transition and metastasis of non-small cell lung carcinoma by regulating snail transcriptional activity and stability显示文摘Metastasis is crucial for the mortality of non-small cell lung carcinoma(NSCLC) patients.The epithelial-mesenchymal transition(EMT) plays a critical role in regulating tumor metastasis.Glioma-associated oncogene 1(Gli1) is aberrantly active in a series of tumor tissues. However, the molecular regulatory relationships between Gli1 and NSCLC metastasis have not yet been identified. Herein,we reported Gli1 promoted NSCLC metastasis. High Gli1 expression was associated with poor survival of NSCLC patients. Ectopic expression of Gli1 in low metastatic A549 and NCI-H460 cells enhanced their migration, invasion abilities and facilitated EMT process, whereas knock-down of Gli1 in high metastatic NCI-H1299 and NCI-H1703 cells showed an opposite effect. Notably, Gli1 overexpression accelerated the lung and liver metastasis of NSCLC in the intravenously injected metastasis model. Further research showed that Gli1 positively regulated Snail expression by binding to its promoter and enhancing its protein stability, thereby facilitating the migration, invasion and EMT of NSCLC. In addition, administration of GANT-61, a Gli1 inhibitor, obviously suppressed the metastasis of NSCLC. Collectively, our study reveals that Gli1 is a critical regulator for NSCLC metastasis and suggests that targeting Gli1 is a prospective therapy strategy for metastatic NSCLC. | Xueping Lei Zhan Li Yihang Zhong Songpei Li Jiacong Chen Yuanyu Ke Sha Lv Lijuan Huang Qianrong Pan Lixin Zhao Xiangyu Yang Zisheng Chen Qiudi Deng Xiyong Yu | 2022 | Acta Pharmaceutica Sinica B2022，12，10： | 0 |
| 15 | Animal biodistribution, safety and validation study of dopamine transporter PET imaging agent ^(18)F-FECNT显示文摘This work was to investigate the pharmacologic characteristics of 18F-FECNT (2β-carbomethoxy-3β- (4-chlorophenyl)-8-(2-[18F]fluoroethyl)nortropane) as a dopamine transporter (DAT) PET imaging agent. Its partition coefficients were determined in n-octanol and phosphate buffer (PB) (pH 7.0 and pH 7.4). 6-Hydroxydopamine (6-OHDA) left-sided lesioned Parkinsonian rats were established and validated by rotational behavior tests. Biodistribution in vivo in mice, autoradiography in normal and hemi-Parkinsonian rat brains, and toxicity test were performed. The results showed that partition coefficients were 34.14 (pH 7.0) and 56.41 (pH 7.4), respectively. Biodistribution exhibited rapid uptake and favorable retention in the mice brains. The major radioactivity was metabolized by the hepatic system. The autoradiography showed that 18F-FECNT was highly concentrated in striatum, and that the left and the right striatal uptake were symmetrical in normal SD rat brains. In left-sided lesioned PD rat brains, the striatal uptake of 18F-FECNT bilaterally decreased in comparison with normal rats. No significant uptake was visible in the 6-OHDA lesioned-sided striatal areas. The results demonstrated that 18F-FECNT binds to DAT was specific. Toxicity trial displayed that the acceptable dose per kilogram to mice was 625 times greater than that to human. These indicate that 18F-FECNT is a potentially safe and useful DAT PET imaging agent in the brain. | WANG Songpei CHEN Zhengping LI Xiaomin TANG Jie LIU Chunyi ZOU Meifen PAN Donghui LU Chunxiong XU Yuping XU Xijie ZHOU Xingqin JIN Jian | 2009 | Nuclear Science and Techniques2009，20，1： | 0 |
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