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| 1 | Dextran sulfate sodium-induced colitis-associated neoplasia:a promising model for the development of chemopreventive interventions显示文摘与 ulcerative 大肠炎诊断的个人面对开发颜色的显著地增加的风险表面的发育异常和癌症在他们的一生期间。迄今为止,注意为葡聚糖硫酸盐钠(决策支持系统)的这个 high-riskpopulation.The 鼠标模型被给了 chemopreventive 干预的开发的很少导致了大肠炎代表两个都描绘面对发炎为肿瘤形成要求的分子的事件并且估计精选代理人的能力到的一个优秀现出症状之前的潜的系统在在长期的大肠炎的建立和颜色的开发喝水结果禁止决策支持系统的 thisprocess.Cyclic 管理有人的联系大肠炎的瘤形成类似于那些的病理学的特征的表面的发育异常和癌症。观察的损害的发生和复合变化取决于使用的鼠标紧张(即,瑞士韦伯斯特, C57BL/6J , CBA , ICR )并且剂量(0.7%-5.0%)和瘤形成的 DSS.Theincidence 的时间表( 1-15 周期与或没有一个随后的恢复时期)能被增加,它到侵略癌症的前进由与已知的冒号致癌物在联合管理决策支持系统显著地加速了( azoxymethane ( AOM ), 2-ammo-3-methylimidazo [ 4,5-f ]喹啉( IQ ), 2-amino-l-methyl-6-phenylimidazo [ 4,5-b ] pyridine ( PhTP ))在遗传上定义的老鼠的联系大肠炎的瘤形成的最近的正式就职拉紧的 oriron.More 提供了新卓见进特定的基因的角色(即, adenomatous polyposiscoli ( Apc ), p53 ,可诱导的氮的氧化物 synthase ( i NOS ), Msh2 )在从 chemopreventive 干预的 colitis-associatedneoplasias.Emerging 数据的开发,研究在禁止导致决策支持系统的瘤形成记录几个代理人的功效并且提供 colitis-associatedcolorectal 瘤形成是可防止的疾病的大诺言。 | Margie Lee CLAPPER Harry Stanley COOPER Wen-Chi Lee CHANG | 2007 | Acta Pharmacologica Sinica2007，28，9： | 17 |
| 2 | Adjuvant heparanase inhibitor PI-88 therapy for hepatocellular carcinoma recurrence显示文摘AIM: To demonstrate that administering heparanase inhibitor PI-88 at 160 mg/d is safe and promising in reducing hepatocellular carcinoma(HCC) recurrence for up to 3 year following curative resection. METHODS: A total of 143 patients(83.1% of the 172 participants in the phase Ⅱ study) participated in the follow-up study. Of these patients, 50 had received no treatment, 48 had received 160 mg/d PI-88, and 45 had received 250 mg/d PI-88 during the phase Ⅱ trial. Safety parameters and the following efficacy endpoints were investigated:(1) time to recurrence;(2) diseasefree survival; and(3) overall survival. RESULTS: PI-88 at 160 mg/d delayed the onset and frequency of HCC recurrence, and provided a clinically significant survival advantage for up to 3 years after treatment compared with those of the control group:(1) the recurrence-free rate increased from 50% to 63%, and(2) time to recurrence at the 36 th percentile was postponed by 78%. The efficacy of administering PI-88 at 250 mg/d was confounded by a high dropout rate(11 out of 54 patients). Additionally, subgroup analyses of patients with(1) multiple tumors or a single tumor ≥ 2 cm; and(2) hepatitis B or C revealed that administering PI-88 at 160 mg/d conferred the most significant survival advantage(56.8% improvement in disease-free survival, P = 0.045) for patients with both risk factors for recurrence. CONCLUSION: Administering PI-88 at 160 mg/d is a safe and well-tolerated dosage that may confer significant clinical benefits for patients with HCC. | Chun-Jen Liu Juliana Chang Po-Huang Lee Deng-Yn Lin Cheng-Chung Wu Long-Bin Jeng Yih-Jyh Lin King-Tong Mok Wei-Chen Lee Hong-Zen Yeh Ming-Chih Ho Sheng-Shun Yang Mei-Due Yang Ming-Chin Yu Rey-Heng Hu Cheng-Yuan Peng Kuan-Lang Lai Stanley Shi-Chung Chang Pei-Jer Chen | 2014 | World Journal of Gastroenterology2014，20，32： | 11 |
| 3 | 黄斑色素与黄斑区视锥细胞功能相互关系的临床观察显示文摘目的 探讨黄斑色素 (macular pigment,MP)与黄斑区视锥细胞功能的相互关系。 方法 对临床确诊的 16例 Stargardt患者的 32只眼 ,3例黄斑裂孔患者的 3只眼用激光扫描检眼镜 (scanninglaserophthalmoscope,SL O)进行黄斑区 MP密度的检测。通过 SL O的氩激光蓝色及红外波段进行 MP的诊断与密度分级。用自编的计算机 C+ + 程序进行 MP密度评估 ,并将 MP分为完整 MP、部分 MP及 MP缺失 3级。对比分析 MP分级与 Snellen视力检查结果的相互关系。 结果 视力低于 2 0 / 2 0 0的 13只眼全部表现为 MP缺失 ;视力等于或高于 2 0 / 4 0的 11只中 10只眼表现为完整 MP,1只眼表现为部分 MP;视力介于两者之间的 11只眼表现为部分 MP。检测结果无病种间的差别。 结论 MP与患者的视力密切相关 ,是黄斑区视锥细胞功能完整的标志。 | 张新媛 Stanley Chang Gaetano Barile Peter Gouras | 2003 | 中华眼底病杂志2003，19，4： | 4 |
| 4 | Heparanase inhibitor PI-88 as adjuvant therapy for hepatocellular carcinoma after curative resection: A randomized phase II trial for safety and optimal dosage显示文摘 | Chun-Jen Liu Po-Huang Lee Deng-Yn Lin Cheng-Chung Wu Long-Bin Jeng Pin-Wen Lin King-Tong Mok Wei-Chen Lee Hong-Zen Yeh Ming-Chih Ho Sheng-Shun Yang Ching-Chih Lee Ming-Chin Yu Rey-Heng Hu Cheng-Yuan Peng Kuan-Lang Lai Stanley Shi-Chung Chang Pei-Jer Chen | 2009 | Journal of Hepatology2009，，5： | 2 |
| 5 | Chemical vapor deposition of Si nanowires nucleated by TiSi2 islands on Si显示文摘 | Kamins T I Stanley Williams R Chang Y L | 2000 | Appl Phys Lett2000，76，5： | 2 |
| 6 | High frequency transforation of Bacillus subtilis protoplasts by plasmid NA 显示文摘 | Chang Stanley N C | 1979 | Molecular Genetics and Genomics1979，165，： | 1 |
| 7 | High frequency transformation of Bacillus subtilis protoplasts by plasmid DNA显示文摘 | Shing Chang Stanley N. Cohen | 1979 | MGG Molecular & General Genetics1979，，1： | 1 |
| 8 | Circumferential ablation of Barrett’s esophagus that contains high-grade dysplasia: a U.S. multicenter registry显示文摘 | Robert A. Ganz Bergein F. Overholt Virender K. Sharma David E. Fleischer Nicholas J. Shaheen Charles J. Lightdale Stephen R. Freeman Ronald E. Pruitt Shiro M. Urayama Frank Gress Darren A. Pavey M. Stanley Branch Thomas J. Savides Kenneth J. Chang V. Rama | 2008 | Gastrointestinal Endoscopy2008，，1： | 1 |
| 9 | Emergence of dynamical complexity related to human heart rate variability显示文摘 | Chang MC Peng CK Stanley HE | 2014 | Physical Review E2014，90，06： | 1 |
| 10 | Future directions in combined modality therapy for rectal cancer: reevaluating the role of total mesorectal excision after chemoradiotherapy显示文摘 | Stanley Liauw Chang Abhishek A. Solanki | 2013 | OncoTargets and Therapy (default)2013，，： | 1 |
| 11 | Emergence of dynamical com- plexity related to human heart rate variability显示文摘 | Chang MC Peng CK Stanley HE | 2014 | Phys Rev E Stat Nonlin Soft Matter Phys2014，90，6： | 1 |
| 12 | Phase II Trial of Neoadjuvant Bevacizumab, Capecitabine, and Radiotherapy for Locally Advanced Rectal Cancer显示文摘 | Christopher H. Crane Cathy Eng Barry W. Feig Prajnan Das John M. Skibber George J. Chang Robert A. Wolff Sunil Krishnan Stanley Hamilton Nora A. Janjan Dipen M. Maru Lee M. Ellis Miguel A. Rodriguez-Bigas | 2010 | International Journal of Radiation Oncology Biology Physics2010，，3： | 1 |
| 13 | High frequency transformation of Bacillus subtilis protoplasts by plasmid DNA显示文摘 | Shing Chang Stanley N. Cohen | 1979 | MGG Molecular & General Genetics1979，，1： | 1 |
| 14 | Low viscosityliquid fluoroehemicals in vitreous surgery显示文摘 | Stanley Chang MD | 1987 | Am J Ophthalmology1987，38，： | 1 |
| 15 | Autofluorescence as a novel approach to diagnosing macular holes显示文摘 | Antonio Pasquale Ciardella Grace C. Lee Kevin Langton Janet Sparrow Stanley Chang | 2004 | American Journal of Ophthalmology2004，，5： | 1 |
| 16 | MLH1 ‐silenced and non‐silenced subgroups of hypermutated colorectal carcinomas have distinct mutational landscapes显示文摘 | Lawrence A Donehower Chad J Creighton Nikolaus Schultz Eve Shinbrot Kyle Chang Preethi H Gunaratne Donna Muzny Chris Sander Stanley R Hamilton Richard A Gibbs David Wheeler | 2012 | J Pathol2012，，1： | 1 |
| 17 | Chronic Administration of Mood Stabilizers Upregulates BDNF and Bcl-2 Expression Levels in Rat Frontal Cortex显示文摘 | Yunyoung C. Chang Stanley I. Rapoport Jagadeesh S. Rao | 2009 | Neurochemical Research2009，，3： | 1 |
| 18 | Fuzzy Least Absolute Deviations Regression Based on The Ranking of Fuzzy Numbers 显示文摘 | Chang P T Stanley L E | 1994 | IEEE1994，07，803： | 1 |
| 19 | High frequency transformation of Bacillus subtilis protoplasts by plasmid DNA显示文摘 | Shing Chang Stanley N. Cohen | 1979 | MGG Molecular & General Genetics1979，，1： | 1 |
| 20 | Fuzzy least absolute deviations regression based on the ranking of fuzzy numbers显示文摘 | Chang Ping-Teng Stanley Lee E | 1994 | IEEE1994，，03： | 1 |
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