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| 1 | Role of autophagy in the pathophysiology of nonalcoholic fatty liver disease:A controversial issue显示文摘Autophagy is a mechanism involved in cellular homeostasis under basal and stressed conditions delivering cytoplasmic content to the lysosomes for degradation to macronutrients.The potential role of autophagy in disease is increasingly recognised and investigated in the last decade.Nowadays it is commonly accepted that autophagy plays a role in the hepatic lipid metabolism.Hence,dysfunction of autophagy may be an underlying cause of non-alcoholic fatty liver disease.However,controversy of the exact role of autophagy in the lipid metabolism exists:some publications report a lipolytic function of autophagy,whereas others claim a lipogenic function.This review aims to give an update of the present knowledge on autophagy in the hepatic lipid metabolism,hepatic insulin resistance,steatohepatitis and hepatic fibrogenesis. | Wilhelmus J Kwanten Wim Martinet Peter P Michielsen Sven M Francque | 2014 | World Journal of Gastroenterology2014，20，23： | 17 |
| 2 | Percutaneous left atrial appendage closure:Technical aspects and prevention of periprocedural complications with the watchman device显示文摘Transcatheter closure of the left atrial appendage has been developed as an alternative to chronic oral anticoagulation for stroke prevention in patients with atrial fibrillation, and as a primary therapy for patients with contraindications to chronic oral anticoagulation. The promise of this new intervention compared with warfarin has been supported by several, small studies and two pivotal randomized trial with the Watchman Device. The results regarding risk reduction for stroke have been favourable although acute complications were not infrequent. Procedural complications, which are mainly related to transseptal puncture and device implantation, include air embolism, pericardial effusions/tamponade and device embolization. Knowledge of nature, management and prevention of complications should minimize the risk of complications and allow transcatheter left atrial appendage closure to emerge as a therapeutic option for patients with atrial fibrillation at risk for cardioembolic stroke. | Sven M bius-Winkler Nicolas Majunke Marcus Sandri Norman Mangner Axel Linke Gregg W Stone Ingo D hnert Gerhard Schuler Peter B Sick | 2015 | World Journal of Cardiology2015，7，2： | 14 |
| 3 | Extended surgical resection for xanthogranulomatous cholecystitis mimicking advanced gallbladder carcinoma: A case report and review of literature显示文摘Xanthogranulomatous 胆汁(XGC ) 是胆囊的破坏煽动性的疾病,很少包含邻近的机关并且模仿国王先进胆囊癌。诊断在病理学的检查以后仅仅通常是可能的。46 42 岁的女人被指我们包含肝核,正确的肝脑叶,恰好结肠的弯曲,和十二指肠的怀疑的胆囊癌症的中心。刷细胞学获得了由内视镜后退胆管造影术(ERC ) 出现了高级发育异常。病人经历了团的在团体切除术,由正确叶切除术,正确的半结肠切除术,和部分十二指肠的切除术组成。出人意料地揭示的病理学的检查一 XGC.Only,为有邻近的机关的直接参与的 XGC 的扩大外科的切除术的六个案例到目前为止被报导了。在这些情况中,与癌给 XGC 的可能的共存,恶意不能被排除,甚至在细胞学和 intraoperative 冰冻切片调查以后。在结论,由于源于在另外的方面上包围机关的高度好攻击的煽动性的侵略的一个方面和可能的复杂并发症上的胆囊癌的差的预后,它似乎这些案例应该被当作恶性瘤直到不那样证明。临床医生们应该包括 XGC 在之中可能微分在肝核群众诊断。 | Antonino Spinelli Guido Schumacher Andreas Pascher Enrique Lopez-Hanninen Hussain Al-Abadi Christoph Benckert Igor M Sauer Johann Pratschke Ulf P Neumann Sven Jonas Jan M Langrehr Peter Neuhaus | 2006 | World Journal of Gastroenterology2006，12，14： | 13 |
| 4 | Spatio-temporal Variability of Soil Water at Three Seasonal Floodplain Sites: A Case Study in Tarim Basin,Northwest China显示文摘The floodplain vegetation of the Tarim River in Northwest China is strongly influenced by irrigated agriculture. The abstraction of river water disturbs the natural dynamics of the floodplain ecosystem. The human impact on the hydrological system by bank dams and the irrigation of cotton plantings have caused adverse changes of the Tarim River and its floodplains, so the current stocks of the typical Tugai vegetation show significant signs of degradation. Field studies of soils and statistical analysis of soil moisture data have shown that the vitality of the Tugai vegetation is primarily determined by its position to the riverbank and the groundwater. There exist complex interactions between soil hydrological conditions and the vitality of the vegetation. But the availability of water is not only influenced by the groundwater level and seasonal flood events. The spatial distribution of stocks at different states of vitality seems also to be decisively influenced by physical soil properties. Our results show that the water supply of plant communities is strongly influenced by the soil texture. Spatial differences of soil moisture and corresponding soil water tensions may be the decisive factors for the zonation of vegetation. Physical soil properties control the water retention and rising of capillary water from deeper soil layers and the phreatic zone and may supply the root systems of the phreatophytic vegetation with water. | Sven GRASHEY-JANSEN Martin KUBA Bernd CYFFKA müt HALIK Tayierjiang AISHAN | 2014 | Chinese Geographical Science2014，24，6： | 3 |
| 5 | 欧亚大陆苔原生态系统的碳循环与甲烷交换显示文摘本文总结了瑞典-俄罗斯94’苔原生态考察期间,在欧亚大陆北部一系列关于痕量气体实际与潜在的交换的研究中所获得的资料和结果。研究发现:①碳在有机苔原土壤中的长期累积速率,即大气CO_2的净吸收与简单的气候参数有关,例如7月份平均气温和年降水量等。②生态系统呼吸释放的碳受到气候条件的强烈影响;温度升高、含水量下降都对CO_2通量有促进作用;然而,土壤有机碳以CO_2形式的释放还受到其他因子的制约,如所贮存的有机化合物的低分解能力。③欧亚大陆北部甲烷在典型苔原生境中的释放稍低于北美地区类似的生境中的释放;这种差异可能与沿俄罗斯北极海岸的温度一般低于北美地区测点的温度有关。 | T.R.Christensen Sven Jonasson TervyV.Callaghan Mats Havstrm FrancisR.Livens 闵庆文 | 1999 | 人类环境杂志1999，28，3： | 3 |
| 6 | A Randomized, Controlled Trial of the Pan-PPAR Agonist Lan ifi branor in NASH显示文摘Methods:In this phase 2b,double-blind,randomized,placebo-controlled trial,patients with noncirrhotic,highly active NASH were randomly assigned in a 1:1:1 ratio to receive 1200 mg or 800 mg of lanifibranor or placebo once daily for 24 weeks.The primary end point was a decrease of at least 2 points in the SAF-A score(the activity part of the Steatosis,Activity,Fibrosis[SAF]scoring system that incorporates scores for ballooning and inflammation)without worsening of fibrosis;SAF-A scores range from 0 to 4,with higher scores indicating more-severe disease activity.Secondary end points included resolution of NASH and regression of fibrosis. | Sven M Francque | 2021 | 四川生理科学杂志2021，43，8： | 3 |
| 7 | Increasing applicability of liver transplantation for patients with hepatitis B–related liver disease显示文摘 | Thomas Steinmüller Daniel Seehofer Nada Rayes Andrea R. Müller Utz Settmacher Sven Jonas Ruth Neuhaus Thomas Berg Uwe Hopf Peter Neuhaus | 2002 | Hepatology2002，，6： | 2 |
| 8 | Solid lipid nanoparticles (SLN) for controlled drug delivery – a review of the state of the art显示文摘 | Rainer H. Müller Karsten M?der Sven Gohla | 2000 | European Journal of Pharmaceutics and Biopharmaceutics2000，，1： | 2 |
| 9 | Increasing applicability of liver transplantation for patients with hepatitis B–related liver disease显示文摘 | Thomas Steinmüller Daniel Seehofer Nada Rayes Andrea R. Müller Utz Settmacher Sven Jonas Ruth Neuhaus Thomas Berg Uwe Hopf Peter Neuhaus | 2002 | Hepatology2002，，6： | 2 |
| 10 | Enhancement of intrinsic tumor cell radiosensitivity induced by a selective cyclooxygenase-2 inhibitor显示文摘 | Sven P Luke M | 2000 | Clin Cancer Res2000，，6： | 1 |
| 11 | Pulmonary arterial hypertension显示文摘 | David M Sven G Peter D | 2013 | OrphanetJ Rare Dis2013，8，： | 1 |
| 12 | Solid lipid nanoparticles (SLN) for controlled drug delivery-a review of the state or the art 显示文摘 | Muller RH Karsten M Sven G | 2000 | Eur J Pharm Biopharm2000，50，1： | 1 |
| 13 | Oral Ibuprofen versus Intravenous Ibuprofen or Intravenous Indomethacin for the Treatment of Patent Ductus Arteriosus in Preterm Infants: A Systematic Review and Meta-Analysis显示文摘 | Neumann Roland Schulzke Sven M Bührer Christoph | 2012 | Neonatology2012，，1： | 1 |
| 14 | Conductivity in polyacetytene 3 ab initio calculations for a two - site model for electron transfer显示文摘 | Lucia R M Sven L | 1996 | J Phys Chem1996，，100： | 1 |
| 15 | Therapeutic potential of oligonucleotides expressing immunosuppressive TTAGGG motifs显示文摘 | KLINMAN D M IHSAN G SVEN K | 2003 | Ann NY Acad Sci2003，1058，： | 1 |
| 16 | Performance of ahigh alloyed stainless steel in marine environments显示文摘 | Sven Bemhardsson Rolf Mellstr^m | 1985 | Anti-Corrosion1985，，： | 1 |
| 17 | Catalytic materials for high-temperature combustion显示文摘 | Marcus F Zwinkels M Sven G | 1993 | Catal Rev1993，35，3： | 1 |
| 18 | Hepatic and extrahepatic malignancies in autoimmune hepatitis. A long-term follow-up in 473 Swedish patients显示文摘 | M?rten Werner Sven Almer Hanne Prytz Stefan Lindgren Sven Wallerstedt Einar Bj?rnsson Annika Bergquist Hanna Sandberg-Gertzén Rolf Hultcrantz Per Sangfelt Ola Weiland ?ke Danielsson | 2008 | Journal of Hepatology2008，，2： | 1 |
| 19 | Solid lipid nanoparticles(SLN)for controlled drug delivery-a review of the state or the art显示文摘 | Müller RH Karsten M Sven G | 2000 | Eur J Pharm Biopham2000，50，6： | 1 |
| 20 | MRI scanning and incus fixation in vibrant soundbridge implantation显示文摘 | Ingo T Rainer OS Sven M | 2004 | Otology & Neurotology2004，25，： | 1 |
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