|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome:A multicenter retrospective study显示文摘BACKGROUND Single-nucleotide polymorphisms(SNPs)of the serotonin type 3 receptor subunit(HTR3)genes have been associated with psychosomatic symptoms,but it is not clear whether these associations exist in irritable bowel syndrome(IBS).AIM To assess the association of HTR3 polymorphisms with depressive,anxiety,and somatization symptoms in individuals with IBS.METHODS In this retrospective study,623 participants with IBS were recruited from five specialty centers in Germany,Sweden,the United States,the United Kingdom,and Ireland.Depressive,anxiety,and somatization symptoms and sociodemographic characteristics were collected.Four functional SNPs—HTR3A c.-42C>T,HTR3B c.386A>C,HTR3C c.489C>A,and HTR3E c.*76G>A—were genotyped and analyzed using the dominant and recessive models.We also performed separate analyses for sex and IBS subtypes.SNP scores were calculated as the number of minor alleles of the SNPs above.The impact of HTR3C c.489C>A was tested by radioligand-binding and calcium influx assays.RESULTS Depressive and anxiety symptoms significantly worsened with increasing numbers of minor HTR3C c.489C>A alleles in the dominant model(F_(depressive)=7.475,P_(depressive)=0.006;F_(anxiety)=6.535,P_(anxiety)=0.011).A higher SNP score(range 0-6)was linked to a worsened depressive symptoms score(F=7.710,P-linear trend=0.006)in IBS.The potential relevance of the HTR3C SNP was corroborated,showing changes in the expression level of 5-HT3AC variant receptors.CONCLUSION We have provided the first evidence that HTR3C c.489C>A is involved in depressive and anxiety symptoms in individuals with IBS.The SNP score indicated that an increasing number of minor alleles is linked to the worsening of depressive symptoms in IBS. | Sabrina Berens Yuanjun Dong Nikola Fritz Jutta Walstab Mauro D'Amato Tenghao Zheng Verena Wahl Felix Boekstegers Justo Lorenzo Bermejo Cristina Martinez Stefanie Schmitteckert Egbert Clevers Felicitas Engel Annika Gauss Wolfgang Herzog Robin Spiller Miriam Goebel-Stengel Hubert Mönnikes Viola Andresen Frieling Thomas Jutta Keller Christian Pehl Christoph Stein-Thöringer Gerard Clarke Timothy G Dinan Eamonn M Quigley Gregory Sayuk Magnus Simrén Jonas Tesarz Gudrun Rappold Lukas van Oudenhove Rainer Schaefert Beate Niesler | 2022 | World Journal of Gastroenterology2022，28，21： | 2 |
| 2 | Localized defects in multilayers coatings显示文摘 | Stearns D G Mirkarimi P B Spiller E | 2004 | Thin Solid Film2004，446，： | 1 |
| 3 | Role of water-soluble dietary fiber in the management of elevated plasma cholesterol in healthy subjects 显示文摘 | Haskell W L Spiller G A Jensen C D | 1992 | The American Journal of Cardiology1992，69，5： | 1 |
| 4 | 查看详情显示文摘 | Losi P Briganti E Magera A Spiller D Ristori C Battolla B Balderi M Kull S Balbarini A Stefano R D Soldani G | | 0，，： | 1 |
| 5 | Time-dependent melting and superheating of lead crystallites显示文摘 | | 1982 | Philos Mag A1982，46，： | 1 |
| 6 | Effect of a diet high in monounsaturated fat from almonds on plasma cholesterol and lipoproteins 显示文摘 | Spiller G A Jenkins D J Cragen L N | 1992 | J Am Coll Nutr1992，11，2： | 1 |
| 7 | Apoptosis is rapidly triggered by antisense depletion of MCL-1 in differentiating U937 cells显示文摘 | Moulding D A Giles R V Spiller D G | 2000 | Blood2000，96，： | 1 |
| 8 | Photo-oxida- tion of sodium sulfide by sulfonated phthalocyanines in oxy- gen-saturated aqueous solutions containing detergents or la- texes显示文摘 | Spiller W Wohrle D Schulz-Ekloff G | 1996 | J Photochem Photobiol A: Chem1996，95，2： | 1 |
| 9 | Apoptosis is rapidly triggered by antisense depletion of MCL-1 in differentiating U937cells显示文摘 | Moulding D A Giles R V Spiller D G | 2000 | Blood2000，96，5： | 1 |
| 10 | Low molecular weight gelator-dextran composites显示文摘 | Chen L Revel S Morris K Spiller D G Serpell L C Adams D J | 2010 | Chem Commun (Camb)2010，46，： | 1 |
| 11 | Measurement of single-cell dynamics 显示文摘 | Spiller D G Wood C D Rand D A | 2010 | Nature2010，465，7299： | 1 |
| 12 | Soluble recombinant coxsackievirus and adenovirus receptor abrogates coxsakievirus B3-mediated pancreatitis and myocarditis in mice 显示文摘 | YANAGAWA B SPILLER O B PROCTOR D G | 2004 | J Infect Dis2004，189，： | 1 |
| 13 | Interactive Segmentation of Clustered Cells via Geodesic Com- mute Distance and Constrained Density Weighted Nystrom Method显示文摘 | Du C J Marcello M Spiller D G | 2010 | Cytometry Part A2010，，12： | 1 |
| 14 | Calcium-dependent regulation of the cell cycle via a novel MAPK- NF-kappaB pathway in Swiss 3 3'3 cells 显示文摘 | See V Rajala N K Spiller D G | 2004 | J Cell Biol2004，166，5： | 1 |
| 15 | Photo-oxidation of sodium sulfide by sulfonated phthalocyanines in oxygen-saturated aqueous solutions containing detergents or latexes显示文摘 | Spiller W Wohrle D Schulz-Ekloff G | 1996 | Journal of Photochemistry and Photubiology A:Chemistry1996，95，2： | 1 |
| 16 | Nucleation and growth of thin-films显示文摘 | Venables J A Spiller G D T Hanbucken M | 1984 | Reports Progr Phys1984，47，4： | 1 |
| 17 | Photooxidation of 2-mercaptoethanol by various water-soluble phthalocyanines in aqueous alkaline solution under irradiation with visible light显示文摘 | Schneider G Wohrle D Spiller W | 1994 | Photochemistry and Photobiology1994，60，4： | 1 |
| 18 | Calcium-dependent regulation of the cell cycle via a novel MAPK-NF-kappaB pathway in Swiss 3T3 cells显示文摘 | SEE V RAJALA N K SPILLER D G | 2004 | J Cell Biol2004，166，5： | 1 |
| 19 | Solar photochemistry:Photooxidation of hydrogen sulfide显示文摘 | Wohrle D Spiller W Schneider G | 1994 | Journal of Information Recording Materials1994，21，56： | 1 |
| 20 | Localized defects in multilayers coatings显示文摘 | Stearns D G Mirkarimi P B Spiller E | 2004 | Thin solid film2004，446，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员