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| 1 | Treatment-related gastrointestinal toxicities and advanced colorectal or pancreatic cancer:A critical update显示文摘Gastrointestinal toxicities(GIT), including oral mucositis,nausea and vomiting, and diarrhea, are common side effects of chemotherapy and targeted agents in patients with advanced colorectal cancer and pancreatic cancer. Being often underreported, it is still difficult to precisely establish their burden in terms of both patient's quality of life and cancer care costs. Moreover, with the use of more intensive upfront combination regimens, the frequency of these toxicities is rapidly growing with a potential negative effect also on patient's outcome, as a result of dose reductions, delays or even discontinuation of active treatments. Thus, identifying patients at higher risk of developing GIT as well as an optimal management are paramount in order to improve patient's compliance and outcome. After the description of the main treatment-induced GIT, we discuss the current knowledge on the pathophysiology of these side effects and comment the scales commonly used to assess and grade them. We then provide a critical update on GIT incidence based on the results of key randomized trials conducted in patients with metastatic colorectal cancer and advanced pancreatic cancer. | Giuseppe Aprile Karim Rihawi Elisa De Carlo Stephen T Sonis | 2015 | World Journal of Gastroenterology2015，21，41： | 7 |
| 2 | Microscopic colitis:A large retrospective analysis from a health maintenance organization experience显示文摘AIM:To examine the demographic data on a large multi-ethnic population of patients with microscopic colitis (MC) in Southern California and to determine the association of MC with inflammatory bowel disease (IBD) and colorectal cancer.METHODS: All patients diagnosed with MC by colonic biopsy from 1996-2005 were identified utilizing a pathology database. All biopsies were reviewed by experienced pathologists utilizing standard histologic criteria. Patients' medical records were reviewed and data regarding patient age, co-morbidities, sex, ethnicity, and medications were analyzed. An age-and sexmatched standard control group was also generated. Chi-square test was used to evaluate the associations of co-morbidities between lymphocytic colitis (LC), collagenous colitis (CC) and the control group.RESULTS: A total of 547 cases of MC were identif ied,376 patients with LC and 171 patients with CC. The female/male ratio was 3:1 in CC and 2.7:1 in LC patients. Celiac disease (P<0.001), irritable bowel syndrome (IBS) (P<0.001), and thyroid diseases (P<0.001) were found to have a higher occurrence in MC compared to the control group. No statistical differences in the occurrence of colorectal cancer, diabetes and IBD were found between the MC group and the control group.CONCLUSION: This is the largest group of patients with MC known to the authors that has been studied to date. Conditions such as celiac disease, IBS, and thyroid diseases were found to be related to MC. Furthermore, neither an increased risk of colorectal cancer nor IBD was associated with MC in this study. | Kevin T Kao Benito A Pedraza Amy C McClune David A Rios Yi-Qiong Mao Robert H Zuch Michael H Kanter Sony Wirio Chris N Conteas | 2009 | World Journal of Gastroenterology2009，15，25： | 5 |
| 3 | Epstein - Barr virus latent infection membrane protein 1 TRAF - binding site induces NIK/IKK alpha - dependent noncanonical NF- kappaB activation显示文摘 | Luftig M Yasui T Soni V | 2004 | Proc Natl Acad Sci USA2004，101，1： | 1 |
| 4 | Treatment of spasticity in a spinal cord-injured patient with intrathecal morphine due to intrathecal baclofen tolerance-a case report and review of literature显示文摘 | Soni BM Mani RM Oo T | 2003 | Spinal Cord2003，41，10： | 1 |
| 5 | Swertiamarin ameliorates oleic acid induced lipid accumulation and oxidative stress by attenuating gluconeogenesis and lipogenesis in hepatic steatosis 显示文摘 | Patel T P Rawal K Soni S | 2016 | Biomed Pharmacother2016，83，： | 1 |
| 6 | Assessment of oral mueositis in clinical trials:impact of lraining on evaluators in a multi-centre trial 显示文摘 | Stokman M A Sonis S T Dijkstra P U | 2005 | Eur J Cancer2005，41，12： | 1 |
| 7 | Real time ultrasound visulization of tongue movement during swallowing显示文摘 | Shawker T Sonies B Stone M | 1983 | J Clin Ultrasound1983，11，： | 1 |
| 8 | Validation of a new scoring system for assessment of clinical trials re- search of oral mucositis induced by radiation or chemo- therapy显示文摘 | Sonis S T Eilers J P Epstein J B | 1999 | Cacer1999，85，10： | 1 |
| 9 | Guaranteed profit margins: A demonstration of retailer power显示文摘 | Krishnan T V Soni H | 1997 | International Journal of Research in Marketing1997，14，： | 1 |
| 10 | Cognitive effects of olzapine and risperidol treatment in chronic schizophrenia显示文摘 | Sharma T Hughes C Soni W | 2003 | Psychopharmacology2003，169，： | 1 |
| 11 | The pathobiology of mucositis显示文摘 | Sonis S T | 2004 | Nat Rev Cancer2004，4，4： | 1 |
| 12 | Defect detection study in austenitic steel welds and the performances of different ultra-sonic transducers显示文摘 | Sony Baby Balasubramanian T Pardikar R J | 2001 | Insight2001，43，11： | 1 |
| 13 | Diagnostic capabili-ty of optical coherence tomography in evaluating the degree ofglaucomatous retinal nerve fiber damage 显示文摘 | Sihota R Sony P Gupta V Dada T Singh R | 2006 | Invest OphthalmolVis Sci’2006，47，5： | 1 |
| 14 | pituitary cystpresenting with hyponatremia and increased secretion of brainnatriuretic peptide显示文摘 | SONI H FUJIMAKI T TSUCHIYA Y | 2005 | Neurosury2005，103，6： | 1 |
| 15 | Ultrasonic study for detection of inner diameter cracking in pipeline girth welds using creeping waves显示文摘 | Sony B Balasubramanian T Pardikar R J | 2003 | International Journal of Pressure Vessels and Piping2003，80，2： | 1 |
| 16 | High rates of recreational druguse in men who have sex with men显示文摘 | Kurka T Soni S Richardson D | 2015 | Sex Transm Infect2015，91，6： | 1 |
| 17 | Validation of a new scoring system for assessment of clinical trials research of oral mucositis induced by radiation or chemotherapy显示文摘 | Sonis S T Eilers J P Epstein J B | 1999 | Cancer1999，85，10： | 1 |
| 18 | Variations in single scattering albedo and Angstrom absorption exponent during different seasons at Delhi, India 显示文摘 | SONI K SINGH S BANO T | 2010 | Atmospheric Environment2010，44，： | 1 |
| 19 | Performance evaluation of 2-D adaptive prediction filters for detection of small objects in image data显示文摘 | Soni T Zeidler J R Ku H | 1993 | IEEE Trans on Image Processing1993，2，3： | 1 |
| 20 | Performance evaluation of2-D adaptive predication filters for detection of small objects in image data显示文摘 | Soni T Zeidler J R | 1993 | IEEE Trans on Aerospace and Electronic Systems1993，2，3： | 1 |
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