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| 1 | Micromolar sodium fluoride mediates anti-osteoclastogenesis in Porphyromonas gingivalis-induced alveolar bone loss显示文摘Osteoclasts are bone-specific multinucleated cells generated by the differentiation of monocyte/macrophage lineage precursors.Regulation of osteoclast differentiation is considered an effective therapeutic approach to the treatment of bone-lytic diseases.Periodontitis is an inflammatory disease characterized by extensive bone resorption. In this study, we investigated the effects of sodium fluoride(Na F) on osteoclastogenesis induced by Porphyromonas gingivalis, an important colonizer of the oral cavity that has been implicated in periodontitis. Na F strongly inhibited the P. gingivalis-induced alveolar bone loss. That effect was accompanied by decreased levels of cathepsin K, interleukin(IL)-1β, matrix metalloproteinase 9(MMP9), and tartrate-resistant acid phosphatase,which were up-regulated during P. gingivalis-induced osteoclastogenesis. Consistent with the in vivo anti-osteoclastogenic effect,Na F inhibited osteoclast formation caused by the differentiation factor RANKL(receptor activator of nuclear factor kB ligand)and macrophage colony-stimulating factor(M-CSF). The RANKL-stimulated induction of the transcription factor nuclear factor of activated T cells(NFAT) c1 was also abrogated by Na F. Taken together, our data demonstrate that Na F inhibits RANKL-induced osteoclastogenesis by reducing the induction of NFATc1, ultimately leading to the suppressed expression of cathepsin K and MMP9.The in vivo effect of Na F on the inhibition of P. gingivalis-induced osteoclastogenesis strengthens the potential usefulness of Na F for treating periodontal diseases. | Ujjal K Bhawal Hye-Jin Lee Kazumune Arikawa Michiharu Shimosaka Masatoshi Suzuki Toshizo Toyama Takenori Sato Ryota Kawamata Chieko Taguchi Nobushiro Hamada Ikuo Nasu Hirohisa Arakawa Koh Shibutani | 2015 | International Journal of Oral Science2015，7，4： | 3 |
| 2 | Long-term outcomes of standard discectomy for lumbar disc herniation:A follow-up study of more than 10 years显示文摘 | Yorimitsu E Chiba K Toyama Y | 2001 | Spine2001，26，6： | 1 |
| 3 | Acta Mater显示文摘 | Mondal K Ohkubo T Toyama T | 2008 | 56 :53292008，56，： | 1 |
| 4 | Region filling and object removal by exemplar-based image inpainting 显示文摘 | CRIMINISI A PEREA P TOYAMA K | 2004 | IEEE Transactions on Image Processing2004，13，9： | 1 |
| 5 | Region filling and object removal by exemplar-based image inpainting 显示文摘 | Criminisi A Perez P Toyama K | 2004 | IEEE Transactions on Image Processing2004，13，9： | 1 |
| 6 | Long term outcomes of standard discectomy for lumbar disc herniation:a follow up study of more than 10 years显示文摘 | Yorimitsu E Chiba K Toyama Y | 2001 | Spine2001，26，6： | 1 |
| 7 | Surgical results and related factors for ossification of posterior longitudinal ligament of the thoracic spine:a multi-institutional retrospective study显示文摘 | Matsumoto M Chiba K Toyama Y | 2008 | Spine2008，33，9： | 1 |
| 8 | Impaired long-term memory retention and working memory in sdy mutant mice with a deletion in Dtnbpl, a susceptibility gene for schizophrenia显示文摘 | TAKAO K TOYAMA K NAKANISHI K | 2008 | Mol Brain2008，1，1： | 1 |
| 9 | Fluoride concentrations and distribution in premolars of children from low and optional fluoride areas 显示文摘 | Takeuchi K Nakagaki H Toyama Y | 1996 | Caries Res1996，30，： | 1 |
| 10 | MAGNET:Ad hoc network system based on mobile agents显示文摘 | KAWAGUCHIA N TOYAMA K INAGAKI Y | 2000 | Computer Communications2000，23，： | 1 |
| 11 | Frequency stability of a Brillouin fiber ring laser 显示文摘 | Nicati P A Toyama K Shaw H J | 1995 | Lightwave Technol1995，13，7： | 1 |
| 12 | Long-term outcomes of standard discectomy for lumbar disc herniation:a follow-up study of more than 10 years显示文摘 | Yorimitsu E Chiba K Toyama Y | | 0，，06： | 1 |
| 13 | Region filling and object removal by exemplar-based image inpainting显示文摘 | Criminisi A Perez P Toyama K | | 0，，13： | 1 |
| 14 | A novel technique for fabricating SMA/CFRP adaptive composites using ultrathin TiNi wires显示文摘 | Xu Y Otsuka K Toyama N | 2004 | Smart Materials & Structures2004，13，1： | 1 |
| 15 | Region filling and object re- moval by examplar-based image inpainting显示文摘 | Crirainisi Perez P Toyama K | 2004 | IEEE Transac- tions on Imagepr Oeessing2004，13，9： | 1 |
| 16 | Long-term outcomes of standard diseectomy for lumbar disc herniation: a follow-up study of more than 10 years显示文摘 | Yorimitsu E Chiba K Toyama Y | 2001 | Spine2001，26，6： | 1 |
| 17 | A new mechanism for the first carbon-carbon bond formation in the MTG process: A theoretical study显示文摘 | TAJIMA N TSUNEDA T TOYAMA F HIRAO K | 1998 | J Am Chem Soc1998，120，32： | 1 |
| 18 | Long-term outcomes of standard discectomy for lumbar disc herniation:a fol ow-up study of more than 10 years显示文摘 | Yorimitsu E Chiba K Toyama Y | | 0，，1976： | 1 |
| 19 | Project lachesis: parsing and modeling location histories 显示文摘 | Hariharan R Toyama K | 2004 | Geographic Information Science2004，，： | 1 |
| 20 | Epidemiology of herpes zester and its relationship to varicella in Japan : A 10-year survey of 48,388 herpes zester cases in Miyazaki prefecture显示文摘 | Toyama N Shiraki K | 2009 | J Med Virol2009，81，12： | 1 |
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