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	题名	作者	年代	出处	被引量
1	Estrogen enhances the functions of CD4^(+)CD25^(+)Foxp3^(+) regulatory T cells that suppress osteoclast differentiation and bone resorption in vitro显示文摘Cross-talk has been shown to occur between the immune system and bone metabolism pathways.In the present study,we investigated the impact of CD4^(+)CD25^(+)Foxp3^(+) regulatory T(Treg)cells on osteoclastogenesis and bone resorption.Treg cells that were isolated and purified from peripheral blood mononuclear cells(PBMCs)of healthy adults inhibited both the differentiation of osteoclasts(OCs)from human embryo bone marrow cells(BMCs)and the pit formation in a dose-dependent manner.In cell cocultures,the production levels of both interleukin-10(IL-10)and transforming growth factor-beta 1(TGF-β1)were proportionally upregulated as the ratio of Treg cells to BMCs was increased,and the inhibition of OC differentiation and bone resorption by Treg cells was completely reversed by anti-IL-10 and anti-TGF-β1 antibodies.Treatment of BMC and Treg cell cocultures with 17β-estradiol(E2)at concentrations between 10^(-7) and 10^(-9) mol/l suppressed OC differentiation and bone resorption more efficiently than it did in cultures of BMCs alone;this enhanced suppression occurred via the stimulation of Treg cell IL-10 and TGF-b1 expression.These data suggest that Treg cells suppress OC differentiation and bone resorption by secreting IL-10 and TGF-β1.E2 enhances the suppressive effects of Treg cells on OC differentiation and bone resorption by stimulating IL-10 and TGF-β1 secretion from these cells.Therefore,Treg cell-derived IL-10 and TGF-b1 are likely involved in the regulation of E2 on bone metabolism and represent potential therapeutic targets for the treatment of postmenopausal osteoporosis(PMO).	CY Luo L Wang C Sun DJ Li	2011	Cellular & Molecular Immunology2011，8，1：	33
2	前蛋白转化酶枯草杆菌蛋白酶kexin-9在肾病综合征相关性高胆固醇血症中的作用显示文摘肾病综合征中,肾脏足细胞损害可导致严重的高胆固醇血症,迫切需要新的治疗方法。前蛋白转化酶枯草杆菌蛋白酶kexin-9(proprotein convertase subtilisin/kexin type 9,PCSK9)逐渐成为血浆总胆固醇水平和治疗目标的重要调节因子。	刘莉叶鹏 Haas ME Levenson AE Sun X Liao WH Rutkowski JM de Ferranti SD Schumacher VA Scherer PE Salant DJ Biddinger SB	2016	中华高血压杂志2016，24，7：	3
3	Corticosteroid pharmacokinetics in the inner ear fluids:an animal study followed by clinical application显示文摘	Parnes LS Sun AH Freeman DJ	1999	Laryngoscope1999，109，：	1
4	Corticosteroid pharmacokinetics in the inner ear fluids : an animal study followed by clinical application 显示文摘	Parnes LS Sun AI-I Freeman DJ	1999	Laryngoscope1999，109，72：	1
5	C orticosteroid phannacokinetics in theinner ear fluids :an animal study followed by clinical application显示文摘	Parnes LS Sun AH Freeman DJ	1999	Larynogoscope1999，109，7：	1
6	Mechanism of ZnO nanotube growth by hydrothermal methods on ZnO film-coated Si substrates 显示文摘	Y Sun DJ Riley MNR Ashfold	2006	Journal of Physical Chemistry B2006，110，15：	1
7	Corticsteroid pharmacokinetics in the inner ear fluids: an animal study followed by clinical application显示文摘	Parnnes LS Sun AH Freeman DJ	1999	Laryngoscope1999，，：	1
8	Inhibition of hepatocarcinoma by systemic delivery of Apoptin gene via the hepatic asialogycoprotein receptor显示文摘	Peng DJ Sun J Wang YZ	2007	Cancer Gene Ther2007，14，1：	1
9	Distinct profiles of REST interactions with its target genes at different stages of neuronal development显示文摘	Sun YM Greenway DJ Johnson R	2005	Mol Biol Cell2005，16，12：	1
10	Inhibition of hepatocarcinoma by systemic delivery of Apoptin gene via the hepatic asialoglycoprotein receptor 显示文摘	Peng DJ Sun J Wang YZ	2007	Cancer Gene Ther2007，14，1：	1
11	Inhibition of hepatocarcinoma by systemic delivery of Apoptin gene via the hepatic asialogycoprotein receptor显示文摘	Peng DJ Sun J Wang YZ	2007	Cancer Gene Ther2007，14，1：	1
12	Expression af vaccinia recombinant HPV 16 L1 and L2 ORF proteins in epithelial cells is sufficient for assembly of HPV virion-like particles显示文摘	Zhou J Sun XY Stenzel DJ	1991	Virology1991，185，1：	1
13	Cooperation in multi-agent bidding显示文摘	WU DJ SUN YJ	2002	Decision Support Systems2002，33，3：	1
14	Expression of vaccinia recombinant HPV 16 L1 and L20RF proteins in epithelial cells is sufficient for assembly of HPV virion-like particles显示文摘	Zhou J Sun XY Stenzel DJ		0，，01：	1
15	Cycin D1 protein plays different roles in modulating chemoresponses in MCF7 and MDAMB231 cells显示文摘	Sun Y Luo D Liao DJ	2012	J Carcinog2012，11，：	1
16	Distinct profiles of REST interactions with its target genes at different stages of neuronal development显示文摘	Yuh-man Sun Greenway DJ Johnson R	2005	Mol Biol Cell2005，16，12：	1
17	Stability and L2-gain analysis for switched delay systems:A delay-dependent method显示文摘	Sun X Zhao J Hill DJ	2006	Automatica2006，42，10：	1
18	Cortico~teroid pharmacokinetics in the inner ear fluids:an animal study followed by clinical application显示文摘	Parnes L$ Sun AH Freeman DJ	1999	aryn6oscope1999，109，8：	1
19	Draft genome of the kiwifruit Actinidia chinensis 显示文摘	Huang SX Ding J Deng DJ Tang W Sun HH Liu DY Zhang L Niu XL Zhang X Meng M Yu JD Liu J Han Y Shi W Zhang DF Cao SQ Wei ZJ Cui YL Xia YH Zeng HP Bao K Lin L Min Y Zhang H Miao M Tang XF Zhu YZ Sui Y Li GW Sun HJ Yue JY Sun JQ Liu FF Zhou LQ Lei L Zheng XQ Liu M Huang L Song J Xu CH Li JW Ye KY Zhong SL Lu BR He GH Xiao FM Wang HL Zheng HK Fei ZJ Liu YS	2013	Nat Commun2013，4，：	1
20	Corticosteroid pharmacokinetice in the inner ear fluids:an animal study followed by clinical application显示文摘	Parnec IS Sun AH Freeman DJ	1999	Laryngoscope1999，109，：	1

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