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| 1 | Therapeutic effects of Clostridium butyricum on experimental colitis induced by oxazolone in rats显示文摘AIM:To evaluate the therapeutic effects of a probiotic supplement(Clostridium butyricum,CGMCC0313)in a chemically-induced rat model of experimental colitis. METHODS:An experimental ulcerative colitis model was established by rectal injection of oxazolone into the colon of 40 Wistar rats randomly divided into four groups.The positive control group was sacrificed 3 d after colitis onset.The remaining groups were fed daily with either 2 mL of C.butyricum(2.3×1011 CFU/L), 2 mL of mesalamine(100 g/L),or 1 mL of sodium butyrate(50 mmol/L)for 21 d.The animals’body weight, behavior,and bowel movements were recorded weekly. After sacrifice,visual and microscopic observations of pathological changes of colon tissue were made,body weight and wet colon mass index were measured and recorded,and serum levels of interleukin-23(IL-23) and TNF-αwere measured using ELISA.Expression of calcitonin gene-related peptide in colon tissue was measured by RT-PCR.Finally,changes in rat intestinal microflora status were measured in all groups. RESULTS:We found that treatment with C.butyricum lowered the serum levels of both IL-23 and tumor necrosis factor-α(TNF-α)with similar or even better efficiency than that of mesalamine or sodium butyrate. The rat intestinal flora appeared to recover more quickly in the group treated with C.butyricum than in the mesalamine and sodium butyrate groups.Finally,we found that the expression level of calcitonin gene related peptide was elevated in colon tissue in the sodium butyrate treated group but not in the C.butyricum or mesalamine treated groups,indicating a sensitization of colon following sodium butyrate treatment.CONCLUSION:In our experimental colitis model, treatment with C.butyricum CGMCC0313,a probiotic supplement,is at least as efficient as treatment with mesalamine. | Hai-Qiang Zhang Tomas T Ding Jun-Sheng Zhao Xin Yang Hai-Xia Zhang Juan-Juan Zhang Yun-Long Cui | 2009 | World Journal of Gastroenterology2009，15，15： | 19 |
| 2 | Leaf gas exchange and chlorophyll fluorescence in relation to leaf angle, azimuth, and canopy position in the tropical pioneer tree, Macaranga conifera 显示文摘 | ISHIDA A TOMA T MARJENAH | 1999 | Tree Physiology1999，19，： | 1 |
| 3 | Determina- tion of SH- and SS-groups in some food pro- teins using Ellman's reagent 显示文摘 | Beveridge T Toma S J Nakai S | 1974 | Journal of Food Science1974，39，： | 1 |
| 4 | Flow injection fluorimetric determination of thiou- rea显示文摘 | PEREZ-RUIZ T MARTINEZ-LOZANO C TOMAS V | 1995 | Talanta1995，42，3： | 1 |
| 5 | Nondestructive characterization of ductile cast iron by magnetic adaptive testing显示文摘 | VERTESY G UCHIMOTO T TOMAS I | 2010 | Journal of Magnetism and Magnetic Materials2010，322，20： | 1 |
| 6 | Sirolimus-eluting stent for in-stent restenosis of left main coronary artery in Takayasu's arteritis显示文摘 | Furukawa Y Tamura T Toma M | 2005 | Circ J2005，69，： | 1 |
| 7 | Mechanisms of immunotherapy in allergic rhinitis显示文摘 | Jayasekera N P Toma T P Williams A | 2007 | Biomed Pharmacother2007，61，1： | 1 |
| 8 | Inoue stent-graft implantation for thoracoabdominal aortic aneurysm involving the visceral arteries显示文摘 | Imai M Kimura T Toma M | 2008 | Eur J Vasc Endovasc Surg2008，35，4： | 1 |
| 9 | Logistics Service Quality Segment-Customized Procss 显示文摘 | John T Mentzer Daniel Flint G Tomas M Hult | 2001 | Journal of Marketing2001，65，4： | 1 |
| 10 | Determination of-SH and-S-S-groups in some food proteins using Ellman,s reagent显示文摘 | BEVERIDGE T TOMA S J NAKAI S | 1974 | Journal of Food Science1974，39，1： | 1 |
| 11 | Differentiation-related expression of the Thomsen-Friedenreich glycotope in developing human lung and in lung carcinoma:lack of association with malignancy显示文摘 | Toma V Sata T Vogt P | 1999 | Cancer1999，85，10： | 1 |
| 12 | Red tide blooms of Cochlodinium polykrikoides in a coastal cove 显示文摘 | TOMAS C R SMAYDA T J | 2008 | Harmful Algae2008，7，： | 1 |
| 13 | Determination of SH- And SS-groups in Some Food Proteins Using EUman's Reagent 显示文摘 | BEVERIDGE T TOMA S J NAKAI S | 1974 | Journal of Food Science1974，39，： | 1 |
| 14 | Sequence of the flouder (Paralichthys olivaceus) growth hormone-encoding gene and its promoter region 显示文摘 | Toma Y Ohkubo T | 1995 | Gene1995，165，： | 1 |
| 15 | Bronchoscopic lung vol- ume reduction for end-stage emphysema: report on the first 98 patients显示文摘 | Wan I Y Toma T P Geddes D M | 2006 | Chest2006，129，： | 1 |
| 16 | Leaf gas exchange and chlorophyll fluorescence in relation to leaf angle, azimuth, and canopy position in the tropical pioneer tree, Macaranga conifera 显示文摘 | Ishida A Toma T Marjenah | 1999 | Tree Physiol1999，19，： | 1 |
| 17 | A new record for Aedes(Neomelaniconion)lineatopennis(Ludlow) in the Ryukyu Islands 显示文摘 | Miyagi I Toma T | 1977 | Mosquito News1977，37，1： | 1 |
| 18 | Sensitive and rapid detection of Shigella and enteroinvasive Escherichia coli by a loop-mediated isothermal amplification method显示文摘 | Song T Toma C Nakasone N | 2005 | FEMS MicroBiol Lett2005，243，： | 1 |
| 19 | Persistence af human papillomavirus infection as a predictor for recurrence in carcinoma of the cervix after radiotherapy显示文摘 | Nagai Y Toma T Moromizato H | 2004 | Am J Obstet Gynecol2004，191，6： | 1 |
| 20 | Intrauterine 10 microg and 20 microg levonorgestrel systems in postmenopausal women receiving oral oestrogen replacement therapy: clinical, endometrial and metabolic response 显示文摘 | Raudaskoski T Tapanainen J Tomas E | 2002 | BJOG2002，109，2： | 1 |
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