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| 1 | Bariatric surgery in patients with non-alcoholic fatty liver disease-from pathophysiology to clinical effects显示文摘Non-alcoholic fatty liver disease(NAFLD) is increasingly recognized as a significant liver disease,and it covers the disease spectrum from simple steatosis with a risk of development of non-alcoholic steatohepatitis(NASH) to fibrosis,subsequent cirrhosis,end-stage liver failure,and liver cancer with a potential need for liver transplantation.NAFLD and NASH are closely related to obesity,metabolic syndrome,and type 2 diabetes(T2 D).The role of gut hormones,especially glucagon-like peptide 1(GLP-1),is important in NAFLD.Bariatric surgery has the potential for inducing great weight loss and may improve the symptoms of metabolic syndrome and T2 D.Recent data demonstrated significant effects of bariatric surgery on GLP-1 and other gut hormones and important lipid metabolic and inflammatory abnormalities in the pathophysiology of NAFLD.Therefore,bariatric surgery may reverse the pathological liver changes in NAFLD and NASH patients.In the present review,we describe NAFLD and NASH pathophysiology and the primary effects of bariatric surgery on metabolic pathways.We performed a systematic review of the beneficial and harmful effects and focused on changes in liver disease severity in NAFLD and NASH patients.The specific focus was liver histopathology as assessed by the invasive liver biopsy.Additionally,we reviewed several non-invasive methods used for the assessment of liver disease severity following bariatric surgery. | Tea L Laursen Christoffer A Hagemann Chunshan Wei Konstantin Kazankov Karen L Thomsen Filip K Knop Henning Grønbæk | 2019 | World Journal of Hepatology2019，11，2： | 11 |
| 2 | Roles of nitric oxide in tumor growth显示文摘 | Jenkins D C Charles I G Thomsen L L | 1995 | Proc Natl Acad Sci USA1995，92，10： | 1 |
| 3 | Nitric oxide is a key molecule in migraine and other vascular headaches 显示文摘 | Olescn J Thomsen L L Iversen H | 1994 | Trends Pharmaeol Sci1994，15，5： | 1 |
| 4 | 查看详情显示文摘 | Siegle H Kaczmarczyk G Filippidis L Litvinchuk A P Hoffmann A Thomsen C | | 0，，： | 1 |
| 5 | Monitoring endangered freshwater biodiversity using environmental DNA显示文摘 | Thomsen P F Kielgast J Iversen L L 2012 | 2012 | Molecular Ecology2012，21，： | 1 |
| 6 | SAR/QSAR Approaches to Solubility Portioning and Sorption of Phthalate显示文摘 | Thomsen M Rasmussen AG Carlsen L | 1999 | Chemosphere1999，38，11： | 1 |
| 7 | Nitricoxide sythaseactivity in human breast cancer显示文摘 | Thomsen LL Miles DW Happerfield L | 1995 | Br J Cancer1995，72，： | 1 |
| 8 | SAR/QSAR approaches to solubility portioning and sorption of phthalate显示文摘 | THOMSEN T A GAND C L | 1999 | Chemosphere1999，38，11： | 1 |
| 9 | Antimicrobial peptides effectively kill a broad spectrum of Listeria monoc ytogenes and Staphylococcus aureus strains independently of origin,sub-type,or virulence factor expression显示文摘 | GOTTLIEB C T THOMSEN L E INGMER H | | 0，，： | 1 |
| 10 | The search for the origin of rhythmicity in intestinal contraction from tissue to single cells显示文摘 | Huizinga JD Robinson TL Thomsen L | 2000 | Neurogastroenterol Motil2000，12，： | 1 |
| 11 | Weak elastic anisotropy 显示文摘 | Thomsen L | 1986 | Geophysics1986，51，10： | 1 |
| 12 | Nonhyperbolic reflection moveout in anisotropic media显示文摘 | Tsvankin I Thomsen L | 1994 | Geophysics1994，59，8： | 1 |
| 13 | The processing of pseudorabies virus glycoprotein gX in infected cells and in an unifected cell line 显示文摘 | Bennet L M Timmins J G Thomsen D R | 1986 | Virology1986，155，2： | 1 |
| 14 | Propane hydrate nucleation:Experimental investigation and correlation显示文摘 | JENSEN L THOMSEN K SOLMS N | 2008 | Chemical Engineering Science2008，63，12： | 1 |
| 15 | Weak Elastic Anisotropy显示文摘 | THOMSEN L | 1986 | Geo- physics1986，51，10： | 1 |
| 16 | Distinct cytoplasmic and nuclear functions of the stress induced protein DDIT3/CHOP/GADDJ53显示文摘 | Jauhiainen A Thomsen C Strombom L | 2012 | PLoS One2012，，33： | 1 |
| 17 | 75-plus years of anisotropy in exploration and reservoir seismic : A historical review of concepts and methods 显示文摘 | Helbig K Thomsen L | 2005 | Geophysics2005，70，6： | 1 |
| 18 | Electrophysiological properties of neurons in the internal and external submucous plexus of newborn pig small intestine 显示文摘 | Thomsen L Pearson G T | 1997 | J Physiology1997，498，3： | 1 |
| 19 | The effects of attention on speech perception:An fMRI study 显示文摘 | Hugdahl K Thomsen T Ersland L | 2003 | Brain and Language2003，85，1： | 1 |
| 20 | Role of Nitric Oxide in Tumor Growth显示文摘 | JENKINS D C CHARLES I G THOMSEN L L | 1995 | Proc Natl Acad Sci USA1995，92，： | 1 |
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