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| 1 | Helicobacter pylori associated chronic gastritis,clinical syndromes,precancerous lesions,and pathogenesis of gastric cancer development显示文摘Helicobacter pylori(H.pylori)infection is well known to be associated with the development of precancerous lesions such as chronic atrophic gastritis(AG),or gastric intestinal metaplasia(GIM),and cancer.Various molecular alterations are identified not only in gastric cancer(GC)but also in precancerous lesions.H.pylori treatment seems to improve AG and GIM,but still remains controversial.In contrast,many studies,including meta-analysis,show that H.pylori eradication reduces GC.Molecular markers detected by genetic and epigenetic alterations related to carcinogenesis reverse following H.pylori eradication.This indicates that these changes may be an important factor in the identification of high risk patients for cancer development.Patients who underwent endoscopic treatment of GC are at high risk for development of metachronous GC.A randomized controlled trial from Japan concluded that prophylactic eradication of H.pylori after endoscopic resection should be used to prevent the development of metachronous GC,but recent retrospective studies did not show the tendency.Patients with precancerous lesions(molecular alterations)that do not reverse after H.pylori treatment,represent the'point of no return'and may be at high risk for the development of GC.Therefore,earlier H.pylori eradication should be considered for preventing GC development prior to the appearance of precancerous lesions. | Jiro Watari Nancy Chen Peter S Amenta Hirokazu Fukui Tadayuki Oshima Toshihiko Tomita Hiroto Miwa Kheng-Jim Lim Kiron M Das | 2014 | World Journal of Gastroenterology2014，20，18： | 60 |
| 2 | Primary Structure of Human Erythrocyte Glycophorin a Isolation and Characterization of Peptides and Complete Amino Acid Sequence显示文摘 | Tomita M Furthmayr H Marchesi V T | 1978 | Biochemistry1978，17，22： | 1 |
| 3 | Human T cell leukemia virus type-I-infected patients with Hashimoto's thyroiditis and Graves' disease显示文摘 | Matsuda T Tomita M Uchihara JN | 2005 | Clin Endocrinol Metab2005，90，10： | 1 |
| 4 | Peripheral gangreme associatedwith Kawasaki disease显示文摘 | Tomita S Chung K Mas M | 1992 | Clin Infect Dis1992，14，： | 1 |
| 5 | Sensorlcss control of permanent-magnet synchronous motors using on-line parameter identification based on system identification theory 显示文摘 | ICHIKAWA S TOMITA M DOKI S OKUMA S | 2006 | IEEE Transactions on Industrial Electronics2006，53，2： | 1 |
| 6 | Paraquat-induced gene expression in rat kidney 显示文摘 | Tomita M Okuyama T Katsuyama H | 2006 | Arch Toxicol2006，，10： | 1 |
| 7 | Space in Systems Biology of Signaling Pathways-Towards Intracellular Molecular Crowding in Silico显示文摘 | Takahashi K Arjunan SNV Tomita M | 2005 | FEBS Letters2005，579，8： | 1 |
| 8 | In-Line Deposition of Organic Light-Emitting Devices for Large Area Applications显示文摘 | May C Tomita Y Toerker M | 2008 | Thin Solid Films2008，516，： | 1 |
| 9 | Biochemical background of paroxysmal he moglobinuri显示文摘 | Tomita M | 1999 | Biochim Biophys Acta1999，1455，6： | 1 |
| 10 | Relationship between apple ripening and browning: chan- ges in polyphenoleontent and polyphenol oxidase 显示文摘 | Murata M Tsurutani M Tomita M Homma S Kaneko K | 1995 | American Chemical Society1995，4，5： | 1 |
| 11 | Bone marrow-derived stem cells can differentiate into retinal cells in injured rat retina显示文摘 | Tomita M Adach Yi Yamada H | 2002 | Stem Cells2002，20，： | 1 |
| 12 | Bone marrow is a source of regenerated cardiomyocytes in duxombicin-induced cantiomyopathy and granulocyte conoy-stinmluting factor enhances migration of bone marrow cells and attenuates cardiotoxicity of doxorubicin under electron microscopy显示文摘 | Tomita S Ishida M Nakatani T | 2004 | J Heart Lung Transplant2004，23，5： | 1 |
| 13 | Alkaloids of Nelumbo nucifera显示文摘 | Tomita M Watannabe Y Tomita M | 1961 | Yakugaku Zasshi1961，81，： | 1 |
| 14 | Neoadiyuvalt chemotherapy for patieants younger tnan 50 years with high-risk squamous cell carcinoma of the cervix显示文摘 | AOKI Y TOMITA M SATO T | 2001 | Gynecol Oncol2001，83，： | 1 |
| 15 | Molecular bases of congenital hypopigmentary disorders in humans and oculocutaneous albinism 1 in Japan显示文摘 | TOMITA Y MIYAMURA Y KONO M | 2000 | Pigment Cell Res2000，13，： | 1 |
| 16 | Important role of local angiotensin I1 activity mediated via type 1 recep tor in the pathogenesis of cardiovascular inflammatory changes induced by chronic blockade of nitric oxide synthesis in rats 显示文摘 | Usui M Egashira K Tomita H | 2000 | Circulation2000，101，： | 1 |
| 17 | Prognostic significance of the combined use of preoperative platelet count and serum carcinoem- bryonic antigen level in non - small - cell lung cancer 显示文摘 | Tomita M Shimizu T Ayabe T | 2010 | Gen Thorac Cardiovasc Surg2010，58，11： | 1 |
| 18 | Impact of preoperative hemoglobin level on survival of non-small cell lung cancer patients 显示文摘 | Tomita M Shimizu T Hara M | 2008 | Anticancer Res2008，28，3： | 1 |
| 19 | The novel formulation design of self-emulsifying drug delivery systems(SEDDS)type O/W microemulsionⅢ:the permeation mechanism of a poorly water soluble drug entrapped O/W microemulsion in rat isolated intestinal membrane by the Ussing chamber method显示文摘 | Araya H Tomita M Hayashi M | 2006 | Drug Metab Pharmacokinet2006，21，1： | 1 |
| 20 | Generation of hybrid transgenic silkworms that express Bombyx mori prolyl-hydroxylase alpha-subunits and human collagens in posterior silk glands:production of cocoons that contained collagens with hydroxylated proline residues显示文摘 | Adachi T Tomita M Shimizu K | 2006 | J Biotechnol2006，126，2： | 1 |
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