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| 1 | Interrelationship between chromosome 8 aneuploidy,C-MYC amplification and increased expression in individuals from northern Brazil with gastric adenocarcinoma显示文摘AIM: To investigate chromosome 8 numerical aberra- tions, C-MYC oncogene alterations and its expression in gastric cancer and to correlate these findings with histo- pathological characteristics of gastric tumors. METHODS: Specimens were collected surgically from seven patients with gastric adenocarcinomas. Immu- nostaining for C-MYC and dual-color fluorescence in situ hybridization (FISH) for C-MYC gene and chromosome 8 centromere were performed. RESULTS: All the cases showed chromosome 8 aneu- ploidy and C-MYC amplification, in both the diffuse and intestinal histopathological types of Lauren. No significant difference (P < 0.05) was observed between the level ofchromosome 8 ploidy and the site, stage or histological type of the adenocarcinomas. C-MYC high amplification, like homogeneously stained regions (HSRs) and double minutes (DMs), was observed only in the intestinal-type. Structural rearrangement of C-MYC, like translocation, was observed only in the diffuse type. Regarding C-MYC gene, a significant difference (P < 0.05) was observed between the two histological types. The C-MYC protein was expressed in all the studied cases. In the intestinal- type the C-MYC immunoreactivity was localized only in the nucleus and in the diffuse type in the nucleus and cytoplasm. CONCLUSION: Distinct patterns of alterations between intestinal and diffuse types of gastric tumors support the hypothesis that these types follow different genetic path- ways. | Danielle Queiroz Calcagno Mariana Ferreira Leal Aline Damaceno Seabra Andre Salim Khayat Elizabeth Suchi Chen Samia Demachki Paulo Pimentel Assumpcao Mario Henrique Girao Faria Silvia Helena Barem Rabenhorst Márcia Valéria Pitombeira Ferreira Marília de Arruda Cardoso Smith Rommel Rodríguez Burbano | 2006 | World Journal of Gastroenterology2006，12，38： | 9 |
| 2 | Chemoprotective potentials of homoisoflavonoids and chalcones of Dracaena cinnabari:modulations of drug-metabolizing enzymes and antioxidant activity显示文摘 | Machala M Kubinova R Suchy V | 2001 | Phytother Res2001，15，2： | 1 |
| 3 | Human bile salt export pump promoter is transactivated by the famesoid X receptorlbile acid receptor显示文摘 | Ananthanarayanan M Balasubramanian N Makishima M Man- gelsdorf D J Suchy FJ | 2001 | J Biol Chem2001，276，28： | 1 |
| 4 | The protein kinase pUL97 of human cytomegalovirus interacts with and phosphotvlatles the DNA polymerase processivity factor pUIA4 显示文摘 | Marschall M Freitag M Suchy P | 2003 | Viroleoy2003，311，1： | 1 |
| 5 | Activation of alkaline peroxide delignificationusing a vanadium peroxide complex显示文摘 | Suchy M Argyropoulos D S | 2000 | Tappi Journal2000，83，6： | 1 |
| 6 | Effect of SiO2 on densification and microstructure development in Nd:YAG transparent ceramics 显示文摘 | STEVENSON A J LI Xin MART1NEZ M A ANDERSON J M SUCHY D L KUPP E R DICKEY1 Z C MUELLER K T MESSING G L | 2011 | J Am Ceram Soc2011，94，： | 1 |
| 7 | Vitrinite reflectance and shear-induced graphitization in orogonic belts:A case study from Kanderstey area,Helvetic Alps,SW itsedand显示文摘 | Frey M Wolf M | 1997 | Int J of Coal Geol1997，34，122： | 1 |
| 8 | Polymorphism in the P-glycoprotein drug transporter MDR1 gene in colon cancer patients 显示文摘 | KURZAWSKI M DROT DZIK M SUCHY J | 2005 | Eur J Clin Pharmacol2005，61，56： | 1 |
| 9 | No effects of atorvastatin on nitric oxide, prostacyclin, thromboxane and oxidative stress in type 2 diabetes mellitus patients of the DALI study显示文摘 | TSIKAS D PHAM V V SUCHY M T | 2015 | Pharmacol Res2015，94，1： | 1 |
| 10 | A tissue-engineeringtech- nique for vascularized laryngotracheal reconstruction显示文摘 | Glatz F Neumeister M Suchy H | 2003 | Arch Otolar- yngol Head Neck Surg2003，129，2： | 1 |
| 11 | Hepatobiliary trans- port: molecular mechanisms of development and cholestasis显示文摘 | Arrese M Ananthananarayanan M Suchy F J | 1998 | Pe- diatr Res1998，44，2： | 1 |
| 12 | Polymorphism in the P - glycoprotein drug transporter MDR1 gene in colon cancer patients 显示文摘 | Kurzawski M Drozdzik M Suchy J | 2005 | Eur J Clin Pharmacol2005，61，56： | 1 |
| 13 | Phytoalexins from Thlaspi arrense, a wild crucifer resistant to virulent Leptosphaeria maculans: structures, synthese and antifungal activiy显示文摘 | Pedras MSC Chumala PB Suchy M | 2003 | Phytochemistry2003，64，5： | 1 |
| 14 | Synthesis,ab- solute configuration, and enantiomeric enrichment of a cruciferous oxindole phytoalexin, (S) -( - ) -spirobras- sinin,and its oxazoline analog显示文摘 | Suchy M Kutschy P Monde K | 2001 | J Org Chem2001，66，： | 1 |
| 15 | Catalysis and activation of oxygen and peroxide delignification of chemical pulps: A review显示文摘 | SUCHY M ARGYROPOILOS D S | 2002 | Tappi J2002，1，2： | 1 |
| 16 | Clinical utility of antioxidant gene expression levels in circulating cancer cell clusters for the detection of prostate cancer in patients with prostate-specific antigen levels of 4-10 ng/mL and disease prognostication after radical prostatectorny显示文摘 | Giesing M Suchy B Driesel G | 2010 | BJU Int2010，105，7： | 1 |
| 17 | Simultaneous UPLC-MS/MS quantification of the endocannabinoids2-arachidonoyl glycerol(2AG),1-arachidonoyl glycerol(1AG),and anandamide in human plasma:minimization of matrixeffects,2AG/1AG isomerization and degradation by toluene solvent extraction显示文摘 | ZOERNER A BATKAI S SUCHY M T | 2011 | J Chromatogr B2011，879，17： | 1 |
| 18 | Activation of alkaline peroxide delignification using a vanadium peroxide complex显示文摘 | Suchy M and Argyropoulos D S | 2000 | Tappi Journal2000，83，6： | 1 |
| 19 | Phytoalexins from Thlaspi arvense, a wild erueifer resistant tovirulent Leptosphaeria maculans: structures, syntheses and antifungal act vity显示文摘 | Pedras M S C Chumala P B Suchy M | 2003 | Phytochemistry2003，64，： | 1 |
| 20 | Once - weekily oral doses of Fluconozole 150mg in the treatment of tinea corporis/cruris and cutaneous Candidiasis 显示文摘 | Suchi P Grei M Roblrs M etal | 1992 | Clin Exp Permatol1992，17，： | 1 |
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