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| 1 | Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse显示文摘Hyaluronan(HA)production by dendritic cells(DCs)is known to promote antigen presentation and to augment T-cell activation and proliferation.We hypothesized that pericellular HA can function as intercellular‘glue’directly mediating T cell–DC binding.Using primary human cells,we observed HA-dependent binding between T cells and DCs,which was abrogated upon pre-treatment of the DCs with 4-methylumbelliferone(4-MU),an agent which blocks HA synthesis.Furthermore,T cells regulate HA production by DCs via T cell-derived cytokines in a T helper(Th)subset-specific manner,as demonstrated by the observation that cell-culture supernatants from Th1 but not Th2 clones promote HA production.Similar effects were seen upon the addition of exogenous Th1 cytokines,IL-2,interferon c(IFN-c)and tumor necrosis factor a(TNF-a).The critical factors which determined the extent of DC–T cell binding in this system were the nature of the pre-treatment the DCs received and their capacity to synthesize HA,as T-cell clones which were pre-treated with monensin,added to block cytokine secretion,bound equivalently irrespective of their Th subset.These data support the existence of a feedforward loop wherein T-cell cytokines influence DC production of HA,which in turn affects the extent of DC–T cell binding.We also document the presence of focal deposits of HA at the immune synapse between T-cells and APC and on dendritic processes thought to be important in antigen presentation.These data point to a pivotal role for HA in DC–T cell interactions at the IS. | Paul L Bollyky Stephen P Evanko Rebecca P Wu Susan Potter-Perigo S Alice Long Brian Kinsella Helena Reijonen Kelly Guebtner Brandon Teng Christina K Chan Kathy R Braun John A Gebe Gerald T Nepom Thomas N Wight | 2010 | Cellular & Molecular Immunology2010,7,3: | 3 |
| 2 | Rest chest pain, negative treadmill exercise electrocardiogram and reverse redistribution in dipyridamole myocardial perfusion imaging might be the features of coronary artery spasm显示文摘 | XIANG D C YIN J L TENG A P | 2007 | Clin Cardiol2007,30,10: | 1 |
| 3 | Climate change: potential impact on plant disease显示文摘 | Chakraborty S Tiedemann A V Teng P S | 2000 | Environmental Pollution2000,108,3: | 1 |
| 4 | simplified preparation of mesoporous carbon and the examination of the carbon accessibility for electric double layer formation 显示文摘 | LIU H Y WANG K P TENG H A | 2005 | Carbon2005,43,: | 1 |
| 5 | 查看详情显示文摘 | Jiang B H Li D F Deng Y P Teng F K Chen J Xue S Kong X Q Luo C Shen X Xu F Yang W G Yin J Wang Y H Chen H Wu W Liu X Guo D A | | 0,,03: | 1 |
| 6 | Pharmacokinetic interaction studies of co-administration of ticagrelor and atorvastatin or simvastatin in healthy volunteers显示文摘 | TENG R MITCHELL P D BUTLER K A | 2013 | Eur J Clin Pharmacol2013,69,: | 1 |
| 7 | Climate change:potential impact on plant diseases显示文摘 | CHAKRABORTY S TIEDEMANN A V TENG P S | 2000 | Environmental Pollution2000,108,: | 1 |
| 8 | Structure-activity relation- ship study of novel necroptosis inhibitors 显示文摘 | Teng X Degterev A Jagtap P | 2005 | Bioorg Med Chem Lett2005,15,22: | 1 |
| 9 | Genetic polymorphism in Gymnodinium galatheanum chloroplast DNA sequences and development of a molecular detection assay显示文摘 | Tengs T Bowers H A Ziman A P | 2001 | Molecular Ecology2001,10,: | 1 |
| 10 | 查看详情显示文摘 | Baker S Robinson J S Haworth C A Teng H Smith R A Chirilǎ C C Lein M Tisch J W G Marangos J P | | 0,,: | 1 |
| 11 | Genetic poly- morphism in Gymnodinium galatheanum chloroplast DNA sequences and development of a molecular detec- tion assay 显示文摘 | Tengs T Bowers H A Ziman A P | 2001 | Molecular Ecology2001,10,: | 1 |
| 12 | Rice pest constraints in tropical Asia: quantification of yield losses due to rice pests in a range of production situation 显示文摘 | Savary S Willocquet L Elazegui F A Castilla N P Teng P S | 2000 | Plant Disease2000,84,3: | 1 |
| 13 | Production and characterisation of the intergeneric hybrids between Dendranthema morifolium and Artemisia vulgaris exhibiting enhanced resistance to chrysanthemum aphid (Macrosiphoniella sanbourni) 显示文摘 | Deng Y M Chen S M Lu A M Chen F D Tang F P Guan Z Y Teng N J | 2010 | Planta2010,231,: | 1 |
| 14 | Reprocessing of used tires into activated carbon and other products显示文摘 | TENG H SERIO M A WOJTOWICZ M A BASSILAKIS R SOLOMON P R | 1995 | Ind Eng Chem Res1995,34,15: | 1 |
| 15 | Rest chesl pain, negative treadmill exercise electrocardiogram and reverse redistribution in dipyridamole myocardial perfusion imaging might be the features of coronary artery spasm显示文摘 | XIANG D C YIN J L TENG A P | 2007 | Clin Cardiol2007,30,10: | 1 |
| 16 | Rest chest pain, negative treadmill exercise electrocardiogram and reverse redistribution in dipyridamole myocardial perfusion imaging might be the features of coronary artery spasm显示文摘 | XIANG D C YIN J L TENG A P | 2007 | Clin Cardiol2007,30,10: | 1 |
| 17 | Combination of multiple resistance traits from wild relative species in chrysanthemum via trigeneric hybridization 显示文摘 | Deng Y M Jiang J F Chen S M Teng N J Song A P Guan Z Y Fang W M Chen F D | 2012 | PLoS One2012,7,44: | 1 |
| 18 | Structure-activity relationship study of novel necroptosis inlaibitors 显示文摘 | Teng X Degterev A Jagtap P | 2005 | Bioorg Med Chem Lett2005,15,22: | 1 |
| 19 | Genetic polymorphism in Gymnodinium galatheanum chloroplast DNA sequences and development of a molecular detection assay 显示文摘 | Tengs T Bowers H A Ziman A P | 2001 | Molecular Ecology2001,10,: | 1 |
| 20 | FungalTraits:a user-friendly traits database of fungi and fungus-like stramenopiles显示文摘The cryptic lifestyle of most fungi necessitates molecular identification of the guild in environmental studies.Over the past decades,rapid development and affordability of molecular tools have tremendously improved insights of the fungal diversity in all ecosystems and habitats.Yet,in spite of the progress of molecular methods,knowledge about functional properties of the fungal taxa is vague and interpretation of environmental studies in an ecologically meaningful manner remains challenging.In order to facilitate functional assignments and ecological interpretation of environmental studies we introduce a user friendly traits and character database FungalTraits operating at genus and species hypothesis levels.Combining the information from previous efforts such as FUNGuild and FunFun together with involvement of expert knowledge,we reannotated 10,210 and 151 fungal and Stramenopila genera,respectively.This resulted in a stand-alone spreadsheet dataset covering 17 lifestyle related traits of fungal and Stramenopila genera,designed for rapid functional assignments of environmental stud-ies.In order to assign the trait states to fungal species hypotheses,the scientific community of experts manually categorised and assigned available trait information to 697,413 fungal ITS sequences.On the basis of those sequences we were able to summarise trait and host information into 92,623 fungal species hypotheses at 1%dissimilarity threshold. | Sergei Põlme Kessy Abarenkov RHenrik Nilsson Björn D.Lindahl Karina Engelbrecht Clemmensen Havard Kauserud Nhu Nguyen Rasmus Kjøller Scott T.Bates Petr Baldrian Tobias Guldberg Frøslev Kristjan Adojaan Alfredo Vizzini Ave Suija Donald Pfister Hans-Otto Baral Helle Järv Hugo Madrid Jenni Nordén Jian-Kui Liu Julia Pawlowska Kadri Põldmaa Kadri Pärtel Kadri Runnel Karen Hansen Karl-Henrik Larsson Kevin David Hyde Marcelo Sandoval-Denis Matthew E.Smith Merje Toome-Heller Nalin N.Wijayawardene Nelson Menolli Jr Nicole K.Reynolds Rein Drenkhan Sajeewa S.N.Maharachchikumbura Tatiana B.Gibertoni Thomas Læssøe William Davis Yuri Tokarev Adriana Corrales Adriene Mayra Soares Ahto Agan Alexandre Reis Machado Andrés Argüelles-Moyao Andrew Detheridge Angelina de Meiras-Ottoni Annemieke Verbeken Arun Kumar Dutta Bao-Kai Cui C.K.Pradeep César Marín Daniel Stanton Daniyal Gohar Dhanushka N.Wanasinghe Eveli Otsing Farzad Aslani Gareth W.Griffith Thorsten H.Lumbsch Hans-Peter Grossart Hossein Masigol Ina Timling Inga Hiiesalu Jane Oja John Y.Kupagme József Geml Julieta Alvarez-Manjarrez Kai Ilves Kaire Loit Kalev Adamson Kazuhide Nara Kati Küngas Keilor Rojas-Jimenez Krišs Bitenieks Laszlo Irinyi LászlóGNagy Liina Soonvald Li-Wei Zhou Lysett Wagner M.Catherine Aime MaarjaÖpik María Isabel Mujica Martin Metsoja Martin Ryberg Martti Vasar Masao Murata Matthew PNelsen Michelle Cleary Milan C.Samarakoon Mingkwan Doilom Mohammad Bahram Niloufar Hagh-Doust Olesya Dulya Peter Johnston Petr Kohout Qian Chen Qing Tian Rajasree Nandi Rasekh Amiri Rekhani Hansika Perera Renata dos Santos Chikowski Renato L.Mendes-Alvarenga Roberto Garibay-Orijel Robin Gielen Rungtiwa Phookamsak Ruvishika S.Jayawardena Saleh Rahimlou Samantha C.Karunarathna Saowaluck Tibpromma Shawn P.Brown Siim-Kaarel Sepp Sunil Mundra Zhu-Hua Luo Tanay Bose Tanel Vahter Tarquin Netherway Teng Yang Tom May Torda Varga Wei Li Victor Rafael Matos Coimbra Virton Rodrigo Targino de Oliveira Vitor Xavier de Lima Vladimir S.Mikryukov Yongzhong Lu Yosuke Matsuda Yumiko Miyamoto Urmas Kõljalg Leho Tedersoo | 2020 | Fungal Diversity2020,,6: | 1 |