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| 1 | Long-term result of endoscopic Histoacryl (N-butyl-2-cyanoacrylate)injection for treatment of gastric varices显示文摘AIM:To evaluate the long-term efficacy and safety of endoscopic obliteration with Histoacryl for treatment of gastric variceal bleeding and prophylaxis.METHODS:Between January 1994 and March 2010 at SoonChunHyang University Hospital,a total of 127 patients with gastric varices received Histoacryl injections endoscopically.One hundred patients underwent endoscopic Histoacryl injections because of variceal bleeding,the other 27 patients received such injections as a prophylactic procedure.RESULTS:According to Sarin classification,56 patients were GOV1,61 patients were GOV2 and 10 patients were IGV.Most of the varices were large(F2 or F3,111 patients).The average volume of Histoacryl per each session was 1.7±1.3 cc and mean number of sessions was 1.3±0.6.(1 session-98 patients,2 sessions-25 patients,≥3 sessions-4 patients).Twenty-seven patients with high risk of bleeding(large or fundal or RCS+or Child C) received Histoacryl injection as a primary prophylactic procedure.In these patients,hepatitis B virus was the major etiology of cirrhosis,25 patients showed GOV1 or 2(92.6%)and F2 or F3 accounted for 88.9%(n=24).The rate of initial hemostasis was 98.4%and recurrent bleeding within one year occurred in 18.1%of patients.Successful hemostasis during episodes of rebleeding was achieved in 73.9%of cases.Median survival was 50 mo (95%CI 30.5-69.5).Major complications occurred in 4 patients(3.1%).The rebleeding rate in patients with hepatocellular carcinoma or GOV2 was higher than in those with other conditions.None of the 27 subjects who were treated prophylactically experienced treatment-related complications.Cumulative survival rates of the 127 patients at 6 mo,1,3,and 5 years were 92.1%,84.2%,64.2%,and 45.3%,respectively.The 6 mo cumulative survival rate of the 27 patients treated prophylactically was 75%.CONCLUSION:Histoacryl injection therapy is an effective treatment for gastric varices and also an effective prophylactic treatment of gastric varices which carry high risk of bleeding. | Eun Jung Kang Soung Won Jeong Jae Young Jang Joo Young Cho Sae Hwan Lee Hyun Gun Kim Sang Gyune Kim Young Seok Kim Young Koog Cheon Young Deok Cho Hong Soo Kim Boo Sung Kim | 2011 | World Journal of Gastroenterology2011，17，11： | 41 |
| 2 | Comparison of hepatic venous pressure gradient and endoscopic grading of esophageal varices显示文摘AIM: To determine the correlation between the hepatic venous pressure gradient and the endoscopic grade of esophageal varices.METHODS: From September 2009 to March 2013, a total of 176 measurements of hepatic venous pressure gradient(HVPG) were done in 146 patients. Each transjugular HVPG was measured twice, first using an end whole catheter(EH-HVPG), and then using a balloon catheter(B-HVPG). The HVPG was compared with the endoscopic grade of esophageal varices(according to the general rules for recording endoscopic findings of esophagogastric varices), which was recorded within a month of the measurement of HVPG.RESULTS: The study included 110 men and 36 women, with a mean age of 56.1 years(range, 43-76 years). The technical success rate of the pressure measurements was 100% and there were no complication related to the procedures. Mean HVPG was 15.3 mm Hg as measured using the end hole catheter method and 16.5 mm Hg as measured using the balloon catheter method. Mean HVPG(both EHHVPG and B-HVPG) was not significantly different among patients with different characteristics, including sex and comorbid factors, except for cases with hepatocellular carcinoma(B-HVPG, P = 0.01; EH-HVPG, P = 0.02). Portal hypertension(> 12 mm Hg HVPG) occurred in 66% of patients according to EH-HVPG and 83% of patients according to B-HVGP, and significantly correlated with Child's status(B-HVPG, P < 0.000; EHHVGP, P < 0.000) and esophageal varies observed upon endoscopy(EH-HVGP, P = 0.003; B-HVGP, P = 0.006). One hundred and thirty-five endoscopies were performed, of which 15 showed normal findings, 27 showed grade 1 endoscopic esophageal varices, 49 showed grade 2 varices, and 44 showed grade 3 varices. When comparing endoscopic esophageal variceal grades and HVPG using univariate analysis, the P value was 0.004 for EH-HVPG and 0.002 for B-HVPG. CONCLUSION: Both EH-HVPG and B-HVPG showed a positive correlation with the endoscopic grade of esophageal varices, with B-HVPG showing a stronger correlation than EH-HVPG. | Eun Ji Lee Yong Jae Kim Dong Erk Goo Seung Boo Yang Hyun-Joo Kim Jae Young Jang Soung Won Jeong | 2016 | World Journal of Gastroenterology2016，22，11： | 11 |
| 3 | Diagnostic value for extrahepatic metastases of hepatocellular carcinoma in positron emission tomography/computed tomography scan显示文摘AIM: To evaluated the value of 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) scan in diagnosis of hepatocellular carcinoma (HCC) and extrahepatic metastases. METHODS: A total of 138 patients with HCC who had both conventional imaging modalities and 18F-FDG PET/CT scan done between November 2006 and March 2011 were enrolled. Diagnostic value of each imaging modality for detection of extrahepatic metastases was evaluated. Clinical factors and tumor characteristics including PET imaging were analyzed as indicative factors for metastases by univariate and multivariate methods. RESULTS: The accuracy of chest CT was significantly superior compared with the accuracy of PET imaging for detecting lung metastases. The detection rate of metastatic pulmonary nodule ≥ 1 cm was 12/13 (92.3%), when < 1 cm was 2/10 (20%) in PET imaging. The accuracy of PET imaging was significantly superior compared with the accuracy of bone scan for detecting bone metastases. In multivariate analy- sis, increased tumor size (≥ 5 cm) (P = 0.042) and increased average standardized uptake value (SUV) uptake (P = 0.028) were predictive factors for extrahepatic metastases. Isometabolic HCC in PET imaging was inversely correlated in multivariate analysis (P = 0.035). According to the receiver operating characteristic curve, the optimal cutoff of average SUV to predict extrahepatic metastases was 3.4. CONCLUSION: 18F-FDG PET/CT scan is invaluable for detection of lung metastases larger than 1 cm and bone metastases. Primary HCC having larger than 5 cm and increased average SUV uptake more than 3.4 should be considered for extrahepatic metastases. | Ji Eun Lee Jae Young Jang Soung Won Jeong Sae Hwan Lee Sang Gyune Kim Sang-Woo Cha Young Seok Kim Young Deok Cho Hong Soo Kim Boo Sung Kim So Young Jin Deuk Lin Choi | 2012 | World Journal of Gastroenterology2012，18，23： | 10 |
| 4 | Mutational analysis of EGFR and K-RAS genes in lung adenocarcinomas 显示文摘 | Soung YH Lee JW Kim SY | 2005 | Virchows Arch2005，446，5： | 1 |
| 5 | An intergrated approach for interdependent information system project selection 显示文摘 | Jin Woo Lee Soung Hie Kim | 2001 | International Journal of Project Management2001，19，： | 1 |
| 6 | PIK3CA gene is frequently mutated in breast and hepatocellular carcinomas显示文摘 | Lee J W Soung Y H Kim S Y | 2005 | Oncogene2005，24，8： | 1 |
| 7 | Somatic mutations of EGFR gene in squamous cell carcinoma of the head and neck显示文摘 | Lee J W Soung Y H Kim S Y | 2005 | Clin Cancer Res2005，11，8： | 1 |
| 8 | Loss of PTEN expression in paraffin-embedded primary prostate cancer correlates with high Gleason score and advanced stage显示文摘 | McMenamin M E Soung P Perera S | 1999 | Cancer Res1999，59，17： | 1 |
| 9 | Matching algorithms for three-stagebufferless Clos network switches 显示文摘 | H Jonathan Chao Zhigang Jing Soung Y Liew | 2003 | IEEE Communication Magazine2003，41，10： | 1 |
| 10 | Fast Algorithms for Joint Power Control and Scheduling in Wireless Networks 显示文摘 | Liqun F Soung C L Jianwei H | 2010 | IEEE Transaction on Wire- less Communication2010，9，3： | 1 |
| 11 | Inactivating mutations of caspase - 8 gene in eoloreetal carcinomas显示文摘 | Kim HS Lee JW Soung YH | 2003 | Gastroenlerology2003，125，3： | 1 |
| 12 | Loss of PTEN expression in paraffin-embeeded primary prostate cancer correlates with high gleason score and advanced stage显示文摘 | McMenamin ME Soung P Perera S | 1999 | Cancer Res1999，59，17： | 1 |
| 13 | Mutational analysis of proapoptotic integrin beta 3 cytoplasmic domain in common human cancers显示文摘 | Yoo NJ Soung YH Lee SH | 2007 | Tumori2007，93，3： | 1 |
| 14 | Effect of the strength of ad- sorption of hepatitis B surface antigen to aluminum hydroxide adjuvant on the immune response显示文摘 | Hansen B Belfast M Soung G | 2009 | Vaccine2009，27，6： | 1 |
| 15 | Loss of PTEN expression in paraffin-embedded primary prostate cancer correlates with high Gleason score and advanced stage显示文摘 | McMemanin Soung P Perera S | 1999 | Cancer Res1999，59，： | 1 |
| 16 | Curcumin inhibition of the functional interaction between integrin c6134 and the epidermal growth factor receptor 显示文摘 | Soung YH Chung J | 2011 | Mol Cancer The2011，10，5： | 1 |
| 17 | The clinical features of drug-induced Liver injury observed through liver biopsy: fo- cus on relevancy to autoimmune hepatitis显示文摘 | HYE Y J JAE Y J SOUNG W J | 2012 | Cfin Mol Hep- atology2012，18，2： | 1 |
| 18 | Antithrombotic activities of saponins fromIlex pubescens显示文摘 | Yong Nam Han Soung Kyung Baik Tae Hee Kim Byung Hoon Han | 1987 | Archives of Pharmacal Research1987，，2： | 1 |
| 19 | Somatic mutations of ERBB2 kinase domain in gastric, colorcctal, and breast carcinomas 显示文摘 | Lee JW Soung YH Sen SH | 2006 | Clin Cancer Res2006，12，1： | 1 |
| 20 | Somatic mutations of ERBB2 kinase domain in gastric, colorectal, and breast carcinomas 显示文摘 | Lee WJ Soung YH Seo SH | 2006 | Clin Cancer Res2006，12，1： | 1 |
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