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| 1 | Mycobacterium avium subspecies paratuberculosis causes Crohn's disease in some inflammatory bowel disease patients显示文摘Crohn’s disease(CD)is a chronic inflammatory condition that plagues millions all over the world.This debilitating bowel disease can start in early childhood and continue into late adulthood.Signs and symptoms are usually many and multiple tests are often required for the diagnosis and confirmation of this disease.However,little is still understood about the cause(s)of CD.As a result,several theories have been proposed over the years.One theory in particular is that Mycobacterium avium subspecies paratuberculosis(MAP)is intimately linked to the etiology of CD.This fastidious bacterium also known to cause Johne’s disease in cattle has infected the intestines of animals for years.It is believed that due to the thick,waxy cell wall of MAP it is able to survive the process of pasteurization as well as chemical processes seen in irrigation purification systems.Subsequently meat,dairy products and water serve as key vehicles in the transmission of MAP infection to humans(from farm to fork)who have a genetic predisposition,thus leading to the development of CD.The challenges faced in culturing this bacterium from CD are many.Examples include its extreme slow growth,lack of cell wall,low abundance,and its mycobactin dependency.In this review article,data from 60 studies showing the detection and isolation of MAP by PCR and culture techniques have been reviewed.Although this review may not be 100%comprehensive of all studies,clearly the majority of the studies overwhelmingly and definitively support the role of MAP in at least30%-50%of CD patients.It is very possible that lack of detection of MAP from some CD patients may be due to the absence of MAP role in these patients.The latter statement is conditional on utilization of methodology appropriate for detection of human MAP strains.Ultimately,stratification of CD and inflammatory bowel disease patients for the presence or absence of MAP is necessary for appropriate and effective treatment which may lead to a cure. | Saleh A Naser Sudesh R Sagramsingh Abed S Naser Saisathya Thanigachalam | 2014 | World Journal of Gastroenterology2014，20，23： | 9 |
| 2 | Biodegradation of gelatin graft copolymers Ⅵ显示文摘 | SUDESH K G KALPAGAM V NANDI U S | 1985 | J Appl Polym Sci1985，30，3： | 1 |
| 3 | Post- transcriptional silencing of flavonol synthase mRNA in tobacco leads to fruits with arrested seed set 显示文摘 | Monika M Pammvir S A Sudesh K Y | 2011 | PLoS One2011，6，28： | 1 |
| 4 | The negative psyehosocial impact of strabismus in adults显示文摘 | Olitsky S E Sudesh S Graziano A | 1999 | J AA POS1999，3，4： | 1 |
| 5 | Spectrum of fungal keratitis at Wills Eye Hospital, Philadelphia, Pennsylvania 显示文摘 | Tanure MAG Cohen E J Sudesh S | 2000 | Cornea2000，19，3： | 1 |
| 6 | Spectrum of fungal keratitis at Wills eye hospital, Philadelphia, Pennsylvania 显示文摘 | Tanure MAG Cohen E J Sudesh S | 2000 | Cornea2000，19，： | 1 |
| 7 | Spectrum of fungalkeratitis at wills eye hospital,philadelphia,pennsylvania显示文摘 | Tanure MA Cohen EJ Sudesh S | 2000 | Cornea2000，19，3： | 1 |
| 8 | Pediatric femoral neck fractures: Our 10 years of experience显示文摘 | Bali K Sudesh P Patel S | 2011 | Clin Orthop Surg2011，3，4： | 1 |
| 9 | Spectramd fungal keratifis at Wills Eye Hospital, Philadelphia, Pennsylvania显示文摘 | Tanure MAG Cohen EJ Sudesh S | 2000 | Cornea2000，19，30： | 1 |
| 10 | The negative psychosocial impact of strabismus in adults显示文摘 | Olitsky SE Sudesh S Graziano A Hamblen J Brooks SE Shaha SH | 1999 | J AAPOS1999，3，4： | 1 |
| 11 | Pediatric femoral neck fractures: our 10 years of experience 显示文摘 | Bali K Sudesh P Patel S | 2011 | Clin Orthop Surg2011，3，4： | 1 |
| 12 | Effect of graphene oxide doping on superconducting properties of bulk MgB2 显示文摘 | Sudesh Kumar N Das S | 2013 | Superconductor Science and Technology2013，26，9： | 1 |
| 13 | Role of advanced glycation end products in hypertension and athcrosclero sis: therapeutic implication 显示文摘 | Sudesh V Vicki G Pawan S | 2007 | Cell Biochem Biophy2007，49，： | 1 |
| 14 | Speetnlm of fungal kerati- tis at Wills Eye Hospital, Philadelphia, Pennsylvania显示文摘 | Tallure MA Cohen E J Sudesh S | 2000 | Cornea2000，19，3： | 1 |
| 15 | Biodegradabili- ty studies of poly ( butylene succinate )/organo-montmoril- lonite nanocomposites under controlled compost soil condi- tions: Effects of clay loading and compatibiliser 显示文摘 | PHUA Y J LAU N S SUDESH K | 2012 | Polym Degrad Stab2012，97，8： | 1 |
| 16 | Biodegradability studies of poly (butylene succinate)/organo-montmorillonite nanocomposites under controlled compost soil conditions:Effects of clay loading and compatibiliser显示文摘 | Y J Phua N S Lauc K Sudesh | | 0，，08： | 1 |
| 17 | Spectrum of fungal keratitis at Wills Eye Hospital, Philadelphia, Pennsylvania 显示文摘 | Tanure MA Cohen EJ Sudesh S | 2000 | Cornea2000，19，： | 1 |
| 18 | Spectrum of fungal keratitis at Wills Eye Hospital,Philadelphia,Pennsylvania显示文摘 | Tanure MA Cohen EJ Sudesh S | 2000 | Cornea2000，19，3： | 1 |
| 19 | Pediatric femoral neck fractures:our 10 years of experience显示文摘 | Bali K Sudesh P Patel S | | 0，，04： | 1 |
| 20 | Spectrum of fungae Ker- attis at Wills Eye Hopspital显示文摘 | Tanure MAG Gohen E J Sudesh S | 2000 | Philadelphia Pennsylvania Cornea2000，19，3： | 1 |
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