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您的检索式：作者名="TAN ChengMin"
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| 1 | Phosphorylation inhibition of protein-tyrosine phosphatase 1B tyrosine-152 induces bone regeneration coupled with angiogenesis for bone tissue engineering显示文摘A close relationship has been reported to exist between cadherin-mediated cell-cell adhesion and integrin-mediated cell mobility,and protein tyrosine phosphatase 1B(PTP1B)may be involved in maintaining this homeostasis.The stable residence of mesenchymal stem cells(MSCs)and endothelial cells(ECs)in their niches is closely related to the regulation of PTP1B.However,the exact role of the departure of MSCs and ECs from their niches during bone regeneration is largely unknown.Here,we show that the phosphorylation state of PTP1B tyrosine-152(Y152)plays a central role in initiating the departure of these cells from their niches and their subsequent recruitment to bone defects.Based on our previous design of a PTP1B Y152 region-mimicking peptide(152RM)that significantly inhibits the phosphorylation of PTP1B Y152,further investigations revealed that 152RM enhanced cell migration partly via integrinαvβ3 and promoted MSCs osteogenic differentiation partly by inhibiting ATF3.Moreover,152RM induced type H vessels formation by activating Notch signaling.Demineralized bone matrix(DBM)scaffolds were fabricated with mesoporous silica nanoparticles(MSNs),and 152RM was then loaded onto them by electrostatic adsorption.The DBM-MSN/152RM scaffolds were demonstrated to induce bone formation and type H vessels expansion in vivo.In conclusion,our data reveal that 152RM contributes to bone formation by coupling osteogenesis with angiogenesis,which may offer a potential therapeutic strategy for bone defects. | Yong Tang Keyu Luo Yin Chen Yueqi Chen Rui Zhou Can Chen Jiulin Tan Moyuan Deng Qijie Dai Xueke Yu Jian Liu Chengmin Zhang Wenjie Wu Jianzhong Xu Shiwu Dong Fei Luo | 2021 | Bioactive Materials2021，6，7： | 3 |
| 2 | Broadband radio spectral observations of the solar eclipse on 2008-08-01 and its implications on the quiet Sun atmospheric model显示文摘Based on the joint-observations of the radio broadband spectral emissions of the solar eclipse on August 1, 2008 at Jiuquan (total eclipse) and Huairou (partial eclipse) at the frequencies of 2.00-5.60 GHz (Jiuquan), 2.60-3.80 GHz (Chinese solar broadband radiospectrometer, SBRS/Huairou), and 5.20-7.60 GHz (SBRS/Huairou), the authors assemble a successive series of broadband spectra with a frequency of 2.60-7.60 GHz to observe the solar eclipse synchronously. This is the first attempt to analyze the solar eclipse radio emission under the two telescopes located at different places with broadband frequencies in the periods of total and partial eclipses. With these analyses, the authors made a semiempirical model of the coronal plasma density of the quiet Sun, which can be expressed as ne 1.42×109(r-2+1.93r-5) (cm-3), in the space range of r=1.039-1.212 R , and made a comparison with the classic model. | TAN BaoLin YAN YiHua ZHANG Yin TAN ChengMin HUANG Jing LIU YuYing FU QiJun CHEN ZhiJun LIU Fei CHEN LinJie JI GuoShu | 2009 | Science China(Physics,Mechanics & Astronomy)2009，52，11： | 2 |
| 3 | A Solar Radio Spectrometer at 5.2–7.6?GHz显示文摘 | Huirong Ji Qijun Fu Yuying Liu Congling Cheng Zhijun Chen Yihua Yan Leping Zheng Zongjun Ning Chengmin Tan Debang Lao Shuke Li Jiyong Gao Zhiqiang Wang Minhong Yu | 2003 | Solar Physics2003，，2： | 1 |
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