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| 1 | Calcitriol analog ZK191784 ameliorates acute and chronic dextran sodium sulfate-induced colitis by modulation of intestinal dendritic cell numbers and phenotype显示文摘AIM: To investigate the effects of ZK1916784, a low calcemic analog of calcitriol on intestinal inflammation. METHODS: Acute and chronic colitis was induced by dextran sodium sulfate (DSS) according to standard procedures. Mice were treated intraperitoneally with ZK1916784 or placebo and colonic inflammation was evaluated. Cytokine production by mesenterial lymph node (MLN) cells was measured by ELISA. Immunohistochemistry was performed to detect intestinal dendritic cells (DCs) within the colonic tissue, and the effect of the calcitriol analog on DCs was investigated. RESULTS: Treatment with ZK191784 resulted in significant amelioration of disease with a reduced histological score in acute and chronic intestinal inflammation. In animals with acute DSS colitis, down- regulation of colonic inflammation was associated with a dramatic reduction in the secretion of the proinflammatory cytokine interferon (IFN)-γ and a significant increase in intereleukin (IL)-10 by MLN cells. Similarly, in chronic colitis, IL-10 expression in colonic tissue increased 1.4-fold when mice were treated with ZK191784, whereas expression of the Th1-specific transcription factor T-beta decreased by 81.6%. Lower numbers of infiltrating activated CD11c+ DCs were found in the colon in ZK191784-treated mice with acute DSScolitis, and secretion of proinflammatory cytokines by primary mucosal DCs was inhibited in the presence of the calcitriol analog. CONCLUSION: The calcitriol analog ZK191784 demonstrated significant anti-inflammatory properties in experimental colitis that were at least partially mediated by the immunosuppressive effects of the derivate on mucosal DCs. | Ulrike G Strauch Florian Obermeier Nicole Grunwald Nadja Dunger Heiko C Rath Jürgen Schlmerich A Steinmeyer U Zügel HH Herfarth | 2007 | World Journal of Gastroenterology2007，13，48： | 4 |
| 2 | Loss of CD103^+ intestinal dendritic cells during colonic inflammation显示文摘AIM:To investigate possible differences in dendritic cells(DC)within intestinal tissue of mice before and after induction of colitis. METHODS:Mucosal DC derived from intestinal tissue,as well as from mesenteric lymph nodes and spleen,were analyzed by fluorescence activated cell sorting(FACS) analysis.Supernatants of these cells were analyzed for secretion of different pro-and anti-inflammatory cytokines. Immunohistochemistry and immunofluorescence were performed on cryosections of mucosal tissue derived from animals with colitis as well as from healthy mice. RESULTS:It was shown that DC derived from healthy intestinal lamina propria(LP)represented an immature phenotype as characterized by low-level expression of costimulatory cytokines.In contrast to DC from spleen and mesenteric lymph nodes(MLN)that secreted proinflammatory cytokines,LP-DC produced high levels of the anti-inflammatory cytokine IL-10.After induction of mu-rine colitis in a CD4 + CD62L + transfer model or in chronic Dextran sulfate sodium-colitis,a marked increase of activated CD80 + DC could be observed within the inflamed colonic tissue.Interestingly,in contrast to splenic DC,a significant population of DC within MLN and colonic LP expressed the mucosal integrin CD103 which was lost during colitis. CONCLUSION:The constitutive secretion of antiinflammatory cytokines by immature DC within the intestinal LP might regulate the homeostatic balance between mucosal immunity and tolerance.CD103 + DC could mediate this important function. | Ulrike G Strauch Nicole Grunwald Florian Obermeier Sonja Gürster Heiko C Rath | 2010 | World Journal of Gastroenterology2010，16，1： | 2 |
| 3 | Threshold controlling scheme for adaptive modulation and coding system显示文摘 | TAKEDA D CHOW Y C STRAUCH P | 2006 | IEICE Transactions on Communications2006，89，5： | 1 |
| 4 | 查看详情显示文摘 | Strauch F W Williams C J | | 0，，： | 1 |
| 5 | Is the bentall procedure for ascending aorta or aortic valve replacement the best approach for long-term event-free survival 显示文摘 | Hagl C Strauch JT Spiclvogel D | 2003 | Ann Thorae Surg2003，76，3： | 1 |
| 6 | Is the bentall procedure for ascending aorta or aortic valve replacement the best approach for long-term event-free survival显示文摘 | Hagl C Strauch JT Spielvogel D | 2003 | Ann thorac Surg2003，76，3： | 1 |
| 7 | Characterization of enterocoliticin,a phage tail-like bacteriocin,and its effect on pathogenic Yersinia enterocolitica strains显示文摘 | STRAUCH E KASPAR H SCHAUDINN C | 2001 | Appl Environ Microbiol2001，67，12： | 1 |
| 8 | Morphometric analysis of neointimal formation in murine cardiac allografts显示文摘 | Armstrong A T Strauch A R Staring R C | 1997 | Transplantation1997，63，8： | 1 |
| 9 | First-time isolation and characterization of a bacteriophage encoding the Shiga toxin 2c variant,which is globally spread in strains of Escherichia coli O157显示文摘 | Strauch E Schaudinn C Beutin L | 2004 | Infect Immun2004，72，12： | 1 |
| 10 | Is the Bentall Procedure for Ascending Aorta or Aortic Valve Replacement the Best Approach for Long-Term Event-Free Survival?显示文摘 | Hagl C Strauch JT Spielvogel D | 2003 | Ann Thorac Surg2003，76，： | 1 |
| 11 | First-time isolation and characterization of a bacteriophage encoding the Shiga toxin 2c variant,which is globally spread in strains of Escherichia coli O157显示文摘 | STRAUCH E SCHAUDINN C BEUTIN L | 2004 | Infection and Immunity2004，72，12： | 1 |
| 12 | Effects of lasalocid on circulating concentration of leptin and insulin-likegrowth factor-Ⅰ and reproductive performance of postpartum Brahman cows显示文摘 | Strauch T A Neuendorff D Brownetal C G | 2003 | J Anim Sci2003，81，： | 1 |
| 13 | Management of esophageal perforations 显示文摘 | Schmidt S C Strauch S Rfisch T | 2010 | Surg Endosc2010，24，11： | 1 |
| 14 | Transcrip- tional regulation of the redD transcriptional activator gene ac- counts for growth-phase-dependent production of the antibiotic undecylprodigiosin in Streptomyces coelieolor A3 ( 2 ) 显示文摘 | TAKANO E GRAMAJ O H C STRAUCH E | 1992 | Mol Microbiol1992，6，19： | 1 |
| 15 | Biowaiver monographs for immediate release solid oral dosage forms: Doxy- cyeline hyclate 显示文摘 | JANTRATID E STRAUCH S BECKER C | 2010 | J Pharm Sci2010，99，4： | 1 |
| 16 | The association between skin collagen glucosepane and past progression of microvascular and neuropathic complications in type 1 diabetes显示文摘 | Monnier VM Sell DR Strauch C | 2013 | J Diabetes Complications2013，27，2： | 1 |
| 17 | M- anagement of esophageal perforations 显示文摘 | SCHMIDT S C STRAUCH S ROSCH T | 2010 | Surg Endosc2010，24，： | 1 |
| 18 | Reporter protein-targeted probes for magnetic resonance imaging 显示文摘 | Strauch R C Mastarone D J Sukerkar P A | 2011 | J Am Chem Soe2011，133，16： | 1 |
| 19 | 2-Aminoadipic acid is a marker of protein carbonyl oxidation in the aging human skin: effects of diabetes, renal failure and sepsis显示文摘 | Sell D Strauch C Shen W | 2007 | Biochem J2007，404，： | 1 |
| 20 | Analytical Methods for Characterizing Magnetic Resonance Probes显示文摘 | Manus L M Strauch R C Hung A H | 2012 | Anal Chem2012，84，15： | 1 |
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