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| 1 | From diagnosis to treatment of hepatocellular carcinoma: An epidemic problem for both developed and developing world显示文摘Hepatocellular carcinoma(HCC) is the most frequent primary liver malignancy and the third cause of cancer-related death in the Western Countries. The well-established causes of HCC are chronic liver infections such as hepatitis B virus or chronic hepatitis C virus, nonalcoholic fatty liver disease, consumption of aflatoxins and tobacco smocking. Clinical presentation varies widely; patients can be asymptomatic while symptomatology extends from right upper abdominal quadrant paint and weight loss to obstructive jaundice and lethargy. Imaging is the first key and one of the most important aspects at all stages of diagnosis, therapy and follow-up of patients with HCC. The Barcelona Clinic Liver Cancer Staging System remains the most widely classification system used for HCC management guidelines. Up until now, HCC remains a challenge to early diagnose, and treat effectively; treating management is focused on hepatic resection, orthotopic liver transplantation, ablative therapies, chemoembolization and systemic therapies with cytotocix drugs, and targeted agents. This review article describes the current evidence on epidemiology, symptomatology, diagnosis and treatment of hepatocellular carcinoma. | Dimitrios Dimitroulis Christos Damaskos Serena Valsami Spyridon Davakis Nikolaos Garmpis Eleftherios Spartalis Antonios Athanasiou Demetrios Moris Stratigoula Sakellariou Stylianos Kykalos Gerasimos Tsourouflis Anna Garmpi Ioanna Delladetsima Konstantinos Kontzoglou Gregory Kouraklis | 2017 | World Journal of Gastroenterology2017，23，29： | 44 |
| 2 | Transforaminal Percutaneous Endoscopic Discectomy using Transforaminal Endoscopic Spine System technique: Pitfalls that a beginner should avoid显示文摘Transforaminal Percutaneous Endoscopic Discectomy(TPED) is a minimally invasive technique mainly used for the treatment of lumbar disc herniation from a lateral approach. Performed under local anesthesia, TPED has been proven to be a safe and effective technique which has been also associated with shorter rehabilitation period, reduced blood loss, trauma, and scar tissue compared to conventional procedures. However, the procedure should be performed by a spine surgeon experienced in the specific technique and capable of recognizing or avoiding various challenging conditions. In this review, pitfalls that a novice surgeon has to be mindful of, are reported and analyzed. | Stylianos Kapetanakis Grigorios Gkasdaris Antonios G Angoules Panagiotis Givissis | 2017 | World Journal of Orthopedics2017，8，12： | 27 |
| 3 | Helicobacter pylori and colorectal neoplasia:Is there acausal link?显示文摘Ever since Helicobacter pylori(H. pylori) was recognized as an infectious cause of gastric cancer, there has been increasing interest in examining its potential role in colorectal carcinogenesis. Data from casecontrol and cross-sectional studies, mostly relying on hospital-based samples, and several meta-analyses have shown a positive statistical relationship between H. pylori infection and colorectal neoplasia. However, the possibility exists that the results have been influenced by bias, including the improper selection of patients and disparities with respect to potential confounders. While the evidence falls short of a definitive causal link, it appears that infection with H. pylori /H. pylori-related gastritis is associated with an increased, although modest, risk of colorectal adenoma and cancer. The pathogenic mechanisms responsible for this association remain uncertain. H. pylori has been detected in colorectal malignant tissues; however, the possibility that H. pylori is a direct activator of colonic carcinogenesis remains purely hypothetical. On the other hand, experimental data have indicated a series of potential oncogenic interactions between these bacteria and colorectal mucosa, including induction and perpetuation of inflammatory responses, alteration of gut microflora and release of toxins and/or hormonal mediators, such as gastrin, which may contribute to tumor formation. | Vasilios Papastergiou Stylianos Karatapanis Sotirios D Georgopoulos | 2016 | World Journal of Gastroenterology2016，22，2： | 22 |
| 4 | Treatment of Helicobacter pylori infection:Meeting the challenge of antimicrobial resistance显示文摘Treatment of Helicobacter pylori(H.pylori)infection is paramount for the management of prevalent gastrointestinal disorders including peptic ulcer disease and gastric cancer.Due to the wide increase in prevalence of H.pylori resistance to antibiotics,clarithromycin-based triple therapies are not any more suitable for unconditional empiric use,and should not be recommended,unless local resistance to this antibiotic is low(<20%).Alternative strategies have been proposed to overcome the issue of increasing clarithromycin resistance,and some of them are already implemented in clinical practice.These comprise:(1)adoption of novel,more effective,empirical treatments:bismuth quadruple,sequential,non-bismuth quadruple(concomitant),dual-concomitant(hybrid),and levofloxacin-based regimens,the latter mainly designated as second-line/rescue options;(2)perspectives for a susceptibility-guided(tailored)therapeutic approach based on culture-free molecular testing methods;and(3)adjunct use of probiotics to improve eradication rates.The present article is aimed to provide a comprehensive overview of current and emerging strategies in the treatment of H.pylori infection,focusing on the challenge of antimicrobial resistance. | Vasilios Papastergiou Sotirios D Georgopoulos Stylianos Karatapanis | 2014 | World Journal of Gastroenterology2014，20，29： | 18 |
| 5 | A new pancreaticojejunostomy technique: A battle against postoperative pancreatic fistula显示文摘AIM:To present a new technique of end-to-side, ductto-mucosa pancreaticojejunostomy with seromuscular jejunal flap formation, and insertion of a silicone stent. METHODS:We present an end-to-side, duct-to-mucosa pancreaticojejunostomy with seromuscular jejunal flap formation, and the insertion of a silicone stent. This technique was performed in thirty-two consecutive patients who underwent a pancreaticoduodenectomy procedure by the same surgical team, from January 2005 to March 2011. The surgical procedure performed in all cases was classic pancreaticoduodenectomy, without preservation of the pylorus. The diagnosis of pancreatic leakage was defined as a drain output of any measurable volume of fluid on or after postoperative day 3 with an amylase concentration greater than three times the serum amylase activity. RESULTS:There were 32 patients who underwent end-to-side, duct-to-mucosa pancreaticojejunostomy with seromuscular jejunal flap formation. Thirteen of them were women and 19 were men. These data correspond to 40.6% and 59.4%, respectively. The mean age was 64.2 years, ranging from 55 to 82 years. The mean operative time was 310.2 ± 40.0 min, and was defined as the time period from the intubation up to the extubation of the patient. Also, the mean time needed to perform the pancreaticojejunostomy was 22.7 min, ranging from 18 to 25 min. Postoperatively, one patient developed a low output pancreatic fistula, three patients developed surgical site infection, and one patient developed pneumonia. The rate of overall morbidity was 15.6%. There was no 30-d postoperative mortality. CONCLUSION:This modification appears to be a significantly safe approach to the pancreaticojejunostomy without adversely affecting operative time. | Stylianos Katsaragakis Andreas Larentzakis Sotirios-Georgios Panousopoulos Konstantinos G Toutouzas Dimitrios Theodorou Spyridon Stergiopoulos Georgios Androulakis | 2013 | World Journal of Gastroenterology2013，19，27： | 12 |
| 6 | Overview of coronary artery variants, aberrations and anomalies显示文摘Coronary artery anomalies and variants are relatively uncommon congenital disorders of the coronary artery anatomy and constitute the second most common cause of sudden cardiac death in young competitive athletes. The rapid advancement of imaging techniques, including computed tomography, magnetic resonance imaging, intravascular ultrasound and optical coherence tomography, have provided us with a wealth of new information on the subject. Anomalous origin of a coronary artery from the contralateral sinus is the anomaly most frequently associated with sudden cardiac death, in particular if the anomalous coronary artery has a course between the aorta and the pulmonary artery. However, other coronary anomalies, like anomalous origin of the left coronary artery from the pulmonary artery, atresia of the left main stem and coronary fistulae, have also been implicated in cases of sudden cardiac death. Patients are usually asymptomatic, and in most of the cases, coronary anomalies are discovered incidentally during coronary angiography or on autopsy following sudden cardiac death. However, in some cases, symptoms like angina, syncope, heart failure and myocardial infarction may occur. The aims of this article are to present a brief overview of the diverse coronary variants and anomalies, focusing especially on anatomical features, clinical manifestations, risk of sudden cardiac death and pathophysiologic mechanism of symptoms, as well as to provide valuable information regarding diagnostic workup, follow-up, therapeutic choices and timing of surgical treatment. | Stylianos Kastellanos Konstantinos Aznaouridis Charalambos Vlachopoulos Eleftherios Tsiamis Evangelos Oikonomou Dimitris Tousoulis | 2018 | World Journal of Cardiology2018，10，10： | 12 |
| 7 | Treatment of Helicobacter pylori infection: Past, present and future显示文摘Helicobacter pylori(H. pylori) is a major human patho-gen associated with significant morbidity and mortal-ity. However, after decades of efforts, treatment of H. pylori remains a challenge for physicians, as there is no universally effective regimen. Due to the rising prevalence of antimicrobial resistance, mainly to clar-ithromycin, efficacy of standard triple therapies has declined to unacceptably low levels in most parts of the world. Novel regimens, specifically experimented to improve the therapeutic outcome against antibiotic-resistant H. pylori strains, are now recommended as first-line empirical treatment options providing high ef-ficacy(reportedly > 90% in intention to treat analysis) even in high clarithromycin resistance settings. These include the bismuth quadruple, concomitant, sequential and hybrid therapies. Due to the rapid development of quinolone resistance, levofloxacin-based regimens should be reserved as second-line/rescue options. Adjunct use of probiotics has been proposed in order to boost eradication rates and decrease occurrence of treatment-related side effects. Molecular testing meth-ods are currently available for the characterization of H. pylori therapeutic susceptibility, including genotypic detection of macrolide resistance and evaluation of the cytochrome P450 2C19 status known to affect the me-tabolism of proton pump inhibitors. In the future, use of these techniques may allow for culture-free, non-invasive tailoring of therapy for H. pylori infection. | Vasilios Papastergiou Sotirios D Georgopoulos Stylianos Karatapanis | 2014 | World Journal of Gastrointestinal Pathophysiology2014，5，4： | 11 |
| 8 | Effects of laparoscopic cholecystectomy on lung function:A systematic review显示文摘AIM:To present and integrate findings of studies investigating the effects of laparoscopic cholecystectomy on various aspects of lung function.METHODS:We extensively reviewed literature of the past 24 years concerning the effects of laparoscopic cholecystectomy in comparison to the open procedure on many aspects of lung function including spirometricvalues,arterial blood gases,respiratory muscle performance and aspects of breathing control,by critically analyzing physiopathologic interpretations and clinically important conclusions.A total of thirty-four articles were used to extract information for the meta-analysis concerning the impact of the laparoscopic procedure on lung function and respiratory physiopathology.The quality of the literature reviewed was evaluated by the number of their citations and the total impact factor of the corresponding journals.A fixed and random effect meta-analysis was used to estimate the pooled standardized mean difference of studied parameters for laparoscopic(LC)and open(OC)procedures.A crude comparison of the two methods using all available information was performed testing the postoperative values expressed as percentages of the preoperative ones using the Mann-Whitney two-sample test.RESULTS:Most of the relevant studies have investigated and compared changes in spirometric parameters.The median percentage and interquartile range(IQR)of preoperative values in forced vital capacity(FVC),forced expiratory volume in 1 s and forced expiratory flow(FEF)at 25%-75%of FVC(FEF25%-75%)expressed as percentage of their preoperative values 24 h after LC and OC were respectively as follows:[77.6(73.0,80.0)L vs 55.4(50.0,64.0)L,P<0.001;76.0(72.3,81.0)L vs 52.5(50.0,56.7)L,P<0.001;and 78.8(68.8,80.9)L/s vs 60.0(36.1,66.1)L/s,P=0.005].Concerning arterial blood gases,partial pressure of oxygen[Pa O2(k Pa)]at 24 or 48 h after surgical treatment showed reductions that were significantly greater in OC compared with LC[LC median 1.0,IQR(0.6,1.3);OC median 2.4,IQR(1.2,2.6),P=0.019].Fewer studies have investigated the effect of LC on respiratory muscle performance showing less impact of this surgical method on maximal respiratory pressures(P<0.01);and changes in the control of breathing after LC evidenced by increase in mean inspiratory impedance(P<0.001)and minimal reduction of duty cycle(P=0.01)compared with preoperative data.CONCLUSION:Laparoscopic cholecystectomy seems to be associated with less postoperative derangement of lung function compared to the open procedure. | George D Bablekos Stylianos A Michaelides Antonis Analitis Konstantinos A Charalabopoulos | 2014 | World Journal of Gastroenterology2014，20，46： | 10 |
| 9 | Low T3 syndrome and long-term mortality in chronic hemodialysis patients显示文摘AIM:To investigate the predictive value of low free T3 for long-term mortality in chronic hemodialysis(HD) patients and explore a possible causative role of chronic inflammation.METHODS:One hundred fourteen HD patients(84 males) consecutively entered the study and were assessed for thyroid function and two established markers of inflammation,high sensitivity C-reactive protein(hs CRP) and interleukin-6(IL-6).Monthly blood samples were obtained from all patients for three consecutive months during the observation period for evaluation of thyroid function and measurement of inflammatory markers.The patients were then divided in two groups based on the cut-off value of 1.8 pg/m L for mean plasma free T3,and were prospectively studied for a mean of 50.3 ± 30.8 mo regarding cumulative survival.The prognostic power of low serum f T3 levels for mortality was assessed using the Kaplan-Meier method and univariate and multivariate regression analysis.RESULTS:Kaplan-Meier survival curve showed a negative predictive power for low free T3.In Cox regression analysis low free T3 remained a significant predictor of mortality after adjustment for age,diabetes mellitus,hypertension,hs CRP,serum creatinine and albumin.Regarding the possible association with inflammation,free T3 was correlated with hs CRP,but not IL-6,and only at the first month of the study.CONCLUSION:In chronic hemodialysis patients,low plasma free T3 is a significant predictor of all-cause mortality.Further studies are required to identify the underlying mechanisms of this association. | Stylianos Fragidis Konstantinos Sombolos Elias Thodis Stylianos Panagoutsos Euthymia Mourvati Maria Pikilidou Aikaterini Papagianni Ploumis Pasadakis Vasilios Vargemezis | 2015 | World Journal of Nephrology2015，4，3： | 9 |
| 10 | Surgical management of chronic pancreatitis显示文摘BACKGROUND: Treatment of chronic pancreatitis (CP) is a challenging condition for surgeons. During the last decades, increasing knowledge about pathophysiology of CP, improved results of major pancreatic resections, and integration of sophisticated diagnostic methods in clinical practice have resulted in significant changes in surgery for CP. DATA SOURCES: To detail the indications for CP surgery, the surgical procedures, and outcome, a Pubmed database search was performed. The abstracts of searched articles about surgical management of CP were reviewed. The articles could be identified and further scrutinized. Further references were extracted by cross-referencing. RESULTS: Main indications of CP for surgery are intractable pain, suspicion of malignancy, and involvement of adjacent organs. The goal of surgical treatment is to improve the quality of life of patients. The surgical approach to CP should be individualized according to pancreatic anatomy, pain characteristics, baseline exocrine and endocrine function, and medical co-morbidity. The approach usually involves pancreatic duct drainage and resection including longitudinal pancreatojejunostomy, pancreatoduodenectomy (Whipple's procedure), pylorus-preserving pancreatoduodenectomy, distal pancreatectomy, total pancreatectomy, duodenum- preserving pancreatic head resection (Beger's procedure), and local resection of the pancreatic head with longitudinal pancreatojejunostomy (Frey's procedure). Non-pancreatic and endoscopic management of pain has also been advocated. CONCLUSIONS: Surgical procedures provide long-term pain relief, a good postoperative quality of life withpreservation of endocrine and exocrine pancreatic function, and are associated with low early and late mortality and morbidity. In addition to available results from randomized controlled trials, new studies are needed to determine which procedure is the most effective for the management of patients with CP. | Stavros Gourgiotis Stylianos Germanos Marco Pericoli Ridolfini | 2007 | Hepatobiliary & Pancreatic Diseases International2007，6，2： | 8 |
| 11 | Flecainide: Current status and perspectives in arrhythmia management显示文摘Flecainide acetate is a class IC antiarrhythmic agent and its clinical efficacy has been confirmed by the results of several clinical trials. Nowadays, flecainide is recommended as one of the first line therapies for pharmacological conversion as well as maintenance of sinus rhythm in patients with atrial fibrillation and/or supraventricular tachycardias. Based on the Cardiac Arrhythmia Suppression Trial study results, flecainide is not recommended in patients with structural heart disease due to high proarrhythmic risk. Recent data support the role of flecainide in preventing ventricular tachyarrhythmias in patients with catecholaminergic polymorphic ventricular tachycardia associated both with ryanodine receptor and calsequestrin mutations. We herein review the current clinical data related to flecainide use in clinical practice and some concerns about its role in the management of patients with coronary artery disease. | George K Andrikopoulos Sokratis Pastromas Stylianos Tzeis | 2015 | World Journal of Cardiology2015，7，2： | 8 |
| 12 | Respiratory mechanics in brain injury: A review显示文摘Several clinical and experimental studies have shown that lung injury occurs shortly after brain damage. The responsible mechanisms involve neurogenic pulmonary edema, inflammation, the harmful action of neurotransmitters, or autonomic system dysfunction. Mechanical ventilation, an essential component of life support in brain-damaged patients(BD), may be an additional traumatic factor to the already injured or susceptible to injury lungs of these patients thus worsening lung injury, in case that non lung protective ventilator settings are applied. Measurement of respiratory mechanics in BD patients, as well as assessment of their evolution during mechanical ventilation, may lead to preclinical lung injury detection early enough, allowing thus the selection of the appropriate ventilator settings to avoid ventilatorinduced lung injury. The aim of this review is to explore the mechanical properties of the respiratory system in BD patients along with the underlying mechanisms, and to translate the evidence of animal and clinical studies into therapeutic implications regarding the mechanical ventilation of these critically ill patients. | Antonia Koutsoukou Maria Katsiari Stylianos E Orfanos Anastasia Kotanidou Maria Daganou Magdalini Kyriakopoulou Nikolaos G Koulouris Nikoletta Rovina | 2016 | World Journal of Critical Care Medicine2016，5，1： | 7 |
| 13 | Transanal polypectomy using single incision laparoscopic instruments显示文摘Transanal excision of rectal polyps with laparoscopic instrumentation and a single incision laparoscopic port is a novel technique that uses technology originally developed for abdominal procedures from the natural orifice of the rectum. Transanal endoscopic microsurgery (TEM) is a well established surgical approach for certain benign or early malignant lesions of the rectum, under specific indications. Our technique is a hybrid technique of transanal surgery, a reasonable method for polyp resection without the need of the sophisticated and expensive instrumentation of TEM which can be applied whenever endoscopic or conventional transanal surgical removal is not feasible. | Dimitrios Dardamanis Dimitrios Theodorou George Theodoropoulos Andreas Larentzakis Maria Natoudi Georgia Doulami Christina Zoumpouli Haridimos Markogiannakis Stylianos Katsaragakis George C Zografos | 2011 | World Journal of Gastrointestinal Surgery2011，3，4： | 6 |
| 14 | Impact of CYP2D*6 in the adjuvant treatment of breast cancer patients with tamoxifen显示文摘Biotransformation of tamoxifen to the potent antiestrogen endoxifen is performed by cytochrome P450(CYP) enzymes, in particular the CYP2D6 isoform. CYP2D6*4 is one of the most frequent alleles associated with loss of enzymatic activity. The incidence of CYP2D6*4 among Caucasians is estimated up to 27%, while it is present in up to 90% of all poor metabolizers within the Caucasian population. The hypothesis under question is whether the presence of one or two non-functioning(null) alleles predicts an inferior outcome in postmenopausal women with breast cancer receiving adjuvant treatment with tamoxifen. The numerous existing studies investigating the association of CYP2D6 with treatment failure in breast cancer are inconsistent and give rather conflicting results. Currently, routine CYP2D6 testing among women with breast cancer is not recommended and the significance of CYP2D6 phenotype in decision making regarding the administration of tamoxifen is unclear. The present study summarizes current literature regarding clinical studies on CYP2D6*4, par-ticularly in terms of response to tamoxifen therapy and breast cancer outcome. | Christos Markopoulos Stylianos Kykalos Dimitrios Mantas | 2014 | World Journal of Clinical Oncology2014，5，3： | 4 |
| 15 | Nonbismuth Quadruple “Concomitant” Therapy Versus Standard Triple Therapy, Both of the Duration of 10 Days, for First-Line H. Pylori Eradication: A Randomized Trial显示文摘 | Sotirios Georgopoulos Vasilios Papastergiou Elias Xirouchakis Foteini Laoudi Philipos Lisgos Charikleia Spiliadi Nikitas Papantoniou Stylianos Karatapanis | 2013 | Journal of Clinical Gastroenterology2013，，3： | 3 |
| 16 | Current status and emerging challenges in the treatment of hepatitis C virus genotypes 4 to 6显示文摘Hepatitis C virus(HCV) genotypes 4, 5 and 6 are mainly present in Africa, the Middle East and Asia and they have been less extensively studied with respect to epidemiology, natural disease history and therapeutic endpoints. Response rates to a 48-wk combined peginterferon/ribavirin treatment range to 40%-69% for HCV 4, 55%-60% for HCV 5 and 60%-90% for HCV 6. Response-guided schedules are recommended to optimize the outcomes of peginterferon/ribavirin treatment in HCV 4 and, in form of preliminarydata, for HCV 6, but no data are yet available to support such an individualization of therapy for HCV 5. Recently, the direct-acting antivirals(DAAs) with pan-genotypic activities simeprevir, sofosbuvir and daclatasvir have been recommended in triple regimens with peginterferon/ribavirin for the treatment of HCV genotypes 4 to 6 infections. In the future, DAA-based interferon-free therapies are awaited to drastically improve treatment outcomes in HCV. However, efforts to improve treatment outcomes with peginterferon/ribavirin should continue, as the HCV 4-6 infected population is mainly based in resource-limited settings with restricted access to the costly DAAs. | Vasilios Papastergiou Stylianos Karatapanis | 2015 | World Journal of Clinical Cases2015，3，3： | 3 |
| 17 | Current options for the treatment of Helicobacter pylori显示文摘 | Sotirios D Georgopoulos Vasilios Papastergiou Stylianos Karatapanis | 2013 | Expert Opinion on Pharmacotherapy2013，，2： | 3 |
| 18 | Transcatheter versus surgical aortic valve replacement in severe, symptomatic aortic stenosis显示文摘大动脉的狭窄(作为) 是瓣膜的心疾病在的最普通的类型老。外科的大动脉的阀门代替(SAVR ) 是为对待的标准实践严重、作为征兆,却最近新治疗选择出现了。Transcatheter 大动脉的阀门代替(TAVR ) 现在是在在高外科的风险的病人的一种确定的治疗选择。在这评论,我们集中于最近的开发并且以功效和安全在特定的人口比较二个治疗方法(例如在有优先的胸的外科的历史的病人,采用的麻醉打字,存取使用的地点或为永久踱步需要) 。comorbidities (肺的高血压,动脉的高血压和肥胖悖论) 的影响,在象应得进一步的调查的问题一样的 transcatheter 阀门技术的 TAVR 对 SAVR 和进展的划算进一步被讨论。而且,在不同风险范畴(极其高、高、中间、低的风险) 的病人的 TAVR 的结果和复杂并发症被分析。我们强烈相信在下列年期间, TAVR 可以在病人的一个更宽广的组作为选择的治疗演变与与中间、高风险的特征作为并且在那些以外征兆。 | Tsigkas Grigorios Despotopoulos Stefanos Makris Athanasios Koniari Ioanna Armylagos Stylianos Davlouros Periklis Hahalis George | 2018 | Journal of Geriatric Cardiology2018，15，1： | 2 |
| 19 | Nonbismuth Quadruple “Concomitant” Therapy Versus Standard Triple Therapy, Both of the Duration of 10 Days, for First-Line H. Pylori Eradication: A Randomized Trial显示文摘 | Sotirios Georgopoulos Vasilios Papastergiou Elias Xirouchakis Foteini Laoudi Philipos Lisgos Charikleia Spiliadi Nikitas Papantoniou Stylianos Karatapanis | 2013 | Journal of Clinical Gastroenterology2013，，3： | 2 |
| 20 | Innovation Portfolio Management for Small-medium Enterprises显示文摘For small and medium sized enterprises,portfolio management can be a difficult exercise;especially when the available paths forwards are shrouded in mystery.To overcome this,they are required to research and decide upon the path to follow,but this can be difficult when the information to gather is unclear,leading to ad-hoc processes and inconsistency.The motivation for this project originated from a small and medium sized enterprise experiencing this problem of unknown critical information and a technological portfolio with significant potential.With no procedure or method in place,they conducted the research in an ad-hoc way resulting in uncertainty and low repeatability of decisions.To tackle this problem,innovation structuring frameworks were synthesised with appropriate risks and context to pose a new structure for information capture.The resulting structure was tested within the small and medium sized enterprise to investigate the repeatability of the information capture and the subsequent ranking.The proposed structure was also analysed by-process experts for its wider applicability.For the small and medium sized enterprise,this led to a consistent and repeatable method that delivered increased confidence about selecting a path forwards for its portfolio.In addition,it was found to be applicable to external organisations increasing the moders worth and applicability.The implications of this work have led to a change in the operational procedure of the small and medium sized enterprise to utilise the defined process for researching new ideas for their portfolio which can lead to repeatable and trustworthy decisions.This also has applicability to other similar companies and could lead them through a repeatable process as presented here. | Daniel Pashley Theo Tryfonas Andy Crossley Chris Setchell Stylianos Karatzas | 2020 | Journal of Systems Science and Systems Engineering2020，29，5： | 2 |
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