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| 1 | Human neural stem cells promote proliferation of endogenous neural stem cells and enhance angiogenesis in ischemic rat brain显示文摘Transplantation of human neural stem cells into the dentate gyrus or ventricle of rodents has been reportedly to enhance neurogenesis. In this study, we examined endogenous stem cell proliferation and angiogenesis in the ischemic rat brain after the transplantation of human neural stem cells. Focal cerebral ischemia in the rat brain was induced by middle cerebral artery occlusion. Human neural stem cells were transplanted into the subventricular zone. The behavioral performance of human neural stem cells-treated ischemic rats was significantly improved and cerebral infarct volumes were reduced compared to those in untreated animals. Numerous transplanted human neural stem cells were alive and preferentially localized to the ipsilateral ischemic hemisphere. Furthermore, 5-bromo-2′-deoxyuridine-labeled endogenous neural stem cells were observed in the subventricular zone and hippocampus, where they differentiated into cells immunoreactive for the neural markers doublecortin, neuronal nuclear antigen Neu N, and astrocyte marker glial fibrillary acidic protein in human neural stem cells-treated rats, but not in the untreated ischemic animals. The number of 5-bromo-2′-deoxyuridine-positive ? anti-von Willebrand factor-positive proliferating endothelial cells was higher in the ischemic boundary zone of human neural stem cells-treated rats than in controls. Finally, transplantation of human neural stem cells in the brains of rats with focal cerebral ischemia promoted the proliferation of endogenous neural stem cells and their differentiation into mature neural-like cells, and enhanced angiogenesis. This study provides valuable insights into the effect of human neural stem cell transplantation on focal cerebral ischemia, which can be applied to the development of an effective therapy for stroke. | Sun Ryu Seung-Hoon Lee Seung U.Kim Byung-Woo Yoon | 2016 | Neural Regeneration Research2016，11，2： | 22 |
| 2 | Reinfection rate and endoscopic changes after successful eradication of Helicobacter pylori显示文摘AIM:To determine the long-term outcomes regarding reinfection with Helicobacter pylori(H.pylori)and endoscopic changes after successful H.pylori eradication. METHODS:From June 1994 to January 2007,186 patients(M:F=98:88;mean age 50.0±11.4 years), in whom H.pylori had been successfully eradicated, were enrolled.The mean duration of follow up was 41.2±24.0 mo. RESULTS:H.pylori reinfection occurred in 58 patients (31.2%).The average annual reinfection rate was 9.1% per patient year.No recurrence of peptic ulcer was detected at the follow up endoscopy.There were no significant differences between the H.pylori eradication regimens for the reinfection rate and no significant differences in endoscopic findings between the H.pylorirecurred group and the H.pylori-cured group.CONCLUSION:The reinfection rate in Korea is 9.1% which represents a decreasing trend.There was no relationship between H.pylori infection status and changes in endoscopic findings.There was also no recurrence or aggravation of ulcers. | Kum Hei Ryu Sun Young Yi Youn Ju Na Su Jung Baik Su Jin Yoon Hae-Sun Jung Hyun Joo Song | 2010 | World Journal of Gastroenterology2010，16，2： | 14 |
| 3 | Endoscopic submucosal tunnel dissection salvage technique for ulcerative early gastric cancer显示文摘Endoscopic submucosal dissection is an effective treatment modality for early gastric cancer(EGC), though the submucosal fibrosis found in ulcerative EGC is an obstacle for successful treatment. This report presents two cases of ulcerative EGC in two males, 73- and 80-year-old, with severe fibrosis. As endoscopic ultrasonography suggested that the EGCs had invaded the submucosal layer, the endoscopic submucosal tunnel dissection salvage technique was utilized for complete resection of the lesions. Although surgical gastrectomy was originally scheduled, the two patients had severe coronary heart disease, and surgeries were refused because of the risks associated with their heart conditions. The endoscopic submucosal tunnel dissection salvage technique procedures described in these cases were performed under conscious sedation, and were completed within 30 min. The complete en bloc resection of EGC using endoscopic submucosal tunnel dissection salvage technique was possible with a free resection margin, and no other complications were noted during the procedure. This is the first known report concerning the use of the endoscopic submucosal tunnel dissection salvage technique salvage technique for treatment of ulcerative EGC. We demonstrate that endoscopic submucosal tunnel dissection salvage technique it is a feasible method showing several advantages over endoscopic submucosal dissection for cases of EGC with fibrosis. | Hyuk Soon Choi Hoon Jai Chun Min Ho Seo Eun Sun Kim Bora Keum Yeon Seok Seo Yoon Tae Jeen Hong Sik Lee Soon Ho Um Chang Duck Kim Ho Sang Ryu | 2014 | World Journal of Gastroenterology2014，20，27： | 8 |
| 4 | Controlling hypoxia-inducible factor-2α is critical for maintaining bone homeostasis in mice显示文摘Pathological bone loss is caused by an imbalance between bone formation and resorption.The bone microenvironments are hypoxic,and hypoxia-inducible factor (HIF) is known to play notable roles in bone remodeling.However,the relevant functions of HIF-2α are not well understood.Here,we have shown that HIF-2α deficiency in mice enhances bone mass through its effects on the differentiation of osteoblasts and osteoclasts.In vitro analyses revealed that HIF-2α inhibits osteoblast differentiation by targeting Twist2 and stimulates RANKL-induced osteoclastogenesis via regulation of Traf6.In addition,HIF-2α appears to contribute to the crosstalk between osteoblasts and osteoclasts by directly targeting RANKL in osteoprogenitor cells.Experiments performed with osteoblast- and osteoclast-specific conditional knockout mice supported a role of HIF-2α in this crosstalk.HIF-2α deficiency alleviated ovariectomy-induced bone loss in mice,and specific inhibition of HIF-2α with ZINC04179524 significantly blocked RANKLmediated osteoclastogenesis.Collectively,our results suggest that HIF-2α functions as a catabolic regulator in bone remodeling,which is critical for the maintenance of bone homeostasis. | Sun Young Lee Ka Hyon Park Hyung-Gu Yu Eunbyul Kook Won-Hyun Song Gyuseok Lee Jeong-Tae Koh Hong-In Shin Je-Yong Choi Yun Hyun Huh Je-Hwang Ryu | 2019 | Bone Research2019，7，2： | 5 |
| 5 | Microbiology and risk factors for gram-positive Cocci bacteremia in biliary infections显示文摘Background:The rapid antibiotics treatment targeted to a specific pathogen can improve clinical outcomes of septicemia.We aimed to evaluate the clinical characteristics and outcomes of biliary septicemia caused by cholangitis or cholecystitis according to causative organisms.Methods:We performed a retrospective cohort study in 151 patients diagnosed with cholangitis or cholecystitis with bacterial septicemia from January 2013 to December 2015.All patients showed clinical evidence of biliary tract infection and had blood isolates that demonstrated septicemia.Results:Gram-negative,gram-positive,and both types of bacteria caused 84.1%(127/151),13.2%(20/151),and 2.6%(4/151)episodes of septicemia,respectively.The most common infecting organisms were Escherichia coli among gram-negative bacteria and Enterococcus species(Enterococcus casseliflavus and Enterococcus faecalis)among gram-positive bacteria.There were no differences in mortality,re-admission rate,and need for emergency decompression procedures between the gram-positive and gram-negative septicemia groups.In univariate analysis,previous gastrectomy history was associated with gram-positive bacteremia.Multivariate analysis also showed that previous gastrectomy history was strongly associated with gram-positive septicemia(Odds ratio=5.47,95%CI:1.19–25.23;P=0.029).Conclusions:Previous gastrectomy history was related to biliary septicemia induced by gram-positive organisms.This information would aid the choice of empirical antibiotics. | Ik Hyun Jo Yeon-Ji Kim Woo Chul Chung Jaeyoung Kim Seonhoo Kim Eun Sun Lim Honggeun Ahn Seong Yul Ryu | 2020 | Hepatobiliary & Pancreatic Diseases International2020，19，5： | 4 |
| 6 | Korean red ginseng promotes hippocampal neurogenesis in mice显示文摘Neurogenesis in the adult hippocampus plays a major role in cognitive ability of animals including learning and memory.Korean red ginseng (KRG) has long been known as a medicinal herb with the potential to improve learning and memory;however,the mechanisms are still elusive.Therefore,we evaluated whether KRG can promote cognitive function and enhance neurogenesis in the hippocampus.Eight-week-old male C57BL/6 mice received 50 mg/kg of 5-bromo-2′-deoxyuridine (BrdU) intraperitoneally and 100 mg/kg of KRG or vehicle orally once a day for 14 days.Pole,Rotarod and Morris water maze tests were performed and the brains were collected after the last behavioral test.Changes in the numbers of BrdU- and BrdU/ doublecortin (DCX;a marker for neuronal precursor cells and immature neurons)-positive cells in the dentate gyrus and the gene expression of proliferating cell nuclear antigen (a marker for cell differentiation),cerebral dopamine neurotrophic factor and ciliary neurotrophic factor in the hippocampus were then investigated.KRG-treated mice came down the pole significantly faster and stood on the rotarod longer than vehicle-treated mice.The Morris water maze test showed that KRG administration enhanced the learning and memory abilities significantly.KRG also significantly increased BrdU- and BrdU/DCX-positive cells in the dentate gyrus as well as the proliferating cell nuclear antigen,cerebral dopamine neurotrophic factor and ciliary neurotrophic factor mRNA expression levels in the hippocampus compared to vehicle.Administration of KRG promotes learning and memory abilities,possibly by enhancing hippocampal neurogenesis.This study was approved by the Pusan National University Institutional Animal Care and Use Committee (approval No.PNU-2016-1071) on January 19,2016. | Sun Ryu Hyongjun Jeon Hee-Young Kim Sungtae Koo Seungtae Kim | 2020 | Neural Regeneration Research2020，15，5： | 4 |
| 7 | Cytomegalovirus ileitis in an immunocompetent elderly adult显示文摘Cytomegalovirus 肠炎最通常与为人的免疫不全病毒积极的病人被联系或免疫镇压了 transplant 病人。胃肠道可以从食管被影响在任何地方到冒号,但是小肠参与是稀罕的。我们在一个免疫能力的成年人报导 cytomegalovirus 回肠炎的一个案例,它被组织病理学说的调查结果通过 colonoscopic 活体检视证实。 | Kum Hei Ryu Sun Young Yi | 2006 | World Journal of Gastroenterology2006，12，31： | 3 |
| 8 | Serial blood concentration of polyethoxylated tallow amine and clinical presentations in acute herbicide poisoning显示文摘Most commercially available herbicides contain surfactants as co-formulants to increase adhesion and absorption by plant leaves.Ethoxylated amines,one of the most used surfactants,are non-ionic and derived from animal fats.They represent a class of surfactants with similar structural features,including polyethoxylated tallow amine(POEA).POEA is widely used in glyphosate,glufosinate-containing herbicides.In 2015,the European Food Safety Society(EFSA)concluded that POEA was more toxic than glyphosate when tested in glyphosate-based formulations.[1]They also attributed the poisoning following ingestion by humans to the presence of POEA. | Jungsoo Park Sun Cheun Kim Youngjoon Jeon Yong Chul Cho Changshin Kang Yeonho You Hong Joon Ahn Seung Ryu Jihan Lee Wonjoon Jeong | 2022 | World Journal of Emergency Medicine2022，13，4： | 2 |
| 9 | In vitro anti-rotavirus activity of polyphenol compounds isolated from the roots of Glycyrrhiza uralensis显示文摘 | Hyung-Jun Kwon Ha-Hyun Kim Young Bae Ryu Jang Hoon Kim Hyung Jae Jeong Seung-Woong Lee Jong Sun Chang Kyoung-Oh Cho Mun-Chual Rho Su-Jin Park Woo Song Lee | 2010 | Bioorganic & Medicinal Chemistry2010，，21： | 2 |
| 10 | Ginkgo biloba extract enhances antiplatelet and antithrombotic effects of cilostazol without prolongation of bleeding time显示文摘 | Keun Ho Ryu Hye Young Han So Young Lee Sun Duck Jeon Guang-Jin Im Bong Yong Lee Keunyoung Kim Kyung-Min Lim Jin-Ho Chung | 2009 | Thrombosis Research2009，，3： | 2 |
| 11 | N-terminal pro-B-type natriuretic peptide as prognostic marker for patients of non ST-segment elevation myocardial infarction显示文摘In this work, we analyzed only the patients of the NSTEMI (non ST-segment elevation myocardial infarction) who arrived at the hospital within 12 h after symptoms started. Using NSTEMI follow-up data within, the characteristics of the clinical data, the risk factor, and the blood tested in the hospital visit were analyzed for MACE (major adverse cardiac events) patients. MACE includes cardiac death, MI (myocardial infarction), Re-PCI, and CABG (coronary artery bypass graft). As a result, from the NSTEMI patients which can be followed up for over 12 m, NT-ProBNP (p=0.014) and age (p=0.045) are found to be the independent risk factors related to MACE. Accordingly, they can be useful for the diagnosis and prognosis for NSTEMI patients as a biomarker. | SHON Ho Sun HWANG Kyung Kuk BAE Jang Whan KIM Kyung Ah LEE Jong Yun RYU Keun Ho | 2013 | Journal of Central South University2013，20，8： | 2 |
| 12 | Symmetric redox supercapacitor with conducting polyaniline electrodes显示文摘 | Kwang Sun Ryu Kwang Man Kim Nam-Gyu Park Yong Joon Park Soon Ho Chang | 2002 | Journal of Power Sources2002，，2： | 2 |
| 13 | Heteroatom substitution-induced asymmetric A–D–A type non-fullerene acceptor for efficient organic solar cells显示文摘Research on asymmetric A–D–A structured non-fullerene acceptors has lagged far behind the development of symmetric counterpart.In this contribution,by simply replacing one sulfur atom in indacenodithiophene unit with a selenium atom,an asymmetric building block Se PT and a corresponding asymmetric non-fullerene acceptor Se PT-IN have been developed.Asymmetric Se PT-IN achieved a high efficiency of 10.20% in organic solar cells when blended with PBT1-C,much higher than that of symmetric TPT-IN counterpart(8.91%).Our results demonstrated an effective heteroatom substitution strategy to develop asymmetric A–D–A structured non-fullerene acceptors. | Chao Lia Jiali Song Yunhao Cai Guangchao Han Wenyu Zheng Yuanping Yi Hwa Sook Ryu Han Young Woo Yanming Sun | 2020 | Journal of Energy Chemistry2020，29，1： | 2 |
| 14 | Plasma transforming growth factor-β_1 levels in patients with erectile dysfunction显示文摘Aim: To evaluate the plasma TGF-β1 level in erectile dysfunction (ED) patients of various causes. Methods:Sixty-two patients with ED and 26 potent men were subjected to the study. Based on multidisciplinary work-ups,including medical history, physical examinations, blood tests with lipid profile and hormones, penile duplex Doppler ultrasonogram and neurophysiological tests, causes for ED were classified as psychogenic (n= 15), neurogenic (n=16)and vasculogenic (n=31). The plasma TGF-β1 level was measured by the ELISA method. Results: The plasma TGF-β1 level was significantly increased in the ED group (6.7±4.9 ng/mL), compared to the control (4.0±2.1 ng/mL) (P<0.01). In the ED groups, there was a significant increase in the vasculogenic group (9.0±5.5 ng/mL), compared to the psychogenic (3.8±1.8 ng/mL) and neurogenic groups (4.8±3.2 ng/mL) (P<0.01). Of the vascular risk factors,both the smoking (7.5±4.7 ng/mL) and dyslipidemia groups (7.4±4.4 ng/mL) showed significantly increased plasma TGF-β1 levels, compared to the non-smokers (5.5±2.8 ng/mL), and those without dyslipidemia (4.8±2.8ng/mL) (P<0.05). Conclusion: Vascular risk factors are associated with an elevated plasma TGF-β1 level, which may contribute to cavernous fibrosis and ED. (Asian J Androl 2004 Dec; 6: 349-353) | Ji-Kan Ryu Sun U.Song Hyung-Ki Choi Do-Hwan Seong Sang-Min Yoon Seong-Jin Kim Jun-Kyu Suh | 2004 | Asian Journal of Andrology2004，6，4： | 2 |
| 15 | Activation of macrophages by polysaccharide isolated from Paecilomyces cicadae through toll-like receptor 4显示文摘 | Hyung Sook Kim Yeon Jin Kim Hong Kyung Lee Hwa Sun Ryu Ji Sung Kim Mi Jung Yoon Jong Soon Kang Jin Tae Hong Youngsoo Kim Sang-Bae Han | 2012 | Food and Chemical Toxicology2012，，9： | 1 |
| 16 | An Activity of Lowering Blood-glucose Levels According to Preparative Condition of Silkworm Powder显示文摘 | Kang Sun Ryu Heui Sam Lee Sung Hyun Chung | 1997 | Koeran J Seric Sci1997，39，1： | 1 |
| 17 | Comparison of lithium//polyaniline secondary batteries with different dopants of HC1 and lithium ionic salts显示文摘 | Kwann Sun Ryu Kwann Man Kim Seong-Gu Kang Jinsoo Joo Soon Ho Chang | 2000 | Journal of Power Sources2000，88，2： | 1 |
| 18 | Polyaniline doped with dimethyl sul?fate as a nucleophilic dopant and its electrochemical proper?ties as an electrode in a lithium secondary battery and a re?dox supercapacitor显示文摘 | Kwang Sun Ryu et a1 | 2007 | J Phys Chern B2007，111，： | 1 |
| 19 | An Activity,of,Lowering Blood-glucose Levels According to Preparative Condi-tion of Silkworm Powder显示文摘 | Kang Sun Ryu Heui Sam Lee Sung Hyun Chung | 1997 | Koeran J Seric Sci1997，39，1： | 1 |
| 20 | A randomized, prospective trial on efficacy and tolerability of low-volume bowel preparation methods for colonoscopy显示文摘 | In Kyung Yoo Jong Soo Lee Hoon Jai Chun Yoon Tae Jeen Bora Keum Eun Sun Kim Hyuk Soon Choi Jae Min Lee Seung Han Kim Seung Joo Nam Hyo Sung Kang Hong Sik Lee Chang Duck Kim Soon Ho Um Yeon Seok Seo Ho Sang Ryu | 2014 | Digestive and Liver Disease2014，，： | 1 |
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