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| 1 | Recurrent aggressive mesenteric desmoid tumor successfully treated with sorafenib: A case report and literature review显示文摘BACKGROUND Desmoid tumors(DT) are locally advanced but histologically benign monoclonal neoplasms that can occur from any musculoaponeurotic structure. The aim of this report is to analyze a rare clinical case of an aggressive intra-abdominal DT successfully treated with sorafenib.CASE SUMMARY A 36-year-old man presented with increasing colicky abdominal pain and a selfpalpable mass in his left abdomen. Fourteen years earlier he was diagnosed with a large intra-abdominal tumor, which adhered to the left colonic flexure, part of the major gastric curvature and the spleen. Subsequent exploratory laparotomy revealed a voluminous mass in the epigastrium, arising from the posterior surface of the stomach and invading the superior mesenteric vessels, transverse mesocolon and the small bowel mesentery. As the tumor was unresectable, a jejunojejunal bypass was performed. Traditional therapeutic interventions proved insufficient, and the patient was started on sorafenib with a subsequent fulldisease response.CONCLUSIONDT's pathogenesis has been associated with mutations in the adenomatous polyposis coli(APC) gene or beta-catenin gene CTNNB1, sex steroids or previous surgical trauma. Local treatment modalities, such as surgery or radiotherapy, are implemented in aggressively progressing or symptomatic patients. Sorafenib is a hopeful therapeutic option against DTs, while several pharmacological agents have been successfully used. | Aikaterini Mastoraki Dimitrios Schizas Chrysovalantis Vergadis Leon Naar Alexios Strimpakos Michail G Vailas Natasha Hasemaki George Agrogiannis Theodore Liakakos Nikolaos Arkadopoulos | 2019 | World Journal of Clinical Oncology2019，10，4： | 4 |
| 2 | Novel agents and new combination treatments on phase Ⅰ studies on solid tumors and pancreatic cancer显示文摘 | Strimpakos AS Syrigos KN Saif MW | 2012 | JOP2012，13，4： | 1 |
| 3 | Histones and lung cancer: Are the histone deacetylases a promising therapeutic target ? 显示文摘 | PETTA V GKIOZOS I STRIMPAKOS A | 2013 | Cancer Chemoth Pharma2013，72，5： | 1 |
| 4 | The role of mTOR in the management of solid tumors: an overview显示文摘 | Strimpakos AS Karapanagiotou EM Saif MW | 2009 | Cancer Treat Rev2009，35，2： | 1 |
| 5 | Theimpact of carcinoembryonic antigen flare in patients with ad-vanced colorectal cancer receiving first-line chemotherapy显示文摘 | Strimpakos AS Cunningham D Mikropoulos C | 2010 | Ann Oncol2010，21，5： | 1 |
| 6 | Pulmonary function of pa- tients with chronic neck pain: a spirometry study显示文摘 | Dimitriadis Z Kapreli E Strimpakos N | 2014 | Respir Care2014，59，4： | 1 |
| 7 | Curcumin: preventive and therapeutic properties in laboratory studies and clinical trials 显示文摘 | Strimpakos AS Sharma RA | 2008 | Antioxid Redox Signal2008，10，3： | 1 |
| 8 | Cervical joint posi- tion sense: an intra- and inter-examiner reliability study显示文摘 | Strimpakos N Sakellari V Gioftsos G | 2006 | Gait Posture2006，23，1： | 1 |
| 9 | Azithromycinpulses for the treatment of epidermal growth factor receptor in-hipitor-related papulopustular eruption: an effective and conve-nie'nt alternative to tetracyclines显示文摘 | Nikolaou V Strimpakos AS Stratigos A | 2012 | Dermatology2012，224，4： | 1 |
| 10 | Clinical studies in the second line setting of advanced pancreatic cancer: are we making any progress?显示文摘 | Ramfidis VS Strimpakos AS Syrigos KN | 2012 | JOP2012，13，： | 1 |
| 11 | Pancreatic cancer: From molecular pathogenesis to targeted therapy显示文摘 | Strimpakos A Sail MW Syrigos KN | 2008 | Cancer Metas- tasis Rev2008，27，： | 1 |
| 12 | Curcumin:preventive and therapeutic properties in laboratory studies and clinical trials显示文摘 | Strimpakos AS Sharma RA | 2008 | Antioxid Redox Signal2008，10，3： | 1 |
| 13 | Pancreatic cancer:from molecular pathogenesis to targeted therapy显示文摘 | Strimpakos A Saif MW Syrigos KN | 2008 | Cancer Metastasis Rev2008，27，3： | 1 |
| 14 | Curcumin: preventive and thera- peutic properties in laboratory studies and clinical trials 显示文摘 | Strimpakos AS Sharma RA | 2008 | Antioxid Redox Signal2008，10，3： | 1 |
| 15 | Pancreatic cancer: from molecular pathogenesis to targeted therapy显示文摘 | Strimpakos A Saif MW Syrigos KN | 2008 | Cancer Metastasis Rev2008，27，3： | 1 |
| 16 | Curcumin: preventive and therapeutic properties in laboratory studies and clinical trials显示文摘 | Strimpakos AS Sharma RA | 2008 | Antioxid Rcdox Sigmal2008，10，3： | 1 |
| 17 | Curcumin: preventive and therapeutic properties in laboratory studies and elinical trials 显示文摘 | Strimpakos AS Sharma RA | 2008 | Antioxid Redox Signal2008，10，3： | 1 |
| 18 | Curcumin:Preventive and therapeutic properties in laboratory studies and clinical trails显示文摘 | Strimpakos AS Sharama RA | 2008 | Antioxid Redox Signal2008，10，3： | 1 |
| 19 | Cytology-versus histology-based diagnosis in small cell lung cancer:is there any clinical implication显示文摘 | Strimpakos AS Ramfidis V Maragkos C | | 0，，： | 1 |
| 20 | Curcumin:preventive and therapeutic properties in laboratory studies and clinical trails显示文摘 | Strimpakos AS Sharama RA | 2008 | Antioxid Redox Signal2008，10，3： | 1 |
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