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| 1 | Reaction environment self-modification on low-coordination Ni^(2+)octahedra atomic interface for superior electrocatalytic overall water splitting显示文摘Large scale synthesis of high-efficiency bifunctional electrocatalyst based on cost-effective and earth-abundant transition metal for overall water splitting in the alkaline environment is indispensable for renewable energy conversion.In this regard,meticulous design of active sites and probing their catalytic mechanism on both cathode and anode with different reaction environment at molecular-scale are vitally necessary.Herein,a coordination environment inheriting strategy is presented for designing low-coordination Ni^(2+)octahedra(L-Ni-8)atomic interface at a high concentration(4.6 at.%).Advanced spectroscopic techniques and theoretical calculations reveal that the self-matching electron delocalization and localization state at L-Ni-8 atomic interface enable an ideal reaction environment at both cathode and anode.To improve the efficiency of using the self-modification reaction environment at L-Ni-8,all of the structural features,including high atom economy,mass transfer,and electron transfer,are integrated together from atomic-scale to macro-scale.At high current density of 500 mA/cm2,the samples synthesized at gram-scale can deliver low hydrogen evolution reaction(HER)and oxygen evolution reaction(OER)overpotentials of 262 and 348 mV,respectively. | Kaian Sun Lei Zhao Lingyou Zeng Shoujie Liu Houyu Zhu Yanpeng Li Zheng Chen Zewen Zhuang Zhaoling Li Zhi Liu Dongwei Cao Jinchong Zhao Yunqi Liu Yuan Pan Chen Chen | 2020 | Nano Research2020，13，11： | 12 |
| 2 | Iron-group electrocatalysts for ambient nitrogen reduction reaction in aqueous media显示文摘Electrochemical nitrogen reduction reaction(NRR)is considered as an alternative to the industrial Haber-Bosch process for NH3 production due to both low energy consumption and environment friendliness.However,the major problem of electrochemical NRR is the unsatisfied efficiency and selectivity of electrocatalyst.As one group of the cheapest and most abundant transition metals,iron-group(Fe,Co,Ni and Cu)electrocatalysts show promising potential on cost and performance advantages as ideal substitute for traditional noble-metal catalysts.In this minireview,we summarize recent advances of iron-group-based materials(including their oxides,hydroxides,nitrides,sulfides and phosphides,etc.)as non-noble metal electrocatalysts towards ambient N2-to-NH3 conversion in aqueous media.Strategies to boost NRR performances and perspectives for future developments are discussed to provide guidance for the field of NRR studies. | Benyuan Ma Haitao Zhao Tingshuai Li Qian Liu Yongsong Luo Chengbo Li Siyu Lu Abdullah M.Asiri Dongwei Ma Xuping Sun | 2021 | Nano Research2021，14，3： | 8 |
| 3 | Porous LaFeO3 nanofiber with oxygen vacancies as an efficient electrocatalyst for N2 conversion to NH3 under ambient conditions显示文摘Electrocatalytic N2 reduction to NH3 under ambient conditions is an eco-friendly and sustainable alternative to the traditional Haber-Bosch process. However, inhibited by the high activation barrier of N2, this process needs efficient electrocatalysts to adsorb and activate the N2, enabling the N2 reduction reaction(NRR). Herein, we report that porous LaFeO3 nanofiber with oxygen vacancies acts as an efficient NRR electrocatalyst with abundant active sites to enhance the adsorption and activation of N2. When tested in 0.1 M HCl, such electrocatalyst achieves a high Faradaic efficiency of 8.77% and a large NH3 yield rate of 18.59 μg h–1 mgcat–1.at-0.55 V versus reversible hydrogen electrode. This catalyst also shows high long-term electrochemical stability and excellent selectivity for NH3 formation. Density functional theory calculations reveal that, by introducing oxygen vacancy on LaFeO3, the subsurface metallic ions are exposed with newly localized electronic states near the Fermi level, which facilitates the adsorption and activation of N2 molecules as well as the subsequent hydrogenation reactions. | Chengbo Li Dongwei Ma Shiyong Mou Yongsong Luo Benyuan Ma Siyu Lu Guanwei Cui Quan Li Qian Liu Xuping Sun | 2020 | Journal of Energy Chemistry2020，29，11： | 6 |
| 4 | Medicinal chemistry strategies towards the development of effective SARS-CoV-2 inhibitors显示文摘Novel therapies are urgently needed to improve global treatment of SARS-CoV-2 infection.Herein,we briefly provide a concise report on the medicinal chemistry strategies towards the development of effective SARS-CoV-2 inhibitors with representative examples in different strategies from the medicinal chemistry perspective. | Shenghua Gao Tianguang Huang Letian Song Shujing Xu Yusen Cheng Srinivasulu Cherukupalli Dongwei Kang Tong Zhao Lin Sun Jian Zhang Peng Zhan Xinyong Liu | 2022 | Acta Pharmaceutica Sinica B2022，12，2： | 5 |
| 5 | Enhancing electrocatalytic N_(2)-to-NH_(3) fixation by suppressing hydrogen evolution with alkylthiols modified Fe_(3)P nanoarrays显示文摘Electrocatalytic N_(2) reduction provides an attractive alternative to Haber-Bosch process for artificial NH_(3) synthesis.The difficulty of suppressing competing proton reduction,however,largely impedes its practical use.Herein,we design a hydrophobic octadecanethiol-modified Fe_(3)P nanoarrays supported on carbon paper(C18@Fe_(3)P/CP)to effectively repel water,concentrate N_(2),and enhance N_(2)-to-NH_(3) conversion.Such catalyst achieves an NH_(3) yield of 1.80×10^(-10) mol s^(-1)·cm^(-2) and a high Faradaic efficiency of 11.22%in 0.1 M Na_(2)SO_(4),outperforming the non-modified Fe_(3)P/CP(2.16×10^(-11) mol s^(-1)·cm^(-2),0.9%)counterpart.Significantly,C18@Fe_(3)P/CP renders steady Nrfixing activlty/selectivity in cycling test and exhibits durability for at least 25 h.First-principles calculations suggest that the surface electronic structure and chemical activity of Fe_(3)P can be well tuned by the thiol modification,which facilitates N_(2) electroreduction activity and catalytic formation of NH_(3). | Tong Xu Jie Liang Yuanyuan Wang Shaoxiong Li Zhaobai Du Tingshuai Li Qian Liu Yonglan Luo Fang Zhang Xifeng Shi Bo Tang Qingquan Kong Abdullah M.Asiri Chun Yang Dongwei Ma Xuping Sun | 2022 | Nano Research2022，15，2： | 4 |
| 6 | RP11-40C6.2 Inactivates Hippo Signaling by Attenuating YAP1 Ubiquitylation in Hepatitis B Virus-associated Hepatocellular Carcinoma显示文摘Background and Aims:Chronic hepatitis caused by hepatitis B virus(HBV)infection is a leading cause of hepatocellular carcinoma(HCC).We investigated the roles of oncogenic HBV infection-associated long noncoding RNAs in HCC.Methods:Bioinformatics analysis of data from the Cancer Genome Atlas(TCGA)was performed to screen potential oncogenic HBV-related lncRNAs.Next,we assessed their expression in clinical samples and investigated their correlation with clinical characteristics.The detailed oncogenic effects were analyzed by performing in vitro and in vivo studies.Results:RP11-40C6.2,an HBV infection-related lncRNA,was identified by analysis of the TCGA–Liver Hepatocellular Carcinoma database.Gene Set Enrichment Analysis and Kyoto Encyclopedia of Genes and Genomes(KEGG)enrichment analysis of differentially expressed genes revealed a strong association of RP11-40C6.2 with the Hippo signaling pathway.RP11-40C6.2 was overexpressed in HCC patients with HBV infection compared to those without HBV infection.RP11-40C6.2 transcription showed a positive association with HBV-X protein(HBx),but not HBV core protein(HBc)expression,both of which are carcinogenic proteins.Luciferase gene reporter and ChIP assays revealed that YAP1/TAZ/TEADs complex enhanced RP11-40C6.2 transcription by binding to its promoter area.RP11-40C6.2 showed oncogenic characteristics in HCC cell lines and in animal models that were mediated via activation of YAP1.In vitro ubiquitylation assay revealed that RP11-40C6.2 can promote the stabilization of YAP1 by stopping phosphorylation at its s127 residue and further stopping its degradation through binding to 14-3-3.Conclusions:RP11-40C6.2 is an HBV infection-related lncRNA that exerts its oncogenic effects by targeting the Hippo signaling pathway. | Han Zhuo Chen Wu Junwei Tang Feihong Zhang Zhenggang Xu Dongwei Sun Yue Teng Zhongming Tan | 2023 | Journal of Clinical and Translational Hepatology2023，11，2： | 3 |
| 7 | Superhydrophobic fluoride conversion coating on bioresorbable magnesium alloy——fabrication,characterization,degradation and cytocompatibility with BMSCs显示文摘A micro-nano structure CaF_(2)chemical conversion layer was prepared on fluoride-treated AZ31 alloy,then the composite fluoride conversion film(CaF_(2)/MgF_(2))was modified by stearic acid(SA)and fabricated a superhydrophobic surface.The fluoride-treated magnesium,fluoride conversion film and superhydrophobic coating were characterized by SEM,EDS,XRD and FTIR.The properties of coatings1 adhesion and corrosion resistance were evaluated via tape test and electrochemical measurement.The cytocompatibility of the MgF_(2),CaF_(2)and superhydrophobic CaF_(2)/SA surface was investigated with bone marrow-derived mesenchymal stem cells(BMSCs)by direct culture for 24 h.The results showed that the superhydrophobic fluoride conversion coating composed of inner MgF_(2)layer and the outer CaF_(2)/SA composite layer had an average water contact angle of 152°.SA infiltrated into the micro-nano structure CaF_(2)layer and formed a strong adhesion with CaF_(2)layer.Furthermore,the super-hydrophobic coating showed higher barrier properties and corrosion resistance compared with the fluoride conversion film and fluoride-treated AZ31 alloy.The BMSC adhesion test results demonstrated MgF_(2)CaF_(2)and CaF_(2)/SA coatings were all nontoxic to BMSC.At the condition of in direct contact with cells,MgF_(2)showed higher cell density and enhanced the BMSCs proliferation,while CaF_(2)and CaF_(2)/SA coating showed no statistically difference in cell density compared with glass reference but the CaF_(2)and CaF_(2)/SA coating were not conducive to BMSCs adhesion. | Chunyan Zhanga Shiyu Zhang Dongwei Sun Jiajia Lin Fancheng Meng Huinan Liu | 2021 | Journal of Magnesium and Alloys2021，9，4： | 3 |
| 8 | Validation results of NmF2 and hmF2 derived from ionospheric density profiles of GNOS on FY-3C satellite显示文摘The first Global Navigation Satellite System Occultation Sounder(GNOS) which is compatible of both Bei Dou System(BDS)and Global Positioning System(GPS) was successfully launched into orbit onboard the Feng Yun 3 C satellite(FY-3 C) on September 23, 2013, and it has already gathered a large amount of ionosphere radio occultation(RO) data so far. However, the detailed analysis and validation of GPS ionosphere RO data have not been done up to now. Therefore, this paper discusses the configuration of the FY-3 C GNOS, the methods and results of GPS ionosphere occultation processment, the quality analysis of the GPS ionosphere RO products, and the precision consistency between the GNOS GPS ionosphere RO product and ionosonde data. The peak electron density(Nm F2) correlation coefficient is 0.97, the corresponding standard deviation is 16.08%. The peak value altitude(hm F2) correlation coefficient is 0.89, and the corresponding standard deviation is 23.79 km. The in-orbit operation of GNOS provides a basis data set for the monitoring, forecasting and research of ionosphere's space weather. | YANG GuangLin SUN YueQiang BAI WeiHua ZHANG XiaoXin LIU CongLiang MENG XiangGuang BI YanMeng WANG DongWei ZHAO DanYang | 2018 | Science China(Technological Sciences)2018，61，9： | 2 |
| 9 | Recent developments in the medicinal chemistry of single boron atom-containing compounds显示文摘Various boron-containing drugs have been approved for clinical use over the past two decades,and more are currently in clinical trials.The increasing interest in boron-containing compounds is due to their unique binding properties to biological targets;for example,boron substitution can be used to modulate biological activity,pharmacokinetic properties,and drug resistance.In this perspective,we aim to comprehensively review the current status of boron compounds in drug discovery,focusing especially on progress from 2015 to December 2020.We classify these compounds into groups showing anticancer,antibacterial,antiviral,antiparasitic and other activities,and discuss the biological targets associated with each activity,as well as potential future developments. | Shu Song Ping Gao Lin Sun Dongwei Kang Jacob Kongsted Vasanthanathan Poongavanam Peng Zhan Xinyong Liu | 2021 | Acta Pharmaceutica Sinica B2021，11，10： | 1 |
| 10 | Recombinant human bone morphogenetic protein - 2 - induced ossification of the ligamen- tum flavum in rats and the associated global modification of histone H3 显示文摘 | HOU Xiaofei FAN Dongwei SUN Chuiguo | 2014 | Journal of Neurosurgery Spine2014，21，3： | 1 |
| 11 | The synthesis of chitosan-based silver nanoparticles and their antibacterial activity显示文摘 | Wei Dongwei Sun Wuyong Qian Weiping | 2009 | Carbohydrate Research2009，344，： | 1 |
| 12 | Cu_(2)Sb decorated Cu nanowire arrays for selective electrocatalytic CO_(2)to CO conversion显示文摘The advancement of cost-effective and selective electrocatalyst towards CO_(2) to CO conversion is crucial for renewable energy conversion and storage,thus to achieve carbon-neutral cycle in a sustainable manner.In this communication,we report that CujSb decorated Cu nanowire arrays on Cu foil act as a highly active and selective electrocatalyst for CO_(2) to CO conversion.In CO_(2)-saturated 0.1 M KHCO_(3),it achieves a high Faraday efficiency(FE)of 86.5%for CO,at-0.90 V vs.reversible hydrogen electrode(RHE).The H_(2)/CO ratio is tunable from 0.08:1 to 5.9:1 by adjusting the potential.It is worth noting that HCOO-product was totally suppressed on such catalyst,compared with Sb counterpart.The improving selectivity for CO could be attributed to the bimetallic effect and nanowire arrays structure. | Shiyong Mou Yonghao Li Luchao Yue Jie Liang Yonglan Luo Qian Liu Tingshuai Li Siyu Lu Abdullah M.Asiri Xiaoli Xiong Dongwei Ma Xuping Sun | 2021 | Nano Research2021，14，8： | 1 |
| 13 | In vitro evaluation of degradation,cytocompatibility and antibacterial property of polycaprolactone/hydroxyapatite composite coating on bioresorbable magnesium alloy显示文摘Polycaprolactone/hydroxyapatite(PCL/HA)composite coating was fabricated by a combination of hydrothermal and dipping methods to delay the degradation of Mg alloy AZ31 as bioresorbable materials.The PCL/HA coating was composed of nano rod-shape HA crystals and PCL filled in the space of HA crystals.Compared with the single HA coating,the binding strength between the PCL/HA composite coating and Mg alloy was obviously improved and the PCL/HA coating still adhered to the surface of AZ31 substrate even after 38 days of immersion.The electrochemical corrosion rate of HA coated sample was reduced by ten times after being filled by PCL.The electrochemical impedance spectroscopy(EIS)and immersion test results showed that the PCL/HA composite coating could provide a more effective barrier for Mg substrate than the HA coating alone.The cytocompatibility and the antibacterial property of HA coating and PCL/HA coating were evaluated by culturing with bone marrow-derived mesenchymal stem cells(BMSCs)and methicillin-resistant staphylococcus aureus(MRSA)for 24 h under direct culture conditions,respectively.The PCL/HA composite coating showed better BMSC cell compatibility,more suitable for BMSC adhesion than HA coating alone and showed a potential application prospect as a biological materials.However,from the perspective of clinical applications,the antibacterial property of PCL/HA composite coating needs to be further improved. | Zhang Chunyan Cheng Lan Lin Jiajia Sun Dongwei Zhang Jun Liu Huinan | 2022 | Journal of Magnesium and Alloys2022，10，8： | 1 |
| 14 | Numerical investigation on flow and heat transfer characteristics of corrugated tubes with non-uniform corrugation in turbulent flow显示文摘Based on finite volume method, the pressure drop and heat transfer characteristics of one smooth tube and ten different axisymmetric corrugated tubes, including two with uniform corrugation and eight with non-uniform corrugation, have been studied. A physical model of the corrugated tube was built, then the numerical simulation of the model was carried out and the numerical simulation results were compared with the empirical formula.The results show that: the friction factor decreases with the increase of Reynolds number ranging from 6000 to 57000, the value of which in the corrugated tubes with non-uniform corrugation(tube 03–10) are smaller than those with uniform corrugation(tube 01–02). The geometry parameters of tube(01) have advantages on the heat transfer enhancement in low Reynolds number flow region(from 6000 to 13000) and tube(07–08)have advantages on the heat transfer enhancement in high Reynolds number flow region(from 13000 to 57000). The vortex, existed in each area between two adjacent corrugations called second flow region, is the root of the enhancement on heat transfer in the corrugated tubes. The effectiveness factor decreases with the increasing of Reynolds number and the performances of the corrugated tubes with pitch of 12.5 mm have advantages than these of 10 mm under the same corrugation geometric parameter. | Dongwei Zhang Hanzhong Tao Yuan Xu Zishuai Sun | 2018 | Chinese Journal of Chemical Engineering2018，26，3： | 1 |
| 15 | The synthesis of chitosan-based silver nanoparticles and their antibacterial activity显示文摘 | Wei Dongwei Sun Wuyong Qian Weiping | 2009 | Carbohydrate Research2009，344，17： | 1 |
| 16 | Boronic acid-containing diarylpyrimidine derivatives as novel HIV-1NNRTIs: Design, synthesis and biological evaluation显示文摘Drug resistance remains to be a serious problem with type Ⅰ human immunodeficiency virus(HIV-1) nonnucleoside reverse transcriptase inhibitors(NNRTIs). A series of novel boronic acid-containing diarylpyrimidine(DAPY) derivatives were designed via bioisosterism and scaffold-hopping strategies,taking advantage of the ability of a boronic acid group to form multiple hydrogen bonds. The target compounds were synthesized and evaluated for their anti-HIV activities and cytotoxicity in MT-4 cells.Compound 10 j yielded the most potent activity and turned out to be a single-digit nanomolar inhibitor towards the HIV-1 ⅢB [wild-type(WT) strain], L100 I and K103 N strains, with 50% effective concentration(EC_(50)) values of 7.19–9.85 nmol/L. Moreover, 10 j inhibited the double-mutant strain RES056 with an EC_(50) value of 77.9 nmol/L, which was 3.3-more potent than that of EFV(EC_(50)= 260 nmol/L) and comparable to that of ETR(EC_(50)= 32.2 nmol/L). 10j acted like classical NNRTIs with high affinity for WT HIV-1 reverse transcriptase(RT) with 50% inhibition concentration(IC_(50)) value of 0.1837 μmol/L. Furthermore,molecular dynamics simulation indicated that 10 j was proposed as a promising molecule for fighting against HIV-1 infection through inhibiting RT activity. Overall, the results demonstrated that 10 j could serve as a lead molecule for further modification to address virus-drug resistance. | Da Feng Fenju Wei Yanying Sun Prem Prakash Sharma Tao Zhang Hao Lin Brijesh Rathi Erik De Clercq Christophe Pannecouque Dongwei Kang Peng Zhan Xinyong Liu | 2021 | Chinese Chemical Letters2021，32，12： | 1 |
| 17 | The synthesis of chitosan - based silver nanoparticles and their antibacteri- al activity 显示文摘 | Wei Dongwei Sun Wuyong Qian Weiping | 2009 | Carbohydrate Research2009，344，17： | 1 |
| 18 | The NAC transcription factor LuNAC61 negatively regulates fiber development in flax (Linum usitatissimum L.)显示文摘Flax is a crucial fiber crop that exhibits excellent textile properties and serves as a model plant for investigating phloem fiber development. The regulation of multiple genes significantly influences fiber development, notably involving NAC(NAM, ATAF1/2, CUC2) transcription factors in forming the fiber secondary cell wall(SCW).Overexpression of LuNAC61 in flax resulted in sparse top meristematic zone leaves and significantly reduced stem cellulose content. Scanning electron microscopy and staining observations revealed a significant reduction in fiber bundles. β-Glucuronidase(GUS) staining analysis demonstrated high activity of the LuNAC61 promoter in the bast fibers of the flax stem. Additionally, several members of the LuPLATZ and LuCesA families exhibited significant coexpression with LuNAC61. Subcellular localization indicated the presence of LuPLATZ24 protein in the nucleus and cytoplasm, LuNAC61 protein exclusively in the nucleus, and LuCesA10 in the nucleus and endoplasmic reticulum. LuPLATZ24 positively regulates LuNAC61, whereas LuNAC61 negatively affects LuCesA10, suggesting the involvement of a metabolic network in regulating flax fiber development. In conclusion, this study provides a critical opportunity for a comprehensive and in-depth analysis of the mechanisms governing flax fiber development and the potential use of biotechnology to enhance flax fiber yield. | Dongwei Xie Jing Li Wan Li Lijun Sun Zhigang Dai Wenzhi Zhou Jianguang Su Jian Sun | 2024 | Journal of Integrative Agriculture2024，23，3： | 0 |
| 19 | Medicinal chemistry strategies towards the development of non-covalent SARS-CoV-2 Mpro inhibitors显示文摘The main protease(M^(pro))of SARS-CoV-2 is an attractive target in anti-COVID-19 therapy for its high conservation and major role in the virus life cycle.The covalent M^(pro)inhibitor nirmatrelvir(in combination with ritonavir,a pharmacokinetic enhancer)and the non-covalent inhibitor ensitrelvir have shown efficacy in clinical trials and have been approved for therapeutic use.Effective antiviral drugs are needed to fight the pandemic,while non-covalent M^(pro)inhibitors could be promising alternatives due to their high selectivity and favorable druggability.Numerous non-covalent M^(pro)inhibitors with desirable properties have been developed based on available crystal structures of M^(pro).In this article,we describe medicinal chemistry strategies applied for the discovery and optimization of non-covalent M^(pro)inhibitors,followed by a general overview and critical analysis of the available information.Prospective viewpoints and insights into current strategies for the development of non-covalent M^(pro)inhibitors are also discussed. | Letian Song Shenghua Gao Bing Ye Mianling Yang Yusen Cheng Dongwei Kang Fan Yi Jin-Peng Sun Luis Menéndez-Arias Johan Neyts Xinyong Liu Peng Zhan | 2024 | Acta Pharmaceutica Sinica B2024，14，1： | 0 |
| 20 | Response of spatial structure of cotton root to soil-wetting patterns under mulched drip irrigation显示文摘The matching relationship between the spatial structure of cotton cluster root systems and soil-wetting patterns under mulched drip irrigation forms the theoretical basis for the technical design of mulched drip irrigation.A 2-year field experiment was conducted,in which different soil-wetting patterns were produced by setting different emitter discharge rates.The envelopes of cotton cluster root length densities were derived using the topological methodology and used to examine the effects of different soil-wetting patterns on the spatial structure of root systems and water uptake capacity within row spaces.The results showed that the root systems in rows of cotton grown under narrower and deeper soil-wetting patterns exhibited a single-peak distribution,while those under wider and shallower soil-wetting patterns exhibited a two-peak distribution.Furthermore,cotton rows grown near mulch edges experienced lower moisture stress,and wider and shallower soil-wetting patterns contributed to greater root growth rates in the vertical direction and resulted in more even potential water uptake capacities.The findings of this study revealed that wider and shallower soil-wetting patterns were more desirable for mulched drip irrigation of cotton and should be considered in the technical design of drip irrigation systems. | Dongwei Li Mingsi Li Xiaojun Shen Xinguo Zhou Hao Sun Yulong Zhao Wenjuan Chen | 2020 | International Journal of Agricultural and Biological Engineering2020，13，5： | 0 |
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