| 3 | A synopsis on flavonoids from the roots of Scutellaria baicalensis with some insights on baicalein and its anti-cancer properties显示文摘Flavones are the most dominant type of flavonoids isolated from the roots of Scutellaria baicalensis(Radix Scutellariae), which is a traditional medicinal plant in East Asian countries, including China, Japan and Korea.Most of the flavones are derivatives with methoxyl and hydroxyl groups, and they include baicalein, baicalin, chrysin, norwogonin, oroxylin A and wogonin.Baicalein possesses anti-cancer activities against a wide spectrum of human cancer cells by inducing apoptosis and cell cycle arrest, and by inhibiting angiogenesis, metastasis and inflammation.Some examples of the effects of baicalein on apoptosis, cell cycle arrest and metastasis are presented with discussion on the molecular targets and pathways.Studies on the structure-activity relationships of flavonoid cytotoxicity towards human cancer cells show that the potent cytotoxic activities of baicalein can be attributed to its-OH groupsat C5, C6 and C7(triple hydroxylation) of ring A, carbonyl group at C4 of ring C, and C2–C3 double bond of ring C.Studies on structural modifications of baicalein have shown that the configurations at C6 of ring A are critical factors influencing its anti-proliferative activity.Considering the remarkable anti-cancer properties, the future prospects for developing baicalein into an anti-cancer drug are promising. | Eric Wei Chiang Chan Siu Kuin Wong Joseph Tangah Tomomi Inoue Hung Tuck Chan | 2019 | Journal of Chinese Pharmaceutical Sciences2019，28，4： | 0 |
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