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| 1 | Discovery of biclonal origin and a novel oncogene SLC12A5 in colon cancer by single-cell sequencing显示文摘单个房间的定序是为描出的一个强大的工具为个性化的癌症管理的同种细胞的关系和识别关键司机基因。这里,我们执行了结肠癌的一个盒子的单个房间的定序的分析。人口遗传分析在肿瘤房间人口识别了二独立克隆。主要肿瘤克隆作为早 oncogenic 事件怀有 APC 和 TP53 变化,而次要的克隆包含了优势的 CDC27 和 PABPC1 变化。在这二克隆的次要的克隆支持的 APC 和 TP53 变化的缺席从二细胞的起源被导出。体的变化等位基因频率系列的检查另外 21 个整个织物的定序 exome 的盒子在结肠癌揭示了同种细胞的起源的异质。下次,我们识别了在单个房间的水平显示出变化的高频率,但是在人口水平展出了低流行的变异的基因 SLC12A5。变异的 SLC12A5 的功能的描述在结肠癌揭示了它的潜在的 oncogenic 效果。我们的学习在单个房间的水平支持提供第一条 exome 宽的证据那结肠癌能具有 biclonal 起源,并且建议在一个队的低流行的变化可以也在单个水平起重要 protumorigenic 作用。 | Chang Yu Jun Yu Xlaotlan Yao Wllham KK Wu Youyong Lu Senwel Tang Xiangchun Li Li Bao Xiaoxing Li Yong Hou Renhua Wu Min Jian Ruoyan Chen Fan Zhang Lixia Xu Fan Fan Jun He Qiaoyi Liang Hongyi Wang Xueda Hu Minghui He Xiang Zhang Hancheng Zheng Qibin Li Hanjie Wu Yan Chen Xu Yang Shida Zhu Xun Xu Huanming Yang Jian Wang Xiuqing Zhang Joseph JY Sung Yingrui Li Jun Wang | 2014 | Cell Research2014，，6： | 16 |
| 2 | Association of chronic viral hepatitis B with insulin resistance显示文摘AIM:To investigate the relationship between chronic viral hepatitis B(CVHB) and insulin resistance(IR) in Korean adults.METHODS:A total of 7880 adults(3851 men,4029 women) who underwent a comprehensive medical examination were enrolled in this study.Subjects diagnosed with either diabetes mellitus,or any other disorder that could influence their insulin sensitivity,were rejected.Anthropometry,metabolic risk factors,hepatitis B surface antigen,hepatitis B surface antibody,hepatitis B core antibody,fasting plasma glucose and insulin were measured for all subjects.Homeostasis model assessment(HOMA),quantitative insulin check index(QUICKI),and Mf fm index were used for determining insulin sensitivity.Each participant was categorized into a negative,recovery,or CVHB group.To compare variables between groups,a t-test and/or one-way analysis of variance were used.Partial correlation coefficients were computed to present the association between insulin resistance and other variables.Multiple logistic regression analysis was used to assess the independent association between CVHB and IR.RESULTS:The mean age of men and women were 48.9 and 48.6 years,respectively.Subjects in the CVHB group had significantly higher waist circumference [(86.0 ± 7.7 cm vs 87.3 ± 7.8 cm,P = 0.004 in men),(78.3 ± 8.6 cm vs 80.5 ± 8.5 cm,P < 0.001 in women)],cystatin C [(0.96 ± 0.15 mg/dL vs 1.02 ± 0.22 mg/dL,P < 0.001 in men),(0.84 ± 0.15 mg/dL vs 0.90 ± 0.16 mg/dL,P < 0.001 in women)],fasting insulin [(5.47 ± 3.38 U/mL vs 6.12 ± 4.62 U/mL,P < 0.001 in men),(4.57 ± 2.82 U/mL vs 5.06 ± 3.10 U/mL,P < 0.001 in women)] and HOMA index [(1.24 ± 0.86 vs 1.43 ± 1.24,P < 0.001 in men),(1.02 ± 0.76 vs 1.13 ± 0.87,P = 0.033 in women)] compared to control group.The HOMA index revealed a positive correlation with body mass index(BMI)(r = 0.378,P < 0.001),waist circumference(r =0.356,P < 0.001),percent body fat(r = 0.296,P < 0.001),systolic blood pressure(r = 0.202,P < 0.001),total cholesterol(r = 0.134,P < 0.001),triglycerides(r = 0.292,P < 0.001),cystatin C(r = 0.069,P < 0.001) and uric acid(r = 0.142,P < 0.001).The QUICKI index revealed a negative correlation with BMI(r =-0.254,P < 0.001),waist circumference(r = 0-0.243,P < 0.001),percent body fat(r =-0.217,P < 0.001),systolic blood pressure(r =-0.132,P < 0.001),total cholesterol(r =-0.106,P < 0.001),triglycerides(r =-0.205,P < 0.001),cystatin C(r =-0.044,P < 0.001) and uric acid(r =-0.096,P < 0.001).For subjects identified with IR,the odds ratio of an accompanying diagnosis of chronic hepatitis B was 1.534(95% CI:1.158-2.031,HOMA index criteria) or 1.566(95% CI:1.124-2.182,QUICKI criteria) after adjustment for age,gender,BMI,and amount of alcohol consumption.CONCLUSION:Our study demonstrates that CVHB is associated with IR.CVHB may need to be monitored for occurrence of IR and diabetes mellitus. | Jeong Gyu Lee Sangyeoup Lee Yun Jin Kim Byung Mann Cho Joo Sung Park Hyung Hoi Kim JaeHun Cheong Dong Wook Jeong Yu Hyun Lee Young Hye Cho Mi Jin Bae Eun Jung Choi | 2012 | World Journal of Gastroenterology2012，18，42： | 10 |
| 3 | Three-Tesla magnetic resonance elastography for hepatic fibrosis:Comparison with diffusion-weighted imaging and gadoxetic acid-enhanced magnetic resonance imaging显示文摘AIM:To evaluate the feasibility of 3-Tesla magnetic resonance elastography(MRE)for hepatic fibrosis and to compare that with diffusion-weighted imaging(DWI)and gadoxetic acid-enhanced magnetic resonance(MR)imaging.METHODS:Forty-two patients were included in the study.On MRE,mean stiffness values were measured on the elastograms in kilopascals.The apparent diffusion coefficient(ADC)of the liver was measured using DWI.On gadoxetic acid enhanced MR,the contrast enhancement index(CEI)was calculated as signal intensity(SI)post/SIpre,where SIpost is liver-to-muscle SI ratio on hepatobiliary phase images and SIpre is that on nonenhanced images.Correlation between aspartate aminotransferase to the platelet ratio index(APRI)and three MR parameters was assessed.Each MR parameter was compared between a hepatic fibrosis(HF)group and non-hepatic fibrosis(n HF)group.RESULTS:Liver stiffness showed strong positive correlation with APRI[Spearman correlation coeffiecient(r)=0.773,P<0.0001],while ADC and CEI showed weak or prominent negative correlation(r=-0.28 and-0.321,respectively).In the HF group,only liver stiffness showed strong correlation with APRI(r=0.731,P<0.0001).Liver stiffness,ADC,and APRI were significantly different between the HF group and n HF group.CONCLUSION:MRE at 3-Tesla could be a feasible method for the assessment of hepatic fibrosis. | Hee Sun Park Young Jun Kim Mi Hye Yu Won Hyeok Choe Sung Il Jung Hae Jeong Jeon | 2014 | World Journal of Gastroenterology2014，20，46： | 9 |
| 4 | Benign gallbladder diseases:Imaging techniques and tips for differentiating with malignant gallbladder diseases显示文摘Benign gallbladder diseases usually present with intraluminal lesions and localized or diffuse wall thickening.Intraluminal lesions of the gallbladder include gallstones,cholesterol polyps,adenomas,or sludge and polypoid type of gallbladder cancer must subsequently be excluded.Polyp size,stalk width,and enhancement intensity on contrast-enhanced ultrasound and degree of diffusion restriction may help differentiate cholesterol polyps and adenomas from gallbladder cancer.Localized gallbladder wall thickening is largely due to segmental or focal gallbladder adenomyomatosis,although infiltrative cancer may present similarly.Identification of Rokitansky-Aschoff sinuses is pivotal in diagnosing adenomyomatosis.The layered pattern,degree of enhancement,and integrity of the wall are imaging clues that help discriminate innocuous thickening from gallbladder cancer.High-resolution ultrasound is especially useful for analyzing the layering of gallbladder wall.A diffusely thickened wall is frequently seen in inflammatory processes of the gallbladder.Nevertheless,it is important to check for coexistent cancer in instances of acute cholecystitis.Ultrasound used alone is limited in evaluating complicated cholecystitis and often requires complementary computed tomography.In chronic cholecystitis,preservation of a two-layered wall and weak wall enhancement are diagnostic clues for excluding malignancy.Magnetic resonance imaging in conjunction with diffusion-weighted imaging helps to differentiate xathogranulomatous cholecystitis from gallbladder cancer by identifying the presence of fat and degree of diffusion restriction.Such distinctions require a familiarity with typical imaging features of various gallbladder diseases and an understanding of the roles that assorted imaging modalities play in gallbladder evaluations. | Mi Hye Yu Young Jun Kim Hee Sun Park Sung Il Jung | 2020 | World Journal of Gastroenterology2020，26，22： | 9 |
| 5 | Assessing significant fibrosis using imaging-based elastography in chronic hepatitis B patients: Pilot study显示文摘BACKGROUND Accurate detection of significant fibrosis(fibrosis stage 2 or higher on the METAVIR scale)is important especially for chronic hepatitis B(CHB)patients with high viral loads but with normal or mildly elevated alanine aminotransferase(ALT)levels because the presence of significant fibrosis is accepted as the indication for antiviral treatment.Liver biopsy is the reference standard for diagnosing significant fibrosis,but it is an invasive procedure.Consequently,noninvasive imaging-based measurements,such as magnetic resonance elastography(MRE)or two-dimensional shear-wave elastography(2DSWE),have been proposed for the quantitative assessment of liver fibrosis.AIM To explore MRE and 2D-SWE to identify fibrosis stage,and to compare their performance with that of serum-based indices.METHODS The study enrolled 63 treatment-na?ve CHB patients with high viral loads but with normal or mildly elevated ALT levels who underwent liver biopsy before a decision was made to initiate antiviral therapy.MRE and 2D-SWE were performed,and serum-based indices,such as FIB-4 and aspartate transaminase to platelet ratio index(APRI),were calculated.The diagnostic performances of MRE,2D-SWE,FIB-4,and APRI for assessing significant fibrosis(≥F2)and cirrhosis(F4)were evaluated with liver histology as the reference standard,using receiver operating characteristic analyses.RESULTS The liver fibrosis stage was F0/F1 in 19,F2 in 14,F3 in 14,and F4 in 16 patients,respectively.MRE significantly discriminated F2 from F0/1(P=0.022),whereas 2D-SWE showed a broad overlap in distinguishing those stages.MRE showed a higher correlation coefficient value with fibrosis stage than 2D-SWE with fibrosis stage(0.869 vs 0.649,Spearman test;P<0.001).Multivariate linear regression analyses showed that fibrosis stage was the only factor affecting the values of MRE(P<0.001),whereas body mass index(P=0.042)and fibrosis stage(P<0.001)were independent factors affecting 2D-SWE values.MRE performance for diagnosing significant fibrosis was better[area under the curve(AUC)=0.906,positive predictive value(PPV)97.3%,negative predictive value(NPV)69.2%]than that of FIB-4(AUC=0.697,P=0.002)and APRI(AUC=0.717,P=0.010),whereas the performance of 2D-SWE(AUC=0.843,PPV 86%,NPV 65%)was not significantly different from that of FIB-4 or APRI.CONCLUSION Compared to SWE,MRE might be more precise non-invasive assessment for depicting significant fibrosis and for making-decision to initiate antiviral-therapy in treatment-na?ve CHB patients with normal or mildly-elevated ALT levels. | Hee Sun Park Won Hyeok Choe Hye Seung Han Mi Hye Yu Young Jun Kim Sung Il Jung Jeong Han Kim So Young Kwon | 2019 | World Journal of Gastroenterology2019，25，25： | 7 |
| 6 | Recent Progress and Development in Extrusion of Rare Earth Free Mg Alloys: A Review显示文摘Mg and its alloys are the lightest structural metals available and are extremely attractive for applications as lightweight components, particularly in the automobile, electronic, and aerospace industries. The global market for wrought Mg alloys has steadily expanded over the past decade. And numerous studies have been carried out to meet this increasing demand of high-performance Mg alloys. However, Mg extrusion alloys have had a very limited usage so far. To overcome existing industrial challenges, one desirable approach is the development of low-cost rare earth(RE) free Mg extrusion alloys with superior mechanical properties. This review will introduce the recent research highlights in the extrusion of Mg alloys, specifi cally focusing on low-cost RE-free Mg alloy. The results from both the literature and our previous study are summarized and critically reviewed. Several aspects of RE-free Mg extrusion alloys are described in detail:(1) novel alloying designs including Mg–Al-, Mg–Zn-, Mg–Ca-, Mg–Sn-, and Mg–Bi-based alloys,(2) advanced extrusion techniques, and(3) extrusion-related severe plastic deformation(SPD) processing. Accordingly, considering the large gap in mechanical properties between the current RE-free Mg alloys and high-performance aluminum alloys, new alloy design, processing route control, and recommendations for future research on RE-free Mg extrusion alloys are also proposed. We hope this review will not only off er insightful information regarding the extrusion of RE-free Mg alloys but also inspire the development of new Mg extrusion technologies. | Shuai-Ju Meng Hui Yu Shao-Da Fan Qi-Zhi Li Sung Hyuk Park Joung Sik Suh Young Min Kim Xiao-Long Nan Ming-Zhe Bian Fu-Xing Yin Wei-Min Zhao Bong Sun You Kwang Seon Shin | 2019 | Acta Metallurgica Sinica(English Letters)2019，32，2： | 6 |
| 7 | Endoscopic and clinicopathologic characteristics of early gastric cancer with high microsatellite instability显示文摘AIM:To investigate endoscopic and clinicopathologic characteristics of early gastric cancer (EGC) according to microsatellite instability phenotype.METHODS:Data were retrospectively collected from a single tertiary referral center.Of 981 EGC patients surgically treated between December 2003 and October 2007,73 consecutive EGC patients with two or more microsatellite instability (MSI) mutation [high MSI (MSI-H)] and 146 consecutive EGC patients with one or no MSI mutation (non-MSI-H) were selected.The endoscopic and clinicopathologic features were compared between the MSI-H and non-MSI-H EGC groups.RESULTS:In terms of endoscopic characteristics,MSI-H EGCs more frequently presented with elevated pattern (OR 4.38,95% CI:2.40-8.01,P < 0.001),moderateto-severe atrophy in the surrounding mucosa (OR 1.91,95% CI:1.05-3.47,P = 0.033),antral location (OR 3.99,95% CI:2.12-7.52,P < 0.001) and synchronous lesions,compared to non-MSI-H EGCs (OR 2.65,95% CI:1.16-6.07,P = 0.021).Other significant clinicopathologic characteristics of MSI-H EGC included predominance of female sex (OR 2.77,95% CI:1.53-4.99,P < 0.001),older age (> 70 years) (OR 3.30,95% CI:1.57-6.92,P = 0.002),better histologic differentiation (OR 2.35,95% CI:1.27-4.34,P = 0.007),intestinal type by Lauren classification (OR 2.34,95% CI:1.15-4.76,P = 0.019),absence of a signet ring cell component (OR 2.44,95% CI:1.02-5.86,P = 0.046),presence of mucinous component (OR 5.06,95% CI:1.27-20.17,P = 0.022),moderate-to-severe lymphoid stromal reaction (OR 3.95,95% CI:1.59-9.80,P = 0.003),and co-existing underlying adenoma (OR 2.66,95% CI:1.43-4.95,P = 0.002).CONCLUSION:MSI-H EGC is associated with unique endoscopic and clinicopathologic characteristics including frequent presentation in protruded type,co-existing underlying adenoma,and synchronous lesions. | Jaehoon Jahng Young Hoon Youn Kwang Hyun Kim Junghwan Yu Yong Chan Lee Woo Jin Hyung Sung Hoon Noh Hyunki Kim Hoguen Kim Hyojin Park Sang In Lee | 2012 | World Journal of Gastroenterology2012，18，27： | 6 |
| 8 | Spindle-like FeySs/N-doped carbon nanohybrids for high-performance sodium ion battery anodes显示文摘Iron sulfides have bee n con sidered as one of the most promising can didates for sodium ion battery anode materials due to their high theoretical capacity and low cost. I n this work, spin dle-like Fe7S8 with n itroge rvdoped carb on (FeiS/N-C) nano hybrids are successfully syn thesized via a solvothermal method by sulfidation iron-based metal organic framework (FeMOF). As sodium ion battery an odes, FeySs/N-C nano hybrids exhibit high reversible capacity of 450.8 mAh g-1 at 200 mA·g^-1, and 406.7 mAh·g^-1 at 500 mA·g^-1 even after 500 cycles. They also show excellent rate properties and delivering the capacity of 327.8 mAh·g^-1 at a very high current density of 3.2 A·g^-1. These outstanding electrochemical performa nces can be attributed to the unique structure of Fe7S8/ N-C nan ohybrids. The nano scale dime nsion in their size can be ben eficial for facile ion and electro n tran sports. Furthermore, the stable n itroge n doped carb on frameworks can also improve electrical conductivity and relieve the problems related to volume expansion. X-ray absorption spectroscopy and X-ray photoelectron spectroscopy analyses have been performed to study reactions occurred in spindle-like FeySs/N-C nanohybrid electrode at both bulk and surface. | Aihua Jin Mi-Ju Kim Kug-Seung Lee Seung-Ho Yu Yung-Eun Sung | 2019 | Nano Research2019，12，3： | 5 |
| 9 | Biliary phytobezoar resulting in intestinal obstruction显示文摘Phytobezoar is the most common type of bezoar.It is composed of indigestible vegetable matter and is usually found in the stomach.Biliary phytobezoar is extremely rare and difficult to diagnose preoperatively.The pathogenesis is not clear,and there have been only a few reports of biliary bezoars associated with sphincteric impairmentat the ampulla of Vater.Here,we present a report of biliary bezoar that resulted in jejunal obstruction.We were unable to identifythe bezoar in the extrahepatic bile duct until it obstructed the small bowel lumen.To our knowledge,this is the first report of small bowel obstruction resulting frommigration of a biliary bezoar. | Yura Kim Beom Jin Park Min Ju Kim Deuk Jae Sung Dong-Sik Kim Young-Dong Yu Jeong Hyeon Lee | 2013 | World Journal of Gastroenterology2013，19，1： | 5 |
| 10 | Role of stem cell therapies in treating chronic wounds:A systematic review显示文摘BACKGROUND The impairment of cutaneous wound healing results in chronic,non-healing wounds that are caused by altered wound environment oxygenation,tissue injury,and permissive microbial growth.Current modalities for the treatment of these wounds inadequately address the complex changes involved in chronic wound pathogenesis.Consequently,stem cell therapies have emerged as a potential therapeutic modality to promote cutaneous regeneration through trophic and paracrine activity.AIM To investigate current literature regarding use of stem cell therapies for the clinical treatment of chronic,non-healing wounds.METHODS PubMed,EMBASE,Cochrane Library,Web of Science,and Scopus were queried with combinations of the search terms“mesenchymal stem cells,”“adult stem cells,”“embryonic stem cells,”“erythroid precursor cells,”“stem cell therapies,”and“chronic wounds”in order to find relevant articles published between the years of 2000 and 2019 to review a 20-year experience.Reference lists from the articles were reviewed to identify additional pertinent articles.Retrieved manuscripts(reviews,case reports/series,retrospective/prospective studies,and clinical trials)were evaluated by the authors for their depiction of clinical stem cell therapy use.Data were extracted from the articles using a standardized collection tool.RESULTS A total of 43 articles describing the use of stem cell therapies for the treatment of chronic wounds were included in this review.While stem cell therapies have been explored in in vitro and in vivo applications in the past,recent efforts are geared towards assessing their clinical role.A review of the literature revealed that adipose-derived stem cells,bone marrow-derived stem cells,bone marrowderived mononuclear cells,epidermally-derived mesenchymal stem cells,fibroblast stem cells,keratinocyte stem cells,placental mesenchymal stem cells,and umbilical cord mesenchymal stem cells have all been employed in the treatment of chronic wounds of various etiologies.Most recently,embryonic stem cells have emerged as a novel stem cell therapy with the capacity for multifaceted germ cell layer differentiation.With the capacity for self-renewal and differentiation,stem cells can enrich existing cell populations in chronic wounds in order to overcome barriers impeding the progression of wound healing.Further,stem cell therapies can be utilized to augment cell engraftment,signaling and activity,and resultant patient outcomes.CONCLUSION Assessing observed clinical outcomes,potential for stem cell use,and relevant therapeutic challenges allows wound care stakeholders to make informed decisions regarding optimal treatment approaches for their patients’chronic wounds. | Anjali C Raghuram Roy P Yu Andrea Y Lo Cynthia J Sung Melissa Bircan Holly J Thompson Alex K Wong | 2020 | World Journal of Stem Cells2020，12，7： | 5 |
| 11 | Effect of a seasonal diffuse pollution migration on natural organic matter behavior in a stratified dam reservoir显示文摘This article aims to describe the influence of diffuse pollution on the temporal and spatial characteristics of natural organic matter (NOM) in a stratified dam reservoir,the Daecheong Dam,on the basis of intensive observation results and the dynamic water quality simulation using CE-QUAL-W2.Turbidity is regarded as a comprehensive representation of allochothonous organic matter from diffuse sources in storm season because the turbidity concentration showed reasonable significance in a statistical correlation with the UV absorbance at 254 nm and total phosphorus.CE-QUAL-W2 simulation results showed good consistency with the observed data in terms of dissolved organic matter (DOM) including refractory dissolved organic carbon (RDOC) and labile DOC and also well explained the internal movement of constituents and stratification phenomenon in the reservoir.Instead turbidity and NOM were related well in the upper region of the reservoir according to flow distance,gradually as changing to dissolved form of organic matter,RDOM affected organic matter concentration of reservoir water quality compared to turbidity.To control the increase of soluble organic matters in the dam reservoir,appropriate dam water discharge gate operation provided effective measurement.Because of the gate operation let avoid the accumulation of organic matter within a dam reservoir by shorten of turbid regime retention time. | Soon Ju Yu Jae Yil Lee Sung Ryong Ha | 2010 | Journal of Environmental Sciences2010，22，6： | 5 |
| 12 | Cell cycle-related kinase reprograms the liver immune microenvironment to promote cancer metastasis显示文摘The liver is an immunologically tolerant organ and a common metastatic site of multiple cancer types.Although a role for cancer cell invasion programs has been well characterized,whether and how liver-intrinsic factors drive metastatic spread is incompletely understood.Here,we show that aberrantly activated hepatocyte-intrinsic cell cycle-related kinase(CCRK)signaling in chronic liver diseases is critical for cancer metastasis by reprogramming an immunosuppressive microenvironment.Using an inducible liverspecific transgenic model,we found that CCRK overexpression dramatically increased both B16F10 melanoma and MC38 colorectal cancer(CRC)metastasis to the liver,which was highly infiltrated by polymorphonuclear-myeloid-derived suppressor cells(PMNMDSCs)and lacking natural killer T(NKT)cells.Depletion of PMN-MDSCs in CCRK transgenic mice restored NKT cell levels and their interferon gamma production and reduced liver metastasis to 2.7% and 0.7%(metastatic tumor weights)in the melanoma and CRC models,respectively.Mechanistically,CCRK activated nuclear factor-kappa B(NF-κB)signaling to increase the PMN-MDSC trafficking chemokine C-X-C motif ligand 1(CXCL1),which was positively correlated with liver-infiltrating PMN-MDSC levels in CCRK transgenic mice.Accordingly,CRC liver metastasis patients exhibited hyperaaivation of hepatic CCRK/NF-κB/CXCL1 signaling,which was associated with accumulation of PMN-MDSCs and paucity of NKT cells compared to healthy liver transplantation donors.In summary,this study demonstrates that immunosuppressive reprogramming by hepatic CCRK signaling undermines antimetastatic immunosurveillance.Our findings offer new mechanistic insights and therapeutic targets for liver metastasis intervention. | Xuezhen Zeng Jingying Zhou Zhewen Xiong Hanyong Sun Weiqin Yang Myth T.S.Mok Jing Wang Jingqing Li Man Liu Wenshu Tang Yu Feng Hector Kwong-Sang W ang Shun-Wa Tsang King-Lau Chow Philip Chun Yeung John Wong Paul Bo-San Lai Anthony Wing-Hung Chan Ka Fai To Stephen Lam Chan Qiang Xia Jing Xue Xiao Chen Jun Yu Sui Peng Joseph Jao-Yiu Sung Ming Kuang Alfred Sze-Lok Cheng | 2021 | Cellular & Molecular Immunology2021，18，4： | 5 |
| 13 | Mitochondria as therapeutic targets for cancer stem cells显示文摘Cancer stem cells(CSCs) are maintained by theirsomatic stem cells and are responsible for tumor initiation, chemoresistance, and metastasis. Evidence for the CSCs existence has been reported for a number of human cancers. The CSC mitochondria have been shown recently to be an important target for cancer treatment, but clinical significance of CSCs and their mitochondria properties remain unclear. Mitochondriatargeted agents are considerably more effective compared to other agents in triggering apoptosis of CSCs, as well as general cancer cells, via mitochondrial dysfunction. Mitochondrial metabolism is altered in cancer cells because of their reliance on glycolytic intermediates, which are normally destined for oxidative phosphorylation. Therefore, inhibiting cancer-specific modifications in mitochondrial metabolism, increasing reactive oxygen species production, or stimulating mitochondrial permeabilization transition could be promising new therapeutic strategies to activate cell death in CSCs as well, as in general cancer cells. This review analyzed mitochondrial function and its potential as a therapeutic target to induce cell death in CSCs. Furthermore, combined treatment with mitochondriatargeted drugs will be a promising strategy for the treatment of relapsed and refractory cancer. | In Sung Song Jeong Yu Jeong Seung Hun Jeong Hyoung Kyu Kim Kyung Soo Ko Byoung Doo Rhee Nari Kim Jin Han | 2015 | World Journal of Stem Cells2015，7，2： | 4 |
| 14 | Highly flexible conductive fabrics with hierarchically nanostructured amorphous nickel tungsten tetraoxide for enhanced electrochemical energy storage显示文摘非结晶的镍钨 tetraoxide (NiWO 4) nanostructures (NS ) 成功地用灵巧的 onestep 在一件灵活传导性的织物(CF ) 上被综合电气化学的免职(编辑) 方法。与应用外部 cathodic 电压(为 15 min 的 1.8 V ) ,有像节的形态学的非结晶的 NiWO 4 NS 在种子涂的 CF 底层上粘住很好。 CF ( NiWO 4 NSs/CF )上的像节的非结晶的 NiWO 4 NS 为 pseudocapacitors 作为一个灵活、没有文件夹的电极被采用,它与高特定的电容(在 2 A/g 的 1,190.2 F/g )展出显著电气化学的性质,优秀周期的稳定性(92%在 10 A/g ),并且在 1 个 M KOH 电解质答案的好率能力(在 20 A/g 的 765.7 F/g )。优异电气化学的性质能被归功于到层次结构和像节的非结晶的 NiWO 4 NSs/CF 的大特定的表面区域。为灵活 CF 上的金属钨 tetraoxide nanomaterials 的合成的这个划算的灵巧的方法能是有希望的为先进电子并且精力存储设备应用。 | Goli Nagaraju Ramesh Kakarla Sung Min Cha Jae Su Yu | 2015 | Nano Research2015，8，12： | 4 |
| 15 | A facile one-step approach to hierarchically assembled core-shell-like MnO2@MnO2 nanoarchitectures on carbon fibers: An efficient and flexible electrode material to enhance energy storage显示文摘层次核心似壳的 MnO 2 nanostructures (NS ) 在碳布(CC ) 上习惯于六角形的 nanoplate 穿的锚 MnO 2(HNPA ) 纤维。NS 被一出新奇一步舞准备电气化学的免职方法。在为 30 min 的 -2.0 V 的外部 cathodic 电压下面,层次核心似壳的 MnO 2-NS-decorated MnO 2 HNPA (MnO 2 NSs@MnO 2 HNPA ) 一致地与可靠粘附在 CC 上被种。阶段纯净和样品的词法性质被各种各样的物理化学的技术描绘。在经常的外部 cathodic 电压, CC 上的 MnO 2 NSs@MnO 2 HNPA 的生长为不同时间时期被带。当为 pseudocapacitors 作为一个灵活、柔韧、没有文件夹的电极利用了时,显示出的 CC 上的层次核心似壳的 MnO 2 NSs@MnO 2 HNPA 清楚地在 1 M Na 2 那么 4 电解质答案。结果显示 CC 上的 MnO 2 NSs@MnO 2 HNPA 在 CC (在 0.5 A/g 当前的密度的 112.1 F/g ) 上与赤裸的 MnO 2 HNPA 的相比与优秀骑车稳定性在 0.5 A/g 的当前的密度有 244.54 F/g 的一个最大的特定的电容。我们相信 pseudocapacitive 电极的优异费用存储表演能主要被归因于有一个大特定的表面区域的层次 MnO 2 NSs@MnO 2 HNPA 积木,提供为有效电气化学的反应的另外的 electroactive 地点。纺织品上的层次 pseudocapacitive 材料的生长的灵巧、单个步的途径基于电极为高效的灵活精力存储设备的制造开创可能性。 | Goli Nagaraju Yeong Hwan Ko Sung Min Cha Sang Hyuk Im Jae Su Yu | 2016 | Nano Research2016，9，5： | 3 |
| 16 | Adjuvant capecitabine plus oxaliplatin for gastric cancer after D2 gastrectomy (CLASSIC): 5-year follow-up of an open-label, randomised phase 3 trial显示文摘 | Sung Hoon Noh Sook Ryun Park Han-Kwang Yang Hyun Cheol Chung Ik-Joo Chung Sang-Woon Kim Hyung-Ho Kim Jin-Hyuk Choi Hoon-Kyo Kim Wansik Yu Jong Inn Lee Dong Bok Shin Jiafu Ji Jen-Shi Chen Yunni Lim Stella Ha Yung-Jue Bang | 2014 | Lancet Oncology2014，，12： | 3 |
| 17 | Ten‐Day Quadruple Therapy Comprising Proton‐Pump Inhibitor, Bismuth, Tetracycline, and Levofloxacin Achieves a High Eradication Rate for H elicobacter pylori Infection after Failure of Sequential Therapy显示文摘 | Ping‐I Hsu Wen‐Chi Chen Feng‐Woei Tsay Chih‐An Shih Sung‐Shuo Kao Huay‐Min Wang Hsien‐Chung Yu Kwok‐Hung Lai Hui‐Hwa Tseng Nan‐Jing Peng Angela Chen Chao‐Hung Kuo Deng‐Chyang Wu | 2014 | Helicobacter2014，，1： | 3 |
| 18 | Influence of Bi addition on dynamic recrystallization and precipitation behaviors during hot extrusion of pure Mg显示文摘Low material cost and high extrudability for ensuring price competitiveness with Al alloys,as well as excellent mechanical properties,are essential for expanding the application range of Mg extrudates.Bi is a promising alloying element for developing extruded Mg alloys that satisfy such requirements.Bi is inexpensive,exhibits a high solubility limit,and forms a thermally stable Mg3Bi2 phase,which improves the commercial viability and enables the high-speed extrusion of Mg–Bi alloys.In this study,the effects of Bi addition on the dynamic recrystallization(DRX)and dynamic precipitation behaviors during hot extrusion of a pure Mg and the resultant microstructure and mechanical properties of the extruded materials were investigated.The addition of 6 wt%and 9 wt%Bi to a pure Mg yielded numerous fine Mg3Bi2 precipitates during the early stage of hot extrusion.Consequently,the area fraction of dynamic recrystallized(DRXed)grains decreased because of DRX-behavior suppression by the Zener pinning effect.However,the DRXed grain size was substantially reduced through the grain-boundary pinning effect.The size and number of undissolved Mg3Bi2 particles in the homogenized billets increased when the Bi content was increased,which resulted in increased DRX fractions owing to the enhanced levels of particle stimulated nucleation.Bi addition yielded considerable strength improvement of the extruded pure Mg.However,the extruded Mg–Bi binary materials were less ductile than the extruded pure Mg material.This lower ductility resulted from the cracking at twins formed in the coarse unDRXed grains of the Mg-6Bi material and the cracking at large undissolved Mg3Bi2 particles in the Mg-9Bi material. | Jongbin Go Jong Un Lee Hui Yu Sung Hyuk Park | 2020 | Journal of Materials Science & Technology2020，44，9： | 3 |
| 19 | Performance of supersonic model combustors with staged injections of supercritical aviation kerosene显示文摘Supersonic model combustors using two-stage injections of supercritical kerosene were experimentally investigated in both Mach 2.5 and 3.0 model combustors with stagnation temperatures of approximately 1,750 K.Supercritical kerosene of approximately 760 K was prepared and injected in the overall equivalence ratio range of 0.5-1.46.Two pairs of integrated injector/flameholder cavity modules in tandem were used to facilitate fuel-air mixing and stable combustion.For single-stage fuel injection at an upstream location,it was found that the boundary layer separation could propagate into the isolator with increasing fuel equivalence ratio due to excessive local heat release,which in turns changed the entry airflow conditions.Moving the fuel injection to a further downstream location could alleviate the problem,while it would result in a decrease in combustion efficiency due to shorter fuel residence time.With two-stage fuel injections the overall combustor performance was shown to be improved and kerosene injections at fuel rich conditions could be reached without the upstream propagation of the boundary layer separation into the isolator.Furthermore,effects of the entry Mach number and pilot hydrogen on combustion performance were also studied. | Feng-Quan Zhong Xue-Jun Fan Gong Yu Jian-Guo Li Chih-Jen Sung | 2010 | Acta Mechanica Sinica2010，26，5： | 3 |
| 20 | Tumor Suppressor Functions of miR-133a in Colorectal Cancer显示文摘 | Yujuan Dong Junhong Zhao Chung-Wah Wu Lijing Zhang Xiaodong Liu Wei Kang Wing-Wah Leung Ning Zhang Francis K.L. Chan Joseph J.Y. Sung Simon S.M. Ng Jun Yu | 2013 | Molecular Cancer Research2013，，9： | 3 |
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