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21篇 您的检索式：作者名="Sun RQ"

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	题名	作者	年代	出处	被引量
1	High expression levels of IKK alpha and IKK beta are necessary for the malignant properties of liver cancer显示文摘IKK-NF-kappa B signaling is regarded as an important factor in hepatocarcinogenesis and a potential target for liver cancer therapy.Therefore,in this study,we analyzed the expression of mRNAs encoding components and targets of NF-kappa B signaling including IKK alpha,IKK beta,RANK,RANKL,OPG,CyclinD3,mammary serine protease inhibitor(Maspin),CyclinD1,c-FLIP,Bcl-x1,Stat3,Cip1 and Cip2 by real-time PCR in 40 patients with liver cancer.After statistical analysis,7 indices including IKK alpha,IKK beta,RANK,Maspin,c-FLIP,Cip2 and cyclinD1 were found to show significant differences between tumor tissue and its corresponding adjacent tissue.When IKK alpha and IKK beta were downregulated in the hepatocellular carcinoma(HCC) cell lines of MHCC-97L and MHCC-97H in vitro,the numbers of BrdU positive cells were decreased in both IKK alpha and IKK beta knockdown cells.Levels of apoptosis were also investigated in IKK alpha and IKK beta knockdown cells.The growth of HCC was inhibited in the subcutaneous implantation model,and lung metastatogenesis was also significantly inhibited in the kidney capsule transplantation model.Downregulation of IKK alpha and IKK beta in HCC cultured in vitro revealed that increased Maspin,OPG and RANKL expression was associated with metastasis of HCC.These findings were associated with downregulation of Bcl-XL and c-FLIP,which may be the reason for increased apoptosis.The therapeutic effect of IKK alpha and IKK beta downregulation depends on extent of NF-kappa B inhibition and the malignant nature of the HCC.We anticipate that IKK-targeted gene therapy can be used in the treatment of HCC,a cancer that is notoriously resistant to radiation and chemotherapy.	Jiang,RQ Xia,YX Li,J Deng,L Zhao,L Shi,J Wang,XH Sun,BC Nanjing Med Univ,Liver Transplantat Ctr,Affiliated Hosp 1,Nanjing,Jiangsu Prov,Peoples R China Nanjing Med Univ,Ctr Canc,Nanjing,Jiangsu Prov,Peoples R China	2010	南京医科大学学报(自然科学版)2010，30，5：	13
2	Temporal and spatial variability of soil organic matter and total nitrogen in an agricultural ecosystem as affected by farming practices显示文摘	Huang B Sun WX Zhao YC Zhu J Yang RQ Zou Z Ding F Su JP	2007	Geoderma2007，139，：	1
3	Calcitonin Gene-Related Peptide Receptor Activation Produces Pka-and Pkc-Dependent Mechanical Hyperalgesia and Central Sensitization 显示文摘	Sun RQ Tu YJ Lawand NB	2004	J Neurophysiol2004，92，：	1
4	Suppression of neuro- pathic pain by peripheral electrical stimulation in rats: mu-opioid receptor and NMDA receptor implicated 显示文摘	Sun RQ Wang HC Wan Y	2004	Experimental Neurology2004，187，：	1
5	Different Effect of Handle Region Peptide on β-Cell Function in Different Sexes of Rats Neonatally Treated with Sodium L-Glutamate 显示文摘	Wu YX Sun RQ Yin GS	2015	Med Sci Monit Basic Res2015，21，5：	1
6	Activation of protein kinase B/Akt signaling pathway contributes to mechanical hypersensi- tivity induced by capsaicin 显示文摘	Sun RQ Tu YJ Yan JY	2006	Pain2006，120，12：	1
7	Activation of protein kinase B/Akt sig-naling pathway contributes to mechanical hypersensitivity induced by capsaicin显示文摘	Sun RQ Tu YJ Yan JY	2006	Pain2006，120，1：	1
8	Restoration of autophagy al- leviates hepatic ER stress and impaired insulin signalling trans- duction in high fructose-fed male mice 显示文摘	Wang H Sun RQ Zeng XY	2015	Endocrinology2015，1，1：	1
9	The role of calcitonin gene-relat- ed peptide(CGRP) in the generation and maintenance of mechani- cal allodynia and hyperalgesiain rats after intradermal injection of capsaicin 显示文摘	Sun RQ Lawand NB Willis WD	2003	Pain2003，104，：	1
10	Temporal and spatial variability of soilorganic matter and total nitrogen in an agriculturalecosystem as affected by farming practices显示文摘	Huang B Sun WX Zhao YC Zhu J Yang RQ Zou Z Ding F Su JP	2007	Geoderma2007，139，33：	1
11	Calcitonin gene-related peptide receptor activation produces PKA- and PKC-dependent mechanical hyperalgesia and central sensitization显示文摘	Sun RQ Tu YJ Lawand NB	2004	Neurophysiology2004，92，5：	1
12	Calcitonin generelated peptide receptor activation produces PKA-and PKC-Dependent mechanical, hyperalgesia and central sensitization显示文摘	Sun RQ Tu Y J Lawand NB	2004	Neurophysiol2004，92，5：	1
13	Outbreak of porcine epidemic diarrhea in suckling piglets,China显示文摘	Sun RQ Cai R J Chen Y Q	2012	Emerg Infect Dis2012，18，1：	1
14	Restoration ofautophagy alleviates hepatic ER stress and impairedinsulin signalling transduction in high fructose-fed malemice显示文摘	Wang H Sun RQ Zeng XY	2015	Endocrinology2015，156，1：	1
15	Outbreak of por- cine epidemic diarrhea in suckling piglets, China 显示文摘	SUN RQ CAI R J CHEN YQ etal	2012	Emerg Infect Dis2012，18，1：	1
16	Outbreak of porcine epidemic diarrhea in suckling piglets, China显示文摘	Sun RQ Cai RJ Chen YQ	2012	Emerging Infectious Diseases2012，18，1：	1
17	Calcitonin gene-related peptide receptor activation produces PKA-and PKC-dependent mechanical hyperalgesia and central sensitization显示文摘	Sun RQ Tu YJ Lawand NB	2004	J Neurophysiol2004，92，5：	1
18	Calcitonin gene-related peptide receptor activation produces PKA- and PKC-dependent mechanical hyperalgesia and central sensitization显示文摘	Sun RQ Tu YJ Lawand NB	2004	J Neurophysiol2004，92，5：	1
19	Calcitonin gene-related peptide receptor activation produces PKA-and PKC-dependent mechanical hyperalgesia and central sensitization显示文摘	Sun RQ Tu YJ Lawand NB	2004	J Neurophysiol2004，92，：	1
20	The role of calcitonin gene- related peptide(CGRP) in the generation and maintenance of mechanical allodynia and hyperalgesia in rats after intradennal injection of capsaicin 显示文摘	Sun RQ Lawand NB Willis WD	2003	Pain2003，104，122：	1

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