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| 1 | Schistosoma mansoni proteins attenuate gastrointestinal motility disturbances during experimental colitis in mice显示文摘AIM:To investigate the therapeutic effect of Schistosoma mansoni(S.mansoni) soluble worm proteins on gastrointestinal motility disturbances during experimental colitis in mice. METHODS:Colitis was induced by intrarectal injection of trinitrobenzene sulphate(TNBS) and 6 h later,mice were treated ip with S.mansoni proteins.Experiments were performed 5 d after TNBS injection.Inflammationwas quantified using validated inflammation parameters. Gastric emptying and geometric center were measured to assess in vivo gastrointestinal motility.Peristaltic activity of distal colonic segments was studied in vitro using a modified Trendelenburg set-up.Cytokine profiles of T-lymphocytes isolated from the colon were determined by real time reverse transcriptase-polymerase chain reaction. RESULTS:Intracolonic injection of TNBS caused severe colitis.Treatment with S.mansoni proteins significantly ameliorated colonic inflammation after 5 d.TNBS did not affect gastric emptying but significantly decreased the geometric center and impaired colonic peristaltic activity 5 d after the induction of colitis.Treatment with S.mansoni proteins ameliorated these in vivo and in vitro motility disturbances.In addition,TNBS injection caused a downregulation of effector T cell cytokines after 5 d,whereas a S.mansoni protein effect was no longer observed at this time point. CONCLUSION:Treatment with S.mansoni proteins attenuated intestinal inflammation and ameliorated motility disturbances during murine experimental colitis. | Nathalie E Ruyssers Benedicte Y De Winter Joris G De Man Natacha D Ruyssers Ann J Van Gils Alex Loukas Mark S Pearson Joel V Weinstock Paul A Pelckmans Tom G Moreels | 2010 | World Journal of Gastroenterology2010，16，6： | 11 |
| 2 | Global, regional, and national prevalence of overweight and obesity in children and adults during 1980–2013: a systematic analysis for the Global Burden of Disease Study 2013显示文摘 | Marie Ng Tom Fleming Margaret Robinson Blake Thomson Nicholas Graetz Christopher Margono Erin C Mullany Stan Biryukov Cristiana Abbafati Semaw Ferede Abera Jerry P Abraham Niveen M E Abu-Rmeileh Tom Achoki Fadia S AlBuhairan Zewdie A Alemu Rafael Alfonso | 2014 | The Lancet2014，，： | 7 |
| 3 | Nutritional modulation of the inflammatory response in inflammatory bowel disease-From the molecular to the integrative to the clinical显示文摘Nutrient deficiencies are common in patients with inflammatory bowel disease (IBD). Both total parenteral and enteral nutrition provide important supportive therapy for IBD patients, but in adults these are not useful for primary therapy. Dietary intervention with omega-3 polyunsaturated fatty acids contained in fish oil may be useful for the care of IBD patients, and recent studies have stressed the role of PPAR on NFκB activity on the potential beneficial effect of dietary lipids on intestinal function. | Gary E Wild Laurie Drozdowski Carmela Tartaglia M Tom Clandinin Alan BR Thomson | 2007 | World Journal of Gastroenterology2007，13，1： | 6 |
| 4 | 系统性药物治疗儿童银屑病的安全性显示文摘银屑病是一种常见的慢性炎症性皮肤病。成年人的发病率为2%~3%,其中大约有三分之一的患者在18岁之前发病。在儿童期,该病的发病率呈线性增长。从1970年至2000年,儿童银屑病的发病率增加了一倍多。尽管对许多轻度银屑病患儿而言,局部治疗已足够,但对更多可能影响生活质量的重度或顽固性的银屑病患儿,则往往需要系统性治疗。 | bronckers imgj seyger mmb west dp lara-corrales i tollefson m tom wl hogeling m belazarian l zachariae c mahé e siegfried e philipp s szalai z vleugels ra holland k murphy r baselga e cordoro k lambert j alexopoulos a mrowietz u kievit w paller as 邓婕(编译) 张锡宝(审校) 无 | 2017 | 皮肤性病诊疗学杂志2017，24，5： | 3 |
| 5 | Causes of encephalitis and differences in their clinical presentations in England: a multicentre, population-based prospective study显示文摘 | Julia Granerod Helen E Ambrose Nicholas WS Davies Jonathan P Clewley Amanda L Walsh Dilys Morgan Richard Cunningham Mark Zuckerman Ken J Mutton Tom Solomon Katherine N Ward Michael PT Lunn Sarosh R Irani Angela Vincent David WG Brown Natasha S Crowcroft | 2010 | The Lancet Infectious Diseases2010，，12： | 2 |
| 6 | Relationship of chlamydia pneumonia infection to severity of human coronary atherosclerosis显示文摘 | Katharia E Tom G P Saldeen G | 2000 | Circulation2000，101，： | 2 |
| 7 | Scientific charge-coupled devices显示文摘 | JANESICK J R TOM E STEWART C | 1987 | Optical Engineering1987，26，8： | 2 |
| 8 | Human cytomegalovirus clinical isolates carry at least 19 genes not found in laboratory strains显示文摘 | Cha TA Tom E Kemble GW | 1996 | J Virol1996，70，1： | 2 |
| 9 | Cerebral magnetic resonance imaging in quiescent Crohn's disease patients with fatigue显示文摘AIM To evaluate brain involvement in quiescent Crohn's disease (CD) patients with fatigue using quantitative magnetic resonance imaging(MRI).METHODS Multiple MRI techniques were used to assess cerebral changes in 20 quiescent CD patients with fatigue(defined with at least 6 points out of an 11-point numeric rating scale compared with 17 healthy age and gender matched controls without fatigue. Furthermore, mental status was assessed by cognitive functioning, based on the neuropsychological inventory including the different domains global cognitive functioning, memory and executive functioning and in addition mood and quality of life scores. Cognitive functioning and mood status were correlated with MRI findings in the both study groups.RESULTS Reduced glutamate + glutamine (Glx = Glu + Gln) concentrations (P = 0.02) and ratios to total creatine(P = 0.02) were found in CD patients compared with controls. Significant increased Cerebral Blood Flow(P = 0.05) was found in CD patients (53.08 ± 6.14 mL/100 g/min) compared with controls (47.60 ± 8.62 mL/100 g/min). CD patients encountered significantly more depressive symptoms (P < 0.001). Cognitive functioning scores related to memory (P = 0.007) and executive functioning (P = 0.02) were lower in CD patients and both scores showed correlation with depression and anxiety. No correlation was found subcortical volumes between CD patients and controls in the T1-weighted analysis. In addition, no correlation was found between mental status and MRI findings.CONCLUSION This work shows evidence for perfusion, neurochemical and mental differences in the brain of CD patients with fatigue compared with healthy controls. | Sanne van Erp Ece Ercan Perla Breedveld Lianne Brakenhoff Eidrees Ghariq Sophie Schmid Matthias van Osch Mark van Buchem Bart Emmer Jeroen van der Grond Ron Wolterbeek Daniel Hommes Herma Fidder Nic van der Wee Tom Huizinga Désirée van der Heijde Huub Middelkoop Itamar Ronen Andrea van der Meulen-de Jong | 2017 | World Journal of Gastroenterology2017，23，6： | 2 |
| 10 | Human cytomegalovirus clinical isolation carry at least 19 gene not found in laboratory strains显示文摘 | Cha TA Tom E Kemble GW | 1996 | J Virol1996，70，1： | 1 |
| 11 | 查看详情显示文摘 | James I L Tom D M Salah E Andrew F Karl H S Russell P N | | 0，，： | 1 |
| 12 | Health-related quality of life in autoimmune hepatitis显示文摘Autoimmune hepatitis(AIH)is a severe chronic autoimmune disease and has a significant impact on the patient’s quality of life,in particular regarding psychological problems such as anxiety and depression.Consistent evidence on which patient-related,disease-related or physician-related factors cause health-related quality of life(HRQoL)impairment in patients with AIH is lacking.Current studies on HRQoL in AIH are mainly single-centered,comprising small numbers of patients,and difficult to compare because of the use of different questionnaires,patient populations,and cutoff values.Literature in the pediatric field is sparse,but suggests that children/adolescents with AIH have a lower HRQoL.Knowledge of HRQoL and cohesive factors in AIH are important to improve healthcare for AIH patients,for example by developing an AIH-specific chronic healthcare model.By recognizing the importance of quality of life beyond the concept of biochemical and histological remission,clinicians allow us to seek enhancements and possible interventions in the management of AIH,aiming at improved health. | Romée JALM Snijders Piotr Milkiewicz Christoph Schramm Tom JG Gevers | 2021 | World Journal of Hepatology2021，13，11： | 1 |
| 13 | Human cytomegalovirus isolates carry at least 19 genes not found in laboratory strains 显示文摘 | Cha TA Tom E Kemble GW | 1996 | J Virol1996，70，1： | 1 |
| 14 | Diagnostic and therapeutic approach to cholestatic liver disease显示文摘 | Pérez Fernandez T López Serrano P Tomás E | | 0，，01： | 1 |
| 15 | Tectonostratigraphic development of the Interior Sudan Rifts,Central Africa显示文摘 | TIM R Mchargue TOM L Heidrick JACK E Livingston | 1992 | Tectonophysics1992，21，3： | 1 |
| 16 | Quality assurance of a helical tomotherapy machine显示文摘 | J D Fenwick W A Tom'e H A Jaradat | 2004 | Phys Med Biol2004，，49： | 1 |
| 17 | Developmental validation of short tandem repeat reagent kit for forensic DNA profiling of canine biological material 显示文摘 | Dayton M Koskinen MT Tom BK Mattila A-M Johnston E Halverson J Fantin D Denise S Budowle B Smith DG Kan- thaswamy S | 2009 | Croatian Medical Journal2009，50，： | 1 |
| 18 | Inescticide toxicity and degradation in horseflies as affecte by naturally occurring food plant components显示文摘 | FUHREMANN TOM W LICHTENSTEIN E P | 1979 | J Agric Food Chem1979，27，1： | 1 |
| 19 | Gelatine-starch films: Physicochemical properties and their appli- cation in extending the post-harvest shelf life of avocado (Persea americana)显示文摘 | AGUILAR-MINDEZ M A MART-MARTfNEZ E S TOM/(S S A | 2008 | Journal of the Science of Food and Agriculture2008，88，2： | 1 |
| 20 | The T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP显示文摘 | YUN C H MENGWASSER K E TOMS A V | 2008 | Proc Nat/ Acad Sci U S A2008，105，6： | 1 |
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